Or6c63 (olfactory receptor family 6 subfamily C member 63) - Rat Genome Database

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Gene: Or6c63 (olfactory receptor family 6 subfamily C member 63) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or6c63
Name: olfactory receptor family 6 subfamily C member 63
RGD ID: 1333670
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane; INTERACTS WITH cadmium dichloride.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 877; olfactory receptor gene Olr877; olfactory receptor Olr877; Olr877
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr872,036,499 - 2,037,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl72,036,499 - 2,051,104 (-)EnsemblGRCr8
mRatBN7.271,452,056 - 1,452,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,452,056 - 1,466,661 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx74,214,122 - 4,215,060 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,089,768 - 6,090,706 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,390,983 - 6,391,921 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,450,050 - 3,450,988 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,450,050 - 3,450,988 (-)Ensemblrn6Rnor6.0
Rnor_5.073,434,760 - 3,435,698 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,336,760 - 2,337,698 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,321,395 - 1,322,333 (-)NCBICelera
RGSC_v3.172,336,759 - 2,337,698 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or6c63
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000066301
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
endocrine system
endoderm
exocrine system
hepatobiliary system
mesenchyme
renal system
reproductive system
1 1 2 2 2 2 5 1 3

Sequence


Ensembl Acc Id: ENSRNOT00000066301   ⟹   ENSRNOP00000062078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl72,036,499 - 2,051,104 (-)Ensembl
mRatBN7.2 Ensembl71,452,056 - 1,466,661 (-)Ensembl
Rnor_6.0 Ensembl73,450,050 - 3,450,988 (-)Ensembl
RefSeq Acc Id: NM_001000707   ⟹   NP_001000707
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr872,036,499 - 2,037,437 (-)NCBI
mRatBN7.271,452,056 - 1,452,994 (-)NCBI
Rnor_6.073,450,050 - 3,450,988 (-)NCBI
Rnor_5.073,434,760 - 3,435,698 (-)NCBI
RGSC_v3.472,336,760 - 2,337,698 (-)RGD
Celera71,321,395 - 1,322,333 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000707 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84779 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062078.2
RefSeq Acc Id: NP_001000707   ⟸   NM_001000707
- UniProtKB: D3Z9V2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062078   ⟸   ENSRNOT00000066301
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9V2-F1-model_v2 AlphaFold D3Z9V2 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333670 AgrOrtholog
BioCyc Gene G2FUF-35314 BioCyc
Ensembl Genes ENSRNOG00000043299 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066301.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
NCBI Gene 404956 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6c63 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043299 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt D3Z9V2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6c63  olfactory receptor family 6 subfamily C member 63  Olr877  olfactory receptor 877  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr877  olfactory receptor 877   Olr877_predicted  olfactory receptor 877 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr877_predicted  olfactory receptor 877 (predicted)      Symbol and Name status set to approved 70820 APPROVED