Fsbp (fibrinogen silencer binding protein) - Rat Genome Database

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Gene: Fsbp (fibrinogen silencer binding protein) Rattus norvegicus
Analyze
Symbol: Fsbp (Ensembl: Rad54b)
Name: fibrinogen silencer binding protein (Ensembl:RAD54 homolog B)
RGD ID: 7611658
Description: Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal cancer and non-Hodgkin lymphoma. Orthologous to several human genes including FSBP (fibrinogen silencer binding protein); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: fibrinogen silencer-binding protein-like; LOC102550523
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,855,340 - 29,861,613 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl529,855,304 - 29,901,964 (+)EnsemblGRCr8
mRatBN7.2525,058,003 - 25,064,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,032,066 - 25,104,616 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx527,188,771 - 27,195,079 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,781,524 - 28,787,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0528,730,228 - 28,736,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd529,997,661 - 30,003,977 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive531,415,542 - 31,421,815 (+)NCBILyon_Normotensive
Lyon_Hypertensive530,848,091 - 30,854,393 (+)NCBILyon_Hypertensive
F344_StmMcwi524,635,476 - 24,641,790 (+)NCBIF344_StmMcwi
Rnor_6.0525,167,350 - 25,173,138 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,168,295 - 25,172,939 (+)Ensemblrn6Rnor6.0
Rnor_5.0529,882,601 - 29,888,195 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera524,395,498 - 24,401,286 (+)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19060904   PMID:20531236   PMID:25416956  


Genomics

Comparative Map Data
Fsbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,855,340 - 29,861,613 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl529,855,304 - 29,901,964 (+)EnsemblGRCr8
mRatBN7.2525,058,003 - 25,064,276 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl525,032,066 - 25,104,616 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx527,188,771 - 27,195,079 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0528,781,524 - 28,787,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0528,730,228 - 28,736,542 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd529,997,661 - 30,003,977 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive531,415,542 - 31,421,815 (+)NCBILyon_Normotensive
Lyon_Hypertensive530,848,091 - 30,854,393 (+)NCBILyon_Hypertensive
F344_StmMcwi524,635,476 - 24,641,790 (+)NCBIF344_StmMcwi
Rnor_6.0525,167,350 - 25,173,138 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl525,168,295 - 25,172,939 (+)Ensemblrn6Rnor6.0
Rnor_5.0529,882,601 - 29,888,195 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera524,395,498 - 24,401,286 (+)NCBICelera
Cytogenetic Map5q13NCBI
FSBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38894,427,716 - 94,436,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl894,378,377 - 94,436,952 (-)Ensemblhg38GRCh38
GRCh37895,439,944 - 95,449,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q22.1NCBI
HuRef890,648,874 - 90,658,114 (-)NCBIHuRef
CHM1_1895,480,195 - 95,489,435 (-)NCBICHM1_1
T2T-CHM13v2.0895,552,557 - 95,561,784 (-)NCBIT2T-CHM13v2.0
Fsbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,579,662 - 11,587,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,579,665 - 11,587,591 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38411,579,662 - 11,587,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,579,665 - 11,587,591 (+)Ensemblmm10GRCm38
MGSCv37411,506,809 - 11,514,964 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera411,391,130 - 11,399,285 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.11NCBI
Fsbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,649,826 - 10,655,545 (-)Ensembl
ChiLan1.0NW_00495541710,649,826 - 10,655,277 (-)NCBIChiLan1.0ChiLan1.0
FSBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27111,759,885 - 111,769,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1887,296,937 - 87,306,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0891,050,692 - 91,059,978 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1892,994,213 - 93,003,441 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl892,939,535 - 93,034,060 (-)EnsemblpanPan2panpan1.1
FSBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,149,402 - 39,159,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,310,351 - 39,320,381 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02939,353,156 - 39,363,197 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2939,293,199 - 39,402,284 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,366,284 - 39,376,318 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02939,361,835 - 39,371,871 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02939,803,330 - 39,813,360 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fsbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,360,535 - 40,371,278 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,426,292 - 7,431,584 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,425,933 - 7,432,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl442,266,605 - 42,369,447 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1442,303,372 - 42,312,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,667,532 - 45,678,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,404,473 - 89,413,721 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl889,404,173 - 89,413,665 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603951,423,853 - 51,434,096 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fsbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247631,825,873 - 1,831,723 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247631,825,599 - 1,831,028 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Fsbp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11131,996,487 - 132,001,919 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fsbp
116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:11
Count of miRNA genes:10
Interacting mature miRNAs:11
Transcripts:ENSRNOT00000020245
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5692228237468560Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 11 140 246 86 85 60 132 54 22 453 313 11 225 72 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020245   ⟹   ENSRNOP00000020245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl525,168,295 - 25,172,939 (+)Ensembl
RefSeq Acc Id: NM_001400957   ⟹   NP_001387886
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,855,340 - 29,861,613 (+)NCBI
mRatBN7.2525,058,003 - 25,064,276 (+)NCBI
Dahl_SR_JrHsd529,997,661 - 30,003,977 (+)NCBI
Lyon_Normotensive531,415,542 - 31,421,815 (+)NCBI
Lyon_Hypertensive530,848,091 - 30,854,393 (+)NCBI
F344_StmMcwi524,635,476 - 24,641,790 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387886 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZXW3 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077486
  ENSRNOP00000077486.1
Ensembl Acc Id: ENSRNOP00000020245   ⟸   ENSRNOT00000020245
RefSeq Acc Id: NP_001387886   ⟸   NM_001400957
- UniProtKB: D3ZXW3 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXW3-F1-model_v2 AlphaFold D3ZXW3 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693573
Promoter ID:EPDNEW_R4091
Type:single initiation site
Name:Fsbp_1
Description:fibrinogen silencer binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0525,168,225 - 25,168,285EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7611658 AgrOrtholog
BioCyc Gene G2FUF-41923 BioCyc
Ensembl Genes ENSRNOG00000015004 Ensembl
  ENSRNOG00000039949 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000104030 ENTREZGENE
  ENSRNOT00000104030.1 UniProtKB/Swiss-Prot
InterPro FSBP UniProtKB/Swiss-Prot
  Myb_DNA-bind_5 UniProtKB/Swiss-Prot
NCBI Gene LOC102550523 ENTREZGENE
PANTHER FIBRINOGEN SILENCER-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR15386 UniProtKB/Swiss-Prot
Pfam Myb_DNA-bind_5 UniProtKB/Swiss-Prot
PhenoGen Fsbp PhenoGen
RatGTEx ENSRNOG00000015004 RatGTEx
  ENSRNOG00000039949 RatGTEx
UniProt A0A8I5ZND1_RAT UniProtKB/TrEMBL
  A0ABK0LQW7_RAT UniProtKB/TrEMBL
  D3ZXW3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-25 Fsbp  fibrinogen silencer binding protein  LOC102550523  fibrinogen silencer-binding protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102550523  fibrinogen silencer-binding protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL