Itm2c (integral membrane protein 2C)

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Gene: Itm2c (integral membrane protein 2C) Rattus norvegicus

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Symbol:

Itm2c

Name:

integral membrane protein 2C

RGD ID:

1309503

Description:

Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in several processes, including negative regulation of amyloid precursor protein biosynthetic process; negative regulation of neuron projection development; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in lysosome and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human ITM2C (integral membrane protein 2C); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

integral membrane protein 3; LOC301575; MGC94903

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ITM2C (integral membrane protein 2C)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Itm2c (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Itm2c (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ITM2C (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ITM2C (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Itm2c (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ITM2C (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ITM2C (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Itm2c (integral membrane protein 2C)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ITM2C (integral membrane protein 2C)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Itm2c (integral membrane protein 2C)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itm2cb (integral membrane protein 2Cb)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	itm2ca (integral membrane protein 2Ca)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C25F6.7	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3662	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	93,993,922 - 94,007,737 (+)	NCBI		GRCr8
mRatBN7.2	9	86,545,927 - 86,559,745 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	86,545,921 - 86,559,742 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	94,963,890 - 94,977,710 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	100,092,388 - 100,106,210 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	98,473,052 - 98,486,892 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	92,916,469 - 92,930,306 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	92,916,469 - 92,930,279 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	92,645,770 - 92,659,607 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	84,611,756 - 84,625,391 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	84,795,174 - 84,808,783 (+)	NCBI
Celera	9	83,967,245 - 83,980,873 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Joubert syndrome 22 (ISO)

Perlman syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-bromohexadecanoic acid (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

cyclosporin A (ISO)

cyproconazole (ISO)

cytarabine (ISO)

DDE (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

gallic acid (ISO)

ivermectin (ISO)

ketamine (EXP)

lead diacetate (ISO)

lead(0) (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (ISO)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

phenylmercury acetate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

propiconazole (ISO)

SB 431542 (ISO)

selenium atom (ISO)

selenomethionine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

tetrachloromethane (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of amyloid precursor protein biosynthetic process (IBA)

negative regulation of neuron projection development (ISO)

neuron differentiation (ISO,ISS)

positive regulation of extrinsic apoptotic signaling pathway (ISO)

Cellular Component

Golgi apparatus (IBA,ISO)

lysosomal membrane (IEA)

lysosome (ISO,ISS)

perinuclear region of cytoplasm (ISO)

plasma membrane (IBA,IEA,ISO,ISS)

Molecular Function

amyloid-beta binding (IBA,ISO)

ATP binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10679242	PMID:12477932	PMID:14592447	PMID:15489334	PMID:18452648	PMID:19056867	PMID:19114711	PMID:19199708	PMID:19849849	PMID:22871113	PMID:23376485

Genomics

Comparative Map Data

Itm2c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	93,993,922 - 94,007,737 (+)	NCBI		GRCr8
mRatBN7.2	9	86,545,927 - 86,559,745 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	86,545,921 - 86,559,742 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	94,963,890 - 94,977,710 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	100,092,388 - 100,106,210 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	98,473,052 - 98,486,892 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	92,916,469 - 92,930,306 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	92,916,469 - 92,930,279 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	92,645,770 - 92,659,607 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	84,611,756 - 84,625,391 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	84,795,174 - 84,808,783 (+)	NCBI
Celera	9	83,967,245 - 83,980,873 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

ITM2C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	230,864,185 - 230,879,254 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	230,864,639 - 230,879,248 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	231,728,900 - 231,743,969 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	231,437,865 - 231,452,207 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	231,555,125 - 231,569,467	NCBI
Celera	2	225,506,038 - 225,520,369 (+)	NCBI		Celera
Cytogenetic Map	2	q37.1	NCBI
HuRef	2	223,571,781 - 223,586,111 (+)	NCBI		HuRef
CHM1_1	2	231,735,449 - 231,749,771 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	231,347,355 - 231,362,416 (+)	NCBI		T2T-CHM13v2.0

Itm2c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	85,822,231 - 85,836,419 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	85,822,002 - 85,836,396 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	85,894,510 - 85,908,698 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	85,894,281 - 85,908,675 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	87,791,085 - 87,805,273 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	87,725,736 - 87,739,863 (+)	NCBI		MGSCv36	mm8
Celera	1	88,859,731 - 88,873,901 (+)	NCBI		Celera
Cytogenetic Map	1	C5	NCBI
cM Map	1	43.94	NCBI

Itm2c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	4,543,476 - 4,557,757 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	4,546,736 - 4,557,649 (-)	NCBI	ChiLan1.0	ChiLan1.0

ITM2C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	133,488,296 - 133,502,794 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	133,503,291 - 133,517,765 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	118,116,228 - 118,131,379 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	236,921,544 - 236,927,392 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

ITM2C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	42,829,825 - 42,842,737 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	42,829,608 - 42,883,055 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	43,390,533 - 43,403,440 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	43,087,071 - 43,099,974 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	43,086,948 - 43,101,722 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	43,015,981 - 43,028,888 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	42,858,683 - 42,871,592 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	43,014,005 - 43,026,924 (+)	NCBI		UU_Cfam_GSD_1.0

Itm2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	185,012,341 - 185,025,221 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	5,914,954 - 5,927,299 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	5,913,913 - 5,927,385 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITM2C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	131,614,743 - 131,628,619 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	131,614,887 - 131,627,428 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	145,293,455 - 145,305,999 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITM2C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	116,902,785 - 116,917,332 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	116,903,113 - 116,917,549 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	82,544,392 - 82,559,437 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itm2c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624843	4,232,588 - 4,242,147 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624843	4,232,482 - 4,243,079 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Itm2c
95 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	130
Count of miRNA genes:	97
Interacting mature miRNAs:	107
Transcripts:	ENSRNOT00000023535
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	48598251	93598251	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	36962359	92058970	Rat
11353957	Bmd92	Bone mineral density QTL 92		0.01	tibia mineral mass (VT:1000283)	volumetric bone mineral density (CMO:0001553)	9	46114199	91114199	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	58163035	100929646	Rat
731171	Glom6	Glomerulus QTL 6	2.8	0.0003	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	9	64573531	109573531	Rat
724547	Cm21	Cardiac mass QTL 21	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	9	79271511	102910209	Rat
61385	Edpm9	Estrogen-dependent pituitary mass QTL 9	3.43	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	63869687	108869687	Rat
2303178	Bp334	Blood pressure QTL 334	3.7	0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	79271511	91616855	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	25268044	114175309	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	36962359	95410867	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	56771635	101771635	Rat
11353951	Bp394	Blood pressure QTL 394			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	44649921	89649921	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	62072275	96470995	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	61381434	104821652	Rat
12879506	Pur33	Proteinuria QTL 33			urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	44649921	89649921	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	75712843	111552878	Rat
4889852	Pur26	Proteinuria QTL 26	15	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	77813894	101597663	Rat
7794784	Mcs31	Mammary carcinoma susceptibility QTL 31	2.98		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	9	77813894	111552878	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	25661188	100929786	Rat
10058949	Gmadr5	Adrenal mass QTL 5	2	0.014	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	9	42791513	87976209	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	62072275	96470995	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	86369631	92058970	Rat

Markers in Region

RH137067

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	86,559,451 - 86,559,671 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	92,930,013 - 92,930,232	NCBI	Rnor6.0
Rnor_5.0	9	92,659,314 - 92,659,533	UniSTS	Rnor5.0
RGSC_v3.4	9	84,625,098 - 84,625,317	UniSTS	RGSC3.4
Celera	9	83,980,580 - 83,980,799	UniSTS
Cytogenetic Map	9	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001009674	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC087127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000023535 ⟹ ENSRNOP00000023535

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	86,545,921 - 86,559,742 (+)	Ensembl
Rnor_6.0 Ensembl	9	92,916,469 - 92,930,279 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103926 ⟹ ENSRNOP00000089071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	86,545,921 - 86,559,742 (+)	Ensembl

RefSeq Acc Id:

NM_001009674 ⟹ NP_001009674

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	93,993,922 - 94,007,737 (+)	NCBI
mRatBN7.2	9	86,545,927 - 86,559,745 (+)	NCBI
Rnor_6.0	9	92,916,469 - 92,930,306 (+)	NCBI
Rnor_5.0	9	92,645,770 - 92,659,607 (+)	NCBI
RGSC_v3.4	9	84,611,756 - 84,625,391 (+)	RGD
Celera	9	83,967,245 - 83,980,873 (+)	RGD

Sequence:

show sequence

GCAAGAAGTAGGCACTGCGATCGAGGTTGCACGGGCAAGGGCTGCAGGGAGCAGGCGCGGGTCA
GCGCAGCCATGGTGAAGATCAGCTTCCAGCCCGCGGTAGCGGGCGTCAAGGCCGAAAAAGCAGA
CAAAGCAGCGGCGTCTGGTCCGGCCTCGGCATCTGCCCCGGCCGCGGAGATTCTGCTGACGCCG
GCGAGGGAGGAACGCCCCCCTCGCCACCGCTCCAGGAAAGGGGGCTCCGTGGGCGGTGTGTGCT
ACCTGTCCATGGGCATGGTTGTACTGCTTATGGGCCTTGTGTTTGCCTCGGTCTACATCTACAG
ATACTTCTTCCTTGCTCAGCTGGCCCGCGATAACTTCTTCCACTGCGGTGTGCTCTACGAAGAC
TCCCTATCCTCCCAGATCCGGACTCGGCTGGAACTGGAGGAGGATGTGAAGATCTATCTTGAGG
AGAACTATGAACGTATTAATGTCCCTGTGCCCCAGTTTGGTGGTGGGGACCCTGCAGACATCAT
CCATGACTTTCAGCGGGGTCTCACTGCCTACCACGACATCTCCCTGGACAAGTGCTACGTCATT
GAGCTCAACACCACCATCGTGCTGCCCCCACGAAACTTCTGGGAGCTCCTCATGAACGTGAAGA
GAGGGACCTACCTCCCACAGACGTACATCATCCAGGAGGAGATGGTGGTGACAGAGCATGTCCG
AGACAAGGAGGCTCTGGGTTCCTTTATCTACCACCTGTGCAACGGGAAGGACACCTATCGGCTG
CGGCGCCGGGCCACCCGGAGGCGGATCAACAAGCGTGGGGCCAAGAACTGCAATGCCATCCGCC
ACTTCGAGAATACATTTGTGGTGGAGACGCTCATCTGTGGGGTGGTGTGAAGCCTTCTCTCCAG
GCTCACCCCTGCCCTCCTCTTCTCCTTCTGGCCACTCTCTGGCCCTCCTCCTCCCTTTGCTTAG
CTTGTACCTTGGGCACTTTTCCATAGATGTGACGTGTCTCACCCATCCTTCCCGGCCCCGCCCT
CCTCCCTGTACCAGGGCTGTGATCTCTCGGGACCTCTGCCTCTGCCGATATTTCAGGCGGGAGA
TGGGAGGGGACAGTTGCCCAAGATGGTTTCTCTAATTCATTATTTTAAGTCAGCTTCCCAGTGG
CTGGGCCCAGGGGAAGGACTAAAGGGAGGGGCTGGACATGTAGAAGCCTGGGGCAGGGGCAGGG
GCAGGGGCAGGGGCATGGATGGGGTTTGGCATGAGGTTCACAAATGGCCCCCACATATGGGGAA
GTCTGAAAGACTTTTATTTTCTTGCACCGCGCACTCCCTCTGTCCTCCTGGTTCTTAGACCTAA
GTGTGGACTAAGGATGGGGAAGTGTGTCCTGGGTTAGACCCATCAGAGCACAAGATAAGGTGGC
TAACCTGGGTTCTTCCCAGGACTCCTGTCAGTGCCTTCAGCCCACCAGTAGGAGCCTGGAGTTG
GCGGGTGGGATGAATCTGCCAAGCACAATTGTTCTCTGAGTGGAACCAAAGAAGTGAGGAGCTA
GGCCGCCCTGGCCTGGCACCTAGGAACACAGGAGCAGGTGGGTATAGAAGTCATCGGCTGTGAG
CTGCAGGCCCTGGGCAGTGGACGGAGCCCATGCCGTGCTTTGCGCCAGGGCTACTGTGAATGGT
GGAAGCAGGAGGGAGAGCCACCTGGTACTTTCGTCCCTGCCTCCTCCTCCGTTCCGGATCTCTC
CCCTCTGTCCAGGGGTGTGTGACGTTTCTCCTGCATGTTTTTACTGATGTTCGTGCTGGCCGCC
CTCAGCCCGGAGCCTGGGAGAGGCTTTGGTGCCTCGCATCAGACTTCGGTGCTCCGTGGCGGTG
AAGCCCTTAAATGCTTTGTATATTTTCTCTATTAGATCTCTTTTCAGAAGTGTCTGTAGAAAAT
TAAAAAAAACAAAAACAAAAAAAAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001009674	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87127	(Get FASTA)	NCBI Sequence Viewer
	EDL75563	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000023535.4
	ENSRNOP00000089071.1
	ENSRNOP00055010182
	ENSRNOP00060009970
GenBank Protein	Q5PQL7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001009674 ⟸ NM_001009674

- UniProtKB:

Q5PQL7 (UniProtKB/Swiss-Prot), A6JWF5 (UniProtKB/TrEMBL), A0A8I6AAT4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVKISFQPAVAGVKAEKADKAAASGPASASAPAAEILLTPAREERPPRHRSRKGGSVGGVCYLS
MGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQIRTRLELEEDVKIYLEENY
ERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGT
YLPQTYIIQEEMVVTEHVRDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFE
NTFVVETLICGVV

hide sequence

Ensembl Acc Id:

ENSRNOP00000023535 ⟸ ENSRNOT00000023535

Ensembl Acc Id:

ENSRNOP00000089071 ⟸ ENSRNOT00000103926

Protein Domains

BRICHOS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5PQL7-F1-model_v2	AlphaFold	Q5PQL7	1-269	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696817

Promoter ID:

EPDNEW_R7342

Type:

initiation region

Name:

Itm2c_1

Description:

integral membrane protein 2C

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	92,916,446 - 92,916,506	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309503	AgrOrtholog
BioCyc Gene	G2FUF-26922	BioCyc
Ensembl Genes	ENSRNOG00000017359	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055007625	UniProtKB/Swiss-Prot
	ENSRNOG00060007985	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000023535.6	UniProtKB/Swiss-Prot
	ENSRNOT00000103926.1	UniProtKB/TrEMBL
	ENSRNOT00055012765	UniProtKB/Swiss-Prot
	ENSRNOT00060013150	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.390.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111761	IMAGE-MGC_LOAD
InterPro	BRICHOS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ITM2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:301575	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:94903	IMAGE-MGC_LOAD
NCBI Gene	301575	ENTREZGENE
PANTHER	INTEGRAL MEMBRANE PROTEIN 2C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10962	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	BRICHOS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Itm2c	PhenoGen
PROSITE	BRICHOS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017359	RatGTEx
	ENSRNOG00055007625	RatGTEx
	ENSRNOG00060007985	RatGTEx
SMART	BRICHOS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AAT4	ENTREZGENE, UniProtKB/TrEMBL
	A6JWF5	ENTREZGENE, UniProtKB/TrEMBL
	ITM2C_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Itm2c	integral membrane protein 2C	Itm2c_predicted	integral membrane protein 2C (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Itm2c_predicted	integral membrane protein 2C (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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