Vsx2 (visual system homeobox 2) - Rat Genome Database

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Gene: Vsx2 (visual system homeobox 2) Rattus norvegicus
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Symbol: Vsx2
Name: visual system homeobox 2
RGD ID: 621215
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of neuroblast proliferation; positive regulation of transcription by RNA polymerase II; and retinal bipolar neuron differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in blindness and isolated microphthalmia 2. Orthologous to human VSX2 (visual system homeobox 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C. elegans ceh-10 homeo domain containing homolog; ceh-10 homeo domain containing homolog; ceh-10 homeo domain containing homolog (C. elegans); Chx10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,932,943 - 109,972,005 (+)NCBIGRCr8
mRatBN7.26104,214,842 - 104,240,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,217,230 - 104,240,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,379,571 - 104,402,356 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,678,655 - 104,701,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,048,242 - 104,071,028 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,285,031 - 108,308,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,285,822 - 108,308,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,237,657 - 117,260,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,638,063 - 108,660,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,647,664 - 108,647,779 (+)NCBI
Celera6102,045,137 - 102,067,982 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Human microphthalmia associated with mutations in the retinal homeobox gene CHX10. Ferda Percin E, etal., Nat Genet 2000 Aug;25(4):397-401.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8630490   PMID:10482234   PMID:15576400   PMID:15767664   PMID:16236706   PMID:16384989   PMID:16547132   PMID:16854970   PMID:19389377  


Genomics

Comparative Map Data
Vsx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86109,932,943 - 109,972,005 (+)NCBIGRCr8
mRatBN7.26104,214,842 - 104,240,264 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,217,230 - 104,240,018 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,379,571 - 104,402,356 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,678,655 - 104,701,440 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,048,242 - 104,071,028 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,285,031 - 108,308,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,285,822 - 108,308,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,237,657 - 117,260,423 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,638,063 - 108,660,830 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16108,647,664 - 108,647,779 (+)NCBI
Celera6102,045,137 - 102,067,982 (+)NCBICelera
Cytogenetic Map6q31NCBI
VSX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,239,449 - 74,262,738 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,239,449 - 74,262,738 (+)EnsemblGRCh38hg38GRCh38
GRCh371474,706,152 - 74,729,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361473,775,928 - 73,799,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 341473,775,927 - 73,799,193NCBI
Celera1454,743,463 - 54,766,749 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1454,873,146 - 54,896,407 (+)NCBIHuRef
CHM1_11474,645,738 - 74,668,970 (+)NCBICHM1_1
T2T-CHM13v2.01468,447,256 - 68,470,582 (+)NCBIT2T-CHM13v2.0
Vsx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,616,602 - 84,642,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,616,536 - 84,642,231 (+)EnsemblGRCm39 Ensembl
GRCm381284,569,828 - 84,595,457 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,569,762 - 84,595,457 (+)EnsemblGRCm38mm10GRCm38
MGSCv371285,910,802 - 85,936,407 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,459,600 - 85,485,205 (+)NCBIMGSCv36mm8
Celera1286,025,411 - 86,051,063 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.28NCBI
Vsx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,193,686 - 1,210,641 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,192,035 - 1,207,949 (-)NCBIChiLan1.0ChiLan1.0
VSX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,328,455 - 75,349,803 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,544,961 - 74,566,309 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01454,797,734 - 54,821,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,651,133 - 73,672,666 (+)NCBIpanpan1.1PanPan1.1panPan2
VSX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,455,337 - 47,473,786 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,455,340 - 47,473,684 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,140,385 - 47,158,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,682,709 - 47,700,996 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,682,709 - 47,700,979 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,351,896 - 47,370,154 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,373,742 - 47,392,004 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,760,454 - 47,778,742 (+)NCBIUU_Cfam_GSD_1.0
Vsx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,561,166 - 28,581,265 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,487,702 - 3,508,191 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,487,718 - 3,507,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VSX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,531,860 - 97,552,033 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,532,021 - 97,551,072 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,375,425 - 103,394,310 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VSX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,446,781 - 51,471,156 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,447,714 - 51,469,345 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,680,858 - 39,704,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vsx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,344,221 - 27,363,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,342,668 - 27,363,372 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vsx2
165 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:625
Count of miRNA genes:271
Interacting mature miRNAs:335
Transcripts:ENSRNOT00000015889
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 113 77 76 45 25 45 6 202 95 93 45 55 31

Sequence


Ensembl Acc Id: ENSRNOT00000015889   ⟹   ENSRNOP00000015889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6104,217,230 - 104,240,018 (+)Ensembl
Rnor_6.0 Ensembl6108,285,822 - 108,308,587 (+)Ensembl
RefSeq Acc Id: NM_001169128   ⟹   NP_001162599
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,948,313 - 109,971,100 (+)NCBI
mRatBN7.26104,217,230 - 104,240,018 (+)NCBI
Rnor_6.06108,285,798 - 108,308,585 (+)NCBI
Rnor_5.06117,237,657 - 117,260,423 (-)NCBI
RGSC_v3.46108,638,063 - 108,660,830 (+)RGD
Celera6102,045,137 - 102,067,982 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594026   ⟹   XP_017449515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86109,932,943 - 109,972,005 (+)NCBI
mRatBN7.26104,214,842 - 104,240,264 (+)NCBI
Rnor_6.06108,285,031 - 108,308,588 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001162599 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449515 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK70506 (Get FASTA)   NCBI Sequence Viewer  
  EDL81517 (Get FASTA)   NCBI Sequence Viewer  
  EDL81518 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015889.6
RefSeq Acc Id: NP_001162599   ⟸   NM_001169128
- UniProtKB: G3V7K0 (UniProtKB/TrEMBL),   A6JDX4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449515   ⟸   XM_017594026
- Peptide Label: isoform X1
- UniProtKB: A6JDX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015889   ⟸   ENSRNOT00000015889
Protein Domains
CVC   Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V7K0-F1-model_v2 AlphaFold G3V7K0 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621215 AgrOrtholog
BioCyc Gene G2FUF-36816 BioCyc
Ensembl Genes ENSRNOG00000011918 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015889.7 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro CVC UniProtKB/TrEMBL
  Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  OAR_dom UniProtKB/TrEMBL
  VSX_homeobox_regulators UniProtKB/TrEMBL
KEGG Report rno:171360 UniProtKB/TrEMBL
NCBI Gene 171360 ENTREZGENE
PANTHER VISUAL SYSTEM HOMEOBOX 2 UniProtKB/TrEMBL
  VISUAL SYSTEM HOMEOBOX 2 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
PhenoGen Vsx2 PhenoGen
PROSITE CVC UniProtKB/TrEMBL
  HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  OAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011918 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A6JDX3 ENTREZGENE, UniProtKB/TrEMBL
  A6JDX4 ENTREZGENE, UniProtKB/TrEMBL
  G3V7K0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-19 Vsx2  visual system homeobox 2  Chx10  ceh-10 homeo domain containing homolog (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Chx10  ceh-10 homeo domain containing homolog (C. elegans)    C. elegans ceh-10 homeo domain containing homolog  Name updated 1299863 APPROVED
2002-08-07 Chx10  C. elegans ceh-10 homeo domain containing homolog      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_other mouse homolog is mutated in the ocular retardationJ mutant 634855