Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Zfp281 | Rat | 17beta-estradiol | affects expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Estradiol affects the expression of ZNF281 mRNA | CTD | PMID:22574217 | Zfp281 | Rat | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of ZFP281 mRNA | CTD | PMID:32145629 | Zfp281 | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Zfp281 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Zfp281 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZFP281 mRNA | CTD | PMID:21570461 and PMID:24058054 | Zfp281 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZFP281 mRNA | CTD | PMID:25270620 | Zfp281 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZFP281 mRNA | CTD | PMID:19770486 | Zfp281 | Rat | 2,4,6-tribromophenol | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Zfp281 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of ZFP281 mRNA | CTD | PMID:21346803 | Zfp281 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of ZFP281 mRNA | CTD | PMID:21346803 | Zfp281 | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of ZNF281 protein | CTD | PMID:31675489 | Zfp281 | Rat | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ZFP281 mRNA | CTD | PMID:26251327 | Zfp281 | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ZNF281 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF281 mRNA | CTD | PMID:28628672 | Zfp281 | Rat | 3-methylcholanthrene | multiple interactions | ISO | ZNF281 (Homo sapiens) | 6480464 | Methylcholanthrene promotes the reaction [AHR protein binds to ZNF281 promoter] | CTD | PMID:20348232 | Zfp281 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Fenretinide results in increased expression of ZNF281 mRNA | CTD | PMID:28973697 | Zfp281 | Rat | aflatoxin B1 | decreases expression | EXP | | 6480464 | Aflatoxin B1 results in decreased expression of ZFP281 mRNA | CTD | PMID:33354967 | Zfp281 | Rat | aristolochic acid A | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ZNF281 mRNA | CTD | PMID:33212167 | Zfp281 | Rat | arsenous acid | increases sumoylation | ISO | ZNF281 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased sumoylation of ZNF281 protein | CTD | PMID:28318385 | Zfp281 | Rat | benzo[a]pyrene | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of ZFP281 mRNA | CTD | PMID:22228805 | Zfp281 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ZNF281 mRNA | CTD | PMID:25181051 | Zfp281 | Rat | bisphenol A | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of ZNF281 protein | CTD | PMID:31675489 | Zfp281 | Rat | bisphenol A | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ZFP281 mRNA | CTD | PMID:33221593 | Zfp281 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of ZFP281 mRNA | CTD | PMID:32145629 | Zfp281 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of ZFP281 mRNA | CTD | PMID:31129395 | Zfp281 | Rat | bisphenol F | multiple interactions | ISO | ZNF281 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF281 mRNA | CTD | PMID:28628672 | Zfp281 | Rat | caffeine | affects phosphorylation | ISO | ZNF281 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of ZNF281 protein | CTD | PMID:35688186 | Zfp281 | Rat | chlorpyrifos | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ZFP281 mRNA | CTD | PMID:37019170 | Zfp281 | Rat | copper(II) sulfate | increases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of ZNF281 mRNA | CTD | PMID:19549813 | Zfp281 | Rat | crocidolite asbestos | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of ZFP281 mRNA | CTD | PMID:29279043 | Zfp281 | Rat | cyclosporin A | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of ZFP281 mRNA | CTD | PMID:19770486 | Zfp281 | Rat | decabromodiphenyl ether | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of ZNF281 protein | CTD | PMID:31675489 | Zfp281 | Rat | dexamethasone | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of ZFP281 mRNA | CTD | PMID:22733784 | Zfp281 | Rat | dexamethasone | multiple interactions | ISO | ZNF281 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF281 mRNA | CTD | PMID:28628672 | Zfp281 | Rat | diarsenic trioxide | increases sumoylation | ISO | ZNF281 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased sumoylation of ZNF281 protein | CTD | PMID:28318385 | Zfp281 | Rat | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of ZFP281 mRNA | CTD | PMID:24136188 | Zfp281 | Rat | FR900359 | increases phosphorylation | ISO | ZNF281 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of ZNF281 protein | CTD | PMID:37730182 | Zfp281 | Rat | geraniol | increases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | geraniol results in increased expression of ZNF281 mRNA | CTD | PMID:27683099 | Zfp281 | Rat | indometacin | multiple interactions | ISO | ZNF281 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZNF281 mRNA | CTD | PMID:28628672 | Zfp281 | Rat | lidocaine | decreases expression | EXP | | 6480464 | Lidocaine results in decreased expression of ZFP281 mRNA | CTD | PMID:35283115 | Zfp281 | Rat | mitomycin C | affects response to substance | ISO | ZNF281 (Homo sapiens) | 6480464 | ZNF281 protein affects the susceptibility to Mitomycin | CTD | PMID:16217747 | Zfp281 | Rat | paracetamol | affects expression | ISO | Zfp281 (Mus musculus) | 6480464 | Acetaminophen affects the expression of ZFP281 mRNA | CTD | PMID:17562736 | Zfp281 | Rat | paracetamol | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ZNF281 mRNA | CTD | PMID:21420995 | Zfp281 | Rat | phenobarbital | affects expression | ISO | Zfp281 (Mus musculus) | 6480464 | Phenobarbital affects the expression of ZFP281 mRNA | CTD | PMID:23091169 | Zfp281 | Rat | pirinixic acid | decreases expression | ISO | Zfp281 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of ZFP281 mRNA | CTD | PMID:18445702 | Zfp281 | Rat | rotenone | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of ZNF281 mRNA | CTD | PMID:29955902 | Zfp281 | Rat | silver atom | increases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Silver results in increased expression of ZNF281 mRNA | CTD | PMID:26014281 | Zfp281 | Rat | silver(0) | increases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Silver results in increased expression of ZNF281 mRNA | CTD | PMID:26014281 | Zfp281 | Rat | sodium arsenite | increases expression | ISO | Zfp281 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of ZFP281 mRNA | CTD | PMID:36209798 | Zfp281 | Rat | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of ZFP281 mRNA | CTD | PMID:19281266 | Zfp281 | Rat | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of ZFP281 mRNA | CTD | PMID:24136188 | Zfp281 | Rat | sunitinib | increases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ZNF281 mRNA | CTD | PMID:31533062 | Zfp281 | Rat | testosterone | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of ZNF281 mRNA | CTD | PMID:33359661 | Zfp281 | Rat | tributylstannane | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with tributyltin] results in increased expression of ZFP281 mRNA | CTD | PMID:31129395 | Zfp281 | Rat | urethane | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Urethane results in decreased expression of ZNF281 mRNA | CTD | PMID:28818685 | Zfp281 | Rat | valproic acid | decreases methylation | ISO | ZNF281 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of ZNF281 gene | CTD | PMID:29154799 | Zfp281 | Rat | valproic acid | decreases expression | ISO | ZNF281 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ZNF281 mRNA | CTD | PMID:23179753 | |