Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)

Advanced Search (OLGA)

Gene: Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1) Rattus norvegicus

Analyze

Symbol:

Pdha1

Name:

pyruvate dehydrogenase E1 subunit alpha 1

RGD ID:

3286

Description:

Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Part of pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC114215; MGC94854; PDHE1-A type I; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase alpha 1; pyruvate dehydrogenase E1 alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pdha1 (pyruvate dehydrogenase E1 alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pdha1 (pyruvate dehydrogenase E1 subunit alpha 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2)	HGNC	OrthoDB, Panther
Alliance orthologs ³
Homo sapiens (human):	PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pdha1 (pyruvate dehydrogenase E1 alpha 1)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	pdha1b (pyruvate dehydrogenase E1 alpha 1 subunit b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pdha1a (pyruvate dehydrogenase E1 alpha 1 subunit a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PDA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7024	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Pdha	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pdha-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pdha1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Pdha1l1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	38,509,158 - 38,522,986 (+)	NCBI		GRCr8
mRatBN7.2	X	34,700,481 - 34,714,309 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	34,700,409 - 34,714,311 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	35,837,874 - 35,851,694 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	39,301,516 - 39,315,336 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	34,467,574 - 34,481,394 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	37,329,779 - 37,343,410 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	37,329,779 - 37,343,410 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	37,640,725 - 37,654,356 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	55,899,491 - 55,913,319 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	55,952,967 - 55,966,789 (+)	NCBI
Celera	X	35,373,056 - 35,386,884 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Coffin-Lowry syndrome (ISO)

developmental and epileptic encephalopathy 2 (ISO)

Disease Progression (ISO)

epilepsy (ISO)

genetic disease (ISO)

glycogen storage disease IXA (ISO)

lactic acidosis (ISO)

Leigh Syndrome, X-Linked (ISO)

mitochondrial metabolism disease (ISO)

Myocardial Ischemia (ISO)

Nance-Horan syndrome (ISO)

Neurodevelopmental Disorders (ISO)

osteoarthritis (ISO)

Prostatic Neoplasms (ISO)

pyruvate decarboxylase deficiency (IMP,ISO)

Pyruvate Dehydrogenase E1 Alpha Deficiency (ISO)

Pyruvate Metabolism, Inborn Errors (ISO)

Stomach Neoplasms (ISO)

sudden infant death syndrome (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrabromodibenzodioxine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-methoxyethanol (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

angiotensin II (EXP)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bezafibrate (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

celastrol (ISO)

ciguatoxin CTX1B (ISO)

cobalt dichloride (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dichloroacetic acid (ISO)

dinophysistoxin 1 (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

duvoglustat (ISO)

epoxiconazole (ISO)

ethanol (EXP,ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

Fusaric acid (ISO)

genistein (EXP)

gentamycin (EXP)

glucose (ISO)

hydrogen peroxide (ISO)

Ile(5)-angiotensin II (EXP)

isotretinoin (ISO)

ivermectin (ISO)

kojic acid (ISO)

maneb (ISO)

metformin (ISO)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

Methylazoxymethanol acetate (EXP)

methylmercury chloride (ISO)

methylparaben (ISO)

mitoxantrone (ISO)

N-acetyl-L-cysteine (ISO)

nefazodone (EXP)

Nutlin-3 (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

PCB138 (EXP)

perfluorooctanoic acid (EXP,ISO)

picoxystrobin (ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quinoline (ISO)

resveratrol (EXP,ISO)

rotenone (EXP)

sodium arsenite (EXP,ISO)

sodium dodecyl sulfate (ISO)

sodium fluoride (ISO)

superoxide (ISO)

temozolomide (ISO)

thiram (ISO)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acetyl-CoA biosynthetic process from pyruvate (IBA,IDA,IEA,ISO)

glucose metabolic process (IEA)

tricarboxylic acid cycle (IEA)

Cellular Component

catalytic complex (ISO)

intracellular membrane-bounded organelle (IEA)

mitochondrial matrix (IEA)

mitochondrion (ISO)

nucleolus (ISO)

pyruvate dehydrogenase complex (IDA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

pyruvate dehydrogenase (acetyl-transferring) activity (IBA,IDA,IEA,ISO,ISS)

pyruvate dehydrogenase (NAD+) activity (ISO)

pyruvate dehydrogenase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	The pyruvate dehydrogenase complex: cloning of the rat somatic E1 alpha subunit and its coordinate expression with the mRNAs for the E1 beta, E2, and E3 catalytic subunits in developing rat brain.	Cullingford TE, etal., J Neurochem 1994 May;62(5):1682-90.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Mutations in the X-linked pyruvate dehydrogenase (E1) alpha subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency.	Lissens W, etal., Hum Mutat 2000;15(3):209-19.
6.	Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat.	Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1a.	Ojano-Dirain C, etal., Mol Genet Metab. 2010 Oct-Nov;101(2-3):183-91. doi: 10.1016/j.ymgme.2010.07.008. Epub 2010 Jul 15.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases.	Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
14.	Mutational study in the PDHA1 gene of 40 patients suspected of pyruvate dehydrogenase complex deficiency.	Quintana E, etal., Clin Genet. 2010 May;77(5):474-82. doi: 10.1111/j.1399-0004.2009.01313.x. Epub 2009 Dec 10.
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:2025639	PMID:11708858	PMID:14651853	PMID:16641100	PMID:17634366	PMID:18586888	PMID:18614015	PMID:19081061	PMID:19429050	PMID:20833797	PMID:21630459	PMID:22809973
PMID:26503465	PMID:27871875	PMID:28376086	PMID:29476059	PMID:35352799

Genomics

Comparative Map Data

Pdha1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	38,509,158 - 38,522,986 (+)	NCBI		GRCr8
mRatBN7.2	X	34,700,481 - 34,714,309 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	34,700,409 - 34,714,311 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	35,837,874 - 35,851,694 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	39,301,516 - 39,315,336 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	34,467,574 - 34,481,394 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	37,329,779 - 37,343,410 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	37,329,779 - 37,343,410 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	37,640,725 - 37,654,356 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	55,899,491 - 55,913,319 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	55,952,967 - 55,966,789 (+)	NCBI
Celera	X	35,373,056 - 35,386,884 (+)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

PDHA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	19,343,927 - 19,361,718 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	19,343,893 - 19,361,718 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	19,362,045 - 19,379,836 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	19,271,972 - 19,287,886 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	19,121,707 - 19,137,622	NCBI
Celera	X	23,483,337 - 23,501,163 (+)	NCBI		Celera
Cytogenetic Map	X	p22.12	NCBI
HuRef	X	17,111,170 - 17,129,001 (+)	NCBI		HuRef
CHM1_1	X	19,393,050 - 19,410,882 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	18,926,645 - 18,944,454 (+)	NCBI		T2T-CHM13v2.0

Pdha1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	158,905,215 - 158,921,426 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	158,905,205 - 158,921,409 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	160,122,219 - 160,138,430 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	160,122,209 - 160,138,413 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	156,560,151 - 156,576,268 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	155,466,324 - 155,482,441 (-)	NCBI		MGSCv36	mm8
Celera	X	143,366,647 - 143,382,812 (-)	NCBI		Celera
Cytogenetic Map	X	F4	NCBI
cM Map	X	73.95	NCBI

Pdha1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955586	97,172 - 114,928 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955586	98,492 - 114,927 (-)	NCBI	ChiLan1.0	ChiLan1.0

PDHA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	21,143,429 - 21,161,379 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	21,146,848 - 21,164,769 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	11,967,944 - 11,985,837 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	19,330,622 - 19,348,443 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	19,330,508 - 19,348,443 (+)	Ensembl	panpan1.1		panPan2

PDHA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	15,338,364 - 15,354,011 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	15,338,202 - 15,387,458 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	15,298,232 - 15,314,012 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	15,298,193 - 15,314,012 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	15,346,993 - 15,362,754 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	15,348,770 - 15,364,534 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	15,416,047 - 15,431,830 (+)	NCBI		UU_Cfam_GSD_1.0

Pdha1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	8,400,113 - 8,416,930 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936844	889,635 - 909,586 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936844	889,720 - 906,631 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDHA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	15,700,050 - 15,718,903 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	15,699,924 - 15,718,908 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	16,947,200 - 16,966,053 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDHA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	17,804,123 - 17,820,087 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	19,671,536 - 19,689,681 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdha1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624829	4,154,066 - 4,169,670 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624829	4,154,143 - 4,170,726 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pdha1
17 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	339
Count of miRNA genes:	219
Interacting mature miRNAs:	257
Transcripts:	ENSRNOT00000038352
Prediction methods:	Miranda, Pita
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598873	Memor2	Memory QTL 2	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	X	20990947	41052531	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
2290375	Gluco34	Glucose level QTL 34	2.75		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	20990947	41203591	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	15297802	60297802	Rat

Markers in Region

AI170398

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	34,714,460 - 34,714,644 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	37,343,562 - 37,343,745	NCBI	Rnor6.0
Rnor_5.0	X	37,654,508 - 37,654,691	UniSTS	Rnor5.0
RGSC_v3.4	X	55,913,471 - 55,913,654	UniSTS	RGSC3.4
Celera	X	35,387,036 - 35,387,219	UniSTS
RH 3.4 Map	X	500.8	UniSTS
Cytogenetic Map	X	q21	UniSTS

RH144218

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	34,712,636 - 34,712,737 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	37,341,738 - 37,341,838	NCBI	Rnor6.0
Rnor_5.0	X	37,652,684 - 37,652,784	UniSTS	Rnor5.0
RGSC_v3.4	X	55,911,647 - 55,911,747	UniSTS	RGSC3.4
Celera	X	35,385,212 - 35,385,312	UniSTS
Cytogenetic Map	X	q21	UniSTS

AA819807

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	34,713,892 - 34,714,106 (+)	MAPPER	mRatBN7.2
mRatBN7.2	16	82,511,694 - 82,511,908 (-)	MAPPER	mRatBN7.2
mRatBN7.2	X	34,713,892 - 34,714,106 (-)	MAPPER	mRatBN7.2
mRatBN7.2	16	82,511,694 - 82,511,908 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	37,342,994 - 37,343,207	NCBI	Rnor6.0
Rnor_6.0	16	88,344,652 - 88,344,865	NCBI	Rnor6.0
Rnor_5.0	16	87,741,383 - 87,741,596	UniSTS	Rnor5.0
Rnor_5.0	X	37,653,940 - 37,654,153	UniSTS	Rnor5.0
RGSC_v3.4	X	55,912,903 - 55,913,116	UniSTS	RGSC3.4
RGSC_v3.4	16	87,958,417 - 87,958,630	UniSTS	RGSC3.4
Celera	16	80,231,365 - 80,231,578	UniSTS
Celera	X	35,386,468 - 35,386,681	UniSTS
Cytogenetic Map	X	q21	UniSTS

RH141520

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	82,512,559 - 82,512,740 (-)	MAPPER	mRatBN7.2
mRatBN7.2	16	82,512,559 - 82,512,740 (+)	MAPPER	mRatBN7.2
mRatBN7.2	X	34,713,049 - 34,713,230 (-)	MAPPER	mRatBN7.2
mRatBN7.2	X	34,713,049 - 34,713,230 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	37,342,151 - 37,342,331	NCBI	Rnor6.0
Rnor_6.0	16	88,345,517 - 88,345,697	NCBI	Rnor6.0
Rnor_5.0	X	37,653,097 - 37,653,277	UniSTS	Rnor5.0
Rnor_5.0	16	87,742,248 - 87,742,428	UniSTS	Rnor5.0
RGSC_v3.4	X	55,912,060 - 55,912,240	UniSTS	RGSC3.4
RGSC_v3.4	16	87,959,282 - 87,959,462	UniSTS	RGSC3.4
Celera	16	80,232,230 - 80,232,410	UniSTS
Celera	X	35,385,625 - 35,385,805	UniSTS
RH 3.4 Map	X	503.51	UniSTS
Cytogenetic Map	16	q12.5	UniSTS
Cytogenetic Map	X	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000038352 ⟹ ENSRNOP00000030279

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	34,700,409 - 34,714,311 (+)	Ensembl
Rnor_6.0 Ensembl	X	37,329,779 - 37,343,410 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088802 ⟹ ENSRNOP00000069789

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	34,704,381 - 34,714,299 (+)	Ensembl
Rnor_6.0 Ensembl	X	37,329,817 - 37,341,807 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110948 ⟹ ENSRNOP00000094690

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	34,704,570 - 34,714,299 (+)	Ensembl

RefSeq Acc Id:

NM_001004072 ⟹ NP_001004072

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	38,509,158 - 38,522,986 (+)	NCBI
mRatBN7.2	X	34,700,481 - 34,714,309 (+)	NCBI
Rnor_6.0	X	37,329,779 - 37,343,410 (+)	NCBI
Rnor_5.0	X	37,640,725 - 37,654,356 (+)	NCBI
RGSC_v3.4	X	55,899,491 - 55,913,319 (+)	RGD
Celera	X	35,373,056 - 35,386,884 (+)	RGD

Sequence:

show sequence

CTGGGTGCCGCGGCTGCCGCGTCAGTCTGCTGCGCTCCATGAGGAAGATGCTTGCCGCTGTGTC
CCGCGTGTTGGCAGGCGCTGCGCAGAAGCCGGCAAGCAGAGTGCTGGTAGCTTCCCGTAATTTC
GCAAATGATGCTACATTTGAGATTAAGAAATGTGACCTTCATCGTCTAGAAGAGGGCCCTCCAG
TCACCACAGTGCTCACCAGAGAGGATGGGCTCAAGTACTACAGGATGATGCAGACCGTGCGCCG
GATGGAGCTCAAGGCGGATCAGCTGTATAAGCAGAAAATTATTCGTGGTTTCTGTCACTTGTGT
GATGGTCAGGAAGCCTGCTGTGTGGGCCTGGAGGCTGGCATAAACCCCACGGACCATCTCATCA
CTGCCTATCGAGCCCATGGCTTCACCTTCACTCGGGGCCTGCCTGTCCGAGCAATTCTTGCAGA
ATTAACAGGACGAAGAGGAGGCTGTGCTAAGGGGAAAGGCGGATCAATGCACATGTACGCCAAG
AACTTCTATGGCGGCAACGGTATCGTTGGAGCTCAGGTGCCCCTGGGTGCAGGAATTGCTCTGG
CCTGCAAGTATAATGGCAAAGATGAGGTCTGTTTGACATTATATGGTGATGGTGCTGCTAACCA
GGGTCAGATATTTGAAGCTTACAATATGGCAGCATTGTGGAAATTACCTTGTATTTTCATCTGT
GAGAATAACCGCTATGGCATGGGCACATCTGTTGAGAGAGCAGCAGCCAGCACGGATTACTACA
AAAGAGGAGATTTCATTCCTGGACTGAGGGTAGATGGAATGGATATCTTGTGTGTCCGAGAGGC
AACAAAGTTTGCAGCTGCCTACTGCAGGTCTGGTAAGGGGCCTATCCTGATGGAGCTACAGACT
TACCGCTACCATGGACATAGTATGAGTGACCCTGGAGTCAGTTATCGCACTCGAGAAGAAATCC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGATAGAATGGTGAACAGCAATCT
TGCAAGTGTTGAAGAATTAAAGGAGATTGATGTGGAAGTGAGGAAAGAAATCGAGGATGCTGCC
CAGTTTGCCACGGCTGATCCGGAGCCGCCATTGGAGGAGCTAGGCTATCATATCTACAGCAGTG
ACCCACCCTTCGAAGTGCGTGGTGCCAACCAGTGGATCAAGTTTAAGTCAGTCAGTTAATGGGA
GAGTATTAGATGGATGGGCGTTTCTCATCCGTTGTAAGAAACTCTTTGTGCTCTCAACTTTGAC
AGGAAATACCCAGACAACAAAAGTCTTGAAAACATGTAAATTAAGGGAGAGTAAAATTGCATGC
AGTTTGTACATTGTTGTATTCGGTGTATTCATGTGAATAAGAGTGTATAGGATTGGAGATGGGT
AATGCAGTTTATAACCTTCATCATGTCCTAGGTCAGTTACTAAAAGGAACAACTCTGCCATTTG
GTGATGTGATCATAGCTTTGAATGACCTTGTGGAGGCATGCTGGGATTAATGCAAAGCACAGGT
TAGAAGTGTATGGTCACCATGAATTGTGGAGGCTGGACTCTGTTTGGCACTGACCGTTATGTCT
TTGATCAAAGGCTATATATAATCATGTGTTTTAAAATAAGGGTACTTCAGTCACTTCAAAGGTA
AAATAATTTAATTTTCTCCATTTAGACATTTAACAAACACAAAATTGTACTCCCATTCCAAGGC
ACACTTTTTAACTTTTCACATTTAAGTAATTACACTGGTTTATAAAATACTTAGGCTTTATCTT
TCCAGCAACTGCTATAAGGTATGCTGACATTTTAAATACTAGGTCAGGAGAGACATTACTTACA
ATCCGGTTTATAAACAAGTATGCTCTAAATCACATGTGCTTGAATGAAACGAACAAGGGTCTTT
CTGTGTAAACGCAGGATTTGTGTGTGCACTAACAGAAGCTTTAATCGTGAGCAGGTGTAGGGTA
CTTTTTGCTCATTCTCCCCAGCTTGGCTTATTGTGAGGACTCCTGCATTTGTCTTCTGTGCTGG
GAGACTGCATGCCAGAGCCTACAGAGGACACCACCACTGCAAAACAATAATTTTCATAAGAAAA
GCAAACTTGAAGCCACCCATCTACTCTTCAAATGTAATCTCTAACTTAAAAGTATGTAACCTTT
TCCTAGACATGGTACCATAGGAACACTGGGTGATCTGGGTAGAGGTGTGGGCATTTAAACAATG
TAAAGAAAGGTCTGGCACCTCATGCCTTGCCAACCTGAGAAAATGAGCTGTGCTTGCTACAACA
TAGGAAAGATAAATTTCAAAGATCGGGGAAACTACCAGCATTAAAAATAAAAGTATTCACATAA
AAAAGCCCCATTTTATTATTTAAATTGTTTGCAGGCTCTCTTACCGTAGTCTGAGGCACCTTAG
GTCTTCCTTAGTGATATCATTGAGAATATCAGAAAGTGTGTAATCTTCTTCAACAATCTGAAAG
ATTCAACATACATTCAACAACATAAGCAGCTTTTCAACAGTATCATAGGAATCCTTTGATTTAG
AAATTTACCTTTTCTATTGTATTTGCATCCACTCCTTGTAGCTGCAACCAGTCTATAAGCTCTC
TGTTGGTTCCCAGTCCGTCATGGGGTGGTGGGTTCTCTGTTCCACCTATAAAGATTCCAATTTT
GTTTTATTGTATAGTAATGTATAACCATAAAATGCTTCAAAAATAACAAAGTGGATGTAATCAT
GTATCCAAACAGAAATGTAAATGTGCTGTGAAAAGGAAATGAATTAAACTTGTTTGACCCGCAA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004072	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98897	(Get FASTA)	NCBI Sequence Viewer
	EDL96148	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000030279.7
	ENSRNOP00000069789.2
	ENSRNOP00000094690.1
GenBank Protein	P26284	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004072 ⟸ NM_001004072
- Peptide Label:	precursor
- UniProtKB:	P26284 (UniProtKB/Swiss-Prot), Q4FZZ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRKMLAAVSRVLAGAAQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKY YRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRG LPVRAILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLT LYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDG MDILCVREATKFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLL KDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWI KFKSVS hide sequence

Ensembl Acc Id:

ENSRNOP00000030279 ⟸ ENSRNOT00000038352

Ensembl Acc Id:

ENSRNOP00000069789 ⟸ ENSRNOT00000088802

Ensembl Acc Id:

ENSRNOP00000094690 ⟸ ENSRNOT00000110948

Protein Domains

Dehydrogenase E1 component

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P26284-F1-model_v2	AlphaFold	P26284	1-390	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701816

Promoter ID:

EPDNEW_R12333

Type:

initiation region

Name:

Pdha1_1

Description:

pyruvate dehydrogenase E1 alpha 1 subunit

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	37,329,767 - 37,329,827	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3286	AgrOrtholog
BioCyc Gene	G2FUF-2492	BioCyc
Ensembl Genes	ENSRNOG00000025383	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038352.7	UniProtKB/TrEMBL
	ENSRNOT00000088802.2	UniProtKB/TrEMBL
	ENSRNOT00000110948.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.970	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7103543	IMAGE-MGC_LOAD
	IMAGE:7109678	IMAGE-MGC_LOAD
InterPro	DH_E1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PDH_E1_Alpha_Subunit	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pyrv_DH_E1_asu_subgrp-y	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	THDP-binding	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29554	UniProtKB/TrEMBL
MGC_CLONE	MGC:114215	IMAGE-MGC_LOAD
	MGC:94854	IMAGE-MGC_LOAD
NCBI Gene	29554	ENTREZGENE
PANTHER	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, SOMATIC FORM, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	E1_dh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pdha1	PhenoGen
RatGTEx	ENSRNOG00000025383	RatGTEx
Superfamily-SCOP	SSF52518	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JW90_RAT	UniProtKB/TrEMBL
	A0A8I6GKV6_RAT	UniProtKB/TrEMBL
	F7FKI5_RAT	UniProtKB/TrEMBL
	ODPA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q4FZZ4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-12-06	Pdha1	pyruvate dehydrogenase E1 subunit alpha 1	Pdha1	pyruvate dehydrogenase E1 alpha 1 subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-08-23	Pdha1	pyruvate dehydrogenase E1 alpha 1 subunit	Pdha1	pyruvate dehydrogenase alpha 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-06-20	Pdha1	pyruvate dehydrogenase alpha 1	Pdha1	pyruvate dehydrogenase (lipoamide) alpha 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-02-26	Pdha1	pyruvate dehydrogenase (lipoamide) alpha 1	Pdha1	pyruvate dehydrogenase E1 alpha 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Pdha1	Pyruvate dehydrogenase (lipoamide) alpha 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation of the human homolog is detected in patients with pyruvate dehydrogenase complex deficiency disease	731230

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)