Cpa6 (carboxypeptidase A6) - Rat Genome Database

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Gene: Cpa6 (carboxypeptidase A6) Rattus norvegicus
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Symbol: Cpa6
Name: carboxypeptidase A6
RGD ID: 1311764
Description: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC312913
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,309,660 - 13,671,429 (+)NCBIGRCr8
mRatBN7.258,526,708 - 8,888,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl58,526,741 - 8,888,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx510,930,628 - 11,044,410 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,560,219 - 12,674,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,265,294 - 12,379,064 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,215,443 - 8,574,655 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,459,660 - 8,574,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,026,747 - 13,383,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,287,865 - 8,403,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.158,040,001 - 8,403,157 (+)NCBI
Celera58,291,791 - 8,407,096 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Cpa6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,309,660 - 13,671,429 (+)NCBIGRCr8
mRatBN7.258,526,708 - 8,888,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl58,526,741 - 8,888,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx510,930,628 - 11,044,410 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,560,219 - 12,674,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,265,294 - 12,379,064 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,215,443 - 8,574,655 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,459,660 - 8,574,655 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,026,747 - 13,383,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,287,865 - 8,403,566 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.158,040,001 - 8,403,157 (+)NCBI
Celera58,291,791 - 8,407,096 (+)NCBICelera
Cytogenetic Map5q11NCBI
CPA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,422,038 - 67,746,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,422,038 - 67,746,378 (-)EnsemblGRCh38hg38GRCh38
GRCh37868,334,273 - 68,658,595 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,496,962 - 68,821,134 (-)NCBINCBI36Build 36hg18NCBI36
Build 34868,496,961 - 68,821,134NCBI
Celera864,327,814 - 64,651,850 (-)NCBICelera
Cytogenetic Map8q13.2NCBI
HuRef863,826,466 - 64,151,152 (-)NCBIHuRef
CHM1_1868,390,603 - 68,714,811 (-)NCBICHM1_1
T2T-CHM13v2.0867,848,501 - 68,172,795 (-)NCBIT2T-CHM13v2.0
Cpa6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39110,366,016 - 10,790,277 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl110,394,945 - 10,790,170 (-)EnsemblGRCm39 Ensembl
GRCm38110,295,791 - 10,720,053 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,324,720 - 10,719,945 (-)EnsemblGRCm38mm10GRCm38
MGSCv37110,314,808 - 10,710,024 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36110,309,941 - 10,705,157 (-)NCBIMGSCv36mm8
Celera110,300,911 - 10,702,680 (-)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.45NCBI
Cpa6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,624,806 - 11,921,509 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,624,842 - 11,922,293 (+)NCBIChiLan1.0ChiLan1.0
CPA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2783,155,786 - 83,480,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1858,797,970 - 59,122,643 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0863,962,991 - 64,285,840 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1865,623,975 - 65,947,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl865,624,306 - 65,946,848 (-)Ensemblpanpan1.1panPan2
CPA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,914,623 - 17,243,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,914,985 - 17,244,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,230,020 - 17,559,378 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,995,824 - 17,325,739 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,995,976 - 17,325,863 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12917,028,356 - 17,357,862 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02917,126,991 - 17,450,672 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,384,643 - 17,721,112 (-)NCBIUU_Cfam_GSD_1.0
Cpa6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530368,021,252 - 68,147,709 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364966,484,438 - 6,761,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364966,484,438 - 6,761,816 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl467,158,318 - 67,411,593 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1467,157,341 - 67,411,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2473,245,237 - 73,378,004 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CPA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,281,059 - 63,590,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl863,281,180 - 63,374,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603977,914,001 - 78,222,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpa6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474423,478,907 - 23,927,318 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474423,478,907 - 23,928,024 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpa6
1957 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:175
Interacting mature miRNAs:194
Transcripts:ENSRNOT00000007491
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat

Markers in Region
RH127766  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.258,888,025 - 8,888,242 (+)MAPPERmRatBN7.2
Rnor_6.058,574,189 - 8,574,405NCBIRnor6.0
Rnor_5.0513,383,321 - 13,383,537UniSTSRnor5.0
RGSC_v3.458,403,100 - 8,403,316UniSTSRGSC3.4
Celera58,406,630 - 8,406,846UniSTS
Cytogenetic Map5q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 49 89 34 36 16 13 16 6 144 75 77 36 58 20

Sequence


Ensembl Acc Id: ENSRNOT00000007491   ⟹   ENSRNOP00000007492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl58,526,741 - 8,888,485 (+)Ensembl
Rnor_6.0 Ensembl58,459,660 - 8,574,655 (+)Ensembl
RefSeq Acc Id: NM_001415862   ⟹   NP_001402791
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,309,660 - 13,671,429 (+)NCBI
mRatBN7.258,526,708 - 8,888,492 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001402791 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11541 (Get FASTA)   NCBI Sequence Viewer  
  EDM11542 (Get FASTA)   NCBI Sequence Viewer  
  EDM11543 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007492.7
Ensembl Acc Id: ENSRNOP00000007492   ⟸   ENSRNOT00000007491
RefSeq Acc Id: NP_001402791   ⟸   NM_001415862
- Peptide Label: precursor
- UniProtKB: F1M4P0 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M14 carboxypeptidase A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4P0-F1-model_v2 AlphaFold F1M4P0 1-281 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311764 AgrOrtholog
BioCyc Gene G2FUF-42213 BioCyc
Ensembl Genes ENSRNOG00000005655 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007491.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.340 UniProtKB/TrEMBL
  Zn peptidases UniProtKB/TrEMBL
InterPro M14A-like_propep UniProtKB/TrEMBL
  M14A_act_pep UniProtKB/TrEMBL
  Peptidase_M14 UniProtKB/TrEMBL
NCBI Gene 312913 ENTREZGENE
PANTHER CARBOXYPEPTIDASE A6 UniProtKB/TrEMBL
  PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B UniProtKB/TrEMBL
Pfam Peptidase_M14 UniProtKB/TrEMBL
  Propep_M14 UniProtKB/TrEMBL
PhenoGen Cpa6 PhenoGen
PRINTS CRBOXYPTASEA UniProtKB/TrEMBL
PROSITE CARBOXYPEPT_ZN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005655 RatGTEx
SMART Zn_pept UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A6JFE5_RAT UniProtKB/TrEMBL
  F1M4P0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cpa6  carboxypeptidase A6   Cpa6_predicted  carboxypeptidase A6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cpa6_predicted  carboxypeptidase A6 (predicted)      Symbol and Name status set to approved 70820 APPROVED