NFATC3 (nuclear factor of activated T cells 3) - Rat Genome Database

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Gene: NFATC3 (nuclear factor of activated T cells 3) Sus scrofa
Analyze
Symbol: NFATC3
Name: nuclear factor of activated T cells 3
RGD ID: 14023300
Description: ENCODES a protein that exhibits chromatin binding (ortholog); sequence-specific DNA binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN blood vessel remodeling (ortholog); branching involved in blood vessel morphogenesis (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN calcineurin signaling pathway; endothelin signaling pathway; nuclear factor of activated T-cells signaling pathway; ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); keratoconus (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells, cytoplasmic 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,666,549 - 28,806,419 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,836,379 - 25,876,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
NFATC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,666,549 - 28,806,419 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,836,379 - 25,876,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,085,370 - 68,229,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1668,084,751 - 68,229,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,119,273 - 68,263,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,676,876 - 66,818,338 (+)NCBINCBI36Build 36hg18NCBI36
Celera1652,627,801 - 52,769,327 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,992,420 - 54,136,266 (+)NCBIHuRef
CHM1_11669,527,224 - 69,671,199 (+)NCBICHM1_1
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBIT2T-CHM13v2.0
Nfatc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,785,450 - 106,857,169 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,785,472 - 106,857,169 (+)EnsemblGRCm39 Ensembl
GRCm388106,058,818 - 106,130,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,058,840 - 106,130,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,583,503 - 108,654,437 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,949,013 - 109,017,574 (+)NCBIMGSCv36mm8
Celera8110,287,705 - 110,358,321 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.08NCBI
Nfatc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,870,464 - 50,944,992 (+)NCBIGRCr8
mRatBN7.21933,960,643 - 34,035,150 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,776,399 - 40,850,692 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,429,711 - 41,504,000 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,728,856 - 43,803,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01938,039,542 - 38,114,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,039,564 - 38,114,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,906,285 - 48,980,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,907,800 - 35,982,095 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,912,754 - 35,984,893 (+)NCBI
Celera1933,388,369 - 33,462,475 (+)NCBICelera
Cytogenetic Map19q12NCBI
Nfatc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,436,330 - 8,526,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,433,765 - 8,558,005 (-)NCBIChiLan1.0ChiLan1.0
NFATC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,626,490 - 77,774,335 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,537,771 - 83,685,615 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,456,144 - 48,603,306 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,850,860 - 67,998,381 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,888,806 - 67,996,274 (+)Ensemblpanpan1.1panPan2
NFATC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,294,656 - 81,434,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,296,214 - 81,434,250 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,284,804 - 81,424,209 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0581,729,667 - 81,869,214 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl581,729,671 - 81,869,180 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,556,378 - 81,695,850 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,238,820 - 81,378,048 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0581,880,342 - 82,019,645 (-)NCBIUU_Cfam_GSD_1.0
Nfatc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,031,813 - 41,126,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,462,298 - 18,555,220 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,462,424 - 18,557,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,193,139 - 59,346,361 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604721,929,743 - 22,082,004 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,210,401 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NFATC3
2544 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 5 2 1 1
Low 10 2 3 23 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025781   ⟹   ENSSSCP00000021956
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,617,445 - 28,769,936 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048178   ⟹   ENSSSCP00000051545
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,666,652 - 28,806,419 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050722   ⟹   ENSSSCP00000053805
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,666,606 - 28,788,032 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000051936   ⟹   ENSSSCP00000047112
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,666,549 - 28,771,093 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062417   ⟹   ENSSSCP00000056644
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,666,730 - 28,806,314 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000063104   ⟹   ENSSSCP00000053170
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl628,666,546 - 28,771,166 (+)Ensembl
RefSeq Acc Id: XM_021094122   ⟹   XP_020949781
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094123   ⟹   XP_020949782
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,666,502 - 28,806,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094124   ⟹   XP_020949783
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,666,502 - 28,770,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094125   ⟹   XP_020949784
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,688,021 - 28,806,420 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094126   ⟹   XP_020949785
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,666,954 - 28,806,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094128   ⟹   XP_020949787
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,667,011 - 28,806,423 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094129   ⟹   XP_020949788
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,667,011 - 28,770,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021094130   ⟹   XP_020949789
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1628,666,546 - 28,766,946 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020949781   ⟸   XM_021094122
- Peptide Label: isoform X1
- UniProtKB: A0A4X1UG32 (UniProtKB/TrEMBL),   A0A287B5I3 (UniProtKB/TrEMBL),   A0A8D1ZWX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949782   ⟸   XM_021094123
- Peptide Label: isoform X2
- UniProtKB: A0A4X1UD30 (UniProtKB/TrEMBL),   A0A287BJE3 (UniProtKB/TrEMBL),   A0A287BCI3 (UniProtKB/TrEMBL),   A0A287ATC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949783   ⟸   XM_021094124
- Peptide Label: isoform X3
- UniProtKB: A0A287AV99 (UniProtKB/TrEMBL),   A0A4X1UF41 (UniProtKB/TrEMBL),   A0A287ATC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949789   ⟸   XM_021094130
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_020949785   ⟸   XM_021094126
- Peptide Label: isoform X5
- UniProtKB: A0A8D1J0V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949787   ⟸   XM_021094128
- Peptide Label: isoform X6
- UniProtKB: A0A8D0ZPZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949788   ⟸   XM_021094129
- Peptide Label: isoform X7
- UniProtKB: A0A8D1Q9M5 (UniProtKB/TrEMBL),   A0A8D0ZPZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949784   ⟸   XM_021094125
- Peptide Label: isoform X4
- UniProtKB: A0A8D1J0V7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047112   ⟸   ENSSSCT00000051936
RefSeq Acc Id: ENSSSCP00000053805   ⟸   ENSSSCT00000050722
RefSeq Acc Id: ENSSSCP00000021956   ⟸   ENSSSCT00000025781
RefSeq Acc Id: ENSSSCP00000056644   ⟸   ENSSSCT00000062417
RefSeq Acc Id: ENSSSCP00000053170   ⟸   ENSSSCT00000063104
RefSeq Acc Id: ENSSSCP00000051545   ⟸   ENSSSCT00000048178
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029578 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025063089 UniProtKB/TrEMBL
  ENSSSCG00035040674 UniProtKB/TrEMBL
  ENSSSCG00045031481 UniProtKB/TrEMBL
  ENSSSCG00055011057 UniProtKB/TrEMBL
  ENSSSCG00065069085 UniProtKB/TrEMBL
  ENSSSCG00070016344 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048178 ENTREZGENE
  ENSSSCT00000048178.3 UniProtKB/TrEMBL
  ENSSSCT00000051936 ENTREZGENE
  ENSSSCT00000051936.3 UniProtKB/TrEMBL
  ENSSSCT00000062417 ENTREZGENE
  ENSSSCT00000062417.3 UniProtKB/TrEMBL
  ENSSSCT00025086372.1 UniProtKB/TrEMBL
  ENSSSCT00025086587.1 UniProtKB/TrEMBL
  ENSSSCT00035054032.1 UniProtKB/TrEMBL
  ENSSSCT00035054037.1 UniProtKB/TrEMBL
  ENSSSCT00035054040.1 UniProtKB/TrEMBL
  ENSSSCT00035054044.1 UniProtKB/TrEMBL
  ENSSSCT00035054052.1 UniProtKB/TrEMBL
  ENSSSCT00045053897.1 UniProtKB/TrEMBL
  ENSSSCT00045053952.1 UniProtKB/TrEMBL
  ENSSSCT00045054049.1 UniProtKB/TrEMBL
  ENSSSCT00045054137.1 UniProtKB/TrEMBL
  ENSSSCT00045054273.1 UniProtKB/TrEMBL
  ENSSSCT00045054356.1 UniProtKB/TrEMBL
  ENSSSCT00055021836.1 UniProtKB/TrEMBL
  ENSSSCT00055021926.1 UniProtKB/TrEMBL
  ENSSSCT00055022081.1 UniProtKB/TrEMBL
  ENSSSCT00055022097.1 UniProtKB/TrEMBL
  ENSSSCT00065094835.1 UniProtKB/TrEMBL
  ENSSSCT00070032268.1 UniProtKB/TrEMBL
  ENSSSCT00070032273.1 UniProtKB/TrEMBL
  ENSSSCT00070032388.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene NFATC3 ENTREZGENE
PANTHER NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3 UniProtKB/TrEMBL
  PTHR12533 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A287ATC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A287AV99 ENTREZGENE, UniProtKB/TrEMBL
  A0A287B5I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BCI3 ENTREZGENE, UniProtKB/TrEMBL
  A0A287BJE3 ENTREZGENE
  A0A4X1UD30 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UF41 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UG32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SVS0_PIG UniProtKB/TrEMBL
  A0A8D0ZPZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CUD5_PIG UniProtKB/TrEMBL
  A0A8D1IMU0_PIG UniProtKB/TrEMBL
  A0A8D1J0V7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1Q8J2_PIG UniProtKB/TrEMBL
  A0A8D1Q9M5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZWX2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A287BJE3 UniProtKB/TrEMBL
VGNC ID VGNC:90710 ENTREZGENE