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Gene: Dusp16 (dual specificity phosphatase 16) Rattus norvegicus

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Symbol:

Dusp16

Name:

dual specificity phosphatase 16

RGD ID:

1310721

Description:

Predicted to enable phosphoprotein phosphatase activity; protein carrier chaperone; and protein kinase binding activity. Predicted to be involved in dephosphorylation; negative regulation of MAPK cascade; and signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Biomarker of transient cerebral ischemia. Orthologous to human DUSP16 (dual specificity phosphatase 16); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dual specificity protein phosphatase 16; LOC297682; Mkp-7; Mkp7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP16 (dual specificity phosphatase 16)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dusp16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dusp16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dusp16 (dual specificity phosphatase 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DUSP16 (dual specificity phosphatase 16)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dusp16 (dual specificity phosphatase 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dusp16 (dual specificity phosphatase 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MSG5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	vhp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	169,278,118 - 169,361,508 (-)	NCBI		GRCr8
mRatBN7.2	4	167,546,780 - 167,630,173 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	167,548,155 - 167,629,980 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	173,842,654 - 173,887,018 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	169,625,735 - 169,670,100 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	168,249,393 - 168,293,749 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	168,470,141 - 168,551,346 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	168,472,412 - 168,517,177 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	232,751,520 - 232,802,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	171,620,395 - 171,667,593 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	171,868,691 - 171,912,166 (-)	NCBI
Celera	4	156,146,862 - 156,191,111 (-)	NCBI		Celera
Cytogenetic Map	4	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 6 (ISO)

Experimental Liver Cirrhosis (ISO)

transient cerebral ischemia (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

clothianidin (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

DDE (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

entinostat (ISO)

fipronil (EXP)

fluoranthene (ISO)

FR900359 (ISO)

fulvestrant (ISO)

fumonisin B1 (ISO)

gentamycin (EXP)

glycidol (EXP)

glyphosate (ISO)

lead diacetate (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

MeIQx (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

N(4)-hydroxycytidine (ISO)

N-nitrosodimethylamine (EXP)

orphenadrine (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sertraline (ISO)

sevoflurane (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

torcetrapib (ISO)

trichloroethene (EXP)

troglitazone (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IEA)

dephosphorylation (ISO)

negative regulation of MAPK cascade (IBA,ISO)

regulation of transcription by RNA polymerase II (IEA)

signal transduction (IBA)

Cellular Component

cytoplasm (IBA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,ISO)

Molecular Function

calmodulin-dependent protein phosphatase activity (IEA)

histone H2AXS140 phosphatase activity (IEA)

histone H2AXY142 phosphatase activity (IEA)

JUN kinase binding (ISO)

MAP kinase serine/threonine phosphatase activity (IEA)

MAP kinase tyrosine phosphatase activity (IBA)

MAP kinase tyrosine/serine/threonine phosphatase activity (IBA)

mitogen-activated protein kinase binding (ISO)

mitogen-activated protein kinase p38 binding (ISO)

myosin phosphatase activity (IEA)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

phosphatase activity (ISO)

phosphoprotein phosphatase activity (ISO)

protein binding (ISO)

protein carrier chaperone (ISO)

protein tyrosine phosphatase activity, metal-dependent (IEA)

protein tyrosine/threonine phosphatase activity (IBA)

RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity (IEA)

RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Regulation of MAP kinases by MAP kinase phosphatases.	Kondoh K and Nishida E, Biochim Biophys Acta. 2007 Aug;1773(8):1227-37. Epub 2006 Dec 8.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral ischemia in rat hippocampus.	Zhu J, etal., BMC Neurosci. 2013 Jan 2;14:1. doi: 10.1186/1471-2202-14-1.

Additional References at PubMed

PMID:11489891	PMID:24531476

Genomics

Comparative Map Data

Dusp16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	169,278,118 - 169,361,508 (-)	NCBI		GRCr8
mRatBN7.2	4	167,546,780 - 167,630,173 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	167,548,155 - 167,629,980 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	173,842,654 - 173,887,018 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	169,625,735 - 169,670,100 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	168,249,393 - 168,293,749 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	168,470,141 - 168,551,346 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	168,472,412 - 168,517,177 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	232,751,520 - 232,802,419 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	171,620,395 - 171,667,593 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	171,868,691 - 171,912,166 (-)	NCBI
Celera	4	156,146,862 - 156,191,111 (-)	NCBI		Celera
Cytogenetic Map	4	q43	NCBI

DUSP16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	12,473,282 - 12,562,863 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	12,473,282 - 12,562,863 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	12,626,216 - 12,715,797 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	12,520,098 - 12,606,584 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	12,520,097 - 12,606,584	NCBI
Celera	12	17,770,364 - 17,859,590 (-)	NCBI		Celera
Cytogenetic Map	12	p13.2	NCBI
HuRef	12	12,391,458 - 12,480,660 (-)	NCBI		HuRef
CHM1_1	12	12,591,206 - 12,680,469 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	12,342,454 - 12,456,119 (-)	NCBI		T2T-CHM13v2.0

Dusp16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	134,692,431 - 134,769,687 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	134,692,431 - 134,769,588 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	134,715,468 - 134,807,063 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	134,715,468 - 134,792,625 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	134,665,491 - 134,742,646 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	134,681,161 - 134,758,168 (-)	NCBI		MGSCv36	mm8
Celera	6	137,667,708 - 137,745,584 (-)	NCBI		Celera
Cytogenetic Map	6	G1	NCBI
cM Map	6	65.77	NCBI

Dusp16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	9,385,100 - 9,474,711 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	9,404,259 - 9,481,061 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	17,940,580 - 18,028,994 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	17,937,339 - 18,025,752 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	12,497,185 - 12,585,591 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	12,865,400 - 12,963,732 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	12,865,400 - 12,912,502 (-)	Ensembl	panpan1.1		panPan2

DUSP16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	33,728,209 - 33,831,258 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	33,789,557 - 33,832,075 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	12,612,785 - 12,734,244 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	34,055,803 - 34,140,045 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	34,019,158 - 34,137,506 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	33,948,602 - 34,032,763 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	33,898,280 - 33,982,495 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	12,346,927 - 12,468,377 (-)	NCBI		UU_Cfam_GSD_1.0

Dusp16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	94,983,450 - 95,075,107 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936587	4,711,388 - 4,801,382 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936587	4,711,085 - 4,801,030 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	59,915,197 - 59,961,829 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	59,869,902 - 59,961,839 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DUSP16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	12,369,713 - 12,462,134 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	12,372,449 - 12,419,136 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	22,857,949 - 22,950,225 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	25,340,448 - 25,413,561 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	25,340,997 - 25,413,561 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dusp16
305 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	87
Interacting mature miRNAs:	93
Transcripts:	ENSRNOT00000009151
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	132422778	177422778	Rat
1582237	Kidm34	Kidney mass QTL 34	4	0.0001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	4	148090542	168069246	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	124303370	169303370	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	132396220	177396220	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	125590636	170590636	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	124778595	169778595	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123143783	168143783	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
634342	Cia24	Collagen induced arthritis QTL 24	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	146565735	175236377	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat

Markers in Region

RH132035

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	167,546,862 - 167,547,071 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	168,470,224 - 168,470,432	NCBI	Rnor6.0
Rnor_5.0	4	232,751,603 - 232,751,811	UniSTS	Rnor5.0
RGSC_v3.4	4	171,620,480 - 171,620,688	UniSTS	RGSC3.4
Celera	4	156,144,452 - 156,144,660	UniSTS
RH 3.4 Map	4	856.4	UniSTS
Cytogenetic Map	4	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107457	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107458	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285918	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009151 ⟹ ENSRNOP00000009151

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	167,548,155 - 167,629,980 (-)	Ensembl
Rnor_6.0 Ensembl	4	168,472,412 - 168,517,177 (-)	Ensembl

RefSeq Acc Id:

NM_001106624 ⟹ NP_001100094

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,361,508 (-)	NCBI
mRatBN7.2	4	167,546,780 - 167,630,173 (-)	NCBI
Rnor_6.0	4	168,472,609 - 168,516,979 (-)	NCBI
Rnor_5.0	4	232,751,520 - 232,802,419 (-)	NCBI
RGSC_v3.4	4	171,620,395 - 171,667,593 (-)	RGD
Celera	4	156,146,862 - 156,191,111 (-)	NCBI

Sequence:

show sequence

ATGGCCCATGAGATGACTGGAACTCAAATTGTTACTGAGAGGTTGGTGGCTCTGTTGGAAAGCG
GCACCGAGAAAGTGCTGCTAATTGACAGCCGGCCATTTGTGGAGTACAATACGTCCCACATTCT
GGAAGCCATCAATATCAACTGCTCCAAACTGATGAAGCGAAGGCTGCAACAAGACAAAGTATTA
ATTACAGAACTCATCCAGCATTCTGCAAAACATAAGGTTGACATTGACTGCAGTCAGAAGGTGG
TAGTGTATGATCAGAGTTCCCAGGATGTTGGTTCTCTGTCGTCAGACTGCTTTCTCACTGTGCT
TCTGGGTAAGCTGGAGAAGAGCTTCAACTCTGTTCACCTGCTTGCAGGTGGGTTTGCTGAGTTC
TCTCGTTGTTTCCCTGGCCTCTGTGAAGGAAAATCCACTCTAGTCCCTACCTGCATATCTCAGC
CTTGCCTACCTGTTGCCAACACTGGGCCAACTCGAATTCTTCCCAATCTCTATCTCGGCTGCCA
GCGAGATGTCCTCAACAAGGAGCTGATGCAACAGAACGGGATTGGCTATGTGCTAAATGCCAGC
AACACCTGTCCAAAGCCTGACTTCATACCCGAATCTCACTTCCTGCGAGTGCCTGTGAATGACA
GCTTTTGTGAGAAAATCCTGCCCTGGTTGGACAAGTCTGTGGATTTCATTGAGAAAGCAAAAGC
CTCCAACGGCTGTGTGCTGATCCACTGCTTGGCTGGGATCTCCCGCTCGGCCACCATTGCTATT
GCCTATATCATGAAGAGGATGGACATGTCTCTGGATGAGGCTTACAGATTTGTGAAAGAAAAAA
GACCTACTATATCTCCGAACTTTAATTTTATGGGCCAACTCATGGACTATGAGAAGACGATTAG
TAGCCAGACTGGAATGTCCGGGCCGAAGAGCAAACTCAAGCTGCTGCACCTGGACAAAGCCAGT
GAGCCTGTGCCTGCAGCCTCAGAGGGCGGACGGAAGAATGCACTGTCTCTCAGCCCACCCTGTG
CCAACTCTACCTCAGAGGCAGTGGGGCAAAGGCTTGTGCATCCTGCAAGTGTGCCCAGCTTACA
GCCTTCCCTCTTGGAGGACAGTCCGCTGGTACAGGCGCTCAGTGGGCTCCAGCTGTCCTCAGAG
AAGCTGGAAGACAGCAACAGGCTCAAGCGTTCCTTCTCTCTCGATATCAAGTCTGTTTCGTATT
CAGCCAGTGTGGCAGCGTCCTTACACGGCTTCTCGTCAGAGGATGCTATGGAGTACTACAAACC
TTCCGCCACACTGGATGGGACCAGCAAGCTCTGCCAGTTCTCCCCCGTTCAGGAGGTATCAGAA
CAGACTCCAGAGACCAGCCCCGATAAGGAGGAGGCCCACATCCCCAGGCAGCCCCAAGCTACCA
GACCTTCAGAGAGCCAGACCACACGGCTGCACTCAGTGAGAACCAGCAGTACTGGGTCTACCCA
GAGGCCCTTCTTCTCGCCACTGCATCGGAGCGGGAGTGTGGAGGACAACTACCACACCAACTTC
CTTTTTGGCCTTTCCACCAGCCAGCAGCACCTCACCAAGTCTGCTGCAGGGCTTGGCCTCAAGG
GCTGGCACTCAGACATTCTGCCTCCCCAGTCCTCTGCCCCTTCCCTGACCAGCGGTTGGTATTT
TGCTACAGAGCCTTCACACTTCTACTCTGCTTCAGCCATCTATGGAGGCAACGCCAGTTACTCT
GCCTACAGCTGTAGCCAGCTGCCCACTTGCAGTGACCAAATCTATTCTGTTCGTAGGCGGCAGA
AGCCTAGTGACAGAGCTGACTCACGGCGGAGCTGGCATGAAGAGAGCCCCTTTGAGAAGCAGTT
TAAACGCAGGAGCTGCCAAATGGAATTTGGAGAGAGCATTATGTCAGAGAACAGGTCGAGGGAA
GAACTGGGCAAAGTGGGGAGCCAATCTAGCTTTTCAGGAAGCATGGAGGTCATTGAGGTCTCTT
GA

hide sequence

RefSeq Acc Id:

XM_039107456 ⟹ XP_038963384

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,360,250 (-)	NCBI
mRatBN7.2	4	167,546,780 - 167,628,911 (-)	NCBI

RefSeq Acc Id:

XM_039107457 ⟹ XP_038963385

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,361,291 (-)	NCBI
mRatBN7.2	4	167,546,780 - 167,629,929 (-)	NCBI

RefSeq Acc Id:

XM_039107458 ⟹ XP_038963386

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,322,971 (-)	NCBI
mRatBN7.2	4	167,546,780 - 167,591,629 (-)	NCBI

RefSeq Acc Id:

XM_039107459 ⟹ XP_038963387

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,306,356 (-)	NCBI
mRatBN7.2	4	167,546,780 - 167,574,806 (-)	NCBI

RefSeq Acc Id:

XM_063285918 ⟹ XP_063141988

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	169,278,118 - 169,360,068 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001100094	(Get FASTA)	NCBI Sequence Viewer
	XP_038963384	(Get FASTA)	NCBI Sequence Viewer
	XP_038963385	(Get FASTA)	NCBI Sequence Viewer
	XP_038963386	(Get FASTA)	NCBI Sequence Viewer
	XP_038963387	(Get FASTA)	NCBI Sequence Viewer
	XP_063141988	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM01653	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009151.4

RefSeq Acc Id:

NP_001100094 ⟸ NM_001106624

- UniProtKB:

D4A3W6 (UniProtKB/TrEMBL), A6IMD6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHEMTGTQIVTERLVALLESGTEKVLLIDSRPFVEYNTSHILEAININCSKLMKRRLQQDKVL
ITELIQHSAKHKVDIDCSQKVVVYDQSSQDVGSLSSDCFLTVLLGKLEKSFNSVHLLAGGFAEF
SRCFPGLCEGKSTLVPTCISQPCLPVANTGPTRILPNLYLGCQRDVLNKELMQQNGIGYVLNAS
NTCPKPDFIPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLIHCLAGISRSATIAI
AYIMKRMDMSLDEAYRFVKEKRPTISPNFNFMGQLMDYEKTISSQTGMSGPKSKLKLLHLDKAS
EPVPAASEGGRKNALSLSPPCANSTSEAVGQRLVHPASVPSLQPSLLEDSPLVQALSGLQLSSE
KLEDSNRLKRSFSLDIKSVSYSASVAASLHGFSSEDAMEYYKPSATLDGTSKLCQFSPVQEVSE
QTPETSPDKEEAHIPRQPQATRPSESQTTRLHSVRTSSTGSTQRPFFSPLHRSGSVEDNYHTNF
LFGLSTSQQHLTKSAAGLGLKGWHSDILPPQSSAPSLTSGWYFATEPSHFYSASAIYGGNASYS
AYSCSQLPTCSDQIYSVRRRQKPSDRADSRRSWHEESPFEKQFKRRSCQMEFGESIMSENRSRE
ELGKVGSQSSFSGSMEVIEVS

hide sequence

Ensembl Acc Id:

ENSRNOP00000009151 ⟸ ENSRNOT00000009151

RefSeq Acc Id:	XP_038963385 ⟸ XM_039107457
- Peptide Label:	isoform X1
- UniProtKB:	D4A3W6 (UniProtKB/TrEMBL), A6IMD6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963384 ⟸ XM_039107456
- Peptide Label:	isoform X1
- UniProtKB:	D4A3W6 (UniProtKB/TrEMBL), A6IMD6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963386 ⟸ XM_039107458
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038963387 ⟸ XM_039107459
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063141988 ⟸ XM_063285918
- Peptide Label:	isoform X1
- UniProtKB:	A6IMD6 (UniProtKB/TrEMBL), D4A3W6 (UniProtKB/TrEMBL)

Protein Domains

Rhodanese Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3W6-F1-model_v2	AlphaFold	D4A3W6	1-661	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310721	AgrOrtholog
BioCyc Gene	G2FUF-42650	BioCyc
Ensembl Genes	ENSRNOG00000006628	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009151.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.250.10	UniProtKB/TrEMBL
	3.90.190.10	UniProtKB/TrEMBL
InterPro	Dual-sp/Tyr_phosphatase	UniProtKB/TrEMBL
	Dual-sp_phosphatase_cat-dom	UniProtKB/TrEMBL
	Dual-sp_phosphatase_subgr_cat	UniProtKB/TrEMBL
	MAPK_phosph	UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	Rhodanese-like	UniProtKB/TrEMBL
	Rhodanese-like_dom_sf	UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/TrEMBL
KEGG Report	rno:297682	UniProtKB/TrEMBL
NCBI Gene	297682	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/TrEMBL
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 16	UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/TrEMBL
	Rhodanese	UniProtKB/TrEMBL
PhenoGen	Dusp16	PhenoGen
PRINTS	MAPKPHPHTASE	UniProtKB/TrEMBL
PROSITE	RHODANESE_3	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_1	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006628	RatGTEx
SMART	DSPc	UniProtKB/TrEMBL
	RHOD	UniProtKB/TrEMBL
Superfamily-SCOP	Rhodanese-like	UniProtKB/TrEMBL
	SSF52799	UniProtKB/TrEMBL
UniProt	A6IMD6	ENTREZGENE, UniProtKB/TrEMBL
	D4A3W6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Dusp16	dual specificity phosphatase 16	Dusp16_predicted	dual specificity phosphatase 16 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Dusp16_predicted	dual specificity phosphatase 16 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)