Npffr1 (neuropeptide FF receptor 1) - Rat Genome Database

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Gene: Npffr1 (neuropeptide FF receptor 1) Rattus norvegicus
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Symbol: Npffr1
Name: neuropeptide FF receptor 1
RGD ID: 621570
Description: Enables neuropeptide receptor activity. Involved in neuropeptide signaling pathway. Predicted to be active in cilium and plasma membrane. Orthologous to human NPFFR1 (neuropeptide FF receptor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 147; G-protein coupled receptor 147; Gpr147; NPFF1; OT7T022; RFamide-related peptide receptor; RFamide-related peptide receptor OT7T022
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,082,604 - 30,116,752 (+)NCBIGRCr8
mRatBN7.22029,539,795 - 29,573,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,555,746 - 30,587,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,942,024 - 29,973,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,684,511 - 30,715,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,214,950 - 31,248,710 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,997,426 - 33,030,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,983,735 - 28,995,194 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,997,534 - 29,008,994 (+)NCBI
Celera2030,966,998 - 30,998,217 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cilium  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. Bonini JA, etal., J Biol Chem 2000 Dec 15;275(50):39324-31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Hinuma S, etal., Nat Cell Biol 2000 Oct;2(10):703-8.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14696013   PMID:20136694   PMID:22691952   PMID:24088662   PMID:24412804   PMID:25144921   PMID:28154160  


Genomics

Comparative Map Data
Npffr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82030,082,604 - 30,116,752 (+)NCBIGRCr8
mRatBN7.22029,539,795 - 29,573,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,555,746 - 30,587,142 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,942,024 - 29,973,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,684,511 - 30,715,898 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,214,950 - 31,248,710 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,997,426 - 33,030,516 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,983,735 - 28,995,194 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,997,534 - 29,008,994 (+)NCBI
Celera2030,966,998 - 30,998,217 (+)NCBICelera
Cytogenetic Map20q11NCBI
NPFFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,247,329 - 70,284,004 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,247,329 - 70,284,004 (-)EnsemblGRCh38hg38GRCh38
GRCh371072,007,085 - 72,043,760 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,684,719 - 71,707,727 (-)NCBINCBI36Build 36hg18NCBI36
Build 341071,684,718 - 71,696,154NCBI
Celera1065,294,771 - 65,323,520 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,007,982 - 66,036,738 (-)NCBIHuRef
CHM1_11072,296,529 - 72,325,723 (-)NCBICHM1_1
T2T-CHM13v2.01071,116,278 - 71,152,972 (-)NCBIT2T-CHM13v2.0
Npffr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,430,600 - 61,465,243 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,431,271 - 61,464,344 (+)EnsemblGRCm39 Ensembl
GRCm381061,595,295 - 61,629,464 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,595,492 - 61,628,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371061,058,232 - 61,089,133 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,991,514 - 61,021,742 (+)NCBIMGSCv36mm8
Celera1062,696,844 - 62,727,819 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.24NCBI
Npffr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,976,867 - 21,001,194 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,976,867 - 21,001,194 (+)NCBIChiLan1.0ChiLan1.0
NPFFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,401,334 - 82,438,138 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,406,655 - 82,443,459 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,721,483 - 66,758,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,257,022 - 69,291,838 (-)NCBIpanpan1.1PanPan1.1panPan2
NPFFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,191,403 - 21,223,715 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,197,733 - 21,203,099 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,323,904 - 21,351,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,466,975 - 21,492,765 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,473,411 - 21,493,131 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,364,430 - 21,390,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,569,576 - 21,595,343 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0421,920,758 - 21,946,551 (-)NCBIUU_Cfam_GSD_1.0
Npffr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,834,368 - 59,851,935 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,329,153 - 8,342,246 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,327,093 - 8,342,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPFFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,182,892 - 73,205,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,183,585 - 73,195,804 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,103,900 - 79,116,127 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPFFR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1961,030,574 - 61,052,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl961,041,567 - 61,051,960 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,770,185 - 21,792,342 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npffr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,396,759 - 4,406,078 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,390,049 - 4,410,208 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npffr1
264 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:67
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000000675
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 5 34 99 30 25 13 5 13 2 96 56 87 24 59 12

Sequence


Ensembl Acc Id: ENSRNOT00000000675   ⟹   ENSRNOP00000000675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,539,795 - 29,571,196 (+)Ensembl
Rnor_6.0 Ensembl2031,234,493 - 31,245,955 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115618   ⟹   ENSRNOP00000096765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,559,513 - 29,571,196 (+)Ensembl
RefSeq Acc Id: NM_022291   ⟹   NP_071627
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,082,604 - 30,113,997 (+)NCBI
mRatBN7.22029,539,795 - 29,571,196 (+)NCBI
Rnor_6.02031,214,950 - 31,245,955 (+)NCBI
Rnor_5.02032,997,426 - 33,030,516 (+)NCBI
RGSC_v3.42028,983,735 - 28,995,194 (+)RGD
Celera2030,966,998 - 30,998,217 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256485   ⟹   XP_006256547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,102,424 - 30,116,752 (+)NCBI
mRatBN7.22029,559,528 - 29,573,951 (+)NCBI
Rnor_6.02031,234,328 - 31,248,710 (+)NCBI
Rnor_5.02032,997,426 - 33,030,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279491   ⟹   XP_063135561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82030,111,121 - 30,116,752 (+)NCBI
RefSeq Acc Id: NP_071627   ⟸   NM_022291
- UniProtKB: Q9EP86 (UniProtKB/Swiss-Prot),   F1LN94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256547   ⟸   XM_006256485
- Peptide Label: isoform X1
- UniProtKB: Q9EP86 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000675   ⟸   ENSRNOT00000000675
Ensembl Acc Id: ENSRNOP00000096765   ⟸   ENSRNOT00000115618
RefSeq Acc Id: XP_063135561   ⟸   XM_063279491
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EP86-F1-model_v2 AlphaFold Q9EP86 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621570 AgrOrtholog
BioCyc Gene G2FUF-3718 BioCyc
Ensembl Genes ENSRNOG00000000559 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000675.4 UniProtKB/TrEMBL
  ENSRNOT00000115618.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFF_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64107 UniProtKB/TrEMBL
NCBI Gene 64107 ENTREZGENE
PANTHER NEUROPEPTIDE FF RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npffr1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NPFFRECEPTR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000559 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ARK6_RAT UniProtKB/TrEMBL
  A6K402_RAT UniProtKB/TrEMBL
  F1LN94 ENTREZGENE, UniProtKB/TrEMBL
  NPFF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Npffr1  neuropeptide FF receptor 1  Gpr147  G protein-coupled receptor 147  Symbol and Name updated 1299863 APPROVED
2005-01-20 Gpr147  G protein-coupled receptor 147  OT7T022  RFamide-related peptide receptor  Symbol and Name updated 1299863 APPROVED
2002-08-07 OT7T022  RFamide-related peptide receptor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in particular regions of the hypothalamus 61730
gene_expression expressed in dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports 633416