Wwp1 (WW domain containing E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Wwp1 (WW domain containing E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
RGD ID: 1311734
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in several cellular components, including anchoring junction; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human WWP1 (WW domain containing E3 ubiquitin protein ligase 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC297930; NEDD4-like E3 ubiquitin-protein ligase WWP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8537,889,280 - 37,982,743 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl537,895,398 - 37,982,959 (-)EnsemblGRCr8
mRatBN7.2533,092,379 - 33,185,887 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,214,452 - 35,299,903 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0536,807,010 - 36,892,455 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0536,746,156 - 36,831,607 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0533,608,489 - 33,696,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)Ensemblrn6Rnor6.0
Rnor_5.0538,260,478 - 38,350,828 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,238,505 - 34,325,951 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,188,567 - 32,274,141 (-)NCBICelera
RGSC_v3.1534,238,684 - 34,326,130 (-)NCBI
Cytogenetic Map5q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
dichloromethane  (EXP)
dicrotophos  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP)
fenvalerate  (EXP)
finasteride  (EXP)
FR900359  (ISO)
glafenine  (EXP)
glucose  (ISO)
hexane  (EXP)
lead diacetate  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
rimonabant  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulindac  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
anchoring junction  (IEA)
cytoplasm  (IBA,IEA)
cytosol  (IEA)
nucleus  (IEA)
plasma membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11375995   PMID:12477932   PMID:14556380   PMID:16728642   PMID:19047365   PMID:19561640   PMID:23146885   PMID:23533145  


Genomics

Comparative Map Data
Wwp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8537,889,280 - 37,982,743 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl537,895,398 - 37,982,959 (-)EnsemblGRCr8
mRatBN7.2533,092,379 - 33,185,887 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx535,214,452 - 35,299,903 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0536,807,010 - 36,892,455 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0536,746,156 - 36,831,607 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0533,608,489 - 33,696,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)Ensemblrn6Rnor6.0
Rnor_5.0538,260,478 - 38,350,828 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4534,238,505 - 34,325,951 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera532,188,567 - 32,274,141 (-)NCBICelera
RGSC_v3.1534,238,684 - 34,326,130 (-)NCBI
Cytogenetic Map5q13NCBI
WWP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38886,342,547 - 86,468,503 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl886,342,547 - 86,478,420 (+)Ensemblhg38GRCh38
GRCh37887,354,776 - 87,480,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36887,424,110 - 87,549,297 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34887,424,109 - 87,549,292NCBI
Celera883,549,943 - 83,675,018 (+)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef882,564,176 - 82,689,578 (+)NCBIHuRef
CHM1_1887,396,265 - 87,521,678 (+)NCBICHM1_1
T2T-CHM13v2.0887,462,833 - 87,588,744 (+)NCBIT2T-CHM13v2.0
Wwp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39419,608,296 - 19,709,004 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl419,608,303 - 19,708,993 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38419,608,296 - 19,709,004 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl419,608,303 - 19,708,993 (-)Ensemblmm10GRCm38
MGSCv37419,536,820 - 19,636,140 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36419,536,820 - 19,636,140 (-)NCBIMGSCv36mm8
Celera419,371,659 - 19,470,678 (-)NCBICelera
Cytogenetic Map4A3NCBI
cM Map47.56NCBI
Wwp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554174,000,966 - 4,061,908 (+)Ensembl
ChiLan1.0NW_0049554174,011,302 - 4,064,584 (+)NCBIChiLan1.0ChiLan1.0
WWP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27103,746,836 - 103,871,316 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1879,285,404 - 79,410,164 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0883,039,632 - 83,165,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1885,009,945 - 85,134,671 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl885,009,951 - 85,134,671 (+)EnsemblpanPan2panpan1.1
WWP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12932,523,719 - 32,620,507 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2932,533,619 - 32,625,787 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2932,723,880 - 32,846,291 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02932,658,784 - 32,781,246 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,658,688 - 32,775,049 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,702,621 - 32,825,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,727,090 - 32,849,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02933,147,532 - 33,269,942 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wwp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530346,744,643 - 46,827,533 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544979,774 - 1,047,101 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936544965,189 - 1,048,530 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl450,388,464 - 50,503,253 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1450,370,072 - 50,509,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2455,285,901 - 55,426,098 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WWP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1881,529,520 - 81,651,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603959,298,882 - 59,421,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247445,329,535 - 5,435,819 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wwp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11124,017,630 - 124,114,463 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wwp1
823 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:37
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000009047
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)51373115343590997Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)53113042148841739Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat

Markers in Region
BQ200491  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8537,956,344 - 37,956,504 (+)Marker Load Pipeline
mRatBN7.2533,159,442 - 33,159,602 (+)MAPPERmRatBN7.2
Rnor_6.0533,670,065 - 33,670,224NCBIRnor6.0
Rnor_5.0538,324,629 - 38,324,788UniSTSRnor5.0
RGSC_v3.4534,299,486 - 34,299,645UniSTSRGSC3.4
Celera532,247,748 - 32,247,907UniSTS
RH 3.4 Map5165.42UniSTS
Cytogenetic Map5q13UniSTS
RH132168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,098,041 - 33,098,259 (+)MAPPERmRatBN7.2
Rnor_6.0533,608,684 - 33,608,901NCBIRnor6.0
Rnor_5.0538,263,088 - 38,263,305UniSTSRnor5.0
RGSC_v3.4534,238,056 - 34,238,273UniSTSRGSC3.4
Celera532,188,118 - 32,188,335UniSTS
RH 3.4 Map5164.12UniSTS
Cytogenetic Map5q13UniSTS
RH142934  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2533,132,598 - 33,132,821 (+)MAPPERmRatBN7.2
Rnor_6.0533,643,238 - 33,643,460NCBIRnor6.0
Rnor_5.0538,297,642 - 38,297,864UniSTSRnor5.0
RGSC_v3.4534,272,611 - 34,272,833UniSTSRGSC3.4
Celera532,220,901 - 32,221,123UniSTS
RH 3.4 Map5165.12UniSTS
Cytogenetic Map5q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009047   ⟹   ENSRNOP00000009047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl537,895,398 - 37,982,959 (-)Ensembl
mRatBN7.2 Ensembl533,098,494 - 33,186,046 (-)Ensembl
Rnor_6.0 Ensembl533,609,136 - 33,664,435 (-)Ensembl
RefSeq Acc Id: NM_001024757   ⟹   NP_001019928
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,895,395 - 37,982,743 (-)NCBI
mRatBN7.2533,098,491 - 33,185,843 (-)NCBI
Rnor_6.0533,609,133 - 33,696,487 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
RGSC_v3.4534,238,505 - 34,325,951 (-)RGD
Celera532,188,567 - 32,274,141 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237930   ⟹   XP_006237992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,889,280 - 37,982,737 (-)NCBI
mRatBN7.2533,092,379 - 33,185,887 (-)NCBI
Rnor_6.0533,608,489 - 33,696,428 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237931   ⟹   XP_006237993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,889,280 - 37,956,983 (-)NCBI
mRatBN7.2533,098,491 - 33,160,081 (-)NCBI
Rnor_6.0533,609,133 - 33,671,140 (-)NCBI
Rnor_5.0538,260,478 - 38,350,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763591   ⟹   XP_008761813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8537,889,280 - 37,935,902 (-)NCBI
mRatBN7.2533,098,491 - 33,139,000 (-)NCBI
Rnor_6.0533,609,133 - 33,649,773 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001019928 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237992 (Get FASTA)   NCBI Sequence Viewer  
  XP_006237993 (Get FASTA)   NCBI Sequence Viewer  
  XP_008761813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009047
  ENSRNOP00000009047.6
RefSeq Acc Id: NP_001019928   ⟸   NM_001024757
- UniProtKB: Q4V8H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237992   ⟸   XM_006237930
- Peptide Label: isoform X1
- UniProtKB: F7FIK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237993   ⟸   XM_006237931
- Peptide Label: isoform X2
- UniProtKB: Q4V8H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761813   ⟸   XM_008763591
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000009047   ⟸   ENSRNOT00000009047
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8H7-F1-model_v2 AlphaFold Q4V8H7 1-918 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311734 AgrOrtholog
BioCyc Gene G2FUF-41838 BioCyc
Ensembl Genes ENSRNOG00000006328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009047 ENTREZGENE
  ENSRNOT00000009047.7 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7446512 IMAGE-MGC_LOAD
InterPro C2_Ca-dep UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  E3_ubiq-protein_ligase UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:297930 UniProtKB/TrEMBL
MGC_CLONE MGC:114426 IMAGE-MGC_LOAD
NCBI Gene 297930 ENTREZGENE
PANTHER HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
  NEDD4-LIKE E3 UBIQUITIN-PROTEIN LIGASE WWP1 UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Wwp1 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006328 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt F7FIK1 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8H7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Wwp1  WW domain containing E3 ubiquitin protein ligase 1  Wwp1_predicted  WW domain containing E3 ubiquitin protein ligase 1 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wwp1_predicted  WW domain containing E3 ubiquitin protein ligase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED