Mup4l1 (major urinary protein 4 like 1) - Rat Genome Database

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Pathways
Gene: Mup4l1 (major urinary protein 4 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mup4l1 (Ensembl: Mup5)
Name: major urinary protein 4 like 1 (Ensembl:major urinary protein 5)
RGD ID: 1566134
Description: Predicted to enable insulin receptor activity and pheromone binding activity. Predicted to be involved in several processes, including locomotor rhythm; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of primary metabolic process. Located in extracellular space; INTERACTS WITH 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: allergen n I; allergen Rat n I; alpha(2)-euglobulin; alpha-2u globulin PGCL1; alpha-2u globulin PGCL2; alpha-2u-globulin; alpha-2u-globulin (L type); LOC259246; LOC298109; LOC298116; LOC366379; LOC688514; major urinary protein 4 like 2; Mup; Mup4l2; RGD1566134; similar to alpha-2u-globulin; similar to major urinary protein 4
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8580,223,093 - 80,226,566 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2575,221,340 - 75,224,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl575,142,157 - 75,564,845 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx577,326,989 - 77,330,414 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0579,148,643 - 79,152,068 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0579,120,794 - 79,124,219 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd580,277,012 - 80,280,450 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive581,943,656 - 81,947,094 (-)NCBILyon_Normotensive
Lyon_Hypertensive581,165,511 - 81,168,949 (-)NCBILyon_Hypertensive
F344_StmMcwi575,036,481 - 75,039,919 (-)NCBIF344_StmMcwi
Rnor_6.0577,430,657 - 77,433,866 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0581,680,467 - 81,683,359 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4578,707,324 - 78,710,745 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera574,012,421 - 74,015,756 (-)NCBICelera
RGSC_v3.1578,712,436 - 78,715,858 (-)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Length polymorphism in the 3' noncoding region of rat hepatic alpha 2u-globulin mRNAs. Ichiyoshi Y, etal., Biochim Biophys Acta 1987 Oct 9;910(1):43-51.
3. Male urinary protein-1 (Mup-1) expression in the female rat. Kondo Y and Yamada J, J Hered. 1983 Jul-Aug;74(4):280-2.
4. GOA pipeline RGD automated data pipeline
5. Molecular evidence of complex tissue- and sex-specific mRNA expression of the rat alpha(2u)-globulin multigene family. Saito K, etal., Biochem Biophys Res Commun 2000 Jun 7;272(2):337-44.
6. Cloning and sequence of several alpha 2u-globulin cDNAs. Unterman RD, etal., Proc Natl Acad Sci U S A 1981 Jun;78(6):3478-82.
Additional References at PubMed
PMID:1279439   PMID:2005132   PMID:2418834   PMID:2439333   PMID:2447393   PMID:2463987   PMID:2468522   PMID:2473438   PMID:6163771   PMID:6183262   PMID:8645715   PMID:12477932  
PMID:15489334   PMID:15632090   PMID:25797582  


Genomics

Variants

.
Variants in Mup4l1
6 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat


Expression

RNA-SEQ Expression

endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
renal system
7 7 7 12 7 24 12 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001003409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_203512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039109483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB039822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U28152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U31287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: NM_001003409   ⟹   NP_001003409
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,223,093 - 80,226,534 (-)NCBI
mRatBN7.2575,221,340 - 75,224,781 (-)NCBI
Dahl_SR_JrHsd580,277,012 - 80,280,450 (-)NCBI
Lyon_Normotensive581,943,656 - 81,947,094 (-)NCBI
Lyon_Hypertensive581,165,511 - 81,168,949 (-)NCBI
F344_StmMcwi575,036,481 - 75,039,919 (-)NCBI
RefSeq Acc Id: NM_203512   ⟹   NP_988843
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,223,093 - 80,226,534 (-)NCBI
mRatBN7.2575,221,340 - 75,224,781 (-)NCBI
Dahl_SR_JrHsd580,277,012 - 80,280,450 (-)NCBI
Lyon_Normotensive581,943,656 - 81,947,094 (-)NCBI
Lyon_Hypertensive581,165,511 - 81,168,949 (-)NCBI
F344_StmMcwi575,036,481 - 75,039,919 (-)NCBI
Celera574,012,421 - 74,015,756 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109479   ⟹   XP_038965407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,223,093 - 80,226,566 (-)NCBI
mRatBN7.2575,221,340 - 75,224,797 (-)NCBI
RefSeq Acc Id: XM_039109481   ⟹   XP_038965409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,223,093 - 80,226,566 (-)NCBI
mRatBN7.2575,221,340 - 75,224,797 (-)NCBI
RefSeq Acc Id: XM_039109483   ⟹   XP_038965411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8580,223,093 - 80,226,547 (-)NCBI
mRatBN7.2575,221,340 - 75,224,797 (-)NCBI
RefSeq Acc Id: NP_988843   ⟸   NM_203512
- Peptide Label: precursor
- UniProtKB: Q54AE7 (UniProtKB/Swiss-Prot),   P02761 (UniProtKB/Swiss-Prot),   A6KUS2 (UniProtKB/TrEMBL),   F1LQM1 (UniProtKB/TrEMBL),   Q9JJI4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038965411   ⟸   XM_039109483
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965407   ⟸   XM_039109479
- Peptide Label: isoform X1
- UniProtKB: Q54AE7 (UniProtKB/Swiss-Prot),   P02761 (UniProtKB/Swiss-Prot),   A6KUS2 (UniProtKB/TrEMBL),   F1LQM1 (UniProtKB/TrEMBL),   Q9JJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965409   ⟸   XM_039109481
- Peptide Label: isoform X1
- UniProtKB: Q54AE7 (UniProtKB/Swiss-Prot),   P02761 (UniProtKB/Swiss-Prot),   A6KUS2 (UniProtKB/TrEMBL),   F1LQM1 (UniProtKB/TrEMBL),   Q9JJI4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001003409   ⟸   NM_001003409
- Peptide Label: precursor
- UniProtKB: Q54AE7 (UniProtKB/Swiss-Prot),   P02761 (UniProtKB/Swiss-Prot),   A6KUS2 (UniProtKB/TrEMBL),   F1LQM1 (UniProtKB/TrEMBL),   Q9JJI4 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MK41-F1-model_v2 AlphaFold A0A096MK41 1-181 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566134 AgrOrtholog
BioCyc Gene G2FUF-41119 BioCyc
Ensembl Genes ENSRNOG00000042543 Ensembl
  ENSRNOG00000046529 Ensembl
  ENSRNOG00000067602 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000083187 ENTREZGENE
Ensembl Transcript ENSRNOT00000076791 ENTREZGENE
  ENSRNOT00000100434.1 UniProtKB/Swiss-Prot
  ENSRNOT00000120034.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7322607 IMAGE-MGC_LOAD
  IMAGE:7367233 IMAGE-MGC_LOAD
  IMAGE:7370970 IMAGE-MGC_LOAD
  IMAGE:7372252 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocalin_CS UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
  Maj_urinary UniProtKB/Swiss-Prot
KEGG Report rno:298109 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108577 IMAGE-MGC_LOAD
  MGC:108578 IMAGE-MGC_LOAD
  MGC:112596 IMAGE-MGC_LOAD
  MGC:124936 IMAGE-MGC_LOAD
NCBI Gene Mup4l1 ENTREZGENE
PANTHER LIPOCALIN UniProtKB/Swiss-Prot
  MAJOR URINARY PROTEIN 1-RELATED UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Mup4l1 PhenoGen
PRINTS LIPOCALIN UniProtKB/Swiss-Prot
  MAJORURINARY UniProtKB/Swiss-Prot
PROSITE LIPOCALIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000042543 RatGTEx
  ENSRNOG00000046529 RatGTEx
  ENSRNOG00000067602 RatGTEx
  ENSRNOG00000083187 RatGTEx
Superfamily-SCOP Lipocalins UniProtKB/Swiss-Prot
UniProt A0A096MIX6_RAT UniProtKB/TrEMBL
  A6KUS2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQM1 ENTREZGENE
  MUP_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q54AE7 ENTREZGENE
  Q63024_RAT UniProtKB/TrEMBL
  Q9JJI4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q54AE7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-07-13 Mup4l1  major urinary protein 4 like 1  Mup4l2  major urinary protein 4 like 2  Name and Symbol changed 629549 APPROVED
2023-07-13 Mup4l2  major urinary protein 4 like 2  LOC298116  alpha-2u-globulin (L type)  Data merged from RGD:1593271 737654 PROVISIONAL
2023-07-13 Mup4l2  major urinary protein 4 like 2  LOC259246  alpha-2u globulin PGCL1  Data merged from RGD:708506 737654 PROVISIONAL
2022-07-26 Mup4l2  major urinary protein 4 like 2  Mup4l1  major urinary protein 4 like 1  Name and Symbol changed 629549 APPROVED
2022-07-26 Mup4l1  major urinary protein 4 like 1  RGD1566134  similar to alpha-2u-globulin  Name and Symbol changed 629549 APPROVED
2022-06-02 RGD1566134  similar to alpha-2u-globulin  RGD1566134  similar to alpha-2u-globulin  Data merged from RGD:149736135 737654 PROVISIONAL
2021-08-09 RGD1566134  similar to alpha-2u-globulin      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-07-29 RGD1566134  similar to alpha-2u-globulin  LOC688514  similar to major urinary protein 4  Data merged from RGD:1587665 737654 PROVISIONAL
2014-06-27 RGD1566134  similar to alpha-2u-globulin  LOC298109  alpha-2u globulin PGCL2  Data merged from RGD:1593273 737654 APPROVED
2014-06-27 RGD1566134  similar to alpha-2u-globulin  RGD1566134  similar to alpha-2u-globulin  Type changed (type changed from [pseudo] to [protein-coding]) 629549 APPROVED
2008-04-30 RGD1566134  similar to alpha-2u-globulin   RGD1566134_predicted  similar to alpha-2u-globulin (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 RGD1566134_predicted  similar to alpha-2u-globulin (predicted)  LOC682705  similar to alpha-2u-globulin (L type)  Data merged from RGD:1595331 1643240 APPROVED
2006-11-20 LOC298109  alpha-2u globulin PGCL2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC298116  alpha-2u-globulin (L type)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682705  similar to alpha-2u-globulin (L type)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC688514  similar to major urinary protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1566134_predicted  similar to alpha-2u-globulin (predicted)  LOC366379  similar to alpha-2u-globulin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366379  similar to alpha-2u-globulin      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-09-23 LOC259246  alpha-2u globulin PGCL1      Symbol and Name status set to provisional 70820 PROVISIONAL