Sel1l (SEL1L adaptor subunit of SYVN1 ubiquitin ligase) - Rat Genome Database

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Gene: Sel1l (SEL1L adaptor subunit of SYVN1 ubiquitin ligase) Rattus norvegicus
Analyze
Symbol: Sel1l
Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligase (Ensembl:SEL1L adaptor subunit of ERAD E3 ubiquitin ligase)
RGD ID: 620147
Description: Predicted to be involved in protein secretion; retrograde protein transport, ER to cytosol; and triglyceride metabolic process. Predicted to act upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: protein sel-1 homolog 1; sel-1 suppressor of lin-12-like; sel-1 suppressor of lin-12-like (C. elegans); sel-1L; Sel1 (suppressor of lin-12) 1 homolog; Sel1 (suppressor of lin-12) 1 homolog (C. elegans); Sel1h; SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; SEL1L ERAD E3 ligase adaptor subunit; suppressor of lin-12-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86116,466,163 - 116,510,436 (-)NCBIGRCr8
mRatBN7.26110,735,450 - 110,779,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6110,735,450 - 110,779,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6110,867,684 - 110,911,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06111,166,338 - 111,210,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06110,541,009 - 110,585,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06115,572,683 - 115,616,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6115,572,649 - 115,616,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06124,824,105 - 124,868,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46115,431,169 - 115,472,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16115,434,699 - 115,476,393 (-)NCBI
Celera6108,482,543 - 108,524,225 (-)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (EXP)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
inulin  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
piroxicam  (ISO)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (EXP)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. Cattaneo M, etal., Oncogene. 2003 Sep 25;22(41):6359-68.
2. Activin A induces expression of rat Sel-1l mRNA, a negative regulator of notch signaling, in rat salivary gland-derived epithelial cells. Furue M, etal., Biochem Biophys Res Commun 2001 Apr 6;282(3):745-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:20197277   PMID:21454652   PMID:25002582   PMID:25066055   PMID:25660456   PMID:26471130  


Genomics

Comparative Map Data
Sel1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86116,466,163 - 116,510,436 (-)NCBIGRCr8
mRatBN7.26110,735,450 - 110,779,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6110,735,450 - 110,779,648 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6110,867,684 - 110,911,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06111,166,338 - 111,210,632 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06110,541,009 - 110,585,315 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06115,572,683 - 115,616,904 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6115,572,649 - 115,616,859 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06124,824,105 - 124,868,320 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46115,431,169 - 115,472,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16115,434,699 - 115,476,393 (-)NCBI
Celera6108,482,543 - 108,524,225 (-)NCBICelera
Cytogenetic Map6q31NCBI
SEL1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381481,471,547 - 81,533,853 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1481,471,547 - 81,533,853 (-)EnsemblGRCh38hg38GRCh38
GRCh371481,937,891 - 82,000,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361481,007,646 - 81,069,886 (-)NCBINCBI36Build 36hg18NCBI36
Build 341481,007,645 - 81,069,886NCBI
Celera1461,979,138 - 62,040,094 (-)NCBICelera
Cytogenetic Map14q31.1NCBI
HuRef1462,106,955 - 62,169,270 (-)NCBIHuRef
CHM1_11481,875,670 - 81,937,976 (-)NCBICHM1_1
T2T-CHM13v2.01475,686,983 - 75,749,287 (-)NCBIT2T-CHM13v2.0
Sel1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391291,772,817 - 91,815,931 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1291,772,817 - 91,815,931 (-)EnsemblGRCm39 Ensembl
GRCm381291,806,043 - 91,849,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1291,806,043 - 91,849,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv371293,044,483 - 93,087,597 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361292,211,600 - 92,254,714 (-)NCBIMGSCv36mm8
Celera1293,107,703 - 93,150,124 (-)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1245.02NCBI
Sel1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554385,030,915 - 5,082,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554385,030,915 - 5,082,015 (-)NCBIChiLan1.0ChiLan1.0
SEL1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21582,584,452 - 82,645,283 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11481,800,956 - 81,861,770 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01462,050,695 - 62,111,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11481,248,441 - 81,309,597 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1481,248,441 - 81,309,597 (-)Ensemblpanpan1.1panPan2
SEL1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1853,767,799 - 53,824,391 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl853,771,252 - 53,824,298 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha853,325,952 - 53,382,542 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0853,998,407 - 54,055,128 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl854,001,605 - 54,055,110 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1853,678,556 - 53,735,166 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0853,683,173 - 53,739,757 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0854,075,302 - 54,132,159 (-)NCBIUU_Cfam_GSD_1.0
Sel1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864022,165,188 - 22,230,876 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364889,838,092 - 9,903,839 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364889,838,092 - 9,903,780 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEL1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7104,219,411 - 104,283,195 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17104,219,628 - 104,283,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27110,394,880 - 110,446,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEL1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12458,812,553 - 58,877,173 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2458,809,650 - 58,877,054 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605346,524,382 - 46,594,224 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sel1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473420,532,235 - 20,595,784 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473420,532,676 - 20,596,847 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sel1l
105 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:698
Count of miRNA genes:233
Interacting mature miRNAs:297
Transcripts:ENSRNOT00000006143, ENSRNOT00000045870
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat

Markers in Region
RH131418  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26110,753,295 - 110,753,500 (+)MAPPERmRatBN7.2
Rnor_6.06115,590,514 - 115,590,718NCBIRnor6.0
Rnor_5.06124,841,936 - 124,842,140UniSTSRnor5.0
RGSC_v3.46115,446,548 - 115,446,752UniSTSRGSC3.4
Celera6108,497,925 - 108,498,129UniSTS
RH 3.4 Map6772.3UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006143   ⟹   ENSRNOP00000006143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,735,450 - 110,779,648 (-)Ensembl
Rnor_6.0 Ensembl6115,576,576 - 115,616,766 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000045870   ⟹   ENSRNOP00000043232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,735,450 - 110,779,648 (-)Ensembl
Rnor_6.0 Ensembl6115,572,649 - 115,616,859 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097358   ⟹   ENSRNOP00000091209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,735,450 - 110,772,846 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117618   ⟹   ENSRNOP00000085181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6110,735,450 - 110,772,846 (-)Ensembl
RefSeq Acc Id: NM_177933   ⟹   NP_808794
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86116,466,163 - 116,510,361 (-)NCBI
mRatBN7.26110,735,450 - 110,779,648 (-)NCBI
Rnor_6.06115,575,135 - 115,616,857 (-)NCBI
Rnor_5.06124,824,105 - 124,868,320 (-)NCBI
RGSC_v3.46115,431,169 - 115,472,901 (-)RGD
Celera6108,482,543 - 108,524,225 (-)RGD
Sequence:
RefSeq Acc Id: XM_017594162   ⟹   XP_017449651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86116,466,176 - 116,510,436 (-)NCBI
mRatBN7.26110,735,463 - 110,779,695 (-)NCBI
Rnor_6.06115,572,683 - 115,616,904 (-)NCBI
Sequence:
RefSeq Acc Id: NP_808794   ⟸   NM_177933
- Peptide Label: precursor
- UniProtKB: Q80Z70 (UniProtKB/Swiss-Prot),   A6JED2 (UniProtKB/TrEMBL),   G3V9D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449651   ⟸   XM_017594162
- Peptide Label: isoform X1
- UniProtKB: F1LQ92 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006143   ⟸   ENSRNOT00000006143
Ensembl Acc Id: ENSRNOP00000043232   ⟸   ENSRNOT00000045870
Ensembl Acc Id: ENSRNOP00000085181   ⟸   ENSRNOT00000117618
Ensembl Acc Id: ENSRNOP00000091209   ⟸   ENSRNOT00000097358
Protein Domains
Fibronectin type-II

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z70-F1-model_v2 AlphaFold Q80Z70 1-794 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694766
Promoter ID:EPDNEW_R5290
Type:initiation region
Name:Sel1l_1
Description:SEL1L ERAD E3 ligase adaptor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06115,616,859 - 115,616,919EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620147 AgrOrtholog
BioCyc Gene G2FUF-36646 BioCyc
Ensembl Genes ENSRNOG00000004464 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006143.7 UniProtKB/TrEMBL
  ENSRNOT00000045870.6 UniProtKB/TrEMBL
  ENSRNOT00000097358.1 UniProtKB/TrEMBL
  ENSRNOT00000117618.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN_type2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kringle-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sel1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sel1_AlgK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314352 UniProtKB/TrEMBL
NCBI Gene Sel1l ENTREZGENE
PANTHER PROTEIN SEL-1 HOMOLOG 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEL-1-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sel1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sel1l PhenoGen
PRINTS FNTYPEII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004464 RatGTEx
SMART FN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SEL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP HCP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AE21_RAT UniProtKB/TrEMBL
  A0A8I6GCJ9_RAT UniProtKB/TrEMBL
  A6JED2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQ92 ENTREZGENE, UniProtKB/TrEMBL
  G3V9D3 ENTREZGENE, UniProtKB/TrEMBL
  Q80Z70 ENTREZGENE
  Q925P0_RAT UniProtKB/TrEMBL
  SE1L1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-25 Sel1l  SEL1L adaptor subunit of SYVN1 ubiquitin ligase  Sel1l  SEL1L adaptor subunit of ERAD E3 ubiquitin ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-02 Sel1l  SEL1L adaptor subunit of ERAD E3 ubiquitin ligase  Sel1l  SEL1L ERAD E3 ligase adaptor subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-27 Sel1l  SEL1L ERAD E3 ligase adaptor subunit  Sel1l  sel-1 suppressor of lin-12-like (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-19 Sel1l  sel-1 suppressor of lin-12-like (C. elegans)  Sel1h  Sel1 (suppressor of lin-12) 1 homolog (C. elegans)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression is induced in submandibular gland (SMG)-derived epithelial cells by activin A 634015