Krt84 (keratin 84) - Rat Genome Database

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Gene: Krt84 (keratin 84) Rattus norvegicus
Analyze
Symbol: Krt84
Name: keratin 84
RGD ID: 1359402
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization; keratinization; and regulation of keratinocyte differentiation. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in keratin filament. Orthologous to human KRT84 (keratin 84); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kb24; keratin 84, type II; keratin, type II cuticular Hb4; type II keratin Kb24
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,527,787 - 134,535,608 (-)NCBIGRCr8
mRatBN7.27132,649,064 - 132,656,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,649,061 - 132,656,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,451,116 - 134,458,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,680,638 - 136,688,455 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,590,278 - 136,598,099 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,180,212 - 143,187,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,179,835 - 143,187,648 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,981,032 - 140,988,077 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,281,992 - 140,287,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,358,428 - 140,364,189 (-)NCBI
Celera7129,113,991 - 129,119,751 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation. Tobiasch E, etal., Differentiation 1992 Aug;50(3):163-78.
Additional References at PubMed
PMID:10692104   PMID:23533145  


Genomics

Comparative Map Data
Krt84
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,527,787 - 134,535,608 (-)NCBIGRCr8
mRatBN7.27132,649,064 - 132,656,885 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,649,061 - 132,656,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,451,116 - 134,458,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,680,638 - 136,688,455 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,590,278 - 136,598,099 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,180,212 - 143,187,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,179,835 - 143,187,648 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,981,032 - 140,988,077 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,281,992 - 140,287,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,358,428 - 140,364,189 (-)NCBI
Celera7129,113,991 - 129,119,751 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT84
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,377,812 - 52,386,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,377,812 - 52,385,652 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,771,596 - 52,779,436 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,057,863 - 51,065,684 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,057,298 - 51,065,684NCBI
Celera1252,417,750 - 52,425,573 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,815,148 - 49,822,969 (-)NCBIHuRef
CHM1_11252,738,243 - 52,746,057 (-)NCBICHM1_1
T2T-CHM13v2.01252,341,722 - 52,350,890 (-)NCBIT2T-CHM13v2.0
Krt84
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,433,461 - 101,441,255 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,433,461 - 101,441,255 (-)EnsemblGRCm39 Ensembl
GRCm3815101,525,026 - 101,532,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,525,026 - 101,532,820 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,355,457 - 101,363,251 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,353,060 - 101,360,810 (-)NCBIMGSCv36mm8
Celera15103,677,059 - 103,684,855 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.9NCBI
Krt84
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,729,046 - 2,737,142 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555472,729,046 - 2,737,142 (-)NCBIChiLan1.0ChiLan1.0
KRT84
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,809,385 - 41,817,222 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,806,148 - 41,813,985 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,376,965 - 36,384,798 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,153,987 - 37,161,819 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,154,048 - 37,162,672 (+)Ensemblpanpan1.1panPan2
KRT84
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,683,826 - 2,692,267 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,683,792 - 2,692,267 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,561,822 - 43,570,171 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,682,898 - 2,691,247 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,682,907 - 2,691,312 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,699,774 - 2,708,121 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,685,309 - 2,693,649 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,960,019 - 43,968,406 (-)NCBIUU_Cfam_GSD_1.0
Krt84
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,372,488 - 63,381,130 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,784,467 - 9,792,289 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,784,467 - 9,792,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT84
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,698,336 - 17,707,023 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1517,698,343 - 17,706,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,008,417 - 18,017,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT84
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,525,364 - 48,535,567 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,558,537 - 197,566,783 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt84
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904514,338 - 522,228 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624904514,338 - 522,228 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt84
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:18
Count of miRNA genes:18
Interacting mature miRNAs:18
Transcripts:ENSRNOT00000011732
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 3 13 13 13 8 4 24 8 9 6 30 13

Sequence


Ensembl Acc Id: ENSRNOT00000011732   ⟹   ENSRNOP00000011733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,651,060 - 132,656,820 (-)Ensembl
Rnor_6.0 Ensembl7143,181,834 - 143,187,594 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083466   ⟹   ENSRNOP00000071459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,649,061 - 132,656,874 (-)Ensembl
Rnor_6.0 Ensembl7143,179,835 - 143,187,648 (-)Ensembl
RefSeq Acc Id: NM_001008812   ⟹   NP_001008812
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,527,787 - 134,535,608 (-)NCBI
mRatBN7.27132,649,064 - 132,656,885 (-)NCBI
Rnor_6.07143,181,834 - 143,187,594 (-)NCBI
Rnor_5.07140,981,032 - 140,988,077 (-)NCBI
RGSC_v3.47140,281,992 - 140,287,752 (-)RGD
Celera7129,113,991 - 129,119,751 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008812 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02223 (Get FASTA)   NCBI Sequence Viewer  
  EDL86888 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011733.2
  ENSRNOP00000071459.1
RefSeq Acc Id: NP_001008812   ⟸   NM_001008812
- UniProtKB: A0A0G2K0I4 (UniProtKB/TrEMBL),   A6KCQ4 (UniProtKB/TrEMBL),   D3ZSY5 (UniProtKB/TrEMBL),   Q6IG07 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011733   ⟸   ENSRNOT00000011732
Ensembl Acc Id: ENSRNOP00000071459   ⟸   ENSRNOT00000083466
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0I4-F1-model_v2 AlphaFold A0A0G2K0I4 1-608 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695683
Promoter ID:EPDNEW_R6202
Type:single initiation site
Name:Krt84_1
Description:keratin 84
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,187,661 - 143,187,721EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359402 AgrOrtholog
BioCyc Gene G2FUF-31979 BioCyc
Ensembl Genes ENSRNOG00000008819 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011732.4 UniProtKB/TrEMBL
  ENSRNOT00000083466.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Vasodilator-stimulated phosphoprotein UniProtKB/TrEMBL
InterPro IF_rod_dom UniProtKB/TrEMBL
  Intermediate_filament_CS UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
  Keratin_II UniProtKB/TrEMBL
KEGG Report rno:315320 UniProtKB/TrEMBL
NCBI Gene 315320 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  KERATIN, TYPE II CUTICULAR HB4 UniProtKB/TrEMBL
Pfam Filament UniProtKB/TrEMBL
  Keratin_2_head UniProtKB/TrEMBL
PhenoGen Krt84 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/TrEMBL
PROSITE IF_ROD_2 UniProtKB/TrEMBL
  PS00226 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008819 RatGTEx
SMART Filament UniProtKB/TrEMBL
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/TrEMBL
UniProt A0A0G2K0I4 ENTREZGENE, UniProtKB/TrEMBL
  A6KCQ4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSY5 ENTREZGENE, UniProtKB/TrEMBL
  Q6IG07 ENTREZGENE
UniProt Secondary Q6IG07 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 Krt84  keratin 84  Krt84  keratin 84, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt84  keratin 84, type II  Krt84  keratin 84  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt84  keratin 84  Kb24  type II keratin Kb24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 Kb24  type II keratin Kb24      Symbol and Name status set to provisional 70820 PROVISIONAL