Llcfc1 (LLLL and CFNLAS motif containing 1) - Rat Genome Database

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Gene: Llcfc1 (LLLL and CFNLAS motif containing 1) Rattus norvegicus
Analyze
Symbol: Llcfc1
Name: LLLL and CFNLAS motif containing 1
RGD ID: 1595510
Description: Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Orthologous to human LLCFC1 (LLLL and CFNLAS motif containing 1); INTERACTS WITH bisphenol A; 2,4-D (ortholog); 2-palmitoylglycerol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC680112; LOC680112; sperm-egg fusion protein LLCFC1; uncharacterized protein C7orf34 homolog; uncharacterized protein LOC680112
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,532,854 - 71,534,229 (+)NCBIGRCr8
mRatBN7.2470,566,206 - 70,567,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,566,295 - 70,567,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,483,837 - 75,485,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,397,092 - 71,398,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,805,295 - 69,806,586 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,977,476 - 70,978,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,977,556 - 70,978,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04135,764,554 - 135,765,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,390,898 - 69,392,189 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera465,531,224 - 65,532,515 (+)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Llcfc1Rat2,4-D multiple interactionsISOLlcfc1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Llcfc1Rat2-palmitoylglycerol increases expressionISOLLCFC1 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of LLCFC1 mRNACTDPMID:37199045
Llcfc1Rataldehydo-D-glucose multiple interactionsISOLlcfc1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Llcfc1Ratbenzo[a]pyrene increases methylationISOLLCFC1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of LLCFC1 3' UTR and Benzo(a)pyrene results in increased methylation of LLCFC1 promoterCTDPMID:27901495
Llcfc1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of LLCFC1 mRNACTDPMID:25181051
Llcfc1Ratchlorpyrifos increases expressionISOLlcfc1 (Mus musculus)6480464Chlorpyrifos results in increased expression of LLCFC1 mRNACTDPMID:32715474
Llcfc1RatD-glucose multiple interactionsISOLlcfc1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Llcfc1Ratfolic acid decreases expressionISOLLCFC1 (Homo sapiens)6480464Folic Acid results in decreased expression of LLCFC1 mRNACTDPMID:21867686
Llcfc1Ratfructose multiple interactionsISOLlcfc1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Llcfc1Ratglucose multiple interactionsISOLlcfc1 (Mus musculus)6480464[lard co-treated with Cholesterol more ...CTDPMID:37567420
Llcfc1Ratresveratrol multiple interactionsISOLLCFC1 (Homo sapiens)6480464[Plant Extracts co-treated with Resveratrol] results in decreased expression of LLCFC1 mRNACTDPMID:23557933
Llcfc1RatS-(1,2-dichlorovinyl)-L-cysteine increases expressionISOLLCFC1 (Homo sapiens)6480464S-(1 and 2-dichlorovinyl)cysteine results in increased expression of LLCFC1 mRNACTDPMID:35811015
Llcfc1Ratsodium arsenite decreases expressionISOLlcfc1 (Mus musculus)6480464sodium arsenite results in decreased expression of LLCFC1 mRNACTDPMID:37682722

1 to 13 of 13 rows

Biological Process

  


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Llcfc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,532,854 - 71,534,229 (+)NCBIGRCr8
mRatBN7.2470,566,206 - 70,567,592 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,566,295 - 70,567,586 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,483,837 - 75,485,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,397,092 - 71,398,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0469,805,295 - 69,806,586 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0470,977,476 - 70,978,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,977,556 - 70,978,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04135,764,554 - 135,765,920 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,390,898 - 69,392,189 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera465,531,224 - 65,532,515 (+)NCBICelera
Cytogenetic Map4q23NCBI
LLCFC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387142,939,484 - 142,940,868 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7142,939,343 - 142,940,868 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,636,581 - 142,637,955 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,346,721 - 142,348,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 347142,153,439 - 142,154,789NCBI
Celera7137,473,461 - 137,474,817 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7136,974,890 - 136,976,246 (+)NCBIHuRef
CHM1_17142,573,478 - 142,574,842 (+)NCBICHM1_1
T2T-CHM13v2.07144,294,899 - 144,296,279 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,038,472 - 142,039,828 (+)NCBI
Llcfc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,661,321 - 41,662,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,661,365 - 41,662,651 (+)EnsemblGRCm39 Ensembl
GRCm38641,684,387 - 41,685,717 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,684,431 - 41,685,717 (+)EnsemblGRCm38mm10GRCm38
MGSCv37641,634,430 - 41,635,716 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36641,614,038 - 41,615,324 (+)NCBIMGSCv36mm8
Celera641,637,014 - 41,638,300 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map619.86NCBI
Llcfc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955494688,212 - 689,634 (-)NCBIChiLan1.0ChiLan1.0
LLCFC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26179,781,938 - 179,789,367 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1731,792,184 - 31,799,445 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07134,928,345 - 134,940,750 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,421,330 - 147,431,683 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7147,421,354 - 147,422,719 (+)Ensemblpanpan1.1panPan2
LLCFC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,645,433 - 6,646,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,645,734 - 6,646,781 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,559,045 - 7,560,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,556,444 - 6,557,964 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,556,451 - 6,558,214 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,509,858 - 6,511,374 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,361,298 - 6,362,818 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,420,021 - 6,421,535 (-)NCBIUU_Cfam_GSD_1.0
Llcfc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,497,601 - 12,498,959 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527404,596 - 405,501 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527404,596 - 405,501 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LLCFC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl187,279,744 - 7,281,161 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1187,279,560 - 7,282,874 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,551,705 - 7,554,856 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LLCFC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121111,817,332 - 111,818,991 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660728,540,913 - 8,542,607 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Llcfc1
7 total Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
4 69391802 69391803 C T snv SS/JrHsdMcwi (MCW) View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
4 135764630 135764631 G A snv DOB/Oda (KyushuU) View more Information

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:96
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000031984
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat

1 to 10 of 57 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 7 2 30 19 14 4 18 4 1 44 28 22 25 10



Ensembl Acc Id: ENSRNOT00000031984   ⟹   ENSRNOP00000030740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl470,566,295 - 70,567,586 (+)Ensembl
Rnor_6.0 Ensembl470,977,556 - 70,978,847 (+)Ensembl
RefSeq Acc Id: NM_001109392   ⟹   NP_001102862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,532,934 - 71,534,225 (+)NCBI
mRatBN7.2470,566,295 - 70,567,586 (+)NCBI
Rnor_6.0470,977,556 - 70,978,847 (+)NCBI
Rnor_5.04135,764,554 - 135,765,920 (+)NCBI
RGSC_v3.4469,390,898 - 69,392,189 (+)RGD
Celera465,531,224 - 65,532,515 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236383   ⟹   XP_006236445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,532,854 - 71,534,229 (+)NCBI
mRatBN7.2470,566,206 - 70,567,592 (+)NCBI
Rnor_6.0470,977,476 - 70,978,855 (+)NCBI
Rnor_5.04135,764,554 - 135,765,920 (+)NCBI
Sequence:
Protein RefSeqs NP_001102862 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000030740
  ENSRNOP00000030740.2
  ENSRNOP00000099356
RefSeq Acc Id: NP_001102862   ⟸   NM_001109392
- Peptide Label: precursor
- UniProtKB: D4A4Y5 (UniProtKB/TrEMBL),   A6IF49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236445   ⟸   XM_006236383
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000030740   ⟸   ENSRNOT00000031984

Name Modeler Protein Id AA Range Protein Structure
AF-D4A4Y5-F1-model_v2 AlphaFold D4A4Y5 1-106 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693004
Promoter ID:EPDNEW_R3527
Type:multiple initiation site
Name:LOC680112_1
Description:hypothetical protein LOC680112
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,977,513 - 70,977,573EPDNEW


1 to 15 of 15 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-45107 BioCyc
Ensembl Genes ENSRNOG00000025618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031984 ENTREZGENE
  ENSRNOT00000031984.3 UniProtKB/TrEMBL
  ENSRNOT00000148248 ENTREZGENE
InterPro DUF4717 UniProtKB/TrEMBL
KEGG Report rno:680112 UniProtKB/TrEMBL
NCBI Gene 680112 ENTREZGENE
PANTHER PTHR37348 UniProtKB/TrEMBL
  SPERM-EGG FUSION PROTEIN LLCFC1 UniProtKB/TrEMBL
Pfam DUF4717 UniProtKB/TrEMBL
PhenoGen Llcfc1 PhenoGen
RatGTEx ENSRNOG00000025618 RatGTEx
UniProt A6IF49 ENTREZGENE, UniProtKB/TrEMBL
  D4A4Y5 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-05 Llcfc1  LLLL and CFNLAS motif containing 1  LOC680112  hypothetical protein LOC680112  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680112  hypothetical protein LOC680112  LOC684697  hypothetical protein LOC684697  Data merged from RGD:1587877 1643240 APPROVED
2006-11-20 LOC680112  hypothetical protein LOC680112      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684697  hypothetical protein LOC684697      Symbol and Name status set to provisional 70820 PROVISIONAL