Isoc2a (isochorismatase domain containing 2A) - Rat Genome Database

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Gene: Isoc2a (isochorismatase domain containing 2A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Isoc2a
Name: isochorismatase domain containing 2A
RGD ID: 1592677
Description: Predicted to be active in cytoplasm. Orthologous to human ISOC2 (isochorismatase domain containing 2); INTERACTS WITH (1->4)-beta-D-glucan (ortholog); 4,4'-sulfonyldiphenol (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: isochorismatase domain-containing protein 2; isochorismatase domain-containing protein 2A; LOC684270; similar to isochorismatase domain containing 2; uncharacterized protein LOC684270
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8177,967,751 - 77,986,002 (-)NCBIGRCr8
mRatBN7.2168,938,916 - 68,957,179 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,937,759 - 68,957,179 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0172,491,667 - 72,509,433 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,491,780 - 72,509,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,027,564 - 76,044,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera168,165,460 - 68,182,583 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Isoc2a
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000071971
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
M81342  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,954,651 - 68,954,790 (+)MAPPERmRatBN7.2
mRatBN7.21476,987,337 - 76,987,476 (+)MAPPERmRatBN7.2
Rnor_6.01482,272,415 - 82,272,553NCBIRnor6.0
Rnor_6.0172,506,586 - 72,506,724NCBIRnor6.0
Rnor_5.01482,961,971 - 82,962,109UniSTSRnor5.0
Rnor_5.0176,029,780 - 76,029,918UniSTSRnor5.0
RGSC_v3.41482,388,771 - 82,388,909UniSTSRGSC3.4
RGSC_v3.41482,682,536 - 82,682,674UniSTSRGSC3.4
Celera1475,910,689 - 75,910,827UniSTS
Celera168,168,300 - 68,168,438UniSTS
Cytogenetic Map14q21UniSTS
RH129229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,940,249 - 68,940,444 (+)MAPPERmRatBN7.2
Rnor_6.0172,491,740 - 72,491,934NCBIRnor6.0
Rnor_5.0176,044,570 - 76,044,764UniSTSRnor5.0
Celera168,182,316 - 68,182,510UniSTS
RH127661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,940,283 - 68,940,492 (+)MAPPERmRatBN7.2
Rnor_6.0172,491,774 - 72,491,982NCBIRnor6.0
Rnor_5.0176,044,522 - 76,044,730UniSTSRnor5.0
Celera168,182,268 - 68,182,476UniSTS
RH132281  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21476,987,464 - 76,987,668 (+)MAPPERmRatBN7.2
mRatBN7.2168,954,457 - 68,954,663 (+)MAPPERmRatBN7.2
Rnor_6.01482,272,542 - 82,272,745NCBIRnor6.0
Rnor_6.0172,506,392 - 72,506,597NCBIRnor6.0
Rnor_5.01482,962,098 - 82,962,301UniSTSRnor5.0
Rnor_5.0176,029,907 - 76,030,112UniSTSRnor5.0
RGSC_v3.41482,682,663 - 82,682,866UniSTSRGSC3.4
Celera1475,910,816 - 75,911,019UniSTS
Celera168,168,427 - 68,168,632UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000071971   ⟹   ENSRNOP00000066553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl172,491,780 - 72,509,431 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097188   ⟹   ENSRNOP00000094488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,937,759 - 68,957,179 (-)Ensembl
RefSeq Acc Id: NM_001409142   ⟹   NP_001396071
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,967,751 - 77,986,002 (-)NCBI
mRatBN7.2168,938,916 - 68,957,179 (-)NCBI
RefSeq Acc Id: NM_001409143   ⟹   NP_001396072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,967,751 - 77,986,002 (-)NCBI
mRatBN7.2168,938,916 - 68,957,179 (-)NCBI
RefSeq Acc Id: XM_039100618   ⟹   XP_038956546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8177,969,012 - 77,985,995 (-)NCBI
mRatBN7.2168,940,177 - 68,957,178 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001396071 (Get FASTA)   NCBI Sequence Viewer  
  NP_001396072 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956546 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75869 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094488.1
Ensembl Acc Id: ENSRNOP00000066553   ⟸   ENSRNOT00000071971
RefSeq Acc Id: XP_038956546   ⟸   XM_039100618
- Peptide Label: isoform X1
- UniProtKB: A6KNQ0 (UniProtKB/TrEMBL),   A0A8I6GL72 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094488   ⟸   ENSRNOT00000097188
RefSeq Acc Id: NP_001396072   ⟸   NM_001409143
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001396071   ⟸   NM_001409142
- Peptide Label: isoform 1
- UniProtKB: A6KNQ0 (UniProtKB/TrEMBL)
Protein Domains
Isochorismatase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAK2-F1-model_v2 AlphaFold M0RAK2 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689709
Promoter ID:EPDNEW_R217
Type:initiation region
Name:LOC684270_1
Description:similar to isochorismatase domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,509,364 - 72,509,424EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592677 AgrOrtholog
BioCyc Gene G2FUF-60867 BioCyc
Ensembl Genes ENSRNOG00000050348 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097188.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.850 UniProtKB/TrEMBL
InterPro Isochorismatase-like UniProtKB/TrEMBL
  Isochorismatase-like_sf UniProtKB/TrEMBL
  Isochorismatase_domain UniProtKB/TrEMBL
NCBI Gene 684270 ENTREZGENE
PANTHER HYDROLASE UniProtKB/TrEMBL
  ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam Isochorismatase UniProtKB/TrEMBL
PhenoGen Isoc2a PhenoGen
RatGTEx ENSRNOG00000050348 RatGTEx
Superfamily-SCOP SSF52499 UniProtKB/TrEMBL
UniProt A0A8I6GL72 ENTREZGENE, UniProtKB/TrEMBL
  A6KNQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-27 Isoc2a  isochorismatase domain containing 2A  Isoc2a  isochorismatase domain containing 2a  Name changed 629549 APPROVED
2022-10-27 Isoc2a  isochorismatase domain containing 2a  LOC684270  similar to isochorismatase domain containing 2  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC684270  similar to isochorismatase domain containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL