Cish (cytokine inducible SH2-containing protein)

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Gene: Cish (cytokine inducible SH2-containing protein) Rattus norvegicus

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Symbol:

Cish

Name:

cytokine inducible SH2-containing protein

RGD ID:

69261

Description:

Predicted to enable cytokine receptor binding activity. Involved in cytokine-mediated signaling pathway. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-2 signaling pathway; interleukin-3 signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Cis; CIS-1; cytokine inducible SH2-containing protein 1; cytokine-inducible SH2-containing protein; SOCS; suppressor of cytokine signaling

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	116,850,969 - 116,855,917 (+)	NCBI		GRCr8
mRatBN7.2	8	107,972,306 - 107,977,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,972,306 - 107,977,250 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,598,881 - 113,603,836 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	111,798,056 - 111,803,009 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,640,844 - 109,645,801 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,054,547 - 116,059,494 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,054,465 - 116,060,723 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,411,027 - 115,415,974 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,541,034 - 112,545,982 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	112,560,606 - 112,564,500 (+)	NCBI
Celera	8	107,282,095 - 107,287,043 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Bacteremia (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

malaria (ISO)

pre-malignant neoplasm (ISO)

tuberculosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

2-nitrotoluene (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-nitrotoluene (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (EXP,ISO)

amitrole (EXP)

ammonium chloride (EXP)

andrographolide (ISO)

aristolochic acid A (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[ghi]perylene (ISO)

benzoates (ISO)

beta-naphthoflavone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chromium(6+) (ISO)

chrysene (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (EXP)

copper(II) sulfate (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

deoxynivalenol (ISO)

dexamethasone (ISO)

dibenz[a,h]anthracene (ISO)

Dibutyl phosphate (ISO)

diuron (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

eugenol (ISO)

fenofibrate (ISO)

fenvalerate (EXP)

folic acid (ISO)

furan (EXP)

gamma-hexachlorocyclohexane (EXP)

genistein (ISO)

gentamycin (EXP)

glycidol (EXP)

hexachlorobenzene (EXP)

hydrogen peroxide (ISO)

indole-3-methanol (EXP)

inulin (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

melatonin (ISO)

metformin (EXP)

methimazole (EXP)

methotrexate (ISO)

methylmercury(1+) (EXP)

N-acetyl-L-cysteine (EXP)

N-methylformamide (ISO)

N-nitrosodiethylamine (EXP)

nevirapine (ISO)

nickel atom (ISO)

niclosamide (ISO)

nitrofen (EXP)

O-methyleugenol (ISO)

orphenadrine (EXP)

oxazepam (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

progesterone (EXP)

raloxifene (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

stattic (ISO)

sulpiride (EXP)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (IBA,IEP)

intracellular signal transduction (IEA)

negative regulation of cytokine-mediated signaling pathway (IEA,ISO)

negative regulation of receptor signaling pathway via JAK-STAT (IBA)

protein ubiquitination (IEA)

Cellular Component

plasma membrane (IEA,ISO)

Molecular Function

cytokine receptor binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

interleukin-3 signaling pathway (ISO)

interleukin-5 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Endotoxin-induced inhibition of growth hormone receptor signaling in rat liver in vivo.	Mao Y, etal., Endocrinology 1999 Dec;140(12):5505-15.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	1Alpha,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells.	Morales O, etal., J Biol Chem 2002 Sep 20;277(38):34879-84.
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12586763	PMID:12618484	PMID:15118263	PMID:15378659	PMID:16154995	PMID:16357045	PMID:16956890

Genomics

Comparative Map Data

Cish
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	116,850,969 - 116,855,917 (+)	NCBI		GRCr8
mRatBN7.2	8	107,972,306 - 107,977,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,972,306 - 107,977,250 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,598,881 - 113,603,836 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	111,798,056 - 111,803,009 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,640,844 - 109,645,801 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,054,547 - 116,059,494 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,054,465 - 116,060,723 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,411,027 - 115,415,974 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,541,034 - 112,545,982 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	112,560,606 - 112,564,500 (+)	NCBI
Celera	8	107,282,095 - 107,287,043 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

CISH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	50,606,489 - 50,611,774 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	50,606,489 - 50,611,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	50,643,920 - 50,649,205 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,618,924 - 50,624,207 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	50,618,929 - 50,624,207	NCBI
Celera	3	50,616,686 - 50,622,064 (-)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	50,699,815 - 50,705,193 (-)	NCBI		HuRef
CHM1_1	3	50,596,124 - 50,601,502 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	50,636,358 - 50,641,643 (-)	NCBI		T2T-CHM13v2.0

Cish
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,173,858 - 107,179,983 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,173,225 - 107,179,983 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,296,659 - 107,302,784 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,296,026 - 107,302,784 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,199,020 - 107,204,292 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,154,790 - 107,160,062 (+)	NCBI		MGSCv36	mm8
Celera	9	106,902,900 - 106,908,144 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	57.99	NCBI

Cish
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,378,088 - 2,386,000 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,380,380 - 2,386,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

CISH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,586,428 - 50,591,908 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,591,174 - 50,596,668 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,531,870 - 50,537,319 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,769,194 - 51,774,548 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,769,194 - 51,774,548 (-)	Ensembl	panpan1.1		panPan2

CISH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	38,762,239 - 38,767,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	38,762,378 - 38,766,620 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	38,681,549 - 38,686,929 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,116,466 - 39,121,847 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,116,453 - 39,121,845 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	38,484,384 - 38,489,763 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	38,887,993 - 38,893,364 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,167,907 - 39,173,288 (+)	NCBI		UU_Cfam_GSD_1.0

Cish
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	65,358,104 - 65,364,149 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	2,118,325 - 2,124,684 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	2,116,786 - 2,124,469 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CISH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	33,085,286 - 33,090,858 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	33,086,280 - 33,090,540 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	36,354,834 - 36,358,941 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CISH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,993,212 - 11,998,625 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,993,242 - 11,995,375 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	154,987,569 - 154,992,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cish
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	4,435,847 - 4,440,143 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	4,434,817 - 4,440,269 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cish
9 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	103
Interacting mature miRNAs:	122
Transcripts:	ENSRNOT00000040056
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
631653	Bp125	Blood pressure QTL 125	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	66142385	111142385	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	102370617	108923645	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat

Markers in Region

BE107841

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	107,971,875 - 107,972,049 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,054,117 - 116,054,290	NCBI	Rnor6.0
Rnor_5.0	8	115,410,597 - 115,410,770	UniSTS	Rnor5.0
RGSC_v3.4	8	112,540,604 - 112,540,777	UniSTS	RGSC3.4
Celera	8	107,281,665 - 107,281,838	UniSTS
RH 3.4 Map	8	1124.0	UniSTS
Cytogenetic Map	8	q32	UniSTS

PMC156147P14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	107,971,848 - 107,972,100 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,054,090 - 116,054,341	NCBI	Rnor6.0
Rnor_5.0	8	115,410,570 - 115,410,821	UniSTS	Rnor5.0
RGSC_v3.4	8	112,540,577 - 112,540,828	UniSTS	RGSC3.4
Celera	8	107,281,638 - 107,281,889	UniSTS
Cytogenetic Map	8	q32	UniSTS

PMC156147P15

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	107,972,039 - 107,972,198 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,054,281 - 116,054,439	NCBI	Rnor6.0
Rnor_5.0	8	115,410,761 - 115,410,919	UniSTS	Rnor5.0
RGSC_v3.4	8	112,540,768 - 112,540,926	UniSTS	RGSC3.4
Celera	8	107,281,829 - 107,281,987	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF065161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF294256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ243907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000040056 ⟹ ENSRNOP00000041734

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	107,972,306 - 107,977,250 (+)	Ensembl
Rnor_6.0 Ensembl	8	116,054,465 - 116,060,723 (+)	Ensembl

RefSeq Acc Id:

NM_031804 ⟹ NP_113992

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	116,850,969 - 116,855,917 (+)	NCBI
mRatBN7.2	8	107,972,306 - 107,977,254 (+)	NCBI
Rnor_6.0	8	116,054,547 - 116,059,494 (+)	NCBI
Rnor_5.0	8	115,411,027 - 115,415,974 (+)	NCBI
RGSC_v3.4	8	112,541,034 - 112,545,982 (+)	RGD
Celera	8	107,282,095 - 107,287,043 (+)	RGD

Sequence:

show sequence

CGATCGCCGCCGGTACGCCCCGGGACCCTGACCTTCGCACCCCTGGCACCCACTGGCTCCTTTC
TTCTTCCGTCCCGCCGAACTCCGACTCTCGAGCCGCCGTTGCCTCTAGGACATGGTCCTCTGCG
TACAGGGATCTTGTCCTTTGCTGGTTGTGGAGCAAATTGGGCAGCGGCCTCTGTGGGCCCAGTC
CCTGGAGCTGCCCGGGCCAGCCATGCAGCCCTTACCCACTGGGGCATTCCCAGAGGAGGTGACA
GAGGAGACCCCTGTCCAGTCAGAGAATGAACCGAAGGTGCTAGACCCTGAGGGAGATCTGCTGT
GCATAGCCAAGACGTTCTCCTACCTCCGGGAATCTGGTTGGTACTGGGGTTCCATTACAGCCAG
TGAGGCCCGGCAGCATCTACAGAAGATGCCGGAGGGCACATTCCTCGTGCGAGACAGCACCCAC
CCCAGCTACCTGTTTACATTGTCAGTCAAAACCACCCGTGGCCCCACCAATGTACGCATCGAGT
ATGCCGACTCTAGCTTCCGACTGGACTCCAATTGCTTGTCGAGACCTCGAATCCTGGCCTTCCC
AGATGTGGTCAGCCTTGTGCAGCATTACGTGGCCTCCTGTACGGCTGACACCCGGAGTGACAGC
CCAGATCCTGCTCCCACCCCAGCCCTGCCTGTGCCGAAGCCAGATGCACCTGGTGACCCAGTAC
TGCCTATCCCCGTGGCTACTGCTGTGCACCTGAAATTGGTGCAGCCCTTTGTGCGCAGGAGCAG
CGCCCGCAGCTTACAACACCTGTGTCGGCTAGTCATCAACCGACTGGTGACCGATGTGGACTGC
CTACCCCTGCCCCGGCGCATGGCCGACTACCTCCGACAGTACCCGTTCCAGCTCTGACTGGGCC
AGGCACCCTGCCCTGCCTCACACAGTGACATCCCGGAGGGGACACAGGCCCCCAGCTGGACTTG
GGGTTCTGCTGTCCCTTCCTCAGTCATCCTGGTGCCTGCATGCATGTGACAGCTGGACCAGAAA
GTGCCAGCAAGAACAAAGCAGGTGGAGGAGGGGTTATCATACAACTCTGAGGCCAGTGCCTCTC
CAGGTCCCATATGGCTTTGTGGTAAGCCCTATCAGAGCAGAGGGAGACAGGCAGGGCCTCGTCT
CTCCCCAGAGGCTGGACCTAGGCCTCCATTCACTTGCCCCTCCTAGCCACTTGAACTGTGTCTA
TTCTCCCAGCCCTGGTTTCTCAATCTGCTGAGTAGGGCAGGCCCCCTACCCATCTATAGAGTAG
CCAGCCTGTTTCTGGGAGACTGTCAGCCACAGGTTGATCATGCCAAGGCCCCTTGTCGGGGAGC
AGGCTGGGCTAGAGGACTACACAGTTATACAGTATTTATTTATTTATTCTCCTTGCAGGGTTTG
GGGGTGGGGTGATGGTGTGAGCCATCCCGCTTCTCTGCCCTATGCCCTGGGTGGTCCAAAGACC
CCCAGCTCTGGTTCTTCCCTGTGGAGACCCCCATCCCGAGACATTGTTGGGCCCAAAGTAGTCC
CAAATGCCTTAGGCCTGCCAACCTGCCTGCTTGTTTCTCCCAAGCCTCTTTTGGGAGACTGAGT
GACCAGACAGACAGGAGCCAGAAACACAAGGGCTCCCACCCATCTCCTCACAGGGCAGCGCCAC
GGCTTCATAGAGCTGGGTTCTCTATGGTACAGCCCCTGCTGAGGTGCATGTGCTGGGTCAGGAA
GAGGATGCTAGTCCAAGGGCTGCAGCTGCAGCTCTTTTGTGTCTGCTTCCTGCCCAGGAAACTG
CCTGCACGTGAGAGAGGGAGAAATACATACCTAACTAGACTTTATAAAACAAGTATTATAACAC
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113992	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC17502	(Get FASTA)	NCBI Sequence Viewer
	AAG29815	(Get FASTA)	NCBI Sequence Viewer
	AAI61930	(Get FASTA)	NCBI Sequence Viewer
	CAB51743	(Get FASTA)	NCBI Sequence Viewer
	EDL77261	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000041734.3
GenBank Protein	O70512	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113992 ⟸ NM_031804

- UniProtKB:

Q9ERQ1 (UniProtKB/Swiss-Prot), O70512 (UniProtKB/Swiss-Prot), B1WBX9 (UniProtKB/TrEMBL), F7F2E8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLCVQGSCPLLVVEQIGQRPLWAQSLELPGPAMQPLPTGAFPEEVTEETPVQSENEPKVLDPE
GDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN
VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCTADTRSDSPDPAPTPALPVPKPDAP
GDPVLPIPVATAVHLKLVQPFVRRSSARSLQHLCRLVINRLVTDVDCLPLPRRMADYLRQYPFQ
L

hide sequence

Ensembl Acc Id:

ENSRNOP00000041734 ⟸ ENSRNOT00000040056

Protein Domains

SH2 SOCS box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70512-F1-model_v2	AlphaFold	O70512	1-256	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696264

Promoter ID:

EPDNEW_R6789

Type:

multiple initiation site

Name:

Cish_1

Description:

cytokine inducible SH2-containing protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,054,541 - 116,054,601	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69261	AgrOrtholog
BioCyc Gene	G2FUF-29210	BioCyc
Ensembl Genes	ENSRNOG00000029543	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000040056.5	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:8375557	IMAGE-MGC_LOAD
InterPro	CIS_SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS_box-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83681	UniProtKB/TrEMBL
MGC_CLONE	MGC:187704	IMAGE-MGC_LOAD
NCBI Gene	83681	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10155:SF9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cish	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000029543	RatGTEx
SMART	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOCS_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	B1WBX9	ENTREZGENE, UniProtKB/TrEMBL
	CISH_RAT	UniProtKB/Swiss-Prot
	F7F2E8	ENTREZGENE, UniProtKB/TrEMBL
	O70512	ENTREZGENE
	Q9ERQ1	ENTREZGENE
UniProt Secondary	Q9ERQ1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Cish	cytokine inducible SH2-containing protein			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)