Ces2c (carboxylesterase 2C) - Rat Genome Database

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Gene: Ces2c (carboxylesterase 2C) Rattus norvegicus
Analyze
Symbol: Ces2c
Name: carboxylesterase 2C
RGD ID: 621510
Description: Enables retinyl-palmitate esterase activity. Predicted to be involved in retinoid metabolic process. Located in intracellular membrane-bounded organelle. Orthologous to human CES2 (carboxylesterase 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ACH M1; acylcarnitine hydrolase; acylcarnitine hydrolase-like; carboxylesterase 2 (intestine, liver); carboxylesterase 2-like; carboxylic ester hydrolase; CES RL4; Ces2; Ces2l; CESRL4; LOC108348093; rCES2
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81270,377,201 - 270,384,768 (+)NCBIGRCr8
mRatBN7.21260,391,190 - 260,398,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,388,902 - 260,398,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,598,492 - 268,606,058 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01275,304,512 - 275,312,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,958,843 - 267,966,409 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,640,752 - 282,648,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,638,017 - 282,702,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01290,007,967 - 290,021,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,887,420 - 267,894,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11268,098,504 - 268,106,072 (+)NCBI
Celera1256,028,966 - 256,036,533 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthaleneacetic acid  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-bromo-2'-deoxyuridine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
butylated hydroxyanisole  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chrysene  (ISO)
clofibrate  (EXP)
cyanocob(III)alamin  (ISO)
cyproconazole  (EXP)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
epoxiconazole  (EXP)
ethanol  (ISO)
ethoxyquin  (ISO)
fentin chloride  (EXP)
fipronil  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP,ISO)
glycine betaine  (ISO)
GW 4064  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
oltipraz  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
resveratrol  (EXP)
rotenone  (EXP)
sevoflurane  (EXP)
sodium arsenite  (ISO)
spironolactone  (ISO)
streptozocin  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family. Furihata T, etal., Arch Biochem Biophys 2003 Aug 1;416(1):101-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, etal., Mamm Genome. 2010 Oct;21(9-10):427-41. Epub 2010 Oct 8.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate. Sanghani SP, etal., Eur J Biochem 2002 Sep;269(18):4387-98.
Additional References at PubMed
PMID:15632090   PMID:15794950   PMID:16527247   PMID:17392394   PMID:17764701   PMID:19187434  


Genomics

Comparative Map Data
Ces2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81270,377,201 - 270,384,768 (+)NCBIGRCr8
mRatBN7.21260,391,190 - 260,398,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,388,902 - 260,398,790 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1268,598,492 - 268,606,058 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01275,304,512 - 275,312,078 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,958,843 - 267,966,409 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,640,752 - 282,648,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,638,017 - 282,702,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01290,007,967 - 290,021,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,887,420 - 267,894,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11268,098,504 - 268,106,072 (+)NCBI
Celera1256,028,966 - 256,036,533 (+)NCBICelera
Cytogenetic Map1q55NCBI
Ces2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,573,700 - 105,581,115 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,573,700 - 105,581,115 (+)EnsemblGRCm39 Ensembl
GRCm388104,847,068 - 104,854,483 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,847,068 - 104,854,483 (+)EnsemblGRCm38mm10GRCm38
MGSCv378107,370,968 - 107,378,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,736,215 - 107,743,597 (+)NCBIMGSCv36mm8
Celera8109,077,665 - 109,085,082 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI

Variants

.
Variants in Ces2c
139 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:88
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000045656, ENSRNOT00000073241
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1259647732260522016Rat

Markers in Region
RH131401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21260,397,898 - 260,398,537 (+)MAPPERmRatBN7.2
Rnor_6.01282,684,859 - 282,685,497NCBIRnor6.0
Rnor_6.01282,647,461 - 282,648,099NCBIRnor6.0
Rnor_5.01289,983,480 - 289,984,118UniSTSRnor5.0
Rnor_5.01290,021,042 - 290,021,680UniSTSRnor5.0
RGSC_v3.41267,894,129 - 267,894,767UniSTSRGSC3.4
Celera1256,035,675 - 256,036,313UniSTS
Cytogenetic Map1q55UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 1 22 15 9 15 23 11
Below cutoff 13 24 16 10 16 7 9 6 8 33 7

Sequence


RefSeq Acc Id: NM_133586   ⟹   NP_598270
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,377,201 - 270,384,768 (+)NCBI
mRatBN7.21260,391,190 - 260,398,757 (+)NCBI
Rnor_6.01282,640,752 - 282,648,319 (+)NCBI
Rnor_5.01290,007,967 - 290,021,934 (+)NCBI
RGSC_v3.41267,887,420 - 267,894,987 (+)RGD
Celera1256,028,966 - 256,036,533 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598270 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA25690 (Get FASTA)   NCBI Sequence Viewer  
  BAA25692 (Get FASTA)   NCBI Sequence Viewer  
  BAD77829 (Get FASTA)   NCBI Sequence Viewer  
  EDL94590 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064884
  ENSRNOP00000064884.2
  ENSRNOP00000069335.2
  ENSRNOP00000072913.2
GenBank Protein O70631 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598270   ⟸   NM_133586
- Peptide Label: precursor
- UniProtKB: O70631 (UniProtKB/Swiss-Prot),   G3V9D8 (UniProtKB/Swiss-Prot),   A0A0G2K455 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Carboxylesterase type B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70631-F1-model_v2 AlphaFold O70631 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621510 AgrOrtholog
BioCyc Gene G2FUF-55209 BioCyc
Ensembl Genes ENSRNOG00000036571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074303 ENTREZGENE
  ENSRNOT00000074303.2 UniProtKB/TrEMBL
  ENSRNOT00000080995.2 UniProtKB/TrEMBL
  ENSRNOT00000082254.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171118 UniProtKB/Swiss-Prot
NCBI Gene 171118 ENTREZGENE
PANTHER ACYLCARNITINE HYDROLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam COesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ces2c PhenoGen
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036571 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JV37_RAT UniProtKB/TrEMBL
  A0A0G2K455 ENTREZGENE, UniProtKB/TrEMBL
  EST2C_RAT UniProtKB/Swiss-Prot
  G3V9D8 ENTREZGENE
  M0R646_RAT UniProtKB/TrEMBL
  O70631 ENTREZGENE
UniProt Secondary G3V9D8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ces2c  carboxylesterase 2C  LOC108348093  acylcarnitine hydrolase-like  Data merged from RGD:11416512 737654 PROVISIONAL
2016-08-02 LOC108348093  acylcarnitine hydrolase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-11-18 Ces2c  carboxylesterase 2C  Ces2l  carboxylesterase 2-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-23 Ces2l  carboxylesterase 2-like  Ces2  carboxylesterase 2 (intestine, liver)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ces2  carboxylesterase 2 (intestine, liver)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ces2  carboxylesterase 2 (intestine, liver)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the carboxylesterase gene family 634722