PI4KA (phosphatidylinositol 4-kinase alpha) - Rat Genome Database

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Gene: PI4KA (phosphatidylinositol 4-kinase alpha) Canis lupus familiaris
Analyze
Symbol: PI4KA
Name: phosphatidylinositol 4-kinase alpha
RGD ID: 12330103
Description: ENCODES a protein that exhibits 1-phosphatidylinositol 4-kinase activity (ortholog); INVOLVED IN modulation by host of viral process (inferred); phosphatidylinositol phosphate biosynthetic process (inferred); phosphatidylinositol-mediated signaling (inferred); PARTICIPATES IN inositol metabolic pathway; phosphoinositide metabolic pathway; ASSOCIATED WITH autistic disorder (ortholog); CEDNIK syndrome (ortholog); chromosome 22q11.2 deletion syndrome, distal (ortholog); FOUND IN Golgi-associated vesicle membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; PIK4CA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,630,693 - 30,749,158 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,630,261 - 30,749,126 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,589,065 - 30,707,530 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,039,270 - 32,155,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,038,805 - 32,155,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,085,016 - 30,204,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,709,699 - 29,828,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,798,988 - 30,918,013 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PI4KA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,630,693 - 30,749,158 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,630,261 - 30,749,126 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,589,065 - 30,707,530 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,039,270 - 32,155,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,038,805 - 32,155,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,085,016 - 30,204,201 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,709,699 - 29,828,234 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,798,988 - 30,918,013 (+)NCBIUU_Cfam_GSD_1.0
PI4KA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382220,707,691 - 20,858,811 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2220,707,691 - 20,859,417 (-)EnsemblGRCh38hg38GRCh38
GRCh372221,061,979 - 21,213,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362219,391,979 - 19,543,070 (-)NCBINCBI36Build 36hg18NCBI36
Build 342219,386,544 - 19,517,555NCBI
Celera224,557,005 - 4,704,409 (-)NCBICelera
Celera225,492,598 - 5,494,284 (+)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,329,838 - 4,481,241 (-)NCBIHuRef
CHM1_12221,062,151 - 21,213,286 (-)NCBICHM1_1
T2T-CHM13v2.02221,116,400 - 21,267,532 (-)NCBIT2T-CHM13v2.0
Pi4ka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,098,215 - 17,224,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,098,215 - 17,224,178 (-)EnsemblGRCm39 Ensembl
GRCm381617,280,351 - 17,406,314 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,280,351 - 17,406,314 (-)EnsemblGRCm38mm10GRCm38
MGSCv371617,280,444 - 17,406,407 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,193,915 - 17,319,877 (-)NCBIMGSCv36mm8
Celera1617,853,225 - 17,979,271 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.71NCBI
Pi4ka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,113,390 - 97,234,374 (+)NCBIGRCr8
mRatBN7.21183,609,148 - 83,726,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,609,069 - 83,724,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,336,920 - 92,454,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,998,070 - 85,115,233 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,051,678 - 84,168,839 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,858,323 - 87,975,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,858,453 - 87,973,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01190,914,592 - 91,028,242 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,610,281 - 85,726,603 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,650,877 - 85,767,200 (+)NCBI
Celera1182,373,025 - 82,486,238 (+)NCBICelera
Cytogenetic Map11q23NCBI
Pi4ka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544219,446,955 - 19,598,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544219,446,955 - 19,594,790 (+)NCBIChiLan1.0ChiLan1.0
PI4KA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22330,414,241 - 30,565,263 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12232,963,144 - 33,114,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0222,931,523 - 3,082,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Pi4ka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,376,969 - 140,513,432 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,240,266 - 2,377,093 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,240,641 - 2,377,088 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PI4KA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,390,410 - 50,491,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,390,416 - 50,491,983 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,838,856 - 53,940,687 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PI4KA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,648,184 - 4,797,573 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,648,183 - 4,797,396 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,209,589 - 2,351,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pi4ka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624945837,864 - 1,014,684 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624945837,877 - 1,016,041 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PI4KA
1293 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 16 3 6 12 8 10 6
Low 1 5 6 6 3 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000024235   ⟹   ENSCAFP00000022499
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2630,630,261 - 30,749,126 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845044288   ⟹   ENSCAFP00845034705
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2632,038,805 - 32,155,769 (+)Ensembl
RefSeq Acc Id: XM_038437613   ⟹   XP_038293541
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02632,039,270 - 32,155,774 (+)NCBI
RefSeq Acc Id: XM_038512478   ⟹   XP_038368406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12630,085,016 - 30,204,201 (+)NCBI
RefSeq Acc Id: XM_038575976   ⟹   XP_038431904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02630,798,988 - 30,918,013 (+)NCBI
RefSeq Acc Id: XM_038640186   ⟹   XP_038496114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02629,709,699 - 29,828,234 (+)NCBI
RefSeq Acc Id: XM_543569   ⟹   XP_543569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12630,630,693 - 30,749,158 (+)NCBI
Dog10K_Boxer_Tasha2630,589,065 - 30,707,530 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_543569   ⟸   XM_543569
- UniProtKB: A0A8C0TE10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022499   ⟸   ENSCAFT00000024235
RefSeq Acc Id: XP_038368406   ⟸   XM_038512478
RefSeq Acc Id: XP_038496114   ⟸   XM_038640186
RefSeq Acc Id: XP_038293541   ⟸   XM_038437613
- UniProtKB: A0A8C0TE10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038431904   ⟸   XM_038575976
- UniProtKB: A0A8C0TE10 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845034705   ⟸   ENSCAFT00845044288
Protein Domains
PI3K/PI4K catalytic   PIK helical


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015248 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030024737 UniProtKB/TrEMBL
  ENSCAFG00040021148 UniProtKB/TrEMBL
  ENSCAFG00845025057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024235.5 UniProtKB/TrEMBL
  ENSCAFT00000094748.1 UniProtKB/TrEMBL
  ENSCAFT00000103631.1 UniProtKB/TrEMBL
  ENSCAFT00000106938.1 UniProtKB/TrEMBL
  ENSCAFT00030045553.1 UniProtKB/TrEMBL
  ENSCAFT00030045681.1 UniProtKB/TrEMBL
  ENSCAFT00030045811.1 UniProtKB/TrEMBL
  ENSCAFT00030045991.1 UniProtKB/TrEMBL
  ENSCAFT00030046143.1 UniProtKB/TrEMBL
  ENSCAFT00030046262.1 UniProtKB/TrEMBL
  ENSCAFT00030046376.1 UniProtKB/TrEMBL
  ENSCAFT00040039234.1 UniProtKB/TrEMBL
  ENSCAFT00040039511.1 UniProtKB/TrEMBL
  ENSCAFT00040039797.1 UniProtKB/TrEMBL
  ENSCAFT00040039973.1 UniProtKB/TrEMBL
  ENSCAFT00040040206.1 UniProtKB/TrEMBL
  ENSCAFT00845044288 ENTREZGENE
  ENSCAFT00845044288.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/TrEMBL
  PI4K_N UniProtKB/TrEMBL
  PI_Kinase UniProtKB/TrEMBL
NCBI Gene PI4KA ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-KINASE ALPHA UniProtKB/TrEMBL
  PTHR10048 UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/TrEMBL
  PI3Ka UniProtKB/TrEMBL
  PI4K_N UniProtKB/TrEMBL
PROSITE PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/TrEMBL
SMART PI3Ka UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0PDB4_CANLF UniProtKB/TrEMBL
  A0A8C0PDJ8_CANLF UniProtKB/TrEMBL
  A0A8C0PEH3_CANLF UniProtKB/TrEMBL
  A0A8C0PFY2_CANLF UniProtKB/TrEMBL
  A0A8C0PHD8_CANLF UniProtKB/TrEMBL
  A0A8C0PII9_CANLF UniProtKB/TrEMBL
  A0A8C0PM03_CANLF UniProtKB/TrEMBL
  A0A8C0TDW5_CANLF UniProtKB/TrEMBL
  A0A8C0TE10 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TFE9_CANLF UniProtKB/TrEMBL
  A0A8C0Z3L8_CANLF UniProtKB/TrEMBL
  A0A8C0Z3R1_CANLF UniProtKB/TrEMBL
  A0A8I3S947_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0TK70 UniProtKB/TrEMBL
  A0A8P0TNA2 UniProtKB/TrEMBL
  A0A8P0TQ80 UniProtKB/TrEMBL
VGNC ID VGNC:59063 ENTREZGENE