Anapc13 (anaphase promoting complex subunit 13) - Rat Genome Database

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Gene: Anapc13 (anaphase promoting complex subunit 13) Rattus norvegicus
Analyze
Symbol: Anapc13
Name: anaphase promoting complex subunit 13
RGD ID: 1583270
Description: Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein K11-linked ubiquitination; and protein K48-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC13 (anaphase promoting complex subunit 13); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anaphase-promoting complex subunit 13; LOC685029; similar to anaphase promoting complex subunit 13
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,084,405 - 112,092,821 (+)NCBIGRCr8
mRatBN7.28103,205,520 - 103,213,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,205,520 - 103,213,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8108,868,850 - 108,877,264 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,068,013 - 107,076,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08104,910,693 - 104,919,107 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,107,358 - 111,115,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,107,358 - 111,115,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08110,505,168 - 110,513,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48107,591,570 - 107,599,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8102,586,991 - 102,595,407 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16364912   PMID:18485873  


Genomics

Comparative Map Data
Anapc13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,084,405 - 112,092,821 (+)NCBIGRCr8
mRatBN7.28103,205,520 - 103,213,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,205,520 - 103,213,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8108,868,850 - 108,877,264 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08107,068,013 - 107,076,427 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08104,910,693 - 104,919,107 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08111,107,358 - 111,115,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,107,358 - 111,115,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08110,505,168 - 110,513,584 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48107,591,570 - 107,599,914 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8102,586,991 - 102,595,407 (+)NCBICelera
Cytogenetic Map8q32NCBI
ANAPC13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383134,477,704 - 134,486,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3134,477,706 - 134,486,716 (-)EnsemblGRCh38hg38GRCh38
GRCh373134,196,546 - 134,204,865 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363135,679,240 - 135,687,519 (-)NCBINCBI36Build 36hg18NCBI36
Build 343135,679,247 - 135,687,527NCBI
Celera3132,622,829 - 132,631,147 (-)NCBICelera
Cytogenetic Map3q22.2NCBI
HuRef3131,574,190 - 131,582,508 (-)NCBIHuRef
CHM1_13134,160,900 - 134,169,219 (-)NCBICHM1_1
T2T-CHM13v2.03137,222,876 - 137,231,191 (-)NCBIT2T-CHM13v2.0
Anapc13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399102,503,495 - 102,511,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9102,503,495 - 102,511,624 (+)EnsemblGRCm39 Ensembl
GRCm389102,626,296 - 102,634,244 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9102,626,296 - 102,634,425 (+)EnsemblGRCm38mm10GRCm38
MGSCv379102,528,626 - 102,536,574 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369102,482,133 - 102,490,054 (+)NCBIMGSCv36mm8
Celera9102,167,283 - 102,175,247 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map954.64NCBI
Anapc13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,096,026 - 4,103,212 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555014,096,026 - 4,103,212 (+)NCBIChiLan1.0ChiLan1.0
ANAPC13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22132,403,726 - 132,412,121 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13132,408,453 - 132,416,850 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03131,524,227 - 131,532,624 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13138,995,860 - 139,004,190 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3138,995,860 - 139,004,179 (-)Ensemblpanpan1.1panPan2
ANAPC13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12331,241,715 - 31,249,677 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2331,241,716 - 31,249,210 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2331,219,558 - 31,227,545 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02331,756,950 - 31,764,722 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2331,756,955 - 31,764,230 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12331,454,159 - 31,461,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02331,513,376 - 31,521,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,760,570 - 31,768,355 (-)NCBIUU_Cfam_GSD_1.0
Anapc13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560270,808,865 - 70,816,989 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365297,569,362 - 7,577,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANAPC13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1375,599,800 - 75,605,140 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11375,599,797 - 75,605,667 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21383,127,052 - 83,131,952 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ANAPC13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11555,892,385 - 55,901,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1555,895,970 - 55,900,256 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604128,876,192 - 28,885,069 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anapc13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473010,805,250 - 10,810,853 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473010,805,200 - 10,811,341 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Anapc13
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:250
Count of miRNA genes:150
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000011203
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011203   ⟹   ENSRNOP00000011203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8103,205,520 - 103,213,936 (+)Ensembl
Rnor_6.0 Ensembl8111,107,358 - 111,115,774 (+)Ensembl
RefSeq Acc Id: NM_001173983   ⟹   NP_001167454
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,084,405 - 112,092,821 (+)NCBI
mRatBN7.28103,205,520 - 103,213,936 (+)NCBI
Rnor_6.08111,107,358 - 111,115,774 (+)NCBI
Rnor_5.08110,505,168 - 110,513,584 (+)NCBI
Celera8102,586,991 - 102,595,407 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006243681   ⟹   XP_006243743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,084,676 - 112,092,782 (+)NCBI
mRatBN7.28103,205,831 - 103,213,734 (+)NCBI
Rnor_6.08111,107,678 - 111,115,572 (+)NCBI
Rnor_5.08110,505,168 - 110,513,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039082157   ⟹   XP_038938085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,086,738 - 112,092,782 (+)NCBI
mRatBN7.28103,207,853 - 103,213,891 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001167454   ⟸   NM_001173983
- UniProtKB: D4A427 (UniProtKB/TrEMBL),   A6I2H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243743   ⟸   XM_006243681
- Peptide Label: isoform X1
- UniProtKB: D4A427 (UniProtKB/TrEMBL),   A6I2H8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011203   ⟸   ENSRNOT00000011203
RefSeq Acc Id: XP_038938085   ⟸   XM_039082157
- Peptide Label: isoform X1
- UniProtKB: D4A427 (UniProtKB/TrEMBL),   A6I2H8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A427-F1-model_v2 AlphaFold D4A427 1-74 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696223
Promoter ID:EPDNEW_R6748
Type:initiation region
Name:Anapc13_1
Description:anaphase promoting complex subunit 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08111,107,367 - 111,107,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583270 AgrOrtholog
BioCyc Gene G2FUF-29348 BioCyc
Ensembl Genes ENSRNOG00000008459 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011203 ENTREZGENE
  ENSRNOT00000011203.5 UniProtKB/TrEMBL
InterPro Apc13p UniProtKB/TrEMBL
KEGG Report rno:685029 UniProtKB/TrEMBL
NCBI Gene 685029 ENTREZGENE
PANTHER ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 UniProtKB/TrEMBL
  PTHR28672 UniProtKB/TrEMBL
Pfam Apc13p UniProtKB/TrEMBL
PhenoGen Anapc13 PhenoGen
RatGTEx ENSRNOG00000008459 RatGTEx
UniProt A6I2H8 ENTREZGENE, UniProtKB/TrEMBL
  D4A427 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-21 Anapc13  anaphase promoting complex subunit 13  LOC685029  similar to anaphase promoting complex subunit 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685029  similar to anaphase promoting complex subunit 13  LOC683931  similar to anaphase promoting complex subunit 13  Data merged from RGD:1596563 1643240 APPROVED
2006-11-20 LOC683931  similar to anaphase promoting complex subunit 13      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC685029  similar to anaphase promoting complex subunit 13      Symbol and Name status set to provisional 70820 PROVISIONAL