Asb9 (ankyrin repeat and SOCS box-containing 9) - Rat Genome Database

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Gene: Asb9 (ankyrin repeat and SOCS box-containing 9) Rattus norvegicus
Analyze
Symbol: Asb9
Name: ankyrin repeat and SOCS box-containing 9
RGD ID: 1560537
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in membrane. Predicted to be part of Cul5-RING ubiquitin ligase complex. Orthologous to human ASB9 (ankyrin repeat and SOCS box containing 9); INTERACTS WITH bisphenol A; trichloroethene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and SOCS box protein 9; ankyrin repeat and SOCS box-containing 9-like; ankyrin repeat and SOCS box-containing protein 9; LOC367785; RGD1560537; similar to ankyrin repeat and SOCS box-containing protein 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,588,484 - 33,633,285 (-)NCBIGRCr8
mRatBN7.2X29,956,576 - 30,001,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,956,576 - 30,001,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,996,068 - 31,031,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,426,480 - 34,462,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,620,402 - 30,656,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,700,637 - 31,745,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,700,633 - 31,780,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,074,331 - 32,119,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,712,265 - 50,748,863 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,303,294 - 30,339,406 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17148442  


Genomics

Comparative Map Data
Asb9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,588,484 - 33,633,285 (-)NCBIGRCr8
mRatBN7.2X29,956,576 - 30,001,436 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX29,956,576 - 30,001,105 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX30,996,068 - 31,031,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,426,480 - 34,462,346 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,620,402 - 30,656,160 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X31,700,637 - 31,745,790 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX31,700,633 - 31,780,425 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,074,331 - 32,119,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X50,712,265 - 50,748,863 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX30,303,294 - 30,339,406 (-)NCBICelera
Cytogenetic MapXq14NCBI
ASB9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,243,987 - 15,270,467 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,235,288 - 15,270,467 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,262,109 - 15,288,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,172,030 - 15,203,654 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,021,767 - 15,047,840NCBI
CeleraX19,377,104 - 19,404,177 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,019,996 - 13,047,217 (-)NCBIHuRef
CHM1_1X15,293,063 - 15,319,543 (-)NCBICHM1_1
T2T-CHM13v2.0X14,826,046 - 14,853,350 (-)NCBIT2T-CHM13v2.0
Asb9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X163,280,899 - 163,322,748 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX163,289,323 - 163,322,748 (+)EnsemblGRCm39 Ensembl
GRCm38X164,497,903 - 164,539,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,506,327 - 164,539,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,935,835 - 160,977,684 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,830,579 - 159,883,857 (+)NCBIMGSCv36mm8
CeleraX147,711,671 - 147,753,666 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.73NCBI
Asb9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,902,802 - 2,941,433 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,902,802 - 2,941,358 (+)NCBIChiLan1.0ChiLan1.0
ASB9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,041,763 - 17,069,493 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,045,430 - 17,073,160 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X7,869,174 - 7,896,783 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,152,698 - 15,179,218 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,152,698 - 15,179,182 (-)Ensemblpanpan1.1panPan2
ASB9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,505,941 - 11,533,335 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,505,941 - 11,533,135 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,413,188 - 11,440,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,468,028 - 11,495,417 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,468,043 - 11,503,671 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,530,975 - 11,558,331 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,522,320 - 11,549,680 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,550,393 - 11,577,769 (-)NCBIUU_Cfam_GSD_1.0
Asb9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,660,432 - 4,692,363 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,660,443 - 4,692,173 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,660,417 - 4,692,175 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASB9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX11,799,636 - 11,828,000 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X11,800,546 - 11,828,251 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X12,761,112 - 12,788,824 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASB9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X13,708,256 - 13,738,740 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX13,708,259 - 13,737,790 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,548,877 - 15,576,631 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asb9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482963,605 - 78,016 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462482963,524 - 86,042 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asb9
296 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:71
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000041515
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
BF387721  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X30,043,059 - 30,043,250 (+)MAPPERmRatBN7.2
Rnor_6.0X31,786,850 - 31,787,040NCBIRnor6.0
Rnor_5.0X32,160,601 - 32,160,791UniSTSRnor5.0
RGSC_v3.4X50,799,509 - 50,799,699UniSTSRGSC3.4
RGSC_v3.4X50,735,019 - 50,735,209UniSTSRGSC3.4
CeleraX30,389,741 - 30,389,931UniSTS
CeleraX30,325,562 - 30,325,752UniSTS
RH 3.4 MapX422.11UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 33 32 41 48 32 12 32 125 52 28 33 35 16

Sequence


Ensembl Acc Id: ENSRNOT00000004693   ⟹   ENSRNOP00000004693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX30,014,754 - 30,036,677 (-)Ensembl
Rnor_6.0 EnsemblX31,758,565 - 31,780,425 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041515   ⟹   ENSRNOP00000038983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,956,576 - 30,001,105 (-)Ensembl
Rnor_6.0 EnsemblX31,700,633 - 31,759,161 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108098   ⟹   ENSRNOP00000081538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX29,992,416 - 30,037,807 (-)Ensembl
RefSeq Acc Id: NM_001191913   ⟹   NP_001178842
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,588,484 - 33,624,357 (-)NCBI
mRatBN7.2X29,956,576 - 29,992,448 (-)NCBI
Rnor_6.0X31,700,637 - 31,736,596 (-)NCBI
Rnor_5.0X32,074,331 - 32,119,069 (-)NCBI
CeleraX30,303,294 - 30,339,406 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602120   ⟹   XP_017457609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X33,588,484 - 33,633,285 (-)NCBI
mRatBN7.2X29,956,576 - 30,001,436 (-)NCBI
Rnor_6.0X31,700,637 - 31,745,790 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178842 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457609 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90527 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038983.6
  ENSRNOP00000081538.1
RefSeq Acc Id: NP_001178842   ⟸   NM_001191913
- UniProtKB: F1M6U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457609   ⟸   XM_017602120
- Peptide Label: isoform X1
- UniProtKB: F1M6U5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038983   ⟸   ENSRNOT00000041515
Ensembl Acc Id: ENSRNOP00000004693   ⟸   ENSRNOT00000004693
Ensembl Acc Id: ENSRNOP00000081538   ⟸   ENSRNOT00000108098
Protein Domains
SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6U5-F1-model_v2 AlphaFold F1M6U5 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560537 AgrOrtholog
BioCyc Gene G2FUF-2596 BioCyc
Ensembl Genes ENSRNOG00000003452 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000067365 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041515.6 UniProtKB/TrEMBL
  ENSRNOT00000108098.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  SOCS box UniProtKB/TrEMBL
InterPro Ankyrin-SOCS_box_domain UniProtKB/TrEMBL
  Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  SOCS_box_dom_like UniProtKB/TrEMBL
  SOCS_C UniProtKB/TrEMBL
KEGG Report rno:367785 UniProtKB/TrEMBL
NCBI Gene 367785 ENTREZGENE
PANTHER ANKYRIN REPEAT AND SOCS BOX PROTEIN 11 UniProtKB/TrEMBL
  ANKYRIN REPEAT AND SOCS BOX PROTEIN 9 UniProtKB/TrEMBL
  SOWAH (DROSOPHILA) HOMOLOG UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
PhenoGen Asb9 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  SOCS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003452 RatGTEx
  ENSRNOG00000067365 RatGTEx
SMART ANK UniProtKB/TrEMBL
  SOCS_box UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  SSF158235 UniProtKB/TrEMBL
UniProt A0A8I5ZSR2_RAT UniProtKB/TrEMBL
  F1M6U5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Asb9  ankyrin repeat and SOCS box-containing 9  LOC100364446  ankyrin repeat and SOCS box-containing 9-like  Data merged from RGD:2321014 1643240 APPROVED
2010-05-05 LOC100364446  ankyrin repeat and SOCS box-containing 9-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Asb9  ankyrin repeat and SOCS box-containing 9  Asb9  ankyrin repeat and SOCS box-containing protein 9   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Asb9  ankyrin repeat and SOCS box-containing protein 9   Asb9_predicted  ankyrin repeat and SOCS box-containing protein 9 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Asb9_predicted  ankyrin repeat and SOCS box-containing protein 9 (predicted)  LOC684606  similar to ankyrin repeat and SOCS box-containing protein 9  Data merged from RGD:1587966 1643240 APPROVED
2006-11-19 LOC684606  similar to ankyrin repeat and SOCS box-containing protein 9      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Asb9_predicted  ankyrin repeat and SOCS box-containing protein 9 (predicted)  RGD1560537_predicted  similar to ankyrin repeat and SOCS box-containing protein 9 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560537_predicted  similar to ankyrin repeat and SOCS box-containing protein 9 (predicted)  LOC367785  similar to ankyrin repeat and SOCS box-containing protein 9  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367785  similar to ankyrin repeat and SOCS box-containing protein 9      Symbol and Name status set to provisional 70820 PROVISIONAL