Mtnr1a (melatonin receptor 1A) - Rat Genome Database

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Gene: Mtnr1a (melatonin receptor 1A) Rattus norvegicus
Analyze
Symbol: Mtnr1a
Name: melatonin receptor 1A
RGD ID: 620797
Description: Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Involved in camera-type eye development; circadian rhythm; and negative regulation of insulin secretion. Located in neuronal cell body. Biomarker of type 2 diabetes mellitus. Orthologous to human MTNR1A (melatonin receptor 1A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: mel-1A-R; mel1a melatonin receptor; mel1a receptor; melatonin receptor type 1A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,876,964 - 53,896,421 (-)NCBIGRCr8
mRatBN7.21647,144,461 - 47,163,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1647,144,461 - 47,163,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,537,231 - 52,556,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,914,702 - 55,934,153 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,176,623 - 51,196,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,339,358 - 50,358,809 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,339,358 - 50,358,809 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01650,060,173 - 50,079,905 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,439,407 - 50,458,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,440,049 - 50,458,436 (-)NCBI
Celera1645,133,125 - 45,152,577 (-)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Induction of GDNF mRNA expression by melatonin in rat C6 glioma cells. Armstrong KJ and Niles LP, Neuroreport 2002 Mar 25;13(4):473-5.
2. Expression of mt1 melatonin receptor in rat retina: evidence for multiple cell targets for melatonin. Fujieda H, etal., Neuroscience. 1999;93(2):793-9.
3. Gene regulation of melatonin and dopamine receptors during eye development. Fujieda H, etal., Neuroscience. 2003;120(2):301-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth. Hill SM, etal., Curr Aging Sci. 2013 Feb;6(1):125-33.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Melatonin influences insulin secretion primarily via MT(1) receptors in rat insulinoma cells (INS-1) and mouse pancreatic islets. Muhlbauer E, etal., J Pineal Res. 2012 May;52(4):446-59. doi: 10.1111/j.1600-079X.2012.00959.x. Epub 2012 Jan 30.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):135-43.
10. MT1 melatonin receptor mRNA expression exhibits a circadian variation in the rat suprachiasmatic nuclei. Poirel VJ, etal., Brain Res 2002 Aug 9;946(1):64-71.
11. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Reppert SM, etal., Neuron 1994 Nov;13(5):1177-85.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. The melatonin MT1 receptor axis modulates mutant Huntingtin-mediated toxicity. Wang X, etal., J Neurosci. 2011 Oct 12;31(41):14496-507. doi: 10.1523/JNEUROSCI.3059-11.2011.
17. Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis. Zhang Y, etal., Neurobiol Dis. 2013 Jul;55:26-35. doi: 10.1016/j.nbd.2013.03.008. Epub 2013 Mar 26.
Additional References at PubMed
PMID:10531408   PMID:12000116   PMID:12062899   PMID:12644299   PMID:12697297   PMID:17349023   PMID:18039783   PMID:18384758   PMID:18513209   PMID:19340560   PMID:20424134   PMID:21211212  
PMID:21363938   PMID:22055508   PMID:25714375  


Genomics

Comparative Map Data
Mtnr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81653,876,964 - 53,896,421 (-)NCBIGRCr8
mRatBN7.21647,144,461 - 47,163,919 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1647,144,461 - 47,163,919 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1652,537,231 - 52,556,697 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01655,914,702 - 55,934,153 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01651,176,623 - 51,196,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01650,339,358 - 50,358,809 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,339,358 - 50,358,809 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01650,060,173 - 50,079,905 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,439,407 - 50,458,585 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11650,440,049 - 50,458,436 (-)NCBI
Celera1645,133,125 - 45,152,577 (-)NCBICelera
Cytogenetic Map16q11NCBI
MTNR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384186,533,655 - 186,555,567 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4186,526,792 - 186,555,567 (-)EnsemblGRCh38hg38GRCh38
GRCh374187,454,809 - 187,476,721 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,691,803 - 187,713,531 (-)NCBINCBI36Build 36hg18NCBI36
Build 344187,829,957 - 187,851,686NCBI
Celera4184,775,494 - 184,797,420 (-)NCBICelera
Cytogenetic Map4q35.2NCBI
HuRef4183,202,086 - 183,223,734 (-)NCBIHuRef
CHM1_14187,431,225 - 187,452,953 (-)NCBICHM1_1
T2T-CHM13v2.04189,880,029 - 189,902,297 (-)NCBIT2T-CHM13v2.0
Mtnr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,522,144 - 45,542,270 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl845,522,174 - 45,541,543 (+)EnsemblGRCm39 Ensembl
GRCm38845,069,107 - 45,089,233 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,069,137 - 45,088,506 (+)EnsemblGRCm38mm10GRCm38
MGSCv37846,154,564 - 46,173,860 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36846,568,027 - 46,587,323 (+)NCBIMGSCv36mm8
Celera847,756,698 - 47,775,989 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map824.95NCBI
Mtnr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,636,212 - 22,658,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,636,212 - 22,658,566 (+)NCBIChiLan1.0ChiLan1.0
MTNR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23184,264,624 - 184,293,011 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14184,611,403 - 184,641,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04178,693,869 - 178,720,351 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14190,897,192 - 190,921,677 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,897,192 - 190,921,677 (-)Ensemblpanpan1.1panPan2
MTNR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11644,258,239 - 44,286,761 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1644,744,863 - 44,773,476 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01646,475,550 - 46,506,291 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1646,477,377 - 46,504,258 (+)EnsemblROS_Cfam_1.0 Ensembl
UU_Cfam_GSD_1.01645,187,864 - 45,219,170 (+)NCBIUU_Cfam_GSD_1.0
Mtnr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494335,063,053 - 35,096,930 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,013,050 - 3,047,179 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,013,106 - 3,047,171 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTNR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl178,596,911 - 8,617,657 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1178,597,047 - 8,618,746 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2179,510,039 - 9,522,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MTNR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17132,423,619 - 132,445,881 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7132,424,052 - 132,444,860 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037112,752,358 - 112,774,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtnr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476917,320,107 - 17,355,099 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476917,320,100 - 17,355,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mtnr1a
227 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:65
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000039331
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 1 3 50 21 8 3 17 3 2 50 31 37 6 30 5

Sequence


Ensembl Acc Id: ENSRNOT00000039331   ⟹   ENSRNOP00000034328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1647,144,461 - 47,163,919 (-)Ensembl
Rnor_6.0 Ensembl1650,339,358 - 50,358,809 (-)Ensembl
RefSeq Acc Id: NM_053676   ⟹   NP_446128
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81653,876,964 - 53,896,421 (-)NCBI
mRatBN7.21647,144,461 - 47,163,919 (-)NCBI
Rnor_6.01650,339,358 - 50,358,809 (-)NCBI
Rnor_5.01650,060,173 - 50,079,905 (-)NCBI
RGSC_v3.41650,439,407 - 50,458,585 (-)RGD
Celera1645,133,125 - 45,152,577 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446128 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA57191 (Get FASTA)   NCBI Sequence Viewer  
  AAG18471 (Get FASTA)   NCBI Sequence Viewer  
  AAM18097 (Get FASTA)   NCBI Sequence Viewer  
  BAH03529 (Get FASTA)   NCBI Sequence Viewer  
  EDL78848 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034328.3
GenBank Protein P49218 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446128   ⟸   NM_053676
- UniProtKB: B7X945 (UniProtKB/TrEMBL),   A6JPS4 (UniProtKB/TrEMBL),   Q9ESJ3 (UniProtKB/TrEMBL),   F7F7U1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034328   ⟸   ENSRNOT00000039331
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49218-F1-model_v2 AlphaFold P49218 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620797 AgrOrtholog
BioCyc Gene G2FUF-11309 BioCyc
Ensembl Genes ENSRNOG00000028744 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039331.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mel_1A/1B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Melatonin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114211 UniProtKB/TrEMBL
NCBI Gene 114211 ENTREZGENE
PANTHER B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELATONIN RECEPTOR TYPE 1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mtnr1a PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELATONIN1AR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MELATONINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028744 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JPS4 ENTREZGENE, UniProtKB/TrEMBL
  B7X945 ENTREZGENE
  F7F7U1 ENTREZGENE, UniProtKB/TrEMBL
  MTR1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESJ3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7X945 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Mtnr1a  melatonin receptor 1A      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mtnr1a  melatonin receptor 1A      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression demonstrates a circadian variation in the rat suprachiasmatic nuclei 729107
gene_process upregulates expression of glial cell line-derived neurotrophic factor (GDNF) in C6 glioma cells 727356