Emp2 (epithelial membrane protein 2)

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Gene: Emp2 (epithelial membrane protein 2) Rattus norvegicus

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Symbol:

Emp2

Name:

epithelial membrane protein 2

RGD ID:

1359629

Description:

Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including bleb assembly; early endosome to late endosome transport; and embryonic process involved in female pregnancy. Predicted to act upstream of or within positive regulation of cell-matrix adhesion. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

EMP-2; MGC93695

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EMP2 (epithelial membrane protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Emp2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Emp2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EMP2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EMP2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Emp2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EMP2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EMP2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Emp2 (epithelial membrane protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PHYKPL (5-phosphohydroxy-L-lysine phospho-lyase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	EMP2 (epithelial membrane protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Emp2 (epithelial membrane protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	emp2 (epithelial membrane protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	emp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	5,866,869 - 5,901,533 (+)	NCBI		GRCr8
mRatBN7.2	10	5,360,073 - 5,394,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	5,360,073 - 5,394,733 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	10,056,350 - 10,090,896 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	9,577,512 - 9,612,176 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	5,215,785 - 5,250,323 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	5,433,248 - 5,467,840 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	5,433,248 - 5,467,839 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	4,254,720 - 4,288,863 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	5,311,157 - 5,348,038 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	5,311,156 - 5,348,037 (+)	NCBI
Celera	10	4,376,437 - 4,410,636 (+)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Charcot-Marie-Tooth disease type 1C (ISO)

Landau-Kleffner syndrome (ISO)

MHC class II deficiency (ISO)

nephrotic syndrome type 10 (ISO)

placental insufficiency (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-acetamidofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (ISO)

all-trans-retinoic acid (EXP,ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-hexachlorocyclohexane (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

cantharidin (ISO)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

choline (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

etoposide (ISO)

folic acid (ISO)

furan (EXP,ISO)

genistein (ISO)

gentamycin (EXP)

graphite (EXP)

indometacin (ISO)

inulin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

menadione (ISO)

methylmercury chloride (ISO)

mitomycin C (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-nitrosodiethylamine (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

vancomycin (ISO)

vincaleukoblastine (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament organization (ISO,ISS)

actin-mediated cell contraction (ISO,ISS)

apoptotic process (ISO,ISS)

bleb assembly (ISO,ISS)

blood vessel endothelial cell migration (ISO,ISS)

caveola assembly (ISO,ISS)

cell adhesion (IBA,ISO,ISS)

cell-matrix adhesion (ISO,ISS)

early endosome to late endosome transport (ISO,ISS)

embryo implantation (ISO,ISS)

embryonic process involved in female pregnancy (ISO,ISS)

heart formation (ISO,ISS)

membrane raft assembly (ISO,ISS)

natural killer cell proliferation (ISO,ISS)

neutrophil migration (ISO,ISS)

plasma membrane raft assembly (ISO,ISS)

positive regulation of angiogenesis (ISO,ISS)

positive regulation of cardiac epithelial to mesenchymal transition (ISO,ISS)

positive regulation of cell population proliferation (ISO,ISS)

positive regulation of cell-matrix adhesion (ISO)

positive regulation of integrin-mediated signaling pathway (IBA,ISO)

protein localization to cell surface (ISO,ISS)

protein localization to plasma membrane (ISO,ISS)

regulation of angiogenesis (ISO,ISS)

regulation of cell-matrix adhesion (IBA,ISO)

regulation of endothelial cell migration (ISO,ISS)

regulation of glomerular filtration (ISO,ISS)

regulation of kinase activity (ISO,ISS)

regulation of vasculogenesis (ISO,ISS)

T cell mediated cytotoxicity (ISO,ISS)

Cellular Component

apical part of cell (ISO,ISS)

apical plasma membrane (ISO,ISS)

caveola (ISO,ISS)

cell surface (ISO,ISS)

cytoplasm (IBA,IDA,ISO)

cytoplasmic vesicle (ISO,ISS)

Golgi apparatus (ISO,ISS)

Golgi membrane (IEA)

membrane raft (ISO,ISS)

nucleus (IDA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IBA,ISO,ISS)

Molecular Function

integrin binding (ISO)

kinase binding (ISO)

protein binding (ISO)

protein kinase binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Mutations in EMP2 cause childhood-onset nephrotic syndrome.	Gee HY, etal., Am J Hum Genet. 2014 Jun 5;94(6):884-90. doi: 10.1016/j.ajhg.2014.04.010. Epub 2014 May 8.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion.	Wadehra M, etal., J Biol Chem 2002 Oct 25;277(43):41094-100. Epub 2002 Aug 19.

Additional References at PubMed

PMID:12107182	PMID:12763482	PMID:14978215	PMID:16216233	PMID:16487956	PMID:18400107	PMID:18469192	PMID:19494199	PMID:22728127	PMID:23334331	PMID:23439602	PMID:34495369

Genomics

Comparative Map Data

Emp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	5,866,869 - 5,901,533 (+)	NCBI		GRCr8
mRatBN7.2	10	5,360,073 - 5,394,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	5,360,073 - 5,394,733 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	10,056,350 - 10,090,896 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	9,577,512 - 9,612,176 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	5,215,785 - 5,250,323 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	5,433,248 - 5,467,840 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	5,433,248 - 5,467,839 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	4,254,720 - 4,288,863 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	5,311,157 - 5,348,038 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	5,311,156 - 5,348,037 (+)	NCBI
Celera	10	4,376,437 - 4,410,636 (+)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

EMP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	10,528,422 - 10,580,598 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	10,528,422 - 10,580,632 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	10,622,279 - 10,674,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	10,533,476 - 10,582,040 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	10,533,475 - 10,582,040	NCBI
Celera	16	10,790,221 - 10,843,547 (-)	NCBI		Celera
Cytogenetic Map	16	p13.13	NCBI
HuRef	16	10,541,152 - 10,593,355 (-)	NCBI		HuRef
CHM1_1	16	10,622,208 - 10,674,485 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	10,564,353 - 10,616,512 (-)	NCBI		T2T-CHM13v2.0

Emp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	10,099,613 - 10,131,832 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	10,099,613 - 10,131,832 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	10,281,749 - 10,313,968 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	10,281,749 - 10,313,968 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	10,281,842 - 10,314,061 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	10,195,337 - 10,227,546 (-)	NCBI		MGSCv36	mm8
Celera	16	10,915,145 - 10,947,388 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	5.54	NCBI

Emp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	7,826,738 - 7,860,028 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	7,826,967 - 7,862,035 (+)	NCBI	ChiLan1.0	ChiLan1.0

EMP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	11,072,654 - 11,124,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	14,848,582 - 14,900,614 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	9,465,589 - 9,517,593 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	10,694,425 - 10,744,744 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	10,694,425 - 10,744,744 (-)	Ensembl	panpan1.1		panPan2

EMP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	32,026,908 - 32,060,447 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	32,026,916 - 32,057,693 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	33,409,027 - 33,443,115 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	32,209,301 - 32,239,471 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	32,023,125 - 32,057,265 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	31,897,121 - 31,930,062 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	32,321,409 - 32,355,603 (+)	NCBI		UU_Cfam_GSD_1.0

Emp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	111,008,817 - 111,016,703 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936530	8,854,203 - 8,862,126 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936530	8,854,266 - 8,862,127 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	32,450,604 - 32,492,721 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	32,449,496 - 32,493,245 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	33,257,119 - 33,291,408 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EMP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	10,013,722 - 10,060,880 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	10,014,121 - 10,028,949 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	20,100,209 - 20,153,152 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624824	7,879,425 - 7,915,472 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624824	7,881,258 - 7,915,010 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Emp2
340 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	512
Count of miRNA genes:	268
Interacting mature miRNAs:	344
Transcripts:	ENSRNOT00000003615
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313095	Bss62	Bone structure and strength QTL 62	1.5	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
1576304	Schws7	Schwannoma susceptibility QTL 7		0.0115	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	4765527	19816042	Rat
2313066	Bss63	Bone structure and strength QTL 63	1.4	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	10	5387014	50387014	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat
2313064	Bmd71	Bone mineral density QTL 71	0.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	10	5387014	50387014	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
7387235	Uae41	Urinary albumin excretion QTL 41	5.26	0.1874	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	1	29497586	Rat
2313104	Bss61	Bone structure and strength QTL 61	0.9	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	10	5387014	50387014	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
737820	Alc9	Alcohol consumption QTL 9	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	19233348	Rat
2313081	Bss64	Bone structure and strength QTL 64	1.3	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	10	5387014	50387014	Rat
1549898	Neuinf3	Neuroinflammation QTL 3	26.4		nervous system integrity trait (VT:0010566)	MHC Class II RT1A-positive spinal cord ventral horn area to total spinal cord ventral horn area ratio (CMO:0001980)	10	3406320	5387112	Rat
631828	Alc5	Alcohol consumption QTL 5	2.4		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	10	5144027	17245662	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat

Markers in Region

D10Mit14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	5,387,014 - 5,387,112 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	5,460,119 - 5,460,218	NCBI	Rnor6.0
Rnor_5.0	10	4,281,142 - 4,281,241	UniSTS	Rnor5.0
RGSC_v3.4	10	5,339,759 - 5,339,859	RGD	RGSC3.4
RGSC_v3.4	10	5,339,760 - 5,339,859	UniSTS	RGSC3.4
RGSC_v3.1	10	5,339,760 - 5,339,859	RGD
Celera	10	4,402,915 - 4,403,014	UniSTS
RH 3.4 Map	10	68.5	UniSTS
RH 3.4 Map	10	68.5	RGD
RH 2.0 Map	10	0.0	RGD
Cytogenetic Map	10	q11	UniSTS

D10Rat200

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	5,359,011 - 5,359,247 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	5,432,193 - 5,432,428	NCBI	Rnor6.0
Rnor_5.0	10	4,253,665 - 4,253,900	UniSTS	Rnor5.0
RGSC_v3.4	10	5,310,101 - 5,310,337	RGD	RGSC3.4
RGSC_v3.4	10	5,310,102 - 5,310,337	UniSTS	RGSC3.4
RGSC_v3.1	10	5,310,032 - 5,310,365	RGD
Celera	10	4,375,382 - 4,375,617	UniSTS
FHH x ACI Map	10	4.54	RGD
FHH x ACI Map	10	4.54	UniSTS
Cytogenetic Map	10	q11	UniSTS

RH134327

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	5,394,295 - 5,394,515 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	5,467,402 - 5,467,621	NCBI	Rnor6.0
Rnor_5.0	10	4,288,425 - 4,288,644	UniSTS	Rnor5.0
RGSC_v3.4	10	5,347,600 - 5,347,819	UniSTS	RGSC3.4
Celera	10	4,410,198 - 4,410,417	UniSTS
Cytogenetic Map	10	q11	UniSTS

RH143053

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	5,392,146 - 5,392,262 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	5,465,253 - 5,465,368	NCBI	Rnor6.0
Rnor_5.0	10	4,286,276 - 4,286,391	UniSTS	Rnor5.0
RGSC_v3.4	10	5,345,451 - 5,345,566	UniSTS	RGSC3.4
Celera	10	4,408,049 - 4,408,164	UniSTS
RH 3.4 Map	10	55.2	UniSTS
Cytogenetic Map	10	q11	UniSTS

BE112998

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	5,392,311 - 5,392,507 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	5,465,418 - 5,465,613	NCBI	Rnor6.0
Rnor_5.0	10	4,286,441 - 4,286,636	UniSTS	Rnor5.0
RGSC_v3.4	10	5,345,616 - 5,345,811	UniSTS	RGSC3.4
Celera	10	4,408,214 - 4,408,409	UniSTS
RH 3.4 Map	10	68.2	UniSTS
Cytogenetic Map	10	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000003615 ⟹ ENSRNOP00000003615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	5,360,073 - 5,394,733 (+)	Ensembl
Rnor_6.0 Ensembl	10	5,433,248 - 5,467,839 (+)	Ensembl

RefSeq Acc Id:

NM_001007721 ⟹ NP_001007722

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	5,866,869 - 5,901,533 (+)	NCBI
mRatBN7.2	10	5,360,073 - 5,394,734 (+)	NCBI
Rnor_6.0	10	5,433,248 - 5,467,840 (+)	NCBI
Rnor_5.0	10	4,254,720 - 4,288,863 (+)	NCBI
RGSC_v3.4	10	5,311,157 - 5,348,038 (+)	RGD
Celera	10	4,376,437 - 4,410,636 (+)	RGD

Sequence:

show sequence

CGCCGCGCAGTGCCAGCCCGGAGCTTCAAAACAGCCGGCGCCTCGCCTCACGCGCAGCCCGCCA
CTGTGTCCAGACGCCCGCGCTCGATTTGGAATTGTCTCGCCATCTTTGTCTCCTCATTCCTCTC
TGAACTTCCTGCTGCCTTCGCTGCCCTGTGAACATGTTGGTGATTCTTGCCTTCATCATCGTCT
TCCACATCGTGTCTACGGCACTCTTGTTCATTTCAACCATTGACAATGCCTGGTGGGTAGGAGA
TGGCTTCTCAGCTGACATCTGGAGAGTGTGCACCAACAGCACAAACTGTACAGAGATCAATGAC
CTGAGCAGTACCGAGGAGTTTTCAGGTTACTCTGTGATGCAGGCGGTGCAGGCCACCATGATCC
TCTCCACCATCCTCTCCTGCATCTCCTTCCTCATCTTTCTGCTCCAGCTCTTCCGCCTCAAGCA
GGGAGAGAGGTTCGTCCTGACGGCCATCATCCAGCTCATGTCCTGTCTGTGTGTCATGATCGGG
GCTTCCGTCTATACAGACCGGCGGCAAGACCTTCACCATCAGAACAGCCAGCTCTATTACCTAC
TGCAAGAAGGCAGCTACGGTTACTCCTTCATCCTGGCCTGGGTGGCTTTCGCCTTCACTTTCAT
CAGCGGCCTCATGTACATGATCCTGAGGAAGCGCAAATAGGTGTCGGAAGCCCGGCCACTCCCA
CACTATGGCGTCCAGTCACATAACCATTTTGTATATAATCATTTTTTTTGTGGTTTTTCTAGCA
AACATTGTTTCCTTTAAAAGCTTTTATAGAAGAAGAAGAGAAGACAGAGGCAGAGAAGAGGAGT
TTCTGCATACTTGGGATCACAGAGCAGACCATGGAGGCTGGCATTCAGAATGCTTGCCTACCGA
AAGTCTCAGCAAGATCAGCAATGTAGAAATCTACAGGATGCCTCTCACGGGTGGCTCTGCGCTG
TGGGTGTGGCCAACGGTGGGGAAAGCCAGTCTTTGGGAGCAGACTCTTTGTAGGTGTCTGCCCT
GCCCTCTTCCCCTGCCCACTCCATTCCGACAGCCACAGTGGGATGATAAGGTCCAAATTTGGGA
TATCTATGCTCAGATATTAAACCTAAGTTCATGTAAGAAGTGGGCAAAGACTAGCCCTGGTTTG
TCTGTAAGGAACCCAGAGTTTCCCAACCCCGCTGCCGTGAATTAGGTCATCACACAAATTTGTT
GAGGTTTGCTCATGTTTGCCTTAAGGATAGTGACCCCTTAACCCAGTTGTCATGTTTAGGCACT
GAAGGTCCATAGGTAGTTCCTCAGGGCATCTATCACATGTAGGCTCACAAGTCTACTTCCAAGA
CCCTCAGAATCCTTTATCAAGGGGGTGGTGGGCCTGGGTGTCCGAATTTCTGATGAGCTCCCTG
CAATATGCTAAATGCACTAAAGCCAGGGGTCAGCCCTAGAGCTGGGGGAGCAAAGCCACCCTGA
GAACGTCACCACTCTCATCACAACGAGGGGGCCCCACTGCCAGCCACATCTTGGCTTCCACAGC
TGCTTATATCTGGGACACTTGGAAGGCGGGCTGGTCAGTCTCCTCCCCGACTACACTAGAGGGT
CTCTCTTTTTCTCCCTGCCCTTTCTAATGTGGATGCTTCCATTTGGCCCCTATTTCTGTAGCCT
CAGAAGAGCCATCTTCCATTCATTCATCCACCCATCATTCAACATGAATGAGTCTAAGTGCAAG
GGATACCCTTTCAAAACAATCCCTCACGAGACTCAGTCTAGTGAAAACACACACCAGAAGACAA
ATGGAGAAACTGCCAACCATAATGAAACAGCAGGGATTTGAACCCTCCAGGGTGAGGGGGGCCA
CTTTCTGTGTCTGCTTTTAAGTACCTTGAGAGATCTTGATTGCTCTGAACAGAGGTTCCCTTGT
TCCAGTGCCATTCATTGGGTAGTGCCCACTGGGTTCCACCAGAGAATACTTCTACAGAGCATCC
TTTACTCCCCACAGGGAGACAGGAAAGGATTCCCCCAAGCTGTGGCTCTTAAGATGGTCCTCAA
AGAAAAATCCAGTCATTTCCGAGTGTGCTCTGAAACCGGAGGCCACGGGGAGGTTTTCAGTAGA
GCTGGAGGAGGGATGTGCCACACCCGAGACTCAGGAAATCTATGATGGCAGCCTTCTCCCTCCG
ATACCCTTTCCATTTTTGAGCATGAGTTGGAGAGGTGACTCTGGGACAGGTGTGTATCTGTGTT
TAGACACATTTGCATGTGAGTTGCTCAAGGGAGGGGATATTTGCCAATAGCTCAGTCCCAGTGG
AGCTGGGGGATGTTGGGATCTGAGTGGCTTTTAGGGTCATCATTGGCCACTTCTTCAGTACAAG
ACTGACTTCCCTCCCTTCCTCCCTTTCTTCTATCTTCCTTTCCTTCCTTCCTTAGAGGGACTGC
CAAGGTGACATGGGGCAGTGACAGGACAAATGATCACCTGTTGTCTTAATGTACTTTCTACCGC
TTACTGTTGACTTGATTGTAGAGTTGGCTTCATGTCTTGTGAGTCCCAAGGAAGGAGTCCTCTC
TACTTTCCCCTTGTGGCCTTTTCTGTAATAGCTGATTAACAATTGTTCTGATGATCATGATGGA
AACAGACCACCTCAGAAACAGAGGCACGAAAGTCTGAGCCCGCACAAATTCCCACCTCAGAAAC
CCCCAGGGTTTCTACAGAAGTGCCCTTGTCTAATGCAATGGGGATGGCCCTGTGGGTTGTCTCT
GCTTGCTGCTGTGACCAGCTCAGTGCCTACAGCCACCGGTGGCATGAGAAGTGCTTCTCTCCTG
CTCTATGCCCTGCATTTGGGATGCTAAGAAGAGGTAAGGATGTGAGGAAGAAGAGATCCACCCT
TCTCCTAGGTAGGATCAGCTCTCAATGGTGCTTATCACTAGTCATCAAAGAACATGGCAGTCAG
CTGCGATATCCAAGAAGCAAGTATTAGGACCAAACCTGTCACCGTATTTAAAGGAACTTTAGTT
TGCATATCTTACATTTTTATAAAGTACTGTAATTCAGGGGGGTGGGGCATGTGACAGAGACAGA
CTAACCCGTGTTTGTCATTTGAATAAAAATTATTTTGGGTCTCTGTTTAAAGAATTCAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007722	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81865	(Get FASTA)	NCBI Sequence Viewer
	EDL96228	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000003615.3
	ENSRNOP00055024663
	ENSRNOP00060013487
GenBank Protein	Q66HH2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007722 ⟸ NM_001007721
- UniProtKB:	Q66HH2 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLVILAFIIVFHIVSTALLFISTIDNAWWVGDGFSADIWRVCTNSTNCTEINDLSSTEEFSGYS VMQAVQATMILSTILSCISFLIFLLQLFRLKQGERFVLTAIIQLMSCLCVMIGASVYTDRRQDL HHQNSQLYYLLQEGSYGYSFILAWVAFAFTFISGLMYMILRKRK hide sequence

Ensembl Acc Id:

ENSRNOP00000003615 ⟸ ENSRNOT00000003615

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HH2-F1-model_v2	AlphaFold	Q66HH2	1-172	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696947

Promoter ID:

EPDNEW_R7472

Type:

initiation region

Name:

Emp2_1

Description:

epithelial membrane protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	5,433,256 - 5,433,316	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359629	AgrOrtholog
BioCyc Gene	G2FUF-26127	BioCyc
Ensembl Genes	ENSRNOG00000002664	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00055018096	UniProtKB/Swiss-Prot
	ENSRNOG00060010272	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000003615.5	UniProtKB/Swiss-Prot
	ENSRNOT00055030655	UniProtKB/Swiss-Prot
	ENSRNOT00060017359	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.140.150	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7096470	IMAGE-MGC_LOAD
InterPro	EMP_2	UniProtKB/Swiss-Prot
	PMP-22/EMP/MP20	UniProtKB/Swiss-Prot
	PMP22/EMP/MP20/Claudin	UniProtKB/Swiss-Prot
	PMP22_EMP_MP20	UniProtKB/Swiss-Prot
KEGG Report	rno:360468	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93695	IMAGE-MGC_LOAD
NCBI Gene	360468	ENTREZGENE
PANTHER	EPITHELIAL MEMBRANE PROTEIN-RELATED	UniProtKB/Swiss-Prot
	PTHR10671:SF32	UniProtKB/Swiss-Prot
Pfam	PMP22_Claudin	UniProtKB/Swiss-Prot
PhenoGen	Emp2	PhenoGen
PRINTS	EPMEMFAMILY	UniProtKB/Swiss-Prot
	EPMEMPROT2	UniProtKB/Swiss-Prot
PROSITE	PMP22_1	UniProtKB/Swiss-Prot
	PMP22_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000002664	RatGTEx
	ENSRNOG00055018096	RatGTEx
	ENSRNOG00060010272	RatGTEx
UniProt	EMP2_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-29	Emp2	epithelial membrane protein 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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