Fscb (fibrous sheath CABYR binding protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Fscb (fibrous sheath CABYR binding protein) Rattus norvegicus
Analyze
Symbol: Fscb
Name: fibrous sheath CABYR binding protein
RGD ID: 1561721
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of protein sumoylation. Predicted to be active in sperm fibrous sheath and sperm principal piece. Orthologous to human FSCB (fibrous sheath CABYR binding protein); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); bis(2-ethylhexyl) phthalate (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fibrous sheath CABYR-binding protein; LOC500659; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8688,264,133 - 88,266,925 (-)NCBIGRCr8
mRatBN7.2682,527,849 - 82,530,641 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx682,853,462 - 82,856,254 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0683,152,822 - 83,155,614 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0682,602,830 - 82,605,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0686,220,260 - 86,223,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0695,722,718 - 95,725,510 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4685,795,682 - 85,798,474 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera681,098,527 - 81,101,319 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17855365   PMID:27398160  


Genomics

Comparative Map Data
Fscb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8688,264,133 - 88,266,925 (-)NCBIGRCr8
mRatBN7.2682,527,849 - 82,530,641 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx682,853,462 - 82,856,254 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0683,152,822 - 83,155,614 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0682,602,830 - 82,605,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0686,220,260 - 86,223,052 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0695,722,718 - 95,725,510 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4685,795,682 - 85,798,474 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera681,098,527 - 81,101,319 (-)NCBICelera
Cytogenetic Map6q24NCBI
FSCB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381444,504,149 - 44,507,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1444,504,149 - 44,507,283 (-)EnsemblGRCh38hg38GRCh38
GRCh371444,973,352 - 44,976,486 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361444,043,294 - 44,046,208 (-)NCBINCBI36Build 36hg18NCBI36
Build 341444,043,297 - 44,046,208NCBI
Celera1424,834,054 - 24,837,201 (-)NCBICelera
Cytogenetic Map14q21.2NCBI
HuRef1425,084,764 - 25,087,947 (-)NCBIHuRef
CHM1_11444,911,512 - 44,914,659 (-)NCBICHM1_1
T2T-CHM13v2.01438,695,562 - 38,698,696 (-)NCBIT2T-CHM13v2.0
Fscb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391264,518,107 - 64,521,672 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1264,518,104 - 64,521,464 (-)EnsemblGRCm39 Ensembl
GRCm381264,471,333 - 64,474,898 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1264,471,330 - 64,474,690 (-)EnsemblGRCm38mm10GRCm38
MGSCv371265,572,320 - 65,575,885 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361265,390,107 - 65,393,503 (-)NCBIMGSCv36mm8
MGSCv361259,015,128 - 59,018,524 (-)NCBIMGSCv36mm8
Celera1265,602,165 - 65,605,766 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1226.96NCBI
Fscb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540917,433,213 - 17,435,957 (+)NCBIChiLan1.0ChiLan1.0
FSCB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21545,680,187 - 45,683,247 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11444,896,698 - 44,899,758 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01425,124,746 - 25,127,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11443,453,313 - 43,456,049 (-)NCBIpanpan1.1PanPan1.1panPan2
FSCB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1822,004,599 - 22,033,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl822,004,789 - 22,007,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha821,822,933 - 21,851,708 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0822,163,499 - 22,192,396 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1821,826,346 - 21,855,159 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0821,891,700 - 21,920,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0822,229,047 - 22,257,861 (-)NCBIUU_Cfam_GSD_1.0
Fscb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864053,978,548 - 53,981,509 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365834,707,636 - 4,710,286 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSCB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11174,732,612 - 174,734,834 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21194,527,331 - 194,530,049 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FSCB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12421,611,678 - 21,614,404 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605310,670,844 - 10,673,537 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fscb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473124,149,780 - 24,152,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fscb
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:16
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000046828
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 3 17 9 9 4 4 4 1 13 5 16 1 29 5

Sequence


Ensembl Acc Id: ENSRNOT00000046828   ⟹   ENSRNOP00000051161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl686,220,260 - 86,223,052 (-)Ensembl
RefSeq Acc Id: NM_001271107   ⟹   NP_001258036
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8688,264,133 - 88,266,925 (-)NCBI
mRatBN7.2682,527,849 - 82,530,641 (-)NCBI
Rnor_6.0686,220,260 - 86,223,052 (-)NCBI
Rnor_5.0695,722,718 - 95,725,510 (-)NCBI
Celera681,098,527 - 81,101,319 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258036 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98054 (Get FASTA)   NCBI Sequence Viewer  
  Q4V7A4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258036   ⟸   NM_001271107
- UniProtKB: Q4V7A4 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051161   ⟸   ENSRNOT00000046828

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V7A4-F1-model_v2 AlphaFold Q4V7A4 1-812 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694621
Promoter ID:EPDNEW_R5146
Type:multiple initiation site
Name:Fscb_1
Description:fibrous sheath CABYR binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0686,223,071 - 86,223,131EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561721 AgrOrtholog
BioCyc Gene G2FUF-37340 BioCyc
Ensembl Genes ENSRNOG00000032241 Ensembl
IMAGE_CLONE IMAGE:7457680 IMAGE-MGC_LOAD
InterPro FSCB UniProtKB/Swiss-Prot
KEGG Report rno:500659 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116212 IMAGE-MGC_LOAD
NCBI Gene 500659 ENTREZGENE
PANTHER FIBROUS SHEATH CABYR-BINDING PROTEIN UniProtKB/Swiss-Prot
  PTHR36135 UniProtKB/Swiss-Prot
PhenoGen Fscb PhenoGen
RatGTEx ENSRNOG00000032241 RatGTEx
UniProt FSCB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Fscb  fibrous sheath CABYR binding protein  LOC500659  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500659  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL