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Gene: Ldhal6b (lactate dehydrogenase A-like 6B) Rattus norvegicus

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Symbol:

Ldhal6b

Name:

lactate dehydrogenase A-like 6B

RGD ID:

727955

Description:

Predicted to enable L-lactate dehydrogenase (NAD+) activity. Predicted to be involved in lactate metabolic process and pyruvate catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Orthologous to several human genes including LDHAL6B (lactate dehydrogenase A like 6B); PARTICIPATES IN malonic aciduria pathway; methylmalonic aciduria, cobalamin-related pathway; propanoate metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

L-lactate dehydrogenase A-like 6B; lactate dehydrogenase A -like; Ldhl

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	48,402,997 - 48,404,420 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	48,403,012 - 48,404,851 (-)	Ensembl				GRCr8
mRatBN7.2	1	45,997,845 - 45,999,268 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	45,991,991 - 45,999,272 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	46,550,045 - 46,551,468 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	52,537,299 - 52,538,722 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	46,625,471 - 46,626,894 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	46,307,853 - 46,309,276 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	47,622,971 - 47,624,394 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	40,399,144 - 40,400,567 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	41,691,980 - 41,693,403 (-)	NCBI		Celera
RGSC_v3.1	1	40,402,089 - 40,403,512 (-)	NCBI
Cytogenetic Map	1	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

6-propyl-2-thiouracil (EXP)

Azoxymethane (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

decabromodiphenyl ether (EXP)

dextran sulfate (ISO)

glyphosate (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

pirinixic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

Theaflavin 3,3'-digallate (ISO)

thiram (ISO)

titanium dioxide (ISO)

trovafloxacin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid metabolic process (IEA)

lactate metabolic process (IBA,IEA,ISO)

NAD+ metabolic process (IEA)

pyruvate catabolic process (IBA)

Cellular Component

cytoplasm (IEA,ISO)

mitochondrion (IBA)

Molecular Function

catalytic activity (IEA)

L-lactate dehydrogenase (NAD+) activity (IBA,IEA)

NAD binding (IEA)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cysteine and methionine metabolic pathway (IEA)

gluconeogenesis pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

malonic aciduria pathway (ISO)

methylmalonic aciduria, cobalamin-related pathway (ISO)

propanoate metabolic pathway (IEA,ISO)

pyruvate metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	NCBI rat LocusLink and RefSeq merged data October 15, 2003	NCBI rat LocusLink and RefSeq merged data October 15, 2003
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:18614015	PMID:21630459

Genomics

Comparative Map Data

Ldhal6b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	48,402,997 - 48,404,420 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	48,403,012 - 48,404,851 (-)	Ensembl				GRCr8
mRatBN7.2	1	45,997,845 - 45,999,268 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	45,991,991 - 45,999,272 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	46,550,045 - 46,551,468 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	52,537,299 - 52,538,722 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	46,625,471 - 46,626,894 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	46,307,853 - 46,309,276 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	47,622,971 - 47,624,394 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	40,399,144 - 40,400,567 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	41,691,980 - 41,693,403 (-)	NCBI		Celera
RGSC_v3.1	1	40,402,089 - 40,403,512 (-)	NCBI
Cytogenetic Map	1	q11	NCBI

LDHAL6B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	59,206,843 - 59,208,588 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	59,206,843 - 59,208,588 (+)	Ensembl			hg38	GRCh38
GRCh37	15	59,499,042 - 59,500,787 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	57,286,334 - 57,288,006 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	57,286,333 - 57,287,999	NCBI
Celera	15	36,386,997 - 36,388,669 (+)	NCBI		Celera
Cytogenetic Map	15	q22.2	NCBI
HuRef	15	36,321,043 - 36,322,815 (+)	NCBI		HuRef
CHM1_1	15	59,616,979 - 59,618,751 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	57,008,917 - 57,010,662 (+)	NCBI		T2T-CHM13v2.0

Ldhal6b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	5,467,598 - 5,469,042 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	5,467,598 - 5,469,042 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	5,417,323 - 5,418,767 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	5,417,323 - 5,418,767 (-)	Ensembl			mm10	GRCm38
MGSCv37	17	5,417,323 - 5,418,767 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	5,373,805 - 5,375,249 (-)	NCBI		MGSCv36	mm8
Celera	17	5,959,766 - 5,961,210 (-)	NCBI		Celera
Cytogenetic Map	17	A1	NCBI
cM Map	17	3.17	NCBI

Ldhal6b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955439	4,954,208 - 4,956,660 (+)	NCBI	ChiLan1.0	ChiLan1.0

LDHAL6B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	48,472,031 - 48,473,972 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	52,653,700 - 52,656,295 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	38,176,451 - 38,179,189 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	56,484,213 - 56,485,921 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	56,484,343 - 56,485,488 (+)	Ensembl			panPan2	panpan1.1

LDHAL6B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	46,878,452 - 46,880,160 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	47,723,470 - 47,725,173 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	47,065,791 - 47,067,494 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	47,065,796 - 47,088,615 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	46,944,607 - 46,946,309 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	46,807,518 - 46,809,220 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	47,365,968 - 47,367,670 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ldhal6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	142,029,441 - 142,034,003 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936489	9,281,228 - 9,283,132 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LDHAL6B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	24,304,857 - 24,307,906 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	24,305,289 - 24,306,434 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	117,017,377 - 117,019,236 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ldhal6b
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	193,393,060 - 193,394,477 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ldhal6b
1 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	7746118	52746118	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	29409279	74409279	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
7421626	Bp360	Blood pressure QTL 360		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	6941022	51941022	Rat
1357401	Bw43	Body weight QTL 43	3.75		body mass (VT:0001259)	body weight (CMO:0000012)	1	6909353	51909353	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
631494	Bp95	Blood pressure QTL 95	40	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	17315378	51816258	Rat
5684998	Bss101	Bone structure and strength QTL 101	3.6		tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	1	6909353	51909353	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
5684999	Bss102	Bone structure and strength QTL 102	5.5	7e-07	tibia strength trait (VT:1000284)	tibia stiffness (CMO:0001735)	1	6909353	51909353	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	20508326	65508326	Rat
631508	Sald1	Serum aldosterone level QTL 1	3.7		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	1	11684464	56684464	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889451	Eae29	Experimental allergic encephalomyelitis QTL 29	5.51		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	1	7746121	52746121	Rat
1558642	Prcr2	Prostate cancer resistance QTL 2	4.3		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	1	10379492	55379492	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
2302038	Pia31	Pristane induced arthritis QTL 31	5.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	1	12820494	57820494	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20656420	65656420	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	hemolymphoid system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	sensory system	visual system
1	9	27	48	83	63	6	27	19	16	7	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_183334	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY342428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC078970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000102163 ⟹ ENSRNOP00000093436

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	48,403,012 - 48,404,851 (-)	Ensembl
mRatBN7.2 Ensembl	1	45,991,991 - 45,999,272 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000117941 ⟹ ENSRNOP00000095522

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	45,991,991 - 45,999,272 (-)	Ensembl

RefSeq Acc Id:

NM_183334 ⟹ NP_899163

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	48,402,997 - 48,404,420 (-)	NCBI
mRatBN7.2	1	45,997,845 - 45,999,268 (-)	NCBI
Rnor_6.0	1	46,307,853 - 46,309,276 (-)	NCBI
Rnor_5.0	1	47,622,971 - 47,624,394 (-)	NCBI
RGSC_v3.4	1	40,399,144 - 40,400,567 (-)	RGD
Celera	1	41,691,980 - 41,693,403 (-)	RGD

Sequence:

show sequence

GCAGCCGCAGTGGGAGGGAGGGCTGCGTCTGTACTGCCTGACAACCGCCGTTCTGGCCTCAACT
GTCTTCCTCATCCTGTTCATTTCTTCCATCTGAGTGCGCAGCTATGGCCTGGGCTGTAAGCATC
CTGAGGGCCAGAAGAAGAATGGGTACAGTCAGGGTAGATTTCAAGGACTTGGGCGTAGCTTTAT
GGCCCAGTCAGGTGCTGCGTGTCCCTCCCAACCGGGCCTGGTGGAGCCTCACCCCCACGTCCAC
CATGGCGACTGTGAAGGGTAAACTTCTCCAGCACGTCAGCTCCGAAGAACCCGTTCTCCACAAC
AAGGTCTCCATTATAGGAACTGGATCCGTCGGCATGGCCTGTGCCATCAGCATCATAGCGAAAG
GCTTGACTGATGAGCTTGCTCTTGTTGATAGTAATGAAGGAAAAATGAAGGGTGAGACAATGGA
TCTCCAGCACGGCAGTGTCTTCATGAAAATGCCAAATATTGTTTGCAGCAAGGATTTCCATGTC
ACTGCCAACTCTGAGGTAGTGGTTATCACAGCGGGAGCACGACAAGAGAAAGATGAGACGCGTC
TAAATTTAGTCCAGCGAAACGTATCTATCTTTAAGATAATGTTTGCCAATATTGTCAAGTACAG
CCCTCGCTGCAAAATTATCATTGTTTCCAACCCAGTGGACATCCTAACTTACGTAGCGTGGAAA
TTGAGTGGGTTTCCCAAAAACCGTGTTATTGGAAGTGGCTGTAACCTAGATACAGCTCGTTTCC
GTTACATGCTTGGGCAGAGGCTTGGGATCCACTCTGAAAGCTGTCATGGGTGGGTCCTTGGAGA
GCATGGAGACTCAAGTGTCCCTGTGTGGAGTGGTGTAAACATCGCTGGTGTGCCTCTGAAAGAG
CTGAATTCAGCTATAGGAACTAACAAAGACCCGGAGCAGTGGGGCAATGTCCACAAAGAAGTCA
TTGCCAGTGCCTATAAAATTATCAAAATGAAAGGCTATACTTCCTGGGCCATTGGCCTGTCTGT
AGCTGATATTGCAGAGAGTATTCTGAAGAATCTCAGGAAAACGCACCCAGTTTCCACCAAAATT
AAAGGTTTATACGGAATAAAAGAAGAGGTGTTCCTCAGTGTGCCTTGTGTCCTGGGAGAGAATG
GCATATCTGATATTATAAAGGTGAAGCTGAGCCCTACAGAGGAGGCCCAGATGGTAAAGAGCGC
AGACACTATTTGGAAAATCCAGAAAGATATCAAGTTTTAAGTCACCCTTGTAAAGATATTGAAG
ACAGAAGACGCAGTGATGCCCAGTGTGGGGTGACTGGAGTCTGAAAGCTGGAGCGCCTCCCTTT
AGGTCTCCTGTTATGTAGCACCCAGTGGCTGCGGACTTTACAGTTTCTGGGTGACAGCATTAAA
GGTACTTTTGACTTTAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_899163	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH78970	(Get FASTA)	NCBI Sequence Viewer
	AAQ20046	(Get FASTA)	NCBI Sequence Viewer
	EDL83739	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000093436
	ENSRNOP00000093436.1

RefSeq Acc Id:

NP_899163 ⟸ NM_183334

- UniProtKB:

Q7TNA8 (UniProtKB/TrEMBL), A0A8I6AFT6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAWAVSILRARRRMGTVRVDFKDLGVALWPSQVLRVPPNRAWWSLTPTSTMATVKGKLLQHVSS
EEPVLHNKVSIIGTGSVGMACAISIIAKGLTDELALVDSNEGKMKGETMDLQHGSVFMKMPNIV
CSKDFHVTANSEVVVITAGARQEKDETRLNLVQRNVSIFKIMFANIVKYSPRCKIIIVSNPVDI
LTYVAWKLSGFPKNRVIGSGCNLDTARFRYMLGQRLGIHSESCHGWVLGEHGDSSVPVWSGVNI
AGVPLKELNSAIGTNKDPEQWGNVHKEVIASAYKIIKMKGYTSWAIGLSVADIAESILKNLRKT
HPVSTKIKGLYGIKEEVFLSVPCVLGENGISDIIKVKLSPTEEAQMVKSADTIWKIQKDIKF

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Ensembl Acc Id:

ENSRNOP00000095522 ⟸ ENSRNOT00000117941

Ensembl Acc Id:

ENSRNOP00000093436 ⟸ ENSRNOT00000102163

Protein Domains

Lactate/malate dehydrogenase C-terminal Lactate/malate dehydrogenase N-terminal

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:727955	AgrOrtholog
BioCyc Gene	G2FUF-61637	BioCyc
Ensembl Genes	ENSRNOG00000062741	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000102163	ENTREZGENE
	ENSRNOT00000102163.2	UniProtKB/TrEMBL
Gene3D-CATH	3.90.110.10	UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111795	IMAGE-MGC_LOAD
InterPro	L-lactate/malate_DH	UniProtKB/TrEMBL
	L-lactate_DH	UniProtKB/TrEMBL
	L-lactate_DH_AS	UniProtKB/TrEMBL
	Lactate/malate_DH_C	UniProtKB/TrEMBL
	Lactate/malate_DH_N	UniProtKB/TrEMBL
	Lactate_DH/Glyco_Ohase_4_C	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:369018	UniProtKB/TrEMBL
MGC_CLONE	MGC:93850	IMAGE-MGC_LOAD
NCBI Gene	369018	ENTREZGENE
PANTHER	L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))	UniProtKB/TrEMBL
	L-LACTATE DEHYDROGENASE A-LIKE 6B	UniProtKB/TrEMBL
Pfam	Ldh_1_C	UniProtKB/TrEMBL
	Ldh_1_N	UniProtKB/TrEMBL
PhenoGen	Ldhal6b	PhenoGen
PIRSF	Lac_mal_DH	UniProtKB/TrEMBL
PRINTS	LLDHDRGNASE	UniProtKB/TrEMBL
PROSITE	L_LDH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000062741	RatGTEx
Superfamily-SCOP	Lactate_DH/Glyco_hydro_4_C	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8I6AFT6	ENTREZGENE, UniProtKB/TrEMBL
	Q7TNA8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-08	Ldhal6b	lactate dehydrogenase A-like 6B	Ldhl	lactate dehydrogenase A -like	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)