Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Lrrc17 | Rat | 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | o and p'-DDT results in decreased expression of LRRC17 mRNA | CTD | PMID:18204070 | Lrrc17 | Rat | 1-nitropyrene | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | 1-nitropyrene results in decreased expression of LRRC17 mRNA | CTD | PMID:19041380 | Lrrc17 | Rat | 17beta-estradiol | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of LRRC17 mRNA | CTD | PMID:23019147 | Lrrc17 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of LRRC17 mRNA | CTD | PMID:32145629 | Lrrc17 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LRRC17 mRNA | CTD | PMID:32741896 | Lrrc17 | Rat | 17beta-estradiol | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Estradiol results in increased expression of LRRC17 mRNA | CTD | PMID:19484750 | Lrrc17 | Rat | 17beta-estradiol | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of LRRC17 mRNA and [Estradiol co-treated with TGFB1 protein] results in increased expression of LRRC17 mRNA | CTD | PMID:20660070 and PMID:30165855 | Lrrc17 | Rat | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LRRC17 mRNA | CTD | PMID:32741896 | Lrrc17 | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Lrrc17 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Lrrc17 | Rat | 2-methylcholine | affects expression | ISO | LRRC17 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of LRRC17 mRNA | CTD | PMID:21179406 | Lrrc17 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of LRRC17 mRNA | CTD | PMID:25172293 | Lrrc17 | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | bisphenol S results in decreased expression of LRRC17 mRNA | CTD | PMID:25912373 | Lrrc17 | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [bisphenol S co-treated with Tretinoin] results in decreased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | bisphenol S results in increased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of LRRC17 mRNA | CTD | PMID:28973697 | Lrrc17 | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of LRRC17 mRNA | CTD | PMID:24780913 | Lrrc17 | Rat | 8-Br-cAMP | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of LRRC17 mRNA | CTD | PMID:22079614 | Lrrc17 | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of LRRC17 mRNA | CTD | PMID:28959563 | Lrrc17 | Rat | all-trans-retinoic acid | decreases expression | EXP | | 6480464 | Tretinoin results in decreased expression of LRRC17 mRNA | CTD | PMID:20488242 | Lrrc17 | Rat | all-trans-retinoic acid | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of LRRC17 mRNA and [bisphenol S co-treated with Tretinoin] results in decreased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | all-trans-retinoic acid | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of LRRC17 mRNA | CTD | PMID:23724009 | Lrrc17 | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LRRC17 mRNA | CTD | PMID:35163327 | Lrrc17 | Rat | antirheumatic drug | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of LRRC17 mRNA | CTD | PMID:24449571 | Lrrc17 | Rat | arsenite(3-) | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | arsenite results in decreased expression of LRRC17 mRNA | CTD | PMID:18929588 | Lrrc17 | Rat | belinostat | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | belinostat results in increased expression of LRRC17 mRNA | CTD | PMID:26272509 | Lrrc17 | Rat | benzo[a]pyrene | decreases methylation | ISO | LRRC17 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of LRRC17 5' UTR and Benzo(a)pyrene results in decreased methylation of LRRC17 promoter | CTD | PMID:27901495 | Lrrc17 | Rat | benzo[a]pyrene | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of LRRC17 mRNA | CTD | PMID:32234424 | Lrrc17 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of LRRC17 mRNA | CTD | PMID:25181051 | Lrrc17 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of LRRC17 mRNA | CTD | PMID:32145629 | Lrrc17 | Rat | bisphenol A | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | bisphenol A results in increased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of LRRC17 mRNA | CTD | PMID:30816183 more ... | Lrrc17 | Rat | bisphenol F | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | bisphenol F | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | bisphenol F results in increased expression of LRRC17 mRNA | CTD | PMID:30951980 | Lrrc17 | Rat | boron nitride | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | boron nitride results in decreased expression of LRRC17 mRNA | CTD | PMID:30644070 | Lrrc17 | Rat | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of LRRC17 promoter | CTD | PMID:22457795 | Lrrc17 | Rat | cantharidin | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Cantharidin results in decreased expression of LRRC17 mRNA | CTD | PMID:36907384 | Lrrc17 | Rat | carbon nanotube | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Lrrc17 | Rat | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of LRRC17 mRNA | CTD | PMID:30556269 | Lrrc17 | Rat | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of LRRC17 mRNA | CTD | PMID:30556269 | Lrrc17 | Rat | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of LRRC17 mRNA | CTD | PMID:26577399 | Lrrc17 | Rat | dexamethasone | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of LRRC17 mRNA | CTD | PMID:22185406 | Lrrc17 | Rat | dexamethasone | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of LRRC17 mRNA] | CTD | PMID:22185406 | Lrrc17 | Rat | dibutyl phthalate | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of LRRC17 mRNA | CTD | PMID:21266533 | Lrrc17 | Rat | dioxygen | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of LRRC17 mRNA | CTD | PMID:30529165 | Lrrc17 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of LRRC17 mRNA | CTD | PMID:25152437 | Lrrc17 | Rat | dorsomorphin | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Lrrc17 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of LRRC17 mRNA | CTD | PMID:29391264 | Lrrc17 | Rat | entinostat | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | entinostat results in increased expression of LRRC17 mRNA | CTD | PMID:26272509 | Lrrc17 | Rat | entinostat | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC17 mRNA | CTD | PMID:27188386 | Lrrc17 | Rat | furan | increases expression | EXP | | 6480464 | furan results in increased expression of LRRC17 mRNA | CTD | PMID:27387713 | Lrrc17 | Rat | glycidol | decreases expression | EXP | | 6480464 | glycidol results in decreased expression of LRRC17 mRNA | CTD | PMID:24915197 | Lrrc17 | Rat | iron dichloride | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of LRRC17 mRNA | CTD | PMID:35984750 | Lrrc17 | Rat | ketoconazole | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Ketoconazole results in decreased expression of LRRC17 mRNA | CTD | PMID:36621641 | Lrrc17 | Rat | lead(0) | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Lead results in increased expression of LRRC17 mRNA | CTD | PMID:19921347 | Lrrc17 | Rat | lipopolysaccharide | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of LRRC17 mRNA] | CTD | PMID:22185406 | Lrrc17 | Rat | lipopolysaccharide | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Lipopolysaccharides results in increased expression of LRRC17 mRNA | CTD | PMID:22185406 | Lrrc17 | Rat | maneb | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA | CTD | PMID:18386188 | Lrrc17 | Rat | methotrexate | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Methotrexate results in increased expression of LRRC17 mRNA | CTD | PMID:24449571 | Lrrc17 | Rat | methylmercury chloride | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of LRRC17 mRNA | CTD | PMID:28001369 | Lrrc17 | Rat | methylmercury chloride | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of LRRC17 mRNA | CTD | PMID:34089799 | Lrrc17 | Rat | nickel atom | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Nickel results in decreased expression of LRRC17 mRNA | CTD | PMID:24768652 and PMID:25583101 | Lrrc17 | Rat | ozone | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of LRRC17 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of LRRC17 mRNA | CTD | PMID:27106289 and PMID:34911549 | Lrrc17 | Rat | panobinostat | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC17 mRNA | CTD | PMID:27188386 | Lrrc17 | Rat | panobinostat | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | panobinostat results in increased expression of LRRC17 mRNA | CTD | PMID:26272509 | Lrrc17 | Rat | paraquat | multiple interactions | ISO | Lrrc17 (Mus musculus) | 6480464 | [Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA | CTD | PMID:18386188 | Lrrc17 | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of LRRC17 mRNA | CTD | PMID:35163327 | Lrrc17 | Rat | phenethyl isothiocyanate | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | phenethyl isothiocyanate results in decreased expression of LRRC17 mRNA | CTD | PMID:26678675 | Lrrc17 | Rat | progesterone | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of LRRC17 mRNA | CTD | PMID:20660070 | Lrrc17 | Rat | progesterone | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Progesterone results in decreased expression of LRRC17 mRNA | CTD | PMID:21795739 | Lrrc17 | Rat | quercetin | affects expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Quercetin affects the expression of LRRC17 mRNA | CTD | PMID:21632981 | Lrrc17 | Rat | SB 431542 | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Lrrc17 | Rat | silicon dioxide | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Silicon Dioxide results in decreased expression of LRRC17 mRNA | CTD | PMID:22300531 | Lrrc17 | Rat | silver atom | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Silver results in decreased expression of LRRC17 mRNA | CTD | PMID:27131904 | Lrrc17 | Rat | silver(0) | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Silver results in decreased expression of LRRC17 mRNA | CTD | PMID:27131904 | Lrrc17 | Rat | sodium arsenite | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of LRRC17 mRNA | CTD | PMID:22714537 | Lrrc17 | Rat | sodium arsenite | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of LRRC17 mRNA | CTD | PMID:34032870 | Lrrc17 | Rat | temozolomide | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Temozolomide results in decreased expression of LRRC17 mRNA | CTD | PMID:31758290 | Lrrc17 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of LRRC17 mRNA | CTD | PMID:15336504 | Lrrc17 | Rat | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of LRRC17 mRNA | CTD | PMID:32741896 | Lrrc17 | Rat | titanium dioxide | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of LRRC17 mRNA | CTD | PMID:27760801 | Lrrc17 | Rat | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of LRRC17 mRNA | CTD | PMID:33387578 | Lrrc17 | Rat | trichostatin A | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of LRRC17 mRNA | CTD | PMID:24935251 and PMID:26272509 | Lrrc17 | Rat | trichostatin A | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC17 mRNA | CTD | PMID:27188386 | Lrrc17 | Rat | triclosan | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Triclosan results in decreased expression of LRRC17 mRNA | CTD | PMID:30510588 | Lrrc17 | Rat | trimellitic anhydride | decreases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of LRRC17 mRNA | CTD | PMID:19042947 | Lrrc17 | Rat | valproic acid | affects expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of LRRC17 mRNA | CTD | PMID:25979313 | Lrrc17 | Rat | valproic acid | increases expression | ISO | Lrrc17 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of LRRC17 mRNA | CTD | PMID:24896083 | Lrrc17 | Rat | valproic acid | increases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of LRRC17 mRNA | CTD | PMID:23179753 more ... | Lrrc17 | Rat | valproic acid | decreases expression | ISO | LRRC17 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of LRRC17 mRNA | CTD | PMID:23179753 more ... | Lrrc17 | Rat | valproic acid | multiple interactions | ISO | LRRC17 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of LRRC17 mRNA | CTD | PMID:27188386 | |