Cish (cytokine inducible SH2 containing protein)

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Gene: Cish (cytokine inducible SH2 containing protein) Chinchilla lanigera

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Symbol:

Cish

Name:

cytokine inducible SH2 containing protein

RGD ID:

8739542

Description:

INVOLVED IN cytokine-mediated signaling pathway (ortholog); negative regulation of cytokine-mediated signaling pathway (ortholog); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-2 signaling pathway; interleukin-3 signaling pathway; ASSOCIATED WITH allergic contact dermatitis (ortholog); Bacteremia (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,378,088 - 2,386,000 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,380,380 - 2,386,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

Bacteremia (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

malaria (ISO)

pre-malignant neoplasm (ISO)

tuberculosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (ISO)

negative regulation of cytokine-mediated signaling pathway (ISO)

Cellular Component

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

granulocyte-macrophage colony-stimulating factor signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

interleukin-3 signaling pathway (ISO)

interleukin-5 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cish
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,378,088 - 2,386,000 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,380,380 - 2,386,000 (-)	NCBI	ChiLan1.0	ChiLan1.0

CISH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	50,606,489 - 50,611,774 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	50,606,489 - 50,611,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	50,643,920 - 50,649,205 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,618,924 - 50,624,207 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	50,618,929 - 50,624,207	NCBI
Celera	3	50,616,686 - 50,622,064 (-)	NCBI		Celera
Cytogenetic Map	3	p21.2	NCBI
HuRef	3	50,699,815 - 50,705,193 (-)	NCBI		HuRef
CHM1_1	3	50,596,124 - 50,601,502 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	50,636,358 - 50,641,643 (-)	NCBI		T2T-CHM13v2.0

Cish
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,173,858 - 107,179,983 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,173,225 - 107,179,983 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,296,659 - 107,302,784 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,296,026 - 107,302,784 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,199,020 - 107,204,292 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,154,790 - 107,160,062 (+)	NCBI		MGSCv36	mm8
Celera	9	106,902,900 - 106,908,144 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	57.99	NCBI

Cish
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	116,850,969 - 116,855,917 (+)	NCBI		GRCr8
mRatBN7.2	8	107,972,306 - 107,977,254 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	107,972,306 - 107,977,250 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,598,881 - 113,603,836 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	111,798,056 - 111,803,009 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,640,844 - 109,645,801 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,054,547 - 116,059,494 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,054,465 - 116,060,723 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,411,027 - 115,415,974 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,541,034 - 112,545,982 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	112,560,606 - 112,564,500 (+)	NCBI
Celera	8	107,282,095 - 107,287,043 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

CISH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,586,428 - 50,591,908 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,591,174 - 50,596,668 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,531,870 - 50,537,319 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,769,194 - 51,774,548 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,769,194 - 51,774,548 (-)	Ensembl	panpan1.1		panPan2

CISH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	38,762,239 - 38,767,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	38,762,378 - 38,766,620 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	38,681,549 - 38,686,929 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,116,466 - 39,121,847 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,116,453 - 39,121,845 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	38,484,384 - 38,489,763 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	38,887,993 - 38,893,364 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,167,907 - 39,173,288 (+)	NCBI		UU_Cfam_GSD_1.0

Cish
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	65,358,104 - 65,364,149 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	2,118,325 - 2,124,684 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	2,116,786 - 2,124,469 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CISH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	33,085,286 - 33,090,858 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	33,086,280 - 33,090,540 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	36,354,834 - 36,358,941 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CISH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,993,212 - 11,998,625 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,993,242 - 11,995,375 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	154,987,569 - 154,992,718 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cish
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	4,435,847 - 4,440,143 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	4,434,817 - 4,440,269 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005410305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013507639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01070225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01070226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01280930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000010663 ⟹ ENSCLAP00000010532

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955532	2,378,088 - 2,386,000 (-)	Ensembl

RefSeq Acc Id:

XM_005410305 ⟹ XP_005410362

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955532	2,380,380 - 2,386,000 (-)	NCBI

Sequence:

show sequence

CCGCCGTCCGCCGAGCCCCTCCGGAGCCGCCGCTGCGCCGGGACATGGTCCTCTGCGTCCGGGG
ATCTAGTCCTTTGCTGGCTGTGGAGCAGATTGGGCAGCGGCTCCTGTGGGCCCAGAGCCTAGAG
CTGTCAGAGCCAGCCATGCAGCCTTTCCCTGCCGGGGTCTTCCTGGAAGAGGTGCCAGCGGAGA
CCCCTATCCAACCAGAGAGTGAGCCAAAGGTGCTGGACCCTGAAGAGGATCTGCTGTGCATAGC
CAAGACTTTCTCCTACCTTAGAGAATCTGGCTGGTACTGGGGCTCCATTACAGCCAGTGAGGCC
CGGCAGCACCTGCAGAAGATGCCAGAGGGCACGTTCCTGGTACGAGACAGCACCCACCCCAGCT
ACCTGTTCACGCTCTCAGTCAAAACCACCCGTGGCCCCACCAACGTGCGCATCGAGTATGCTGA
CTCCAGCTTCCGCCTGGACTCCAACTGCTTGTCTCGGCCTCGTATCCTGGCCTTCCCGGATGTG
GTCAGCCTTGTGCAGCACTACGTGGCCTCCTGTGCTGCGGACACCCGAAGCGACAGCCCTGATC
CTGCTCCTGCCCCAGCCCTGCCTGTGCCTAAGGAAGATGCTCCTGGTGACCCAGCACTGCCTGC
CCCTGCCGCCACTGCTGTACACCTGAAACTGGTGCAGCCCTTCGTGCGCAGGAGCAGTGCCCGC
AGCCTGCAGCACCTGTGCCGCCTTGCCATCAACCGCCTGGTAACCGACGTGGACTGCCTGCCGC
TGCCCCGGCGCATGGCCGACTACCTCCGACAGTACCCCTTCCAGCTCTGACTGGGCCTGCTACT
TCGCCCAGCCTCGTGCAGCCACATTCCGGGGGGGACACAGGCTCCTGCTGGACTCGGGCCCCTG
CTGTCCCCCGTGCAGTCCTCATGGTGCCTACATGCATCTGGTAGCTGGACCAGGAAGAGCTAAG
AAGGAGAAGGCAGGGGGAGGAGGGGAGGTGTCACGCAGTTTGTGGCTCCATTGTTGTGAGCCGT
GTGTCAGAGGACAGGGAGACAGGCAGGACCTTGTCTCACCCTGCTGGGTAGGCCTAGGCCTTCA
CTCACCTGCCTGCCCCAGCCTTCTGAACTGTGTAGACTTTCCCAGCCCTGGTTTCTCAGTCCGT
GAGGTGGGGCAGGCCCCCTACCTCCAGCCAGCCTCAGCTGCTAGGAACATGGCCAGGGGAACTG
AGGTTGACAGTGACAGCCCTCTTGTTGAGCAGTGGGCCAGGCTGGGGGACACAGTTATACAGTA
TTTATTTATTTATTCAGCTTGGGGTTGGTCTGAGGTGATCCACCCCACCTCTCTGCCCTGAGCC
CAGGGTTGTCCAGAGATAACTGTTGACTTCTCGGTTCTTCCCTGTGGAGGCTCCATCCTGAGAT
GTTACTGGACCCAAGGCAGGCCTGGGTGTCTTAGCGCTGCCTCACCTGCGTGTGAACATGTGTA
CTCGCTTCTGGCCCCAGCACTGTTCAAGGGGGCGGATGAATGGACAAGAAATTGGAGCCAGAGC
CTCAGTCCCCAGCAGAGCCTGGAGCTCACGCCTTGGGGGACTGGGCTGGAGCTGCACGGCACTG
CCCTCGCTGTCCCACAGGCCTGGAGAGCGGAGTGCTGTGTCGGAGGGGACACCGCACCCAGGAA
GATGCCTGCGTGTGCCAGGGGGAGACGTACGTAGCTGATAAGACTTTATGGAATAATTATTGTA
ACACAGAAACCAGTTTGGTAGTCTTTTCTTCTTCCACTGATTTTTCTGTAATAATAATAAAATT
ACACCTTTCATTTATAGAGCCTGTAATGGGCCTCTTCTGA

hide sequence

RefSeq Acc Id:

XM_013507639 ⟹ XP_013363093

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955532	2,380,380 - 2,384,341 (-)	NCBI

Sequence:

show sequence

ACACACACACACACACACACACACACACGGCCCCAGAATAACTGGTTCCATCTTAGGGTTGAGG
GCAGAGACTCCCAACGTAGCTCTGCTGAAGACCCCACCCCTGGCTGAGTTCACGCCCCTGGCAT
GTGTCCTCAGGCAGGACTCACTGGCTGGGCTCCAAGGCAGGAAAACATGCGCACCTGGAACATA
CCGGCCCCCGCCCTGCCATGACACAGCCAGGGACACACCCCTGCCCAGATATGCAGTCACTCCA
GCCTTTGGAGACCAGCGCAGCCTTTCCACACCCAGATACACATCAGCCCCAGAGCTCCCACGCC
CACACAGGGGAGCTGCGGAGGTTCTGCCAAGCAGTCTGCTGTCCTCCCAGACGTTCTAGCCTAA
CCAGCTAGCTACCCACATGCTCCCAGAGCATGAGGGTGTGAACCAAGGTCTGGACCCCAGAAGG
CAGGTCACCTCAAAATTCTGCCTCCAGCTGCGCAGGCAGGATTCCAGAGAGGCCACAGTGTAGC
CAGGGTATGTGTGGAGAAGTGCTTTACAACCGTAGTGTGTCAGAGTTGTGTGGCCCCTTCTCAC
GCGTGATCCTCGGGCCCTGACCTTCGCAGGGCCACCCCGACTGTGGGGTCCGGCTTCTTTGTCT
GCCGCCAGCTCCTGCCCGTGTCTTCTTGCCTCAGAGGCAGTACCTGGCACTGTATTTCAGGCTG
TCATCTCTGCCTGCAGTGCTTTCCCTTGCCTCCTGCCTTTGGCCAGCACTCAGCTCAGGAGCAG
GCAGACCCTGACTTCCACATGACCCTGTGCTTTTGTGGCTTTGGGTCATAGTTATCCTGAGTGC
CACTTTCCCCAGCCAGTGTAGGCAGAACCCACGATTTTATTTTCTCAGGGTCCTAAGGCCCAGC
AATGATTAGACCAAAATCTGAGGCCTGGGGTTATGTTCTGTTAAGAAGGAGGAAGGACCAGCAG
TCCCTTCCTCAGGAAGCTGGCCAGTCCCTGCCCCACTACCCTGGGGAAGAAGCCCAGGGTCTCC
AAGCTTCTTCGCCAGGCGGAAGCTCTTGTGCAGATTTTGGCCAGCTCAGTTGCCCTAACTCCAG
TCATTTAAGGGTACGATGTGGCCAAACCCCCCAGTGCAGACCCCTCATTGGTGAAAGGAGCACA
GAACCCTGGGGAGGAGCAAGCTATACGTAAGACCTCGGGGCCTCGCGGGGCTCCCTTGCCAAGG
CGGGGTCTGGAGTGCTAGCTGAGTACTCTGCCCTTCAGTGGGAGCTTATGTTTGTGGGAAGTGA
GCCTTGCCTTTGTCTTCAGAGGCCACTGTCTGCTCCTGACTCTCAGCTGGGAGAAACAGAGTCT
CAGCTGGTTCTGACCTCTTGCCATCAACCGCCCGGTAACCGATGCAGACTGCCTGCCGCTGCCC
CGGCGCATGGCCGGCTACCTCCGACAGTACCCCTCCCAGCTCTGACTGGGCCTGCTACTTCGCC
CAGCCTCGTGCAGCCACATTCCAGGACCTGTGTACATCTGATCTAGTCCTTTGCTGGCTGTGGA
GCAGATTGGGCAGCGGCTCCTGTGGGCCCAGAGCCTAGAGCTGTCAGAGCCAGCCATGCAGCCT
TTCCCTGCCGGGGTCTTCCTGGAAGAGGTGCCAGCGGAGACCCCTATCCAACCAGAGAGTGAGC
CAAAGGTGCTGGACCCTGAAGAGGATCTGCTGTGCATAGCCAAGACTTTCTCCTACCTTAGAGA
ATCTGGCTGGTACTGGGGCTCCATTACAGCCAGTGAGGCCCGGCAGCACCTGCAGAAGATGCCA
GAGGGCACGTTCCTGGTACGAGACAGCACCCACCCCAGCTACCTGTTCACGCTCTCAGTCAAAA
CCACCCGTGGCCCCACCAACGTGCGCATCGAGTATGCTGACTCCAGCTTCCGCCTGGACTCCAA
CTGCTTGTCTCGGCCTCGTATCCTGGCCTTCCCGGATGTGGTCAGCCTTGTGCAGCACTACGTG
GCCTCCTGTGCTGCGGACACCCGAAGCGACAGCCCTGATCCTGCTCCTGCCCCAGCCCTGCCTG
TGCCTAAGGAAGATGCTCCTGGTGACCCAGCACTGCCTGCCCCTGCCGCCACTGCTGTACACCT
GAAACTGGTGCAGCCCTTCGTGCGCAGGAGCAGTGCCCGCAGCCTGCAGCACCTGTGCCGCCTT
GCCATCAACCGCCTGGTAACCGACGTGGACTGCCTGCCGCTGCCCCGGCGCATGGCCGACTACC
TCCGACAGTACCCCTTCCAGCTCTGACTGGGCCTGCTACTTCGCCCAGCCTCGTGCAGCCACAT
TCCGGGGGGGACACAGGCTCCTGCTGGACTCGGGCCCCTGCTGTCCCCCGTGCAGTCCTCATGG
TGCCTACATGCATCTGGTAGCTGGACCAGGAAGAGCTAAGAAGGAGAAGGCAGGGGGAGGAGGG
GAGGTGTCACGCAGTTTGTGGCTCCATTGTTGTGAGCCGTGTGTCAGAGGACAGGGAGACAGGC
AGGACCTTGTCTCACCCTGCTGGGTAGGCCTAGGCCTTCACTCACCTGCCTGCCCCAGCCTTCT
GAACTGTGTAGACTTTCCCAGCCCTGGTTTCTCAGTCCGTGAGGTGGGGCAGGCCCCCTACCTC
CAGCCAGCCTCAGCTGCTAGGAACATGGCCAGGGGAACTGAGGTTGACAGTGACAGCCCTCTTG
TTGAGCAGTGGGCCAGGCTGGGGGACACAGTTATACAGTATTTATTTATTTATTCAGCTTGGGG
TTGGTCTGAGGTGATCCACCCCACCTCTCTGCCCTGAGCCCAGGGTTGTCCAGAGATAACTGTT
GACTTCTCGGTTCTTCCCTGTGGAGGCTCCATCCTGAGATGTTACTGGACCCAAGGCAGGCCTG
GGTGTCTTAGCGCTGCCTCACCTGCGTGTGAACATGTGTACTCGCTTCTGGCCCCAGCACTGTT
CAAGGGGGCGGATGAATGGACAAGAAATTGGAGCCAGAGCCTCAGTCCCCAGCAGAGCCTGGAG
CTCACGCCTTGGGGGACTGGGCTGGAGCTGCACGGCACTGCCCTCGCTGTCCCACAGGCCTGGA
GAGCGGAGTGCTGTGTCGGAGGGGACACCGCACCCAGGAAGATGCCTGCGTGTGCCAGGGGGAG
ACGTACGTAGCTGATAAGACTTTATGGAATAATTATTGTAACACAGAAACCAGTTTGGTAGTCT
TTTCTTCTTCCACTGATTTTTCTGTAATAATAATAAAATTACACCTTTCATTTATAGAGCCTGT
AATGGGCCTCTTCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005410362	(Get FASTA)	NCBI Sequence Viewer
	XP_013363093	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010532
	ENSCLAP00000010532.1

RefSeq Acc Id:	XP_005410362 ⟸ XM_005410305
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2VAF4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVLCVRGSSPLLAVEQIGQRLLWAQSLELSEPAMQPFPAGVFLEEVPAETPIQPESEPKVLDPE EDLLCIAKTFSYLRESGWYWGSITASEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTN VRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQHYVASCAADTRSDSPDPAPAPALPVPKEDAP GDPALPAPAATAVHLKLVQPFVRRSSARSLQHLCRLAINRLVTDVDCLPLPRRMADYLRQYPFQ L hide sequence

RefSeq Acc Id:

XP_013363093 ⟸ XM_013507639

- Peptide Label:

isoform X2

- Sequence:

show sequence

MQPFPAGVFLEEVPAETPIQPESEPKVLDPEEDLLCIAKTFSYLRESGWYWGSITASEARQHLQ
KMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFPDVVSLVQ
HYVASCAADTRSDSPDPAPAPALPVPKEDAPGDPALPAPAATAVHLKLVQPFVRRSSARSLQHL
CRLAINRLVTDVDCLPLPRRMADYLRQYPFQL

hide sequence

Ensembl Acc Id:

ENSCLAP00000010532 ⟸ ENSCLAT00000010663

Protein Domains

SH2 SOCS box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007270	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010663	ENTREZGENE
	ENSCLAT00000010663.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
InterPro	CIS_SH2	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
	SOCS_box-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Cish	ENTREZGENE
PANTHER	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT	UniProtKB/TrEMBL
	PTHR10155:SF9	UniProtKB/TrEMBL
Pfam	SH2	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A0A8C2VAF4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Cish	cytokine inducible SH2 containing protein		cytokine inducible SH2-containing protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)