Retnlg (resistin-like gamma) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Retnlg (resistin-like gamma) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Retnlg
Name: resistin-like gamma
RGD ID: 727934
Description: Predicted to enable hormone activity. Predicted to be involved in myeloid dendritic cell chemotaxis and signal transduction. Predicted to be active in extracellular space. Orthologous to human RETNLB (resistin like beta).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RELMgamma; resistin like beta; resistin-like beta; resistin-like molecule gamma; retn1g; retnlb
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,393,907 - 65,395,639 (-)NCBIGRCr8
mRatBN7.21151,930,948 - 51,932,680 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,930,936 - 51,932,830 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,694,172 - 60,695,511 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01153,355,954 - 53,357,293 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01152,461,301 - 52,462,640 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01154,512,950 - 54,514,722 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,513,102 - 54,514,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,674,602 - 57,676,345 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41153,174,617 - 53,175,956 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11153,232,205 - 53,233,545 (-)NCBI
Celera1151,531,289 - 51,532,628 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern. Gerstmayer B, etal., Genomics 2003 Jun;81(6):588-95.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:33407472  


Genomics

Variants

.
Variants in Retnlg
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:72
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000002673
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 31 50 85 84 53 25 53 6 183 78 30 37 39 31

Sequence


Ensembl Acc Id: ENSRNOT00000002673   ⟹   ENSRNOP00000002673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1151,930,936 - 51,932,830 (-)Ensembl
Rnor_6.0 Ensembl1154,513,102 - 54,514,441 (-)Ensembl
RefSeq Acc Id: NM_181625   ⟹   NP_853656
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,393,907 - 65,395,639 (-)NCBI
mRatBN7.21151,930,948 - 51,932,680 (-)NCBI
Rnor_6.01154,513,102 - 54,514,441 (-)NCBI
Rnor_5.01157,674,602 - 57,676,345 (-)NCBI
RGSC_v3.41153,174,617 - 53,175,956 (-)RGD
Celera1151,531,289 - 51,532,628 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_853656 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD56116 (Get FASTA)   NCBI Sequence Viewer  
  EDM11108 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002673.6
GenBank Protein G3V686 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_853656   ⟸   NM_181625
- Peptide Label: precursor
- UniProtKB: G3V686 (UniProtKB/Swiss-Prot),   Q7TN86 (UniProtKB/Swiss-Prot),   A0A8L2Q083 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002673   ⟸   ENSRNOT00000002673

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V686-F1-model_v2 AlphaFold G3V686 1-111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727934 AgrOrtholog
BioCyc Gene G2FUF-21423 BioCyc
Ensembl Genes ENSRNOG00000001943 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002673.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.4230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RELM UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Resistin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:288135 UniProtKB/Swiss-Prot
NCBI Gene 288135 ENTREZGENE
PANTHER PTHR21101 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RESISTIN-LIKE GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Resistin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Retnlg PhenoGen
RatGTEx ENSRNOG00000001943 RatGTEx
Superfamily-SCOP SSF111423 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q083 ENTREZGENE, UniProtKB/TrEMBL
  G3V686 ENTREZGENE
  Q7TN86 ENTREZGENE
  RETNG_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q7TN86 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-12-01 Retnlg  resistin-like gamma  Retnlb  resistin like beta  Symbol and Name updated 1299863 APPROVED
2004-09-10 Retnlb  resistin like beta  retn1g  resistin-like gamma  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains member of the resistin-like molecule/found in inflammatory zone (RELM/FIZZ) family 1299604
gene_expression expressed at highest levels in hematopoietic tissues, also expressed in white adipose tissue 1299604
gene_regulation expression is repressed in nasal epithelium when exposed to cigarette smoke 1299604