Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Proser2 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PROSER2 mRNA] | CTD | PMID:31150632 | Proser2 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PROSER2 mRNA | CTD | PMID:36331819 | Proser2 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of PROSER2 mRNA | CTD | PMID:32145629 | Proser2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Proser2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PROSER2 mRNA | CTD | PMID:24680724 | Proser2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PROSER2 mRNA | CTD | PMID:33387578 | Proser2 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Proser2 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PROSER2 mRNA | CTD | PMID:30951980 | Proser2 | Rat | 4,4'-sulfonyldiphenol | affects methylation | ISO | Proser2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of PROSER2 gene | CTD | PMID:31683443 | Proser2 | Rat | acrolein | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PROSER2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PROSER2 mRNA | CTD | PMID:32699268 | Proser2 | Rat | alpha-pinene | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PROSER2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PROSER2 mRNA | CTD | PMID:32699268 | Proser2 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PROSER2 mRNA | CTD | PMID:35163327 | Proser2 | Rat | amiodarone | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Amiodarone results in increased expression of PROSER2 mRNA | CTD | PMID:19774075 | Proser2 | Rat | atrazine | decreases expression | EXP | | 6480464 | Atrazine results in decreased expression of PROSER2 mRNA | CTD | PMID:36841081 | Proser2 | Rat | azoxystrobin | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA | CTD | PMID:33854195 | Proser2 | Rat | benzo[a]pyrene | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PROSER2 mRNA | CTD | PMID:27858113 | Proser2 | Rat | benzo[a]pyrene | decreases methylation | ISO | PROSER2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PROSER2 5' UTR | CTD | PMID:27901495 | Proser2 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | Proser2 | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PROSER2 mRNA | CTD | PMID:27858113 | Proser2 | Rat | beta-lapachone | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of PROSER2 mRNA | CTD | PMID:38218311 | Proser2 | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of PROSER2 mRNA | CTD | PMID:31163220 | Proser2 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PROSER2 mRNA | CTD | PMID:25181051 | Proser2 | Rat | bisphenol A | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PROSER2 gene | CTD | PMID:31601247 | Proser2 | Rat | bisphenol A | increases expression | ISO | Proser2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PROSER2 mRNA | CTD | PMID:30951980 and PMID:33221593 | Proser2 | Rat | bisphenol F | increases expression | ISO | Proser2 (Mus musculus) | 6480464 | bisphenol F results in increased expression of PROSER2 mRNA | CTD | PMID:30951980 | Proser2 | Rat | buspirone | increases expression | EXP | | 6480464 | Buspirone results in increased expression of PROSER2 mRNA | CTD | PMID:24136188 | Proser2 | Rat | butan-1-ol | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in decreased expression of PROSER2 mRNA | CTD | PMID:29432896 | Proser2 | Rat | caffeine | decreases phosphorylation | ISO | PROSER2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PROSER2 protein | CTD | PMID:35688186 | Proser2 | Rat | calcitriol | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PROSER2 mRNA | CTD | PMID:21592394 | Proser2 | Rat | calcitriol | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of PROSER2 mRNA | CTD | PMID:21592394 | Proser2 | Rat | carbon nanotube | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of PROSER2 mRNA | CTD | PMID:25554681 | Proser2 | Rat | chloroprene | increases expression | ISO | Proser2 (Mus musculus) | 6480464 | Chloroprene results in increased expression of PROSER2 mRNA | CTD | PMID:23125180 | Proser2 | Rat | chlorpyrifos | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA | CTD | PMID:33854195 | Proser2 | Rat | chlorpyrifos | increases expression | ISO | Proser2 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PROSER2 mRNA | CTD | PMID:37019170 | Proser2 | Rat | chlorpyrifos | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PROSER2 mRNA | CTD | PMID:32715474 | Proser2 | Rat | chromium(6+) | affects expression | ISO | Proser2 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of PROSER2 mRNA | CTD | PMID:28472532 | Proser2 | Rat | chrysene | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PROSER2 mRNA | CTD | PMID:27858113 | Proser2 | Rat | clofibrate | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of PROSER2 mRNA | CTD | PMID:23811191 | Proser2 | Rat | copper(II) sulfate | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of PROSER2 mRNA | CTD | PMID:19549813 | Proser2 | Rat | coumarin | affects phosphorylation | ISO | PROSER2 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of PROSER2 protein | CTD | PMID:35688186 | Proser2 | Rat | cyclosporin A | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PROSER2 mRNA | CTD | PMID:20106945 and PMID:25562108 | Proser2 | Rat | Dibutyl phosphate | affects expression | ISO | PROSER2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PROSER2 mRNA | CTD | PMID:37042841 | Proser2 | Rat | dorsomorphin | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Proser2 | Rat | entinostat | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | entinostat results in increased expression of PROSER2 mRNA | CTD | PMID:26272509 and PMID:27188386 | Proser2 | Rat | entinostat | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROSER2 mRNA | CTD | PMID:27188386 | Proser2 | Rat | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of PROSER2 mRNA | CTD | PMID:34044035 | Proser2 | Rat | formaldehyde | decreases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PROSER2 mRNA | CTD | PMID:20655997 | Proser2 | Rat | FR900359 | affects phosphorylation | ISO | PROSER2 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PROSER2 protein | CTD | PMID:37730182 | Proser2 | Rat | fulvestrant | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PROSER2 gene | CTD | PMID:31601247 | Proser2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PROSER2 mRNA | CTD | PMID:33387578 | Proser2 | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of PROSER2 mRNA | CTD | PMID:24915197 | Proser2 | Rat | glyphosate | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA | CTD | PMID:33854195 | Proser2 | Rat | hexadecanoic acid | decreases phosphorylation | ISO | PROSER2 (Homo sapiens) | 6480464 | Palmitic Acid results in decreased phosphorylation of PROSER2 protein | CTD | PMID:28073184 | Proser2 | Rat | hydrogen peroxide | affects expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PROSER2 mRNA | CTD | PMID:20044591 | Proser2 | Rat | imidacloprid | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA | CTD | PMID:33854195 | Proser2 | Rat | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of PROSER2 mRNA | CTD | PMID:24136188 | Proser2 | Rat | leflunomide | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of PROSER2 mRNA | CTD | PMID:28988120 | Proser2 | Rat | levofloxacin | increases expression | EXP | | 6480464 | Levofloxacin results in increased expression of PROSER2 mRNA | CTD | PMID:24136188 | Proser2 | Rat | mercury dibromide | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROSER2 mRNA | CTD | PMID:27188386 | Proser2 | Rat | methotrexate | increases expression | EXP | | 6480464 | Methotrexate results in increased expression of PROSER2 mRNA | CTD | PMID:24136188 | Proser2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of PROSER2 mRNA | CTD | PMID:25729387 | Proser2 | Rat | ozone | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PROSER2 mRNA more ... | CTD | PMID:32699268 | Proser2 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PROSER2 mRNA | CTD | PMID:33387578 | Proser2 | Rat | perfluorohexanesulfonic acid | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of PROSER2 mRNA | CTD | PMID:37995155 | Proser2 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PROSER2 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of PROSER2 mRNA | CTD | PMID:36331819 | Proser2 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PROSER2 mRNA | CTD | PMID:35163327 | Proser2 | Rat | phenylmercury acetate | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of PROSER2 mRNA | CTD | PMID:26272509 | Proser2 | Rat | phenylmercury acetate | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROSER2 mRNA | CTD | PMID:27188386 | Proser2 | Rat | SB 431542 | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Proser2 | Rat | silicon dioxide | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of PROSER2 mRNA | CTD | PMID:25895662 | Proser2 | Rat | silver atom | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Silver results in increased expression of PROSER2 mRNA | CTD | PMID:26014281 and PMID:28959546 | Proser2 | Rat | silver(0) | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Silver results in increased expression of PROSER2 mRNA | CTD | PMID:26014281 and PMID:28959546 | Proser2 | Rat | sodium arsenite | decreases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of PROSER2 mRNA | CTD | PMID:38568856 | Proser2 | Rat | sodium arsenite | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PROSER2 mRNA | CTD | PMID:38568856 | Proser2 | Rat | sunitinib | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PROSER2 mRNA | CTD | PMID:31533062 | Proser2 | Rat | testosterone | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of PROSER2 mRNA | CTD | PMID:21592394 | Proser2 | Rat | testosterone | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PROSER2 mRNA | CTD | PMID:21592394 | Proser2 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PROSER2 mRNA] | CTD | PMID:31150632 | Proser2 | Rat | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PROSER2 mRNA | CTD | PMID:31150632 | Proser2 | Rat | tetraphene | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | benz(a)anthracene results in decreased expression of PROSER2 mRNA | CTD | PMID:26377693 | Proser2 | Rat | tetraphene | multiple interactions | ISO | Proser2 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PROSER2 mRNA | CTD | PMID:27858113 | Proser2 | Rat | thiabendazole | multiple interactions | EXP | | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in decreased expression of PROSER2 mRNA | CTD | PMID:33854195 | Proser2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PROSER2 mRNA | CTD | PMID:34492290 | Proser2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of PROSER2 mRNA | CTD | PMID:25729387 | Proser2 | Rat | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PROSER2 mRNA | CTD | PMID:33387578 | Proser2 | Rat | triphenyl phosphate | affects expression | ISO | PROSER2 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PROSER2 mRNA | CTD | PMID:37042841 | Proser2 | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of PROSER2 mRNA | CTD | PMID:30589522 | Proser2 | Rat | Triptolide | affects expression | ISO | Proser2 (Mus musculus) | 6480464 | triptolide affects the expression of PROSER2 mRNA | CTD | PMID:32835833 | Proser2 | Rat | triptonide | decreases expression | ISO | Proser2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PROSER2 mRNA | CTD | PMID:33045310 | Proser2 | Rat | trovafloxacin | increases expression | EXP | | 6480464 | trovafloxacin results in increased expression of PROSER2 mRNA | CTD | PMID:24136188 | Proser2 | Rat | urethane | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Urethane results in increased expression of PROSER2 mRNA | CTD | PMID:28818685 | Proser2 | Rat | valproic acid | decreases methylation | ISO | PROSER2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of PROSER2 gene | CTD | PMID:29154799 | Proser2 | Rat | valproic acid | affects expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PROSER2 mRNA | CTD | PMID:25979313 | Proser2 | Rat | valproic acid | multiple interactions | ISO | PROSER2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PROSER2 mRNA | CTD | PMID:27188386 | Proser2 | Rat | valproic acid | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PROSER2 mRNA | CTD | PMID:19101580 more ... | Proser2 | Rat | zoledronic acid | increases expression | ISO | PROSER2 (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of PROSER2 mRNA | CTD | PMID:24714768 | |