Andpro (androgen regulated protein) - Rat Genome Database

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Gene: Andpro (androgen regulated protein) Rattus norvegicus
Analyze
Symbol: Andpro
Name: androgen regulated protein
RGD ID: 2115
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Involved in androgen receptor signaling pathway; cellular response to dexamethasone stimulus; and cellular response to testosterone stimulus. Located in extracellular region; INTERACTS WITH ammonium chloride; atrazine; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: androgen regulated 20 kDa protein; androgen-regulated 20 kDa protein; CRP-1; Crp1; cystatin-related protein 1; prostatic 22 kDa glycoprotein P22K16/P22K20; RATANDPRO
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83157,171,739 - 157,178,262 (-)NCBIGRCr8
mRatBN7.23136,718,601 - 136,725,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,718,602 - 136,724,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,713,691 - 140,720,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03149,297,399 - 149,303,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,944,189 - 146,950,550 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,893,005 - 143,899,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,893,006 - 143,899,370 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03150,274,643 - 150,281,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43138,085,660 - 138,092,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,991,232 - 137,997,597 (-)NCBI
Celera3135,466,151 - 135,472,515 (-)NCBICelera
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of rat prostatic secreted proteins using mass spectrometric analysis and androgen-dependent mRNA expression. Fujimoto N, etal., J Androl. 2009 Nov-Dec;30(6):669-78. doi: 10.2164/jandrol.108.005553. Epub 2009 Jul 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Primary structure and androgen regulation of a 20-kilodalton protein specific to rat ventral prostate. Ho KC, etal., Biochemistry 1989 Jul 25;28(15):6367-73.
4. A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity. Ho KC, etal., J Biol Chem. 1993 Dec 25;268(36):27226-35.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. Androgenic induction of cystatin-related protein and the C3 component of prostatic binding protein in primary cultures from the rat lacrimal gland. Vanaken H, etal., Mol Cell Endocrinol. 1996 Aug 9;121(2):197-205.
10. Tissue-specific expression and androgen regulation of different genes encoding rat prostatic 22-kilodalton glycoproteins homologous to human and rat cystatin. Winderickx J, etal., Mol Endocrinol 1990 Apr;4(4):657-67.
11. Molecular targets for diabetes mellitus-associated erectile dysfunction. Yohannes E, etal., Mol Cell Proteomics. 2010 Mar;9(3):565-78. doi: 10.1074/mcp.M900286-MCP200. Epub 2009 Dec 10.
Additional References at PubMed
PMID:7679983   PMID:8462870   PMID:12477932   PMID:22090504   PMID:23580065  


Genomics

Comparative Map Data
Andpro
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83157,171,739 - 157,178,262 (-)NCBIGRCr8
mRatBN7.23136,718,601 - 136,725,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,718,602 - 136,724,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3140,713,691 - 140,720,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03149,297,399 - 149,303,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,944,189 - 146,950,550 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,893,005 - 143,899,609 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,893,006 - 143,899,370 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03150,274,643 - 150,281,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43138,085,660 - 138,092,024 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13137,991,232 - 137,997,597 (-)NCBI
Celera3135,466,151 - 135,472,515 (-)NCBICelera
Cytogenetic Map3q41NCBI
CST4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382023,685,640 - 23,689,038 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2023,685,640 - 23,689,038 (-)EnsemblGRCh38hg38GRCh38
GRCh372023,666,277 - 23,669,675 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362023,614,277 - 23,617,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 342023,614,276 - 23,617,662NCBI
Celera2023,739,545 - 23,742,930 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2023,626,229 - 23,629,613 (-)NCBIHuRef
CHM1_12023,666,297 - 23,669,682 (-)NCBICHM1_1
T2T-CHM13v2.02023,745,196 - 23,748,594 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Andpro
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000049635
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3121056165145956249Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat

Markers in Region
D3Wox17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,723,002 - 136,723,158 (+)MAPPERmRatBN7.2
Rnor_6.03143,897,407 - 143,897,562NCBIRnor6.0
Rnor_5.03150,279,045 - 150,279,200UniSTSRnor5.0
RGSC_v3.43138,090,061 - 138,090,216UniSTSRGSC3.4
Celera3135,470,552 - 135,470,707UniSTS
Cytogenetic Map3q41UniSTS
D3Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,720,274 - 136,720,446 (+)MAPPERmRatBN7.2
Rnor_6.03143,894,679 - 143,894,850NCBIRnor6.0
Rnor_5.03150,276,317 - 150,276,488UniSTSRnor5.0
RGSC_v3.43138,087,333 - 138,087,504UniSTSRGSC3.4
Celera3135,467,824 - 135,467,995UniSTS
Cytogenetic Map3q41UniSTS
D3Wox18  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,462,228 - 136,462,415 (+)MAPPERmRatBN7.2
mRatBN7.23136,722,906 - 136,723,130 (+)MAPPERmRatBN7.2
mRatBN7.23136,445,224 - 136,445,410 (+)MAPPERmRatBN7.2
Rnor_6.03143,332,780 - 143,332,965NCBIRnor6.0
Rnor_6.03143,897,311 - 143,897,534NCBIRnor6.0
Rnor_5.03150,278,949 - 150,279,172UniSTSRnor5.0
Rnor_5.03149,741,318 - 149,741,503UniSTSRnor5.0
Celera3135,680,194 - 135,680,373UniSTS
Celera3135,470,456 - 135,470,679UniSTS
Cytogenetic Map3q41UniSTS
D3Wox29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23136,720,277 - 136,720,448 (+)MAPPERmRatBN7.2
Rnor_6.03143,894,682 - 143,894,852NCBIRnor6.0
Rnor_5.03150,276,320 - 150,276,490UniSTSRnor5.0
RGSC_v3.43138,087,336 - 138,087,506UniSTSRGSC3.4
Celera3135,467,827 - 135,467,997UniSTS
Cytogenetic Map3q41UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 9 3
Below cutoff 2 10 2 7 2 5 5 2 3 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049635   ⟹   ENSRNOP00000040184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3136,718,602 - 136,724,966 (-)Ensembl
Rnor_6.0 Ensembl3143,893,006 - 143,899,370 (-)Ensembl
RefSeq Acc Id: NM_012718   ⟹   NP_036850
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83157,171,740 - 157,178,104 (-)NCBI
mRatBN7.23136,718,602 - 136,724,966 (-)NCBI
Rnor_6.03143,893,006 - 143,899,370 (-)NCBI
Rnor_5.03150,274,643 - 150,281,008 (-)NCBI
RGSC_v3.43138,085,660 - 138,092,024 (-)RGD
Celera3135,466,151 - 135,472,515 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235184   ⟹   XP_006235246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83157,171,739 - 157,178,262 (-)NCBI
mRatBN7.23136,718,601 - 136,725,131 (-)NCBI
Rnor_6.03143,893,005 - 143,899,609 (-)NCBI
Rnor_5.03150,274,643 - 150,281,008 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036850   ⟸   NM_012718
- Peptide Label: precursor
- UniProtKB: Q63674 (UniProtKB/Swiss-Prot),   P22282 (UniProtKB/Swiss-Prot),   A0A0G2JSU6 (UniProtKB/TrEMBL),   A6K7E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235246   ⟸   XM_006235184
- Peptide Label: isoform X1
- UniProtKB: A6K7E2 (UniProtKB/TrEMBL),   A0A0G2JSU6 (UniProtKB/TrEMBL),   A6K7E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000040184   ⟸   ENSRNOT00000049635
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22282-F1-model_v2 AlphaFold P22282 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692509
Promoter ID:EPDNEW_R3034
Type:multiple initiation site
Name:Andpro_1
Description:androgen regulated protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,899,370 - 143,899,430EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2115 AgrOrtholog
BioCyc Gene G2FUF-47480 BioCyc
Ensembl Genes ENSRNOG00000031840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055002427 UniProtKB/Swiss-Prot
  ENSRNOG00055023229 UniProtKB/Swiss-Prot
  ENSRNOG00060002032 UniProtKB/Swiss-Prot
  ENSRNOG00060005718 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049635 ENTREZGENE
  ENSRNOT00000049635.2 UniProtKB/TrEMBL
  ENSRNOT00055003853 UniProtKB/Swiss-Prot
  ENSRNOT00055039915 UniProtKB/Swiss-Prot
  ENSRNOT00060003188 UniProtKB/Swiss-Prot
  ENSRNOT00060009491 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5621067 IMAGE-MGC_LOAD
InterPro Cystatin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25030 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72510 IMAGE-MGC_LOAD
NCBI Gene 25030 ENTREZGENE
PANTHER CYSTATIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATIN 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Andpro PhenoGen
RatGTEx ENSRNOG00000031840 RatGTEx
  ENSRNOG00055002427 RatGTEx
  ENSRNOG00055023229 RatGTEx
  ENSRNOG00060002032 RatGTEx
  ENSRNOG00060005718 RatGTEx
SMART SM00043 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC203926
UniProt 22P1_RAT UniProtKB/Swiss-Prot
  A0A0G2JSU6 ENTREZGENE, UniProtKB/TrEMBL
  A6K7E2 ENTREZGENE, UniProtKB/TrEMBL
  A6K7E5 ENTREZGENE, UniProtKB/TrEMBL
  P22282 ENTREZGENE
  Q63674 ENTREZGENE
UniProt Secondary Q63674 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-04-27 Andpro  androgen regulated protein  Andpro  androgen regulated 20 kDa protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Andpro  Androgen regulated 20 kDa protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in ventral prostate 632205
gene_protein 20 kDa protein 632205
gene_regulation expression is induced by androgen 632205