Tmprss15 (transmembrane serine protease 15) - Rat Genome Database

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Gene: Tmprss15 (transmembrane serine protease 15) Rattus norvegicus
Analyze
Symbol: Tmprss15
Name: transmembrane serine protease 15
RGD ID: 1311046
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in enterokinase deficiency. Orthologous to human TMPRSS15 (transmembrane serine protease 15); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: enteropeptidase; LOC288291; protease, serine, 7 (enterokinase); Prss7; transmembrane protease, serine 15
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81131,164,633 - 31,289,143 (-)NCBIGRCr8
mRatBN7.21117,677,741 - 17,802,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1117,677,741 - 17,802,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1126,309,601 - 26,436,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01119,041,969 - 19,164,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01118,211,875 - 18,339,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01117,561,591 - 17,684,903 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1117,561,596 - 17,684,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01121,207,441 - 21,331,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41118,017,213 - 18,167,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11118,017,779 - 18,167,358 (-)NCBI
Celera1117,646,164 - 17,770,895 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mutations in the proenteropeptidase gene are the molecular cause of congenital enteropeptidase deficiency. Holzinger A, etal., Am J Hum Genet. 2002 Jan;70(1):20-5. Epub 2001 Nov 21.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Comparative Map Data
Tmprss15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81131,164,633 - 31,289,143 (-)NCBIGRCr8
mRatBN7.21117,677,741 - 17,802,255 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1117,677,741 - 17,802,255 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1126,309,601 - 26,436,803 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01119,041,969 - 19,164,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01118,211,875 - 18,339,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01117,561,591 - 17,684,903 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1117,561,596 - 17,684,903 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01121,207,441 - 21,331,294 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41118,017,213 - 18,167,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11118,017,779 - 18,167,358 (-)NCBI
Celera1117,646,164 - 17,770,895 (-)NCBICelera
Cytogenetic Map11q11NCBI
TMPRSS15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382118,269,116 - 18,485,884 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2118,269,116 - 18,485,879 (-)EnsemblGRCh38hg38GRCh38
GRCh372119,641,433 - 19,858,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362118,563,561 - 18,697,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 342118,563,560 - 18,697,844NCBI
Celera214,817,153 - 4,951,365 (-)NCBICelera
Cytogenetic Map21q21.1ENTREZGENE
HuRef215,029,535 - 5,163,909 (-)NCBIHuRef
CHM1_12119,202,776 - 19,336,992 (-)NCBICHM1_1
T2T-CHM13v2.02116,628,929 - 16,845,526 (-)NCBIT2T-CHM13v2.0
Tmprss15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391678,749,896 - 78,887,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1678,749,896 - 78,887,985 (-)EnsemblGRCm39 Ensembl
GRCm381678,953,008 - 79,091,097 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1678,953,008 - 79,091,097 (-)EnsemblGRCm38mm10GRCm38
MGSCv371678,953,709 - 79,091,342 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361678,835,600 - 78,973,689 (-)NCBIMGSCv36mm8
Celera1679,181,889 - 79,317,059 (-)NCBICelera
Cytogenetic Map16C3.1- C3.2NCBI
cM Map1645.41NCBI
Tmprss15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540719,510,453 - 19,626,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540719,510,453 - 19,626,668 (-)NCBIChiLan1.0ChiLan1.0
TMPRSS15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22214,761,295 - 14,897,704 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1219,590,944 - 9,725,067 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0215,003,446 - 5,137,314 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12118,366,968 - 18,500,307 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2118,367,810 - 18,500,157 (-)Ensemblpanpan1.1panPan2
TMPRSS15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13114,605,314 - 14,725,973 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3114,607,971 - 14,726,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3114,627,411 - 14,745,246 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03114,636,161 - 14,754,456 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3114,636,162 - 14,754,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13114,639,033 - 14,757,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03114,638,481 - 14,756,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03115,049,371 - 15,167,423 (-)NCBIUU_Cfam_GSD_1.0
Tmprss15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497115,685,922 - 15,806,090 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650510,606,113 - 10,725,760 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650510,605,831 - 10,725,760 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPRSS15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13182,829,843 - 182,987,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113182,829,822 - 183,000,734 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213192,997,371 - 193,144,467 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPRSS15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1274,195,626 - 74,326,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl274,196,111 - 74,326,593 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605079,676,409 - 79,812,087 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmprss15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247456,759,021 - 6,883,616 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247456,759,021 - 6,883,616 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmprss15
905 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:53
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000051213
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)11121836709Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 3 43 10 13 2 11 2 2 19 13 39 20 11

Sequence


Ensembl Acc Id: ENSRNOT00000051213   ⟹   ENSRNOP00000042615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1117,677,741 - 17,802,255 (-)Ensembl
Rnor_6.0 Ensembl1117,561,596 - 17,684,903 (-)Ensembl
RefSeq Acc Id: NM_001105895   ⟹   NP_001099365
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81131,164,633 - 31,289,143 (-)NCBI
mRatBN7.21117,677,741 - 17,802,255 (-)NCBI
Rnor_6.01117,561,596 - 17,684,903 (-)NCBI
Rnor_5.01121,207,441 - 21,331,294 (-)NCBI
RGSC_v3.41118,017,213 - 18,167,545 (-)RGD
Celera1117,646,164 - 17,770,895 (-)RGD
Sequence:
RefSeq Acc Id: XM_063270432   ⟹   XP_063126502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81131,165,245 - 31,289,074 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099365 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126502 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10612 (Get FASTA)   NCBI Sequence Viewer  
  EDM10613 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042615.3
RefSeq Acc Id: NP_001099365   ⟸   NM_001105895
- UniProtKB: A6JL47 (UniProtKB/TrEMBL),   D4A911 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042615   ⟸   ENSRNOT00000051213
RefSeq Acc Id: XP_063126502   ⟸   XM_063270432
- Peptide Label: isoform X1
Protein Domains
CUB   MAM   Peptidase S1   SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A911-F1-model_v2 AlphaFold D4A911 1-859 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698012
Promoter ID:EPDNEW_R8537
Type:initiation region
Name:Tmprss15_1
Description:transmembrane protease, serine 15
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01117,684,908 - 17,684,968EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311046 AgrOrtholog
BioCyc Gene G2FUF-22123 BioCyc
Ensembl Genes ENSRNOG00000001916 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051213.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  3.10.250.10 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro ConA-like_dom UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classA_rpt UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Ser/Cys_Pept_Trypsin-like UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/TrEMBL
  Srcr_rcpt UniProtKB/TrEMBL
  Srcr_rcpt-rel UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:288291 UniProtKB/TrEMBL
NCBI Gene 288291 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  TRANSMEMBRANE SERINE PROTEASE 15 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  SRCR UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen Tmprss15 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  MAM_1 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
  SRCR_1 UniProtKB/TrEMBL
  SRCR_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001916 RatGTEx
SMART CUB UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
  SM00202 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  CUB UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  Srcr_receptor UniProtKB/TrEMBL
UniProt A6JL47 ENTREZGENE, UniProtKB/TrEMBL
  D4A911 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-26 Tmprss15  transmembrane serine protease 15  Tmprss15  transmembrane protease, serine 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Tmprss15  transmembrane protease, serine 15  Prss7  protease, serine, 7 (enterokinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Prss7  protease, serine, 7 (enterokinase)   Prss7_predicted  protease, serine, 7 (enterokinase) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Prss7_predicted  protease, serine, 7 (enterokinase) (predicted)      Symbol and Name status set to approved 70820 APPROVED