Chchd7 (coiled-coil-helix-coiled-coil-helix domain containing 7) - Rat Genome Database

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Gene: Chchd7 (coiled-coil-helix-coiled-coil-helix domain containing 7) Rattus norvegicus
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Symbol: Chchd7
Name: coiled-coil-helix-coiled-coil-helix domain containing 7
RGD ID: 1592689
Description: Predicted to be involved in mitochondrial respiratory chain complex assembly. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Orthologous to human CHCHD7 (coiled-coil-helix-coiled-coil-helix domain containing 7); INTERACTS WITH (+)-schisandrin B; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil-helix-coiled-coil-helix domain-containing protein 7; LOC684258; similar to coiled-coil-helix-coiled-coil-helix domain containing 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,754,719 - 21,759,274 (+)NCBIGRCr8
mRatBN7.2516,957,127 - 16,961,682 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,957,188 - 16,961,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,197,950 - 19,202,505 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0520,796,439 - 20,800,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,547,938 - 20,552,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0516,843,253 - 16,847,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,845,631 - 16,847,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,619,664 - 21,624,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera516,323,841 - 16,328,149 (+)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015   PMID:34800366  


Genomics

Comparative Map Data
Chchd7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8521,754,719 - 21,759,274 (+)NCBIGRCr8
mRatBN7.2516,957,127 - 16,961,682 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,957,188 - 16,961,184 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx519,197,950 - 19,202,505 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0520,796,439 - 20,800,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0520,547,938 - 20,552,488 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0516,843,253 - 16,847,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,845,631 - 16,847,776 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,619,664 - 21,624,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera516,323,841 - 16,328,149 (+)NCBICelera
Cytogenetic Map5q12NCBI
CHCHD7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,211,789 - 56,218,809 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl856,211,686 - 56,218,809 (+)EnsemblGRCh38hg38GRCh38
GRCh37857,124,348 - 57,131,368 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,286,869 - 57,293,732 (+)NCBINCBI36Build 36hg18NCBI36
Build 34857,286,911 - 57,293,728NCBI
Celera853,115,008 - 53,121,870 (+)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,591,710 - 52,598,572 (+)NCBIHuRef
CHM1_1857,176,153 - 57,183,016 (+)NCBICHM1_1
T2T-CHM13v2.0856,588,778 - 56,595,798 (+)NCBIT2T-CHM13v2.0
Chchd7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,938,847 - 3,951,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,938,888 - 3,951,046 (+)EnsemblGRCm39 Ensembl
GRCm3843,938,840 - 3,951,383 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,938,888 - 3,951,046 (+)EnsemblGRCm38mm10GRCm38
MGSCv3743,866,035 - 3,870,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,866,061 - 3,870,670 (+)NCBIMGSCv36mm8
Celera43,895,371 - 3,900,008 (+)NCBICelera
Cytogenetic Map4A1NCBI
cM Map42.2NCBI
Chchd7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545415,284,104 - 15,286,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545415,284,114 - 15,286,761 (+)NCBIChiLan1.0ChiLan1.0
CHCHD7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2771,869,339 - 71,876,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1847,593,944 - 47,605,467 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0852,658,102 - 52,665,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1850,028,815 - 50,035,706 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl850,028,828 - 50,035,706 (+)Ensemblpanpan1.1panPan2
CHCHD7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,609,556 - 7,615,996 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,610,789 - 7,614,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,921,847 - 7,928,709 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,683,608 - 7,690,470 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,683,693 - 7,690,478 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,697,988 - 7,704,850 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,829,671 - 7,836,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0298,106,704 - 8,113,559 (+)NCBIUU_Cfam_GSD_1.0
Chchd7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530371,922,259 - 71,929,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,855,898 - 2,865,185 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364962,855,944 - 2,862,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHCHD7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1475,640,679 - 75,646,218 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,555,360 - 82,565,556 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHCHD7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1852,251,189 - 52,258,475 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl852,252,455 - 52,257,336 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,538,779 - 89,546,005 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chchd7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248863,822,264 - 3,827,507 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248863,822,264 - 3,827,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chchd7
35 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:125
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000047889
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat


Sequence


Ensembl Acc Id: ENSRNOT00000047889   ⟹   ENSRNOP00000045588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl516,957,188 - 16,961,184 (+)Ensembl
Rnor_6.0 Ensembl516,845,631 - 16,847,776 (+)Ensembl
RefSeq Acc Id: NM_001399637   ⟹   NP_001386566
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8521,754,719 - 21,759,274 (+)NCBI
mRatBN7.2516,957,127 - 16,961,682 (+)NCBI
RefSeq Acc Id: NM_001399638   ⟹   NP_001386567
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8521,754,719 - 21,759,274 (+)NCBI
mRatBN7.2516,957,127 - 16,961,682 (+)NCBI
RefSeq Acc Id: XM_063288421   ⟹   XP_063144491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8521,754,729 - 21,759,274 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386566 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386567 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144491 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11617 (Get FASTA)   NCBI Sequence Viewer  
  EDM11618 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045588.4
Ensembl Acc Id: ENSRNOP00000045588   ⟸   ENSRNOT00000047889
RefSeq Acc Id: NP_001386566   ⟸   NM_001399637
- UniProtKB: A6JFM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386567   ⟸   NM_001399638
- UniProtKB: A6JFM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144491   ⟸   XM_063288421
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC73-F1-model_v2 AlphaFold D4AC73 1-85 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592689 AgrOrtholog
BioCyc Gene G2FUF-42111 BioCyc
Ensembl Genes ENSRNOG00000031769 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047889.4 UniProtKB/TrEMBL
Gene3D-CATH CytochromE C oxidase copper chaperone UniProtKB/TrEMBL
InterPro COX23 UniProtKB/TrEMBL
  COX6B-like UniProtKB/TrEMBL
  Cys_alpha_HP_mot_SF UniProtKB/TrEMBL
NCBI Gene 684258 ENTREZGENE
PANTHER COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
  COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
Pfam COX6B UniProtKB/TrEMBL
PhenoGen Chchd7 PhenoGen
PROSITE CHCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031769 RatGTEx
Superfamily-SCOP MTCP1 UniProtKB/TrEMBL
UniProt A6JFM2 ENTREZGENE, UniProtKB/TrEMBL
  D4AC73_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-13 Chchd7  coiled-coil-helix-coiled-coil-helix domain containing 7  LOC684258  similar to coiled-coil-helix-coiled-coil-helix domain containing 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC684258  similar to coiled-coil-helix-coiled-coil-helix domain containing 7      Symbol and Name status set to provisional 70820 PROVISIONAL