Nfatc3 (nuclear factor of activated T cells 3) - Rat Genome Database

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Gene: Nfatc3 (nuclear factor of activated T cells 3) Heterocephalus glaber
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Symbol: Nfatc3
Name: nuclear factor of activated T cells 3
RGD ID: 18935672
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN blood vessel remodeling (ortholog); branching involved in blood vessel morphogenesis (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN calcineurin signaling pathway; endothelin signaling pathway; nuclear factor of activated T-cells signaling pathway; ASSOCIATED WITH keratoconus (ortholog); Left Ventricular Hypertrophy (ortholog); Right Ventricular Hypertrophy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Nuclear factor of activated T-cells, cytoplasmic 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,210,401 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Nfatc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,210,401 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
NFATC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,085,370 - 68,229,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,084,751 - 68,229,259 (+)Ensemblhg38GRCh38
GRCh371668,119,273 - 68,263,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,676,876 - 66,818,338 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1652,627,801 - 52,769,327 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,992,420 - 54,136,266 (+)NCBIHuRef
CHM1_11669,527,224 - 69,671,199 (+)NCBICHM1_1
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBIT2T-CHM13v2.0
Nfatc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,785,450 - 106,857,169 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,785,472 - 106,857,169 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388106,058,818 - 106,130,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,058,840 - 106,130,537 (+)Ensemblmm10GRCm38
MGSCv378108,583,503 - 108,654,437 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368108,949,013 - 109,017,574 (+)NCBIMGSCv36mm8
Celera8110,287,705 - 110,358,321 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.08NCBI
Nfatc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,870,464 - 50,944,992 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,870,489 - 50,944,992 (+)EnsemblGRCr8
mRatBN7.21933,960,643 - 34,035,150 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,776,399 - 40,850,692 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,429,711 - 41,504,000 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,728,856 - 43,803,148 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1944,657,865 - 44,732,274 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1942,782,713 - 42,857,119 (+)NCBILyon_Normotensive
Lyon_Hypertensive1944,656,050 - 44,730,465 (+)NCBILyon_Hypertensive
F344_StmMcwi1942,415,192 - 42,489,122 (+)NCBIF344_StmMcwi
Rnor_6.01938,039,542 - 38,114,003 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,039,564 - 38,114,003 (+)Ensemblrn6Rnor6.0
Rnor_5.01948,906,285 - 48,980,756 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,907,800 - 35,982,095 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1933,388,369 - 33,462,475 (+)NCBICelera
RGSC_v3.11935,912,754 - 35,984,893 (+)NCBI
Cytogenetic Map19q12NCBI
Nfatc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,436,330 - 8,526,680 (-)Ensembl
ChiLan1.0NW_0049554848,433,765 - 8,558,005 (-)NCBIChiLan1.0ChiLan1.0
NFATC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,626,490 - 77,774,335 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,537,771 - 83,685,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,456,144 - 48,603,306 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,850,860 - 67,998,381 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,888,806 - 67,996,274 (+)EnsemblpanPan2panpan1.1
NFATC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,294,656 - 81,434,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,296,214 - 81,434,250 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha581,284,804 - 81,424,209 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0581,729,667 - 81,869,214 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,729,671 - 81,869,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,556,378 - 81,695,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,238,820 - 81,378,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,880,342 - 82,019,645 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfatc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,031,813 - 41,126,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,462,298 - 18,555,220 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,462,424 - 18,557,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,666,549 - 28,806,419 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,836,379 - 25,876,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,193,139 - 59,346,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604721,929,743 - 22,082,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11725,804,233 - 25,870,045 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000018691   ⟹   ENSHGLP00000018507
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,171,671 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000018692   ⟹   ENSHGLP00000018508
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474618,085,549 - 18,210,401 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000018693   ⟹   ENSHGLP00000018509
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474618,093,998 - 18,210,401 (-)Ensembl
RefSeq Acc Id: XM_004842985   ⟹   XP_004843042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474618,083,051 - 18,210,396 (-)NCBI
RefSeq Acc Id: XM_013071534   ⟹   XP_012926988
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474618,083,051 - 18,210,395 (-)NCBI
RefSeq Acc Id: XM_021256811   ⟹   XP_021112470
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBI
RefSeq Acc Id: XM_021256812   ⟹   XP_021112471
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004843042 (Get FASTA)   NCBI Sequence Viewer  
  XP_012926988 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112470 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112471 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB17048 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000018508
  ENSHGLP00000018509
RefSeq Acc Id: XP_021112470   ⟸   XM_021256811
- Peptide Label: isoform X1
- UniProtKB: A0AAX6STH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112471   ⟸   XM_021256812
- Peptide Label: isoform X2
- UniProtKB: A0AAX6SS00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843042   ⟸   XM_004842985
- Peptide Label: isoform X3
- UniProtKB: A0AAX6P410 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012926988   ⟸   XM_013071534
- Peptide Label: isoform X4
- UniProtKB: G5C687 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000018508   ⟸   ENSHGLT00000018692
Ensembl Acc Id: ENSHGLP00000018509   ⟸   ENSHGLT00000018693
Ensembl Acc Id: ENSHGLP00000018507   ⟸   ENSHGLT00000018691


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013248 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000018692 ENTREZGENE
  ENSHGLT00000018693 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101696341 UniProtKB/TrEMBL
NCBI Gene Nfatc3 ENTREZGENE
PANTHER NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3 UniProtKB/TrEMBL
  PTHR12533 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0AAX6P410 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SS00 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6STH3 ENTREZGENE, UniProtKB/TrEMBL
  G5C687 ENTREZGENE, UniProtKB/TrEMBL