Topbp1 (DNA topoisomerase II binding protein 1) - Rat Genome Database

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Gene: Topbp1 (DNA topoisomerase II binding protein 1) Rattus norvegicus
Analyze
Symbol: Topbp1
Name: DNA topoisomerase II binding protein 1
RGD ID: 1562949
Description: Predicted to enable several functions, including identical protein binding activity; phosphorylation-dependent protein binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including DNA metabolic process; broken chromosome clustering; and mitotic G2/M transition checkpoint. Predicted to act upstream of or within DNA damage checkpoint signaling; double-strand break repair via alternative nonhomologous end joining; and double-strand break repair via homologous recombination. Predicted to be located in PML body; condensed nuclear chromosome; and male germ cell nucleus. Predicted to be part of BRCA1-B complex. Predicted to be active in site of double-strand break. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA topoisomerase 2-binding protein 1; LOC315969; RGD1562949; similar to mKIAA0259 protein; topoisomerase (DNA) II beta binding protein; topoisomerase (DNA) II binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,766,791 - 112,815,203 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,766,508 - 112,810,540 (+)EnsemblGRCr8
mRatBN7.28103,887,805 - 103,931,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,887,865 - 103,931,674 (+)EnsemblmRatBN7.2
Rnor_6.08111,790,655 - 111,835,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,790,678 - 111,827,151 (+)Ensemblrn6Rnor6.0
Rnor_5.08111,182,214 - 111,226,726 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,316,569 - 108,360,753 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,263,981 - 103,308,109 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
hypochlorous acid  (ISO)
idarubicin  (ISO)
Lasiocarpine  (ISO)
methimazole  (EXP)
monocrotaline  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
quinoline yellow  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
succimer  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12773567   PMID:14718568   PMID:17006541   PMID:17696610   PMID:21659603   PMID:22549958   PMID:31904090  


Genomics

Comparative Map Data
Topbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88112,766,791 - 112,815,203 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8112,766,508 - 112,810,540 (+)EnsemblGRCr8
mRatBN7.28103,887,805 - 103,931,662 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8103,887,865 - 103,931,674 (+)EnsemblmRatBN7.2
Rnor_6.08111,790,655 - 111,835,224 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,790,678 - 111,827,151 (+)Ensemblrn6Rnor6.0
Rnor_5.08111,182,214 - 111,226,726 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48108,316,569 - 108,360,753 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8103,263,981 - 103,308,109 (+)NCBICelera
Cytogenetic Map8q32NCBI
TOPBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383133,600,238 - 133,661,941 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3133,598,175 - 133,662,380 (-)Ensemblhg38GRCh38
GRCh373133,319,082 - 133,380,785 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363134,802,177 - 134,863,380 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343134,802,184 - 134,863,388NCBI
Celera3131,746,550 - 131,807,847 (-)NCBICelera
Cytogenetic Map3q22.1NCBI
HuRef3130,698,929 - 130,760,396 (-)NCBIHuRef
CHM1_13133,282,831 - 133,344,118 (-)NCBICHM1_1
T2T-CHM13v2.03136,345,391 - 136,407,104 (-)NCBIT2T-CHM13v2.0
Topbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399103,182,351 - 103,227,627 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9103,182,414 - 103,227,627 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389103,305,167 - 103,350,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9103,305,215 - 103,350,428 (+)Ensemblmm10GRCm38
MGSCv379103,207,657 - 103,252,758 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369103,163,477 - 103,208,578 (+)NCBIMGSCv36mm8
Celera9102,854,061 - 102,901,479 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map955.19NCBI
Topbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,908,137 - 4,976,453 (+)Ensembl
ChiLan1.0NW_0049555014,907,687 - 4,974,995 (+)NCBIChiLan1.0ChiLan1.0
TOPBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22131,546,382 - 131,608,412 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13131,551,116 - 131,613,181 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03130,667,998 - 130,729,569 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13138,143,287 - 138,204,163 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3138,143,893 - 138,203,363 (-)EnsemblpanPan2panpan1.1
TOPBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12330,517,172 - 30,578,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2330,516,125 - 30,578,108 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2330,496,150 - 30,557,663 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02331,036,921 - 31,098,677 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2331,037,038 - 31,098,765 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12330,730,992 - 30,792,698 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02330,788,792 - 30,850,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02331,036,365 - 31,098,102 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Topbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560270,028,281 - 70,081,249 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365296,788,187 - 6,841,888 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365296,788,713 - 6,841,824 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOPBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1374,768,257 - 74,846,340 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11374,768,251 - 74,846,377 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21382,197,685 - 82,230,216 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TOPBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11556,679,333 - 56,740,773 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1556,679,426 - 56,741,566 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604129,662,936 - 29,724,640 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Topbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247309,914,140 - 9,994,775 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247309,916,717 - 9,994,666 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Topbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1894,606,198 - 94,650,510 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Topbp1
267 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000013265
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
D8Rat107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28103,897,218 - 103,897,433 (+)MAPPERmRatBN7.2
Rnor_6.08111,800,214 - 111,800,427NCBIRnor6.0
Rnor_5.08111,191,793 - 111,192,006UniSTSRnor5.0
RGSC_v3.48108,325,793 - 108,326,123RGDRGSC3.4
RGSC_v3.48108,325,875 - 108,326,088UniSTSRGSC3.4
Celera8103,273,349 - 103,273,556UniSTS
RGSC_v3.18108,345,248 - 108,345,578RGD
SHRSP x BN Map866.2399RGD
SHRSP x BN Map866.2399UniSTS
Cytogenetic Map8q32UniSTS
D8Got170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28103,896,990 - 103,897,441 (+)MAPPERmRatBN7.2
mRatBN7.28103,897,143 - 103,897,441 (+)MAPPERmRatBN7.2
Rnor_6.08111,800,139 - 111,800,435NCBIRnor6.0
Rnor_6.08111,799,957 - 111,800,435NCBIRnor6.0
Rnor_5.08111,191,718 - 111,192,014UniSTSRnor5.0
Rnor_5.08111,191,536 - 111,192,014UniSTSRnor5.0
RGSC_v3.48108,325,800 - 108,326,096UniSTSRGSC3.4
RGSC_v3.48108,325,799 - 108,326,096RGDRGSC3.4
Celera8103,273,274 - 103,273,564UniSTS
RGSC_v3.18108,345,254 - 108,345,551RGD
RH 2.0 Map8888.8RGD
Cytogenetic Map8q32UniSTS
RH131225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28103,931,353 - 103,931,546 (+)MAPPERmRatBN7.2
Rnor_6.08111,834,575 - 111,834,767NCBIRnor6.0
Rnor_5.08111,226,418 - 111,226,610UniSTSRnor5.0
RGSC_v3.48108,360,445 - 108,360,637UniSTSRGSC3.4
Celera8103,307,460 - 103,307,652UniSTS
RH 3.4 Map81158.0UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013265   ⟹   ENSRNOP00000013265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8103,887,865 - 103,927,296 (+)Ensembl
Rnor_6.0 Ensembl8111,790,678 - 111,827,151 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109766   ⟹   ENSRNOP00000096497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,766,508 - 112,810,540 (+)Ensembl
mRatBN7.2 Ensembl8103,887,865 - 103,931,674 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115411   ⟹   ENSRNOP00000087421
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8112,769,417 - 112,810,540 (+)Ensembl
mRatBN7.2 Ensembl8103,887,865 - 103,931,674 (+)Ensembl
RefSeq Acc Id: XM_063266447   ⟹   XP_063122517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,766,791 - 112,815,203 (+)NCBI
RefSeq Acc Id: XM_063266448   ⟹   XP_063122518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,766,806 - 112,815,203 (+)NCBI
RefSeq Acc Id: XM_063266449   ⟹   XP_063122519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,769,861 - 112,815,203 (+)NCBI
RefSeq Acc Id: XM_063266450   ⟹   XP_063122520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88112,766,791 - 112,796,385 (+)NCBI
Ensembl Acc Id: ENSRNOP00000013265   ⟸   ENSRNOT00000013265
Ensembl Acc Id: ENSRNOP00000096497   ⟸   ENSRNOT00000109766
Ensembl Acc Id: ENSRNOP00000087421   ⟸   ENSRNOT00000115411
RefSeq Acc Id: XP_063122517   ⟸   XM_063266447
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFZ6 (UniProtKB/TrEMBL),   A6I2J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122520   ⟸   XM_063266450
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122518   ⟸   XM_063266448
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GFZ6 (UniProtKB/TrEMBL),   A6I2J4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122519   ⟸   XM_063266449
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GFZ6 (UniProtKB/TrEMBL)
Protein Domains
BRCT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRG0-F1-model_v2 AlphaFold D3ZRG0 1-1318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696231
Promoter ID:EPDNEW_R6755
Type:initiation region
Name:Topbp1_1
Description:DNA topoisomerase II binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08111,790,690 - 111,790,750EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562949 AgrOrtholog
BioCyc Gene G2FUF-29326 BioCyc
Ensembl Genes ENSRNOG00000009789 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000109766 ENTREZGENE
  ENSRNOT00000109766.2 UniProtKB/TrEMBL
  ENSRNOT00000115411 ENTREZGENE
  ENSRNOT00000115411.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10190 UniProtKB/TrEMBL
InterPro BRCT UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  BRCT_TopBP1_rpt8 UniProtKB/TrEMBL
  TopB1_SLF1_BRCT UniProtKB/TrEMBL
  TopBP1-like_BRCT0 UniProtKB/TrEMBL
  TopBP1_BRCT_1 UniProtKB/TrEMBL
NCBI Gene 315969 ENTREZGENE
PANTHER DNA REPLICATION REGULATOR DPB11-RELATED UniProtKB/TrEMBL
  DNA TOPOISOMERASE 2-BINDING PROTEIN 1 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  BRCT_TopB1_SLF1 UniProtKB/TrEMBL
  PTCB-BRCT UniProtKB/TrEMBL
  TopBP1_BRCT0 UniProtKB/TrEMBL
PhenoGen Topbp1 PhenoGen
PROSITE BRCT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009789 RatGTEx
SMART BRCT UniProtKB/TrEMBL
Superfamily-SCOP BRCT UniProtKB/TrEMBL
UniProt A0A8I6GFZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM39_RAT UniProtKB/TrEMBL
  A6I2J4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Topbp1  DNA topoisomerase II binding protein 1  Topbp1  topoisomerase (DNA) II binding protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-28 Topbp1  topoisomerase (DNA) II binding protein 1  Topbp1  topoisomerase (DNA) II beta binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-03 Topbp1  topoisomerase (DNA) II beta binding protein  RGD1562949_predicted  similar to mKIAA0259 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562949_predicted  similar to mKIAA0259 protein (predicted)  LOC315969  similar to mKIAA0259 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC315969  similar to mKIAA0259 protein      Symbol and Name status set to provisional 70820 PROVISIONAL