Itch (itchy E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Itch (itchy E3 ubiquitin protein ligase) Chinchilla lanigera
Analyze
Symbol: Itch
Name: itchy E3 ubiquitin protein ligase
RGD ID: 8803236
Description: ENCODES a protein that exhibits arrestin family protein binding (ortholog); CXCR chemokine receptor binding (ortholog); ligase activity (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell proliferation (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of CD4-positive, alpha-beta T cell proliferation (ortholog); PARTICIPATES IN Notch signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; tumor necrosis factor mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); long QT syndrome (ortholog); Multisystem Autoimmune Disease with Facial Dysmorphism (ortholog); FOUND IN cell cortex (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase Itchy homolog
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,809,972 - 26,887,123 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,810,829 - 26,918,517 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Itch
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542226,809,972 - 26,887,123 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542226,810,829 - 26,918,517 (-)NCBIChiLan1.0ChiLan1.0
ITCH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382034,363,273 - 34,511,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2034,363,235 - 34,511,773 (+)EnsemblGRCh38hg38GRCh38
GRCh372032,951,079 - 33,099,578 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362032,414,745 - 32,562,858 (+)NCBINCBI36Build 36hg18NCBI36
Build 342032,414,744 - 32,562,858NCBI
Celera2029,700,532 - 29,848,669 (+)NCBICelera
Cytogenetic Map20q11.22NCBI
HuRef2029,732,695 - 29,880,133 (+)NCBIHuRef
CHM1_12032,852,140 - 33,000,398 (+)NCBICHM1_1
T2T-CHM13v2.02036,086,401 - 36,234,950 (+)NCBIT2T-CHM13v2.0
Itch
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,975,401 - 155,068,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,975,429 - 155,068,775 (+)EnsemblGRCm39 Ensembl
GRCm382155,133,481 - 155,226,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2155,133,509 - 155,226,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv372154,959,217 - 155,052,590 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,821,645 - 154,918,295 (+)NCBIMGSCv36mm8
Celera2161,062,175 - 161,159,103 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.94NCBI
Itch
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83164,102,490 - 164,193,932 (+)NCBIGRCr8
mRatBN7.23143,642,348 - 143,733,745 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3143,645,637 - 143,733,543 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3147,511,691 - 147,599,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03156,128,969 - 156,217,097 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,868,517 - 153,956,642 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03150,660,665 - 150,752,016 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3150,686,638 - 150,749,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,055,848 - 157,117,955 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43145,644,315 - 145,707,190 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13145,549,936 - 145,612,812 (+)NCBI
Celera3142,396,380 - 142,459,141 (+)NCBICelera
Cytogenetic Map3q41NCBI
ITCH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22140,093,373 - 40,244,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12040,086,459 - 40,238,028 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02030,690,172 - 30,840,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,822,496 - 31,971,945 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,852,203 - 31,971,945 (+)Ensemblpanpan1.1panPan2
ITCH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12423,476,619 - 23,630,574 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2423,476,736 - 23,627,469 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2423,124,607 - 23,276,323 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02424,168,489 - 24,321,093 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2424,168,521 - 24,320,269 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12423,456,967 - 23,608,609 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02423,551,074 - 23,703,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,990,143 - 24,142,586 (+)NCBIUU_Cfam_GSD_1.0
Itch
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640172,483,787 - 172,608,613 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,140,234 - 6,265,767 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,140,236 - 6,265,734 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITCH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1737,810,235 - 37,918,209 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11737,810,113 - 37,918,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21742,398,530 - 42,404,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITCH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1238,671,170 - 38,808,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl238,701,396 - 38,805,005 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,023,258 - 88,160,983 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itch
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248424,842,419 - 4,935,699 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248424,840,848 - 4,977,785 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000025001   ⟹   ENSCLAP00000024761
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542226,809,972 - 26,887,123 (-)Ensembl
RefSeq Acc Id: XM_013514114   ⟹   XP_013369568
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542226,810,829 - 26,918,517 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013369568 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024761
  ENSCLAP00000024761.1
Reference Protein Sequences
RefSeq Acc Id: XP_013369568   ⟸   XM_013514114
- UniProtKB: A0A8C2W3R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000024761   ⟸   ENSCLAT00000025001
Protein Domains
C2   HECT   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016997 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025001 ENTREZGENE
  ENSCLAT00000025001.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Itch ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A8C2W3R3 ENTREZGENE, UniProtKB/TrEMBL