Irak1 (interleukin-1 receptor-associated kinase 1) - Rat Genome Database

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Gene: Irak1 (interleukin-1 receptor-associated kinase 1) Rattus norvegicus
Analyze
Symbol: Irak1
Name: interleukin-1 receptor-associated kinase 1
RGD ID: 1563841
Description: Enables heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Predicted to be located in several cellular components, including cytosol; lipid droplet; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including cell surface; nucleus; and plasma membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; apoptotic cell death pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC363520; RGD1563841; similar to interleukin-1 receptor associated kinase 1 splice form 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,919,927 - 156,929,825 (-)NCBIGRCr8
mRatBN7.2X151,768,621 - 151,778,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,768,777 - 151,778,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,910,678 - 153,919,674 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,473,895 - 157,482,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,145,709 - 155,154,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,716,469 - 156,726,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,716,604 - 156,725,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,464,303 - 152,474,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,960,184 - 159,969,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,116,523 - 136,125,519 (+)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auranofin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
enalapril  (ISO)
enzyme inhibitor  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
Fusaric acid  (ISO)
genistein  (ISO)
ginsenoside Re  (ISO)
glafenine  (EXP)
glyburide  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
helenalin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipoarabinomannan  (ISO)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
Monobutylphthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
o-anisidine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (ISO)
tetrachloromethane  (ISO)
titanium atom  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tropisetron  (EXP)
Tylophorine  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
xanthones  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. Belarbi K, etal., J Neuroinflammation. 2012 Jan 25;9:23. doi: 10.1186/1742-2094-9-23.
2. The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-Jun N-terminal kinase, and activator protein-1 signaling. Chandrasekar B, etal., J Biol Chem. 2005 Jul 15;280(28):26263-77. Epub 2005 May 11.
3. Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. Chao W, etal., J Biol Chem. 2005 Jun 10;280(23):21997-2005. Epub 2005 Mar 26.
4. The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. Chatzikyriakidou A, etal., Scand J Immunol. 2010 May;71(5):382-5. doi: 10.1111/j.1365-3083.2010.02381.x.
5. Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype. Dieude P, etal., Arthritis Rheum. 2011 Dec;63(12):3979-87. doi: 10.1002/art.30640.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. Halkein J, etal., J Clin Invest. 2013 May 1;123(5):2143-54. doi: 10.1172/JCI64365. Epub 2013 Apr 24.
8. Activation of the heat shock response attenuates the interleukin 1beta-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport. Howard M, etal., Shock. 2013 Feb;39(2):189-96. doi: 10.1097/SHK.0b013e31827e8ea3.
9. miR-146a Enhances the Oncogenicity of Oral Carcinoma by Concomitant Targeting of the IRAK1, TRAF6 and NUMB Genes. Hung PS, etal., PLoS One. 2013 Nov 26;8(11):e79926. doi: 10.1371/journal.pone.0079926.
10. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
11. Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin. Li Y, etal., Shock. 2009 Jan;31(1):55-63. doi: 10.1097/SHK.0b013e3181778ab2.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606.
18. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
19. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
20. Dysregulation of miRNA146a versus IRAK1 induces IL-17 persistence in the psoriatic skin lesions. Xia P, etal., Immunol Lett. 2012 Dec 17;148(2):151-62. doi: 10.1016/j.imlet.2012.09.004. Epub 2012 Sep 24.
21. Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. Yang YF, etal., Neuroscience. 2011 Nov 24;196:25-34. doi: 10.1016/j.neuroscience.2011.08.059. Epub 2011 Sep 10.
Additional References at PubMed
PMID:10383454   PMID:10549626   PMID:10854325   PMID:11397809   PMID:11960013   PMID:12054681   PMID:12477932   PMID:12855817   PMID:15292196   PMID:15946255   PMID:16831874   PMID:17379480  
PMID:17668873   PMID:19717152   PMID:19752193   PMID:21435586   PMID:21708940   PMID:22158417   PMID:23633945   PMID:25515214   PMID:26310493   PMID:26925748   PMID:27830143   PMID:29707878  
PMID:33508876  


Genomics

Comparative Map Data
Irak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,919,927 - 156,929,825 (-)NCBIGRCr8
mRatBN7.2X151,768,621 - 151,778,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,768,777 - 151,778,521 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,910,678 - 153,919,674 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,473,895 - 157,482,891 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X155,145,709 - 155,154,706 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X156,716,469 - 156,726,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,716,604 - 156,725,977 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,464,303 - 152,474,397 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,960,184 - 159,969,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1136,116,523 - 136,125,519 (+)NCBICelera
Cytogenetic MapXq37NCBI
IRAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,010,507 - 154,019,902 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX154,010,506 - 154,019,902 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,275,958 - 153,285,353 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,929,151 - 152,938,536 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,796,808 - 152,806,189NCBI
CeleraX153,509,662 - 153,519,047 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,927,208 - 141,942,770 (-)NCBIHuRef
CHM1_1X153,150,366 - 153,159,748 (-)NCBICHM1_1
T2T-CHM13v2.0X152,284,194 - 152,293,583 (-)NCBIT2T-CHM13v2.0
Irak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,057,520 - 73,067,527 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX73,057,520 - 73,067,524 (-)EnsemblGRCm39 Ensembl
GRCm38X74,013,914 - 74,023,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,013,914 - 74,023,918 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,259,253 - 71,269,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,267,692 - 70,276,641 (-)NCBIMGSCv36mm8
CeleraX65,266,305 - 65,276,311 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.61NCBI
Irak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580661,609 - 668,622 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580663,651 - 668,622 (-)NCBIChiLan1.0ChiLan1.0
IRAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X154,050,776 - 154,060,165 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X154,054,382 - 154,063,770 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X143,560,802 - 143,570,185 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X153,446,827 - 153,458,189 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,446,827 - 153,460,602 (-)Ensemblpanpan1.1panPan2
IRAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,853,340 - 121,862,582 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,819,432 - 121,862,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,180,516 - 107,191,312 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,993,051 - 125,003,852 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,995,644 - 125,003,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,762,292 - 120,773,086 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,277,991 - 123,288,705 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X123,039,025 - 123,049,823 (-)NCBIUU_Cfam_GSD_1.0
Irak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,153,636 - 119,162,536 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809890,717 - 900,326 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936809891,407 - 900,311 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,717,612 - 124,724,860 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,717,604 - 124,724,855 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,283,035 - 142,290,286 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,433,462 - 128,443,126 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,433,465 - 128,443,043 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,307,276 - 66,317,037 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946613,890 - 618,445 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946613,392 - 618,459 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irak1
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:86
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000065177
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat

Markers in Region
RH131803  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,769,053 - 151,769,252 (-)MAPPERmRatBN7.2
Rnor_6.0X156,725,738 - 156,725,936NCBIRnor6.0
Rnor_5.01152,473,772 - 152,473,970UniSTSRnor5.0
RGSC_v3.4X159,959,713 - 159,959,911UniSTSRGSC3.4
Celera1136,125,792 - 136,125,990UniSTS
Cytogenetic MapXq37UniSTS
REN88550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,778,001 - 151,778,245 (-)MAPPERmRatBN7.2
Rnor_6.0X156,716,745 - 156,716,988NCBIRnor6.0
Rnor_5.01152,464,579 - 152,464,822UniSTSRnor5.0
RGSC_v3.4X159,968,661 - 159,968,904UniSTSRGSC3.4
Celera1136,116,799 - 136,117,042UniSTS
Cytogenetic MapXq37UniSTS
REN88551  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X151,778,038 - 151,778,262 (-)MAPPERmRatBN7.2
Rnor_6.0X156,716,728 - 156,716,951NCBIRnor6.0
Rnor_5.01152,464,562 - 152,464,785UniSTSRnor5.0
RGSC_v3.4X159,968,698 - 159,968,921UniSTSRGSC3.4
Celera1136,116,782 - 136,117,005UniSTS
Cytogenetic MapXq37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000092207   ⟹   ENSRNOP00000070832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,769,013 - 151,778,386 (-)Ensembl
Rnor_6.0 EnsemblX156,716,604 - 156,725,977 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102227   ⟹   ENSRNOP00000096669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,768,777 - 151,778,521 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114639   ⟹   ENSRNOP00000080855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,769,013 - 151,778,386 (-)Ensembl
RefSeq Acc Id: NM_001127555   ⟹   NP_001121027
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,920,829 - 156,929,825 (-)NCBI
mRatBN7.2X151,769,525 - 151,778,521 (-)NCBI
Rnor_6.0X156,716,469 - 156,725,465 (+)NCBI
Rnor_5.01152,464,303 - 152,474,397 (+)NCBI
RGSC_v3.4X159,960,184 - 159,969,180 (-)RGD
Celera1136,116,523 - 136,125,519 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229598   ⟹   XP_006229660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,919,927 - 156,929,805 (-)NCBI
mRatBN7.2X151,768,621 - 151,778,501 (-)NCBI
Rnor_6.0X156,716,489 - 156,726,367 (+)NCBI
Rnor_5.01152,464,303 - 152,474,397 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099917   ⟹   XP_038955845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X156,919,927 - 156,927,779 (-)NCBI
mRatBN7.2X151,768,621 - 151,776,565 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001121027 (Get FASTA)   NCBI Sequence Viewer  
  XP_006229660 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66780 (Get FASTA)   NCBI Sequence Viewer  
  EDL84996 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070832.2
  ENSRNOP00000080855.1
  ENSRNOP00000096669.1
RefSeq Acc Id: NP_001121027   ⟸   NM_001127555
- UniProtKB: B2RYH5 (UniProtKB/TrEMBL),   F1LSW4 (UniProtKB/TrEMBL),   A0A8I6AR42 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229660   ⟸   XM_006229598
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYX9 (UniProtKB/TrEMBL),   A0A8I6AR42 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070832   ⟸   ENSRNOT00000092207
RefSeq Acc Id: XP_038955845   ⟸   XM_039099917
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000096669   ⟸   ENSRNOT00000102227
Ensembl Acc Id: ENSRNOP00000080855   ⟸   ENSRNOT00000114639
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYH5-F1-model_v2 AlphaFold B2RYH5 1-710 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702050
Promoter ID:EPDNEW_R12574
Type:initiation region
Name:Irak1_1
Description:interleukin-1 receptor-associated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X156,716,563 - 156,716,623EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563841 AgrOrtholog
BioCyc Gene G2FUF-650 BioCyc
Ensembl Genes ENSRNOG00000060869 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000092207.2 UniProtKB/TrEMBL
  ENSRNOT00000102227.1 UniProtKB/TrEMBL
  ENSRNOT00000114639.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934982 IMAGE-MGC_LOAD
InterPro DEATH-like_dom UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Death_IRAK1 UniProtKB/TrEMBL
  Immune_PlantDef_Kinases UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:363520 UniProtKB/TrEMBL
MGC_CLONE MGC:188560 IMAGE-MGC_LOAD
NCBI Gene 363520 ENTREZGENE
PANTHER OS01G0750732 PROTEIN UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PBL28-RELATED UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Irak1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060869 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JYX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRN5_RAT UniProtKB/TrEMBL
  A0A8I6AR42 ENTREZGENE, UniProtKB/TrEMBL
  B2RYH5 ENTREZGENE, UniProtKB/TrEMBL
  F1LSW4 ENTREZGENE
UniProt Secondary F1LSW4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Irak1  interleukin-1 receptor-associated kinase 1   Irak1_predicted  interleukin-1 receptor-associated kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Irak1_predicted  interleukin-1 receptor-associated kinase 1 (predicted)  RGD1563841_predicted  similar to interleukin-1 receptor associated kinase 1 splice form 3 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563841_predicted  similar to interleukin-1 receptor associated kinase 1 splice form 3 (predicted)  LOC363520  similar to interleukin-1 receptor associated kinase 1 splice form 3  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363520  similar to interleukin-1 receptor associated kinase 1 splice form 3      Symbol and Name status set to provisional 70820 PROVISIONAL