Itch (itchy E3 ubiquitin protein ligase)

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Gene: Itch (itchy E3 ubiquitin protein ligase) Rattus norvegicus

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Symbol:

Itch

Name:

itchy E3 ubiquitin protein ligase

RGD ID:

1359556

Description:

Predicted to enable several functions, including arrestin family protein binding activity; ubiquitin-like protein ligase binding activity; and ubiquitin-ubiquitin ligase activity. Predicted to be involved in several processes, including negative regulation of NF-kappaB transcription factor activity; negative regulation of intracellular signal transduction; and protein ubiquitination. Predicted to act upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein catabolic process. Predicted to be located in several cellular components, including cell cortex; early endosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase); PARTICIPATES IN Notch signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; tumor necrosis factor mediated signaling pathway; INTERACTS WITH 17beta-estradiol; acetamide; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase Itchy homolog; itch E3 ubiquitin ligase; itchy E3 ubiquitin protein ligase homolog; itchy E3 ubiquitin protein ligase homolog (mouse); itchy homolog E3 ubiquitin protein ligase; itchy homolog E3 ubiquitin protein ligase (mouse); itchy, E3 ubiquitin protein ligase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ITCH (itchy E3 ubiquitin protein ligase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Itch (itchy, E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Itch (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ITCH (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ITCH (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Itch (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ITCH (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ITCH (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Itch (itchy E3 ubiquitin protein ligase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ITCH (itchy E3 ubiquitin protein ligase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Itch (itchy, E3 ubiquitin protein ligase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itchb (itchy E3 ubiquitin protein ligase b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itcha (itchy E3 ubiquitin protein ligase a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RSP5	Alliance	DIOPT (Hieranoid\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	Su(dx)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	wwp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	itch	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,102,490 - 164,193,932 (+)	NCBI		GRCr8
mRatBN7.2	3	143,642,348 - 143,733,745 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,645,637 - 143,733,543 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,511,691 - 147,599,817 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,128,969 - 156,217,097 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,868,517 - 153,956,642 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,660,665 - 150,752,016 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,686,638 - 150,749,827 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,055,848 - 157,117,955 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,644,315 - 145,707,190 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	145,549,936 - 145,612,812 (+)	NCBI
Celera	3	142,396,380 - 142,459,141 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glutathione synthetase deficiency (ISO)

glutatione synthetase deficiency with 5-oxoprolinuria (ISO)

hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase (ISO)

long QT syndrome (ISO)

Multisystem Autoimmune Disease with Facial Dysmorphism (ISO)

Obesity and Hypopigmentation (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2-hydroxypropanoic acid (ISO)

3,4-methylenedioxymethamphetamine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

disodium selenite (ISO)

enzalutamide (ISO)

ethanol (ISO)

fenofibrate (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

ivermectin (ISO)

lipopolysaccharide (ISO)

methylmercury chloride (ISO)

ochratoxin A (EXP)

paracetamol (ISO)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tert-butyl hydroperoxide (ISO)

thiram (ISO)

torcetrapib (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CD4-positive, alpha-beta T cell proliferation (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of CD4-positive, alpha-beta T cell proliferation (ISO)

negative regulation of cytoplasmic pattern recognition receptor signaling pathway (ISO)

negative regulation of defense response to virus (ISO)

negative regulation of JNK cascade (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of protein catabolic process (ISO)

positive regulation of receptor catabolic process (ISO)

positive regulation of T cell anergy (ISO)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA,ISO)

protein autoubiquitination (ISO)

protein branched polyubiquitination (ISO)

protein catabolic process (ISO)

protein K29-linked ubiquitination (ISO)

protein K48-linked ubiquitination (ISO)

protein K63-linked ubiquitination (ISO)

protein monoubiquitination (ISO)

protein polyubiquitination (ISO)

protein ubiquitination (ISO)

receptor internalization (ISO)

regulation of protein deubiquitination (ISO)

T cell anergy (ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cell cortex (ISO)

cytoplasm (IBA,ISO)

cytoplasmic vesicle (ISO)

early endosome (ISO)

intracellular membrane-bounded organelle (ISO)

membrane (ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

Molecular Function

arrestin family protein binding (ISO)

CXCR chemokine receptor binding (ISO)

ligase activity (ISO)

protein binding (ISO)

ribonucleoprotein complex binding (ISO)

ubiquitin protein ligase activity (IBA,ISO)

ubiquitin-like protein ligase binding (ISO)

ubiquitin-protein transferase activity (ISO)

ubiquitin-ubiquitin ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

Notch signaling pathway (ISO)

transforming growth factor-beta Smad dependent signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of NF-kappaB by ubiquitination.	Chen J and Chen ZJ, Curr Opin Immunol. 2013 Feb;25(1):4-12. doi: 10.1016/j.coi.2012.12.005. Epub 2013 Jan 8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Deubiquitinases in the regulation of NF-kappaB signaling.	Harhaj EW and Dixit VM, Cell Res. 2011 Jan;21(1):22-39. doi: 10.1038/cr.2010.166. Epub 2010 Nov 30.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.	Perry WL, etal., Nat Genet 1998 Feb;18(2):143-6.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11555636	PMID:14602072	PMID:14973438	PMID:15605377	PMID:15678106	PMID:17028573	PMID:17137798	PMID:17592138	PMID:18246070	PMID:18628966	PMID:18718448	PMID:19116316
PMID:19592251	PMID:19881509	PMID:19946888	PMID:20068034	PMID:22871113	PMID:23146885	PMID:23533145	PMID:23886940	PMID:24790097	PMID:25518932	PMID:25631046	PMID:26796253
PMID:37306338

Genomics

Comparative Map Data

Itch
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	164,102,490 - 164,193,932 (+)	NCBI		GRCr8
mRatBN7.2	3	143,642,348 - 143,733,745 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	143,645,637 - 143,733,543 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	147,511,691 - 147,599,817 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	156,128,969 - 156,217,097 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	153,868,517 - 153,956,642 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	150,660,665 - 150,752,016 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	150,686,638 - 150,749,827 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,055,848 - 157,117,955 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	145,644,315 - 145,707,190 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	145,549,936 - 145,612,812 (+)	NCBI
Celera	3	142,396,380 - 142,459,141 (+)	NCBI		Celera
Cytogenetic Map	3	q41	NCBI

ITCH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	34,363,273 - 34,511,773 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	34,363,235 - 34,511,773 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	32,951,079 - 33,099,578 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	32,414,745 - 32,562,858 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	32,414,744 - 32,562,858	NCBI
Celera	20	29,700,532 - 29,848,669 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	29,732,695 - 29,880,133 (+)	NCBI		HuRef
CHM1_1	20	32,852,140 - 33,000,398 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	36,086,401 - 36,234,950 (+)	NCBI		T2T-CHM13v2.0

Itch
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	154,975,401 - 155,068,775 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	154,975,429 - 155,068,775 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	155,133,481 - 155,226,855 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	155,133,509 - 155,226,855 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	154,959,217 - 155,052,590 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	154,821,645 - 154,918,295 (+)	NCBI		MGSCv36	mm8
Celera	2	161,062,175 - 161,159,103 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	76.94	NCBI

Itch
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	26,809,972 - 26,887,123 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	26,810,829 - 26,918,517 (-)	NCBI	ChiLan1.0	ChiLan1.0

ITCH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	40,093,373 - 40,244,925 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	40,086,459 - 40,238,028 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	30,690,172 - 30,840,504 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	31,822,496 - 31,971,945 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	31,852,203 - 31,971,945 (+)	Ensembl	panpan1.1		panPan2

ITCH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	23,476,619 - 23,630,574 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	23,476,736 - 23,627,469 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	23,124,607 - 23,276,323 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	24,168,489 - 24,321,093 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	24,168,521 - 24,320,269 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	23,456,967 - 23,608,609 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	23,551,074 - 23,703,694 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	23,990,143 - 24,142,586 (+)	NCBI		UU_Cfam_GSD_1.0

Itch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	172,483,787 - 172,608,613 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	6,140,234 - 6,265,767 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	6,140,236 - 6,265,734 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITCH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	37,810,235 - 37,918,209 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	37,810,113 - 37,918,963 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	42,398,530 - 42,404,580 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITCH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	38,671,170 - 38,808,621 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	38,701,396 - 38,805,005 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	88,023,258 - 88,160,983 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itch
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624842	4,842,419 - 4,935,699 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624842	4,840,848 - 4,977,785 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Itch
319 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	105
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000024411
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	120538241	165538241	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
61335	Bp20	Blood pressure QTL 20	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141339236	155617360	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1331726	Bp208	Blood pressure QTL 208	3.129		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	141339013	162184794	Rat
1300173	Rf11	Renal function QTL 11	3.38		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	121056165	145956249	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
10755461	Coatc16	Coat color QTL 16			coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	3	122438700	167438700	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	127162703	168026850	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		0.001	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	3	118839124	163839124	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		kidney mass (VT:0002707)	right kidney wet weight to body weight ratio (CMO:0001953)	3	121056165	157309487	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	140069424	146976080	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.3	0.663	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	3	130193298	161695983	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY600518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078235 ⟹ ENSRNOP00000075116

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,645,637 - 143,733,543 (+)	Ensembl
Rnor_6.0 Ensembl	3	150,686,638 - 150,749,827 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105016 ⟹ ENSRNOP00000083747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,668,084 - 143,733,543 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106366 ⟹ ENSRNOP00000092387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	143,673,816 - 143,733,543 (+)	Ensembl

RefSeq Acc Id:

NM_001005887 ⟹ NP_001005887

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,105,796 - 164,193,932 (+)	NCBI
mRatBN7.2	3	143,645,604 - 143,733,745 (+)	NCBI
Rnor_6.0	3	150,686,759 - 150,749,629 (+)	NCBI
Rnor_5.0	3	157,055,848 - 157,117,955 (+)	NCBI
RGSC_v3.4	3	145,644,315 - 145,707,190 (+)	RGD
Celera	3	142,396,380 - 142,459,141 (+)	RGD

Sequence:

show sequence

ATGGGTAGTCTGACCATGAAATCTCAACTTCAGATTACTGTCATCTCAGCCAAACTTAAAGAAA
ATAAAAAGAATTGGTTTGGACCAAGTCCTTATGTAGAAGTCACAGTAGATGGGCAGTCAAAGAA
GACAGAAAAATGCAACAATACAAACAGCCCCAAGTGGAAGCAGCCCCTCACAGTTATCGTTACC
CCTATGAGTAAATTATGTTTTCGTGTGTGGAGTCACCAGACCCTGAAATCTGATGTTTTATTGG
GAACTGCTGGATTAGATATTTATGAAACATTAAAGTCAAACAATATGAAACTTGAGGAAGTAGT
TATGACTTTGCAGCTTGTAGGTGACAAAGAGCCAACAGAGACAATGGGAGATTTGTCAGTTTGT
CTTGATGGGCTGCAAGTAGAAGCTGAAGTTGTTACTAATGGTGAAACTTCATGCTCAGAGGGTG
CTACACAGAATGACGCTGGCTGCAGACCCAAAGATGAAACAAGAGTGAGCACAAATGGATCAGA
GGACCCTGAGGTTGCAGCCTCGGGGGAGAACAAGAGGGCCAATGGGAACAATTCTCCATCCCTT
TCAAATGGTGGTTTTAAGCCTTCTAGACCTCCTAGACCTTCAAGACCACCTCCACCCACCCCAC
GAAGACCAGCTTCTGTCAATGGCTCACCATCCACGAACTCTGACAGCGATGGATCTAGCACAGG
CTCTTTGCCACCCACAAATACAAATGTAAATTCAAGTGCATCGGAAGGAGCAGCATCTGGGTTA
ATAATTCCTCGTACCATCTCTGGGGGCTCAGGCCCTAGGCCGCTGAATACTGTCAGTCAAGCTC
CCCTCCCACCTGGGTGGGAGCAGAGAGTAGATCAGCATGGGCGTGCTTACTATGTAGACCATGT
TGAAAAGCGAACAACACGGGATAGACCGGAACCTCTACCTCCTGGCTGGGAACGGCGTGTGGAC
AATATGGGACGTATTTATTATGTTGACCATTTCACGAGAACCACAACATGGCAGAGGCCGACCT
TGGAATCTGTCCGGAACTATGAGCAGTGGCAGCTCCAGCGTAGTCAACTTCAGGGAGCAATGCA
GCAGTTTAACCAGAGATTCATCTTTGGGAATCAAGATTTGTTTGCTACATCACAAAACAAAGAG
TTTGATCCCCTTGGTCCTTTGCCCCCTGGATGGGAGAAGAGAACTGATAGCAACGGCAGAGTGT
ATTTTGTCAACCACAACACTCGGATTACACAGTGGGAAGACCCCAGAAGCCAAGGTCAGTTAAA
TGAAAAGCCCTTACCAGAAGGCTGGGAAATGCGATTCACAGTGGATGGAATTCCATATTTTGTG
GACCACAATAGAAGAGCAACTACCTACATAGATCCACGCACAGGAAAGTCAGCCTTAGACAACG
GACCCCAGATAGCCTATGTTCGGGACTTCAAGGCAAAAGTTCAGTATTTCCGGTTCTGGTGTCA
GCAACTGGCCATGCCACAGCATATAAAGATCACAGTGACAAGAAAAACATTGTTTGAGGATTCC
TTTCAACAGATCATGAGCTTCAGTCCGCAAGATCTGAGAAGACGTTTGTGGGTGATTTTCCCAG
GAGAAGAAGGTTTAGATTATGGAGGTGTAGCAAGAGAATGGTTCTTTCTTTTGTCACATGAAGT
GTTGAACCCAATGTATTGCCTGTTTGAATATGCAGGGAAGGATAACTACTGCCTGCAGATAAAC
CCCGCTTCTTATATCAACCCAGACCACCTGAAATACTTCCGTTTTATTGGCAGATTTATTGCCA
TGGCTCTATTCCATGGGAAATTCATAGATACCGGATTTTCTTTACCATTCTATAAACGTATCTT
GAATAAACCAGTGGGACTTAAGGATTTAGAATCTATCGATCCAGAATTTTACAATTCTCTCATC
TGGGTTAAAGAAAACAATATCGAGGAATGTGGTTTGGAAATGTACTTCTCAGTTGATAAAGAAA
TTCTGGGTGAAATTAAGAGTCATGATTTGAAACCCAATGGTGGCAATATTCTGGTGACAGAAGA
AAATAAGGAAGAGTACATCAGGATGGTCGCTGAGTGGAGGTTGTCTCGGGGAGTTGAAGAGCAG
ACACAAGCTTTCTTTGAGGGCTTTAATGAAATTCTTCCTCAGCAATATTTGCAATATTTTGATG
CGAAGGAATTAGAGGTCCTTTTGTGTGGGATGCAGGAGATCGATTTGAATGACTGGCAGAGACA
CGCCATCTACCGTCACTATACCAGGACGAGCAAGCAGATCGTGTGGTTTTGGCAGTTTGTTAAA
GAAATTGATAACGAGAAGAGGATGCGACTTCTGCAGTTTGTTACCGGAACCTGCCGATTGCCAG
TGGGAGGATTTGCTGACCTCATGGGGAGTAATGGACCACAGAAGTTCTGCATCGAAAAAGTTGG
CAAAGAAAATTGGTTACCCAGAAGCCATACTTGTTTTAACCGCCTGGACCTCCCACCCTACAAG
AGCTATGAGCAACTGAAGGAAAAGCTGTTATTTGCCATTGAAGAAACTGAAGGATTTGGACAAG
AGTAA

hide sequence

RefSeq Acc Id:

XM_008762336 ⟹ XP_008760558

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	164,102,490 - 164,193,931 (+)	NCBI
mRatBN7.2	3	143,642,348 - 143,733,745 (+)	NCBI
Rnor_6.0	3	150,660,665 - 150,752,016 (+)	NCBI

Sequence:

show sequence

CAGGACCTTGAGCTTCATACAACATCAGAATGTGGACAGTCATTCCATGTTCTTTGATTCTGGG
CATCAGGTAACACAAAACATGTAACATGCATTTCACAGTGGCCTTCTGGAAACAACGCCTTAAC
CCTCAGAAGTGACTCAACCATTGAGAACTTCAGGTTTGCTGTCTTATTGATGGTATGTCTGACA
GTGCACCACAGCTCGATTCAATGGGTAGCCTGACCATGAAATCTCAACTTCAGATTACTGTCAT
CTCAGCCAAACTTAAAGAAAATAAAAAGAATTGGTTTGGACCAAGTCCTTATGTAGAAGTCACA
GTAGATGGGCAGTCAAAGAAGACAGAAAAATGCAACAATACAAACAGCCCCAAGTGGAAGCAGC
CCCTCACAGTTATCGTTACCCCTATGAGTAAATTATGTTTTCGTGTGTGGAGTCACCAGACCCT
GAAATCTGATGTTTTATTGGGAACTGCTGGATTAGATATTTATGAAACATTAAAGTCAAACAAT
ATGAAACTTGAGGAAGTAGTTATGACTTTGCAGCTTGTAGGTGACAAAGAGCCAACAGAGACAA
TGGGAGATTTGTCAGTTTGTCTTGATGGGCTGCAAGTAGAAGCTGAAGTTGTTACTAATGGTGA
AACTTCATGCTCAGAGGGTGCTACACAGAATGACGCTGGCTGCAGACCCAAAGATGAAACAAGA
GTGAGCACAAATGGATCAGAGGACCCTGAGGTTGCAGCCTCGGGGGAAAACAAGAGGGCCAATG
GGAACAATTCTCCATCCCTTTCAAATGGTGGTTTTAAGCCTTCTAGACCTCCTAGACCTTCAAG
ACCACCTCCACCCACCCCACGAAGACCAGCTTCTGTCAATGGCTCACCATCCACGAACTCTGAC
AGCGATGGATCTAGCACAGGCTCTTTGCCACCCACAAATACAAATGTAAATTCAAGTGCATCGG
AAGGAGCAGCATCTGGGTTAATAATTCCTCTGACCATCTCTGGGGGCTCAGGCCCTAGGCCGCT
GAATACTGTCAGTCAAGCTCCCCTCCCACCTGGGTGGGAGCAGAGAGTAGATCAGCATGGGCGT
GTTTACTATGTAGACCATGTTGAAAAGCGAACAACATGGGATAGACCGGAACCTCTACCTCCTG
GCTGGGAACGGCGTGTGGACAATATGGGACGTATTTATTATGTTGACCATTTCACGAGAACCAC
AACATGGCAGAGGCCGACCTTGGAATCTGTCCGGAACTATGAGCAGTGGCAGCTCCAGCGTAGT
CAACTTCAGGGAGCAATGCAGCAGTTTAACCAGAGATTCATCTTTGGGAATCAAGATTTGTTTG
CTACATCACAAAACAAAGAGTTTGATCCCCTTGGTCCTTTGCCCCCTGGATGGGAGAAGAGAAC
TGATAGCAACGGCAGAGTGTATTTTGTCAACCACAACACTCGGATTACACAGTGGGAAGACCCC
AGAAGCCAAGGTCAGTTAAATGAAAAGCCCTTACCAGAAGGCTGGGAAATGCGATTCACAGTGG
ATGGAATTCCATATTTTGTGGACCACAATAGAAGAGCAACTACCTACATAGATCCACGCACAGG
AAAGTCAGCCTTAGACAACGGACCCCAGATAGCCTATGTTCGGGACTTCAAGGCAAAAGTTCAG
TATTTCCGGTTCTGGTGTCAGCAACTGGCCATGCCACAGCATATAAAGATCACAGTGACAAGAA
AAACATTGTTTGAGGATTCCTTTCAACAGATCATGAGCTTCAGTCCGCAAGATCTGAGAAGACG
TTTGTGGGTGATTTTCCCAGGAGAAGAAGGTTTAGATTATGGAGGTGTAGCAAGAGAATGGTTC
TTTCTTTTGTCACATGAAGTGTTGAACCCAATGTATTGCCTGTTTGAATATGCAGGGAAGGATA
ACTACTGCCTGCAGATAAACCCCGCTTCTTATATCAACCCAGACCACCTGAAATACTTCCGTTT
TATTGGCAGATTTATTGCCATGGCTCTATTCCATGGGAAATTCATAGATACCGGATTTTCTTTA
CCATTCTATAAACGTATCTTGAATAAACCAGTGGGACTTAAGGATTTAGAATCTATCGATCCAG
AATTTTACAATTCTCTCATCTGGGTTAAAGAAAACAATATCGAGGAATGTGGTTTGGAAATGTA
CTTCTCAGTTGATAAAGAAATTCTGGGTGAAATTAAGAGTCATGATTTGAAACCCAATGGTGGC
AATATTCTGGTGACAGAAGAAAATAAGGAAGAGTACATCAGGATGGTCGCTGAGTGGAGGTTGT
CTCGGGGAGTTGAAGAGCAGACACAAGCTTTCTTTGAGGGCTTTAATGAAATTCTTCCTCAGCA
ATATTTGCAATATTTTGATGCGAAGGAATTAGAGGTCCTTTTGTGTGGGATGCAGGAGATCGAT
TTGAATGACTGGCAGAGACACGCCATCTACCGTCACTATACCAGGACGAGCAAGCAGATCGTGT
GGTTTTGGCAGTTTGTTAAAGAAATTGATAACGAGAAGAGGATGCGACTTCTGCAGTTTGTTAC
CGGAACCTGCCGATTGCCAGTGGGAGGATTTGCTGACCTCATGGGGAGTAATGGACCACAGAAG
TTCTGCATCGAAAAAGTTGGCAAAGAAAATTGGTTACCCAGAAGCCATACTTGTTTTAACCGCC
TGGACCTCCCACCCTACAAGAGCTATGAGCAACTGAAGGAAAAGCTGTTATTTGCCATTGAAGA
AACAGAAGGATTTGGACAAGAGTAATTGTTGAGACCTTAGGCCACCAGAGGCCAGGGACTCGTC
TGCAGTGTCTGTCCCTTTCCTTCTCTGCCTGTTGCACATCTTATTGTAAACTTGGACTGTGACT
AGAGAGTTATCTGAGAGTAAGTAAATTAATGTTATCGTTGAGATCTTCCAGTCATTCTGGATTT
CTACTCAACGTTTCCAGAAAGCAGATCTACAAACAGTAGTCAGAAACTTAACATGAGATTTAAC
ACAGCGATGAATTCTCCCTGTCTTACTCCACTAGATTGTTCCCTTAACAACAGTTTGCTGTTTG
TCCGGAGTCTCACTTGGGCGCAGGTCTCTTAGTGGCTGTTGTAAAGGGCTTTGCAGGGACATCT
CAGAAACTGCAGTACACAAGGTCTTCCTGGTAAAGCCTCTAGCTAAGAGGTGCAAGCTTAACCC
AGCGTCTGGGCACACGAGCAGCTGCAGCTTGTGCTCTCCCGCTCTTCTCAGCCTGGCCTGACTG
TTGTTTTTCATTCCTGAAGCATGACCAGTGCACCATCCTGCTGTTATTTCTGGAAGTGACGCAG
GACTTGCATTTCTCTACAAAGTAGTTGTGTCTATTTGAATTCAGGGAAAACTTGGTCCCCGCCA
ACATATGACTTCATACCTCTCTTCATTCAGTTTGTAATTGTTTATTGCCTTGCACATATGAAAC
CATACTTACAGACAGTATCAGCACTGTGGCTCCCTCACGGTTTTTAGAAATTTATCTAGAATTA
AAATAAGTTCAGATGAATTCATGTAAGATCATTCCTGATTTTTAAATTCTACACATAAATTAAA
GCTTAATGGTGTTGATGTAATCCAACACCTTAGTTACATTTCATCCTTGCTAAAATATTCAAAT
TGCAACCATTTTCTAACACAGATGGAGGTCAGTTCAGTGGTGCAGTGTCTGCAGTCAGAACAGC
ATCCAGCAGCCACACAGCTGCGCTGTCTTCACACTCCACTCCTGACACAGCAGGAGCCGTTTCT
ACCTTCTTCAGGTCCTGATCCGCAATAGTTTTCTCACCTCTAAAAATTTTAGATCTCCCTTTTC
TTTCCATGACTCATTTATCTTAGACTGCTCCTTTAGTAACTGATGAATGCACTTTGACCTTCTC
TGTAGTTAATTCACCTTGGCTTAGCATTAGACTGTCAAGATGGCTGCCGCCATAGACATTATGG
GCAATAGGATGAAACCTCAGCCAGTTGAGTCCCTTTTGTAGCCAAATCCCAAAATCAGCCTTAT
TATTCTAATAGGGACCTTGAAAGGTGTTGGTGGCATAGCATAAAGCCAAGAACACAGAGTGTGA
CAAACCCCTGTCCCGTAGGAAAGAGTTTCTGTGTCCCTAGCTGCGCGTCCTGTTCTCGTCCTGG
GACAGTTTGAACCCGTGCAGCTGTACTCCTTAACACTGCCATCATCAGCAGAGACGTGTGACAG
AGGGGTTGCCTCATTGAGAAGCTGTCAGTGAAGGGAGGACTCAGCTCCTCCCCAGCCCTCTTTA
CCCTCATACCACAGCAGATACATGTCATCTCTAGAAGCCCTAGTCATTTCCAAAGTAGGGAATC
TCTGCCTTTGTGTTGGTAGGGTTAAAAATGTATATGCTATTGCTTTGTCTTACAGAGCGAATGT
CTGCCAACTTCCCATTCACTACATAGGCCTGAACTTTGGTAATAAATGACTATAAATATTAAGC
CTTCCACAAAGACTTCCTATTGAATCCAATTCTTGTACTAAAGCATAGTTACCTACCATACTCA
CTAGAGATTTATGAGATAAATTAAGAGATAATGTAAGGAAATAGGCTTTGTTGAGTCTGCATAA
TGCTTCATGATTCGTTTAGGGACCTAGAAATATTATGTGAAAATGTATAAATATCATCCAAAAG
GCTTTCTGCCCTATATTTTTAAAATACAGAAGTTATATTTGAAGTAGTCCTGGCCCTAGTTCTA
TAGGGCTTGGCTATTTAATATTTTTATGGAAGAAATGTTTAGTTCTGGAAAAGGTAAATGCTTG
TATATATTTTTGCAGCCCTGGAGTCTCCCAACTCCACTTTTTCCTTTAATTTAATTGATCACAT
GTATATGTCTTCCCTGCTGTGTTAGAAAAACGGGGGCTGGATATCCCAAGAATCAGAGAGTATA
TAAGATAATGCACCTAAACAGCAGACATAAATATTACCAAATGCTTTCAAATTTTGGTCCAAAA
TGAGTATTTTGGAATAGATTTATTGTGAGTGTTTAATTAGCGATTTTCCTTAAATCTGGACTAA
GTTGCTTTTAAGACCTTTTTCTCTGTAAGCATCATAAATGCTAATCAACCTGTTAAGTTTTTTT
TTTCTTACTGCATGTTACATTGAAATAAAAACAGAGTAAAATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005887	(Get FASTA)	NCBI Sequence Viewer
	XP_008760558	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT46068	(Get FASTA)	NCBI Sequence Viewer
	EDL85936	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075116.2
	ENSRNOP00000083747.1
	ENSRNOP00000092387.1

RefSeq Acc Id:

NP_001005887 ⟸ NM_001005887

- UniProtKB:

A0A0G2K9T1 (UniProtKB/TrEMBL), A6KI19 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPKWKQPLTVIVT
PMSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLVGDKEPTETMGDLSVC
LDGLQVEAEVVTNGETSCSEGATQNDAGCRPKDETRVSTNGSEDPEVAASGENKRANGNNSPSL
SNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSDSDGSSTGSLPPTNTNVNSSASEGAASGL
IIPRTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRAYYVDHVEKRTTRDRPEPLPPGWERRVD
NMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIFGNQDLFATSQNKE
FDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMRFTVDGIPYFV
DHNRRATTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKITVTRKTLFEDS
FQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQIN
PASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLI
WVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQ
TQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSKQIVWFWQFVK
EIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYK
SYEQLKEKLLFAIEETEGFGQE

hide sequence

RefSeq Acc Id:	XP_008760558 ⟸ XM_008762336
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K9T1 (UniProtKB/TrEMBL), A6KI19 (UniProtKB/TrEMBL), Q5YB86 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSDSAPQLDSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNTNSPK WKQPLTVIVTPMSKLCFRVWSHQTLKSDVLLGTAGLDIYETLKSNNMKLEEVVMTLQLVGDKEP TETMGDLSVCLDGLQVEAEVVTNGETSCSEGATQNDAGCRPKDETRVSTNGSEDPEVAASGENK RANGNNSPSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSTNSDSDGSSTGSLPPTNTNVNS SASEGAASGLIIPLTISGGSGPRPLNTVSQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEP LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIFGNQ DLFATSQNKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPLPEGWEMR FTVDGIPYFVDHNRRATTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQQLAMPQHIKIT VTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYA GKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLES IDPEFYNSLIWVKENNIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRHYTRTSK QIVWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTC FNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE hide sequence

Ensembl Acc Id:

ENSRNOP00000075116 ⟸ ENSRNOT00000078235

Ensembl Acc Id:

ENSRNOP00000083747 ⟸ ENSRNOT00000105016

Ensembl Acc Id:

ENSRNOP00000092387 ⟸ ENSRNOT00000106366

Protein Domains

C2 HECT WW

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K9T1-F1-model_v2	AlphaFold	A0A0G2K9T1	1-882	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359556	AgrOrtholog
BioCyc Gene	G2FUF-47148	BioCyc
Ensembl Genes	ENSRNOG00000059043	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078235.2	UniProtKB/TrEMBL
	ENSRNOT00000105016.1	UniProtKB/TrEMBL
	ENSRNOT00000106366.1	UniProtKB/TrEMBL
Gene3D-CATH	2.20.70.10	UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domain	UniProtKB/TrEMBL
	Hect, E3 ligase catalytic domains	UniProtKB/TrEMBL
InterPro	C2_Ca-dep	UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/TrEMBL
	E3_ub_ligase_SMURF1	UniProtKB/TrEMBL
	E3_ubiq-protein_ligase	UniProtKB/TrEMBL
	HECT	UniProtKB/TrEMBL
	Hect_E3_ubiquitin_ligase	UniProtKB/TrEMBL
	WW_dom_sf	UniProtKB/TrEMBL
	WW_Rsp5_WWP	UniProtKB/TrEMBL
KEGG Report	rno:311567	UniProtKB/TrEMBL
NCBI Gene	311567	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG	UniProtKB/TrEMBL
	HECT DOMAIN UBIQUITIN-PROTEIN LIGASE	UniProtKB/TrEMBL
Pfam	HECT	UniProtKB/TrEMBL
	PF00168	UniProtKB/TrEMBL
	PF00397	UniProtKB/TrEMBL
PhenoGen	Itch	PhenoGen
PIRSF	E3_ub_ligase_SMURF1	UniProtKB/TrEMBL
PROSITE	HECT	UniProtKB/TrEMBL
	PS50004	UniProtKB/TrEMBL
	WW_DOMAIN_1	UniProtKB/TrEMBL
	WW_DOMAIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000059043	RatGTEx
SMART	HECTc	UniProtKB/TrEMBL
	SM00239	UniProtKB/TrEMBL
	SM00456	UniProtKB/TrEMBL
Superfamily-SCOP	HECT	UniProtKB/TrEMBL
	SSF49562	UniProtKB/TrEMBL
	WW_Rsp5_WWP	UniProtKB/TrEMBL
UniProt	A0A0G2K9T1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZZU1_RAT	UniProtKB/TrEMBL
	A0A8I6AVL7_RAT	UniProtKB/TrEMBL
	A6KI19	ENTREZGENE, UniProtKB/TrEMBL
	Q5YB86	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-07-18	Itch	itchy E3 ubiquitin protein ligase	Itch	itchy E3 ubiquitin protein ligase homolog (mouse)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-06	Itch	itchy E3 ubiquitin protein ligase homolog (mouse)	Itch	itchy, E3 ubiquitin protein ligase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Itch	itchy, E3 ubiquitin protein ligase	Itch	itchy homolog E3 ubiquitin protein ligase (mouse)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Itch	itchy homolog E3 ubiquitin protein ligase (mouse)		itchy homolog E3 ubiquitin protein ligase	Name updated	1299863	APPROVED
2005-07-29	Itch	itchy homolog E3 ubiquitin protein ligase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)