FSBP (fibrinogen silencer binding protein) - Rat Genome Database

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Gene: FSBP (fibrinogen silencer binding protein) Homo sapiens
Analyze
Symbol: FSBP
Name: fibrinogen silencer binding protein
RGD ID: 5685708
HGNC Page HGNC
Description: Exhibits identical protein binding activity. Localizes to nucleoplasm; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; acrolein; alpha-pinene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fibrinogen silencer-binding protein; FLJ23692
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,378,377 - 94,436,952 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl894,372,170 - 94,436,952 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,427,716 - 94,436,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,439,944 - 95,449,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q22.1NCBI
HuRef890,648,874 - 90,658,114 (-)NCBIHuRef
CHM1_1895,480,195 - 95,489,435 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IDA)
nucleus  (IBA,IDA)

Molecular Function

References

References - curated
1. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11181995   PMID:15489334   PMID:19060904   PMID:20531236   PMID:21873635   PMID:25416956   PMID:25814554   PMID:30021884   PMID:30631154  


Genomics

Comparative Map Data
FSBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl894,378,377 - 94,436,952 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl894,372,170 - 94,436,952 (-)EnsemblGRCh38hg38GRCh38
GRCh38894,427,716 - 94,436,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37895,439,944 - 95,449,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map8q22.1NCBI
HuRef890,648,874 - 90,658,114 (-)NCBIHuRef
CHM1_1895,480,195 - 95,489,435 (-)NCBICHM1_1
Fsbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,579,662 - 11,587,802 (+)NCBIGRCm39mm39
GRCm39 Ensembl411,579,665 - 11,587,591 (+)Ensembl
GRCm38411,579,662 - 11,587,802 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,579,665 - 11,587,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv37411,506,809 - 11,514,964 (+)NCBIGRCm37mm9NCBIm37
Celera411,391,130 - 11,399,285 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.11NCBI
Fsbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2525,058,003 - 25,064,283 (+)NCBI
Rnor_6.0 Ensembl525,168,295 - 25,172,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0525,167,350 - 25,173,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0529,882,601 - 29,888,195 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera524,395,498 - 24,401,286 (+)NCBICelera
Cytogenetic Map5q13NCBI
Fsbp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,649,826 - 10,655,545 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541710,649,826 - 10,655,277 (-)NCBIChiLan1.0ChiLan1.0
FSBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1892,994,213 - 93,003,441 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl892,939,535 - 93,034,060 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0891,050,692 - 91,059,978 (-)NCBIMhudiblu_PPA_v0panPan3
LOC102152707
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,149,402 - 39,159,789 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,310,351 - 39,320,381 (-)NCBI
ROS_Cfam_1.02939,353,156 - 39,363,197 (-)NCBI
UMICH_Zoey_3.12939,366,284 - 39,376,318 (-)NCBI
UNSW_CanFamBas_1.02939,361,835 - 39,371,871 (-)NCBI
UU_Cfam_GSD_1.02939,803,330 - 39,813,360 (-)NCBI
LOC101960969
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530340,360,535 - 40,371,278 (+)NCBI
SpeTri2.0NW_0049365447,425,933 - 7,432,292 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl442,305,705 - 42,315,247 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1442,303,372 - 42,312,148 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,667,532 - 45,678,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103237148
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,404,473 - 89,413,721 (-)NCBI
ChlSab1.1 Ensembl889,404,173 - 89,413,665 (-)Ensembl
Fsbp
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247631,825,599 - 1,831,028 (-)NCBI

Position Markers
D8S1441E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37895,441,040 - 95,441,163UniSTSGRCh37
Build 36895,510,216 - 95,510,339RGDNCBI36
Celera891,627,028 - 91,627,151RGD
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map8qUniSTS
HuRef890,649,974 - 90,650,097UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:923
Count of miRNA genes:589
Interacting mature miRNAs:679
Transcripts:ENST00000481490, ENST00000517506
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system entire extraembryonic component pharyngeal arch
High
Medium 1 2 7 5 1 1
Low 19 11 45 39 415 38 30 4 63 94 121 42 3 2 2
Below cutoff 73 12 186 144 123 144 14 10 32 146 88 100

Sequence


Reference Sequences
RefSeq Acc Id: NM_001256141   ⟹   NP_001243070
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,427,716 - 94,436,944 (-)NCBI
GRCh37895,439,940 - 95,449,180 (-)NCBI
HuRef890,648,874 - 90,658,114 (-)NCBI
CHM1_1895,480,195 - 95,489,435 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001243070 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD09313 (Get FASTA)   NCBI Sequence Viewer  
  AAL96666 (Get FASTA)   NCBI Sequence Viewer  
  EAW91711 (Get FASTA)   NCBI Sequence Viewer  
  O95073 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001243070   ⟸   NM_001256141
- UniProtKB: O95073 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
Myb_DNA-bind_5

Promoters
RGD ID:7213785
Promoter ID:EPDNEW_H12637
Type:multiple initiation site
Name:FSBP_1
Description:fibrinogen silencer binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12635  EPDNEW_H12638  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38894,436,936 - 94,436,996EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1(chr8:94283890-94959597)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053675]|See cases [RCV000053675] Chr8:94283890..94959597 [GRCh38]
Chr8:95296118..95971825 [GRCh37]
Chr8:95365294..96041001 [NCBI36]
Chr8:8q22.1
benign
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-22.1(chr8:78672463-95366868)x1 copy number loss See cases [RCV000054262] Chr8:78672463..95366868 [GRCh38]
Chr8:79584698..96379096 [GRCh37]
Chr8:79747253..96448272 [NCBI36]
Chr8:8q21.13-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:90940996-94538343)x1 copy number loss See cases [RCV000054263] Chr8:90940996..94538343 [GRCh38]
Chr8:91953224..95550571 [GRCh37]
Chr8:92022400..95619747 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92283179-95786443)x1 copy number loss See cases [RCV000054265] Chr8:92283179..95786443 [GRCh38]
Chr8:93295407..96798671 [GRCh37]
Chr8:93364583..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q21.3-22.1(chr8:92287062-95786443)x1 copy number loss See cases [RCV000054277] Chr8:92287062..95786443 [GRCh38]
Chr8:93299290..96798671 [GRCh37]
Chr8:93368466..96867847 [NCBI36]
Chr8:8q21.3-22.1
pathogenic
GRCh38/hg38 8q22.1(chr8:92755532-97792132)x1 copy number loss See cases [RCV000054278] Chr8:92755532..97792132 [GRCh38]
Chr8:93767760..98804360 [GRCh37]
Chr8:93836936..98873536 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8q21.3-24.23(chr8:86300584-137022587)x3 copy number gain See cases [RCV000135621] Chr8:86300584..137022587 [GRCh38]
Chr8:87312813..138034830 [GRCh37]
Chr8:87381929..138104012 [NCBI36]
Chr8:8q21.3-24.23
pathogenic|likely pathogenic
GRCh38/hg38 8q22.1(chr8:93038175-95667782)x1 copy number loss See cases [RCV000136519] Chr8:93038175..95667782 [GRCh38]
Chr8:94050403..96680010 [GRCh37]
Chr8:94119579..96749186 [NCBI36]
Chr8:8q22.1
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q11.1-24.3(chr8:46031340-139285494)x3 copy number gain See cases [RCV000139539] Chr8:46031340..139285494 [GRCh38]
Chr8:46942962..140297737 [GRCh37]
Chr8:47062127..140366919 [NCBI36]
Chr8:8q11.1-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.3-24.3(chr8:93047482-141355635)x3 copy number gain See cases [RCV000511761] Chr8:93047482..141355635 [GRCh37]
Chr8:8q21.3-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841228-142689874)x3 copy number gain See cases [RCV000510854] Chr8:86841228..142689874 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q22.1(chr8:93391781-96572606)x1 copy number loss See cases [RCV000512300] Chr8:93391781..96572606 [GRCh37]
Chr8:8q22.1
likely pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q21.2-23.3(chr8:86841154-116518125)x3 copy number gain not provided [RCV000683045] Chr8:86841154..116518125 [GRCh37]
Chr8:8q21.2-23.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:43653 AgrOrtholog
COSMIC FSBP COSMIC
Ensembl Genes ENSG00000265817 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000420405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000462684 UniProtKB/TrEMBL
Ensembl Transcript ENST00000481490 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000517506 UniProtKB/TrEMBL
GTEx ENSG00000265817 GTEx
HGNC ID HGNC:43653 ENTREZGENE
Human Proteome Map FSBP Human Proteome Map
InterPro FSBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myb_DNA-bind_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:100861412 UniProtKB/Swiss-Prot
NCBI Gene FSBP ENTREZGENE
OMIM 616306 OMIM
PANTHER PTHR15386 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Myb_DNA-bind_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA166049100 PharmGKB
UniProt FSBP_HUMAN UniProtKB/Swiss-Prot
  J3KSW4_HUMAN UniProtKB/TrEMBL
  O95073 ENTREZGENE
UniProt Secondary Q8N4S5 UniProtKB/Swiss-Prot