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Gene: Uqcrc1 (ubiquinol-cytochrome c reductase core protein 1) Ictidomys tridecemlineatus

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Symbol:

Uqcrc1

Name:

ubiquinol-cytochrome c reductase core protein 1

RGD ID:

12549178

Description:

ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN mitochondrial electron transport, ubiquinol to cytochrome c (ortholog); response to activity (ortholog); response to alkaloid (ortholog); PARTICIPATES IN electron transport chain pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); hypertrophic cardiomyopathy (ortholog); PARKINSONISM WITH POLYNEUROPATHY (ortholog); FOUND IN respiratory chain complex III (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome b-c1 complex subunit 1, mitochondrial; LOC101956274

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	63,625,445 - 63,635,735 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	385,851 - 396,230 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	385,942 - 396,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

hypertrophic cardiomyopathy (ISO)

PARKINSONISM WITH POLYNEUROPATHY (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial electron transport, ubiquinol to cytochrome c (ISO)

respiratory electron transport chain (IEA)

response to activity (ISO)

response to alkaloid (ISO)

Cellular Component

mitochondrial inner membrane (IEA)

mitochondrion (IEA)

respiratory chain complex III (IEA,ISO)

Molecular Function

metal ion binding (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

electron transport chain pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Uqcrc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	63,625,445 - 63,635,735 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	385,851 - 396,230 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	385,942 - 396,196 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UQCRC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	48,599,002 - 48,609,646 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	48,599,002 - 48,610,976 (-)	Ensembl			hg38	GRCh38
GRCh37	3	48,636,435 - 48,647,079 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	48,611,436 - 48,622,102 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	48,611,435 - 48,622,102	NCBI
Celera	3	48,592,174 - 48,602,839 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	48,694,682 - 48,705,348 (-)	NCBI		HuRef
CHM1_1	3	48,588,742 - 48,599,408 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	48,627,962 - 48,639,898 (-)	NCBI		T2T-CHM13v2.0

Uqcrc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,765,716 - 108,778,709 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,765,701 - 108,778,691 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	108,936,648 - 108,949,641 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,936,633 - 108,949,623 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	108,838,661 - 108,851,686 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,793,553 - 108,806,578 (+)	NCBI		MGSCv36	mm8
Celera	9	108,494,681 - 108,507,601 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.63	NCBI

Uqcrc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	118,468,223 - 118,479,968 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	118,468,200 - 118,479,964 (+)	Ensembl				GRCr8
mRatBN7.2	8	109,589,735 - 109,601,481 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,589,706 - 109,601,480 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	115,207,272 - 115,219,022 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	113,406,459 - 113,418,209 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	111,249,253 - 111,261,004 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	8	119,355,078 - 119,366,840 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	8	121,460,019 - 121,471,781 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	8	119,949,741 - 119,961,503 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	8	111,351,896 - 111,363,646 (+)	NCBI		F344_StmMcwi
Rnor_6.0	8	117,679,328 - 117,691,073 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,679,278 - 117,691,071 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	117,030,932 - 117,042,820 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	113,955,930 - 113,967,675 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	108,883,471 - 108,895,222 (+)	NCBI		Celera
RGSC_v3.1	8	113,975,384 - 113,987,128 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

LOC102005965
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	685,395 - 696,554 (-)	Ensembl
ChiLan1.0	NW_004955532	685,315 - 691,286 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100977575
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	48,573,688 - 48,584,412 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	48,578,456 - 48,589,180 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	48,520,870 - 48,531,947 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	49,602,770 - 49,613,717 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	49,602,770 - 49,613,717 (-)	Ensembl			panPan2	panpan1.1

UQCRC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	40,507,767 - 40,515,854 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	40,506,907 - 40,520,110 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	40,424,996 - 40,433,095 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	40,993,125 - 41,001,225 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	40,992,686 - 41,001,240 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	40,230,564 - 40,238,664 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,635,079 - 40,643,433 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	40,916,265 - 40,924,365 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

UQCRC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,298,449 - 31,309,516 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	31,298,449 - 31,308,719 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	34,542,911 - 34,553,174 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UQCRC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,000,432 - 10,012,524 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	10,000,864 - 10,012,202 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	157,073,473 - 157,085,359 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101719627
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	2,603,089 - 2,613,828 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	2,603,301 - 2,613,105 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

LOC116907628
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	100,215,623 - 100,226,767 (+)	NCBI		Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005326880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_078043153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JBPVTT010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000010319 ⟹ ENSSTOP00000009259

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936529	385,851 - 396,230 (-)	Ensembl

RefSeq Acc Id:

XM_005326880 ⟹ XP_005326937

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	63,625,445 - 63,635,735 (-)	NCBI
SpeTri2.0	NW_004936529	385,942 - 396,196 (-)	NCBI

Sequence:

show sequence

CGCTCTGCGCATGTGTGACGCGACTGCGCACTAACTGGGCTACAAGATGGCGGCGTCCGCAGTT
TGCCGTGCAGCGGGCACCGGGGCACAAACTCTTCTGCGCGCTCGCCGCTCGCCGGCAGTGCTGA
GGGCGCCTGCCTTACGGGGTGCCGCAACCTTCGCCCAGGCCCTCCAGAGTGTGCCAGAGACACA
GGTCAGCCTATTGGACAATGGGCTGCGAGTGGCCTCGGAGCAGACCTCCCAACCTACCTGCACG
GTGGGAGTATGGATTGATGCTGGCAGTCGTTATGAGACTGAGAAGAACAATGGAGCAGGCTACT
TTGTGGAGCATCTAGCTTTCAAGGGAACAAAGAATCGGCCTAGCAATGCCCTGGAGAAGGAGGT
GGAGAGCATGGGGGCCCATCTGAATGCCTATAGCACTCGGGAGCACACAGCTTACTACATCAAG
GCACTGTCCAGTGACCTGCCGAAAGTGGTGGAGCTACTGGCTGACATTGTGCAGAACTGCAGCC
TGGAAGACTCCCAGATTGAAAAGGAACGAGACGTGATCCTGCGGGAAATGCAGGAGAATGATGC
ATCCTTGCGGGATGTGGTCTTTGACTACTTGCATGCAACAGCGTTCCAAGGCACACCTTTAGCC
CAGTCTGTGGAAGGGCCCAGTGAGAATGTCAGGAAATTGTCTCGTGCAGACTTGACTGAGTATC
TAAGCAGGCATTACAAGGCCCCTCGCATGGTGCTGGCAGCAGCAGGAGGAGTGGAGCACCGTCA
ACTGCTAGACCTCGCCCAGAAGCACTTCAGCAGCGTCTCTGCGACATACCCAGATGACACCGTG
CCTACTCTAAGTCCGTGCCGCTTCACTGGAAGTGAGATTCGCCACCGTGATGATGCCCTGCCCT
TGGCCCATGTGGCCATTGCAGTAGAGGGACCCGGTTGGTCCAACCCAGACAATGTGGCCCTCCA
AGTGGCCAATGCCATGATTGGCCATTACGACTGCACTTATGGTGGTGGTGTGCACCTGTCCAGC
CCACTGGCTTCAGTTGCTGTGGCCAACAAGCTGTGCCAGAGTTTCCAGACCTTCAATATCTGCT
ATGCAGAGACTGGGTTGTTGGGTGCACACTTCGTCTGTGACCGTATGAGCATCGATGACATGAT
ATTCTTCCTGCAGGGCCAGTGGATGCGCCTGTGTACCAGTGCCACGGAAAGTGAGGTTACTCGG
GGCAAAAACATCCTCAGAAATGCCCTGGTATCTCATCTGGATGGCACCACTCCTGTGTGTGAGG
ACATTGGACGCAGCCTCCTGACATATGGCCGCCGCATCCCCCTGGCTGAGTGGGAGAGCCGGAT
TGCGGAGGTGGATGCCCATGTGGTGCATGAAGTCTGCTCCAAGTATTTCTATGACCAGTGTCCA
GCAGTGGCTGGAATGGGCCCAATCGAGCAGCTCCCTGACTACAACCGGATCCGTAGTGGCATGT
TCTGGCTGCGCTTCTAGGCAGGATGCCTGTGCAGGCAAGAGGGTAGGATCGGGGCTCATGATCC
CCCTCTACAAACATGCCACTCTGGCACCTCAAACCCATGCAATAAAGTCCTCCACCAATAAAGT
CCTCTGTTGAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005326937	(Get FASTA)	NCBI Sequence Viewer
	XP_077899279	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000009259.2
	ENSSTOP00015021986
GenBank Protein	KAG3270394	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005326937 ⟸ XM_005326880

- UniProtKB:

I3MF96 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAASAVCRAAGTGAQTLLRARRSPAVLRAPALRGAATFAQALQSVPETQVSLLDNGLRVASEQT
SQPTCTVGVWIDAGSRYETEKNNGAGYFVEHLAFKGTKNRPSNALEKEVESMGAHLNAYSTREH
TAYYIKALSSDLPKVVELLADIVQNCSLEDSQIEKERDVILREMQENDASLRDVVFDYLHATAF
QGTPLAQSVEGPSENVRKLSRADLTEYLSRHYKAPRMVLAAAGGVEHRQLLDLAQKHFSSVSAT
YPDDTVPTLSPCRFTGSEIRHRDDALPLAHVAIAVEGPGWSNPDNVALQVANAMIGHYDCTYGG
GVHLSSPLASVAVANKLCQSFQTFNICYAETGLLGAHFVCDRMSIDDMIFFLQGQWMRLCTSAT
ESEVTRGKNILRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDAHVVHEVCSKY
FYDQCPAVAGMGPIEQLPDYNRIRSGMFWLRF

hide sequence

Ensembl Acc Id:

ENSSTOP00000009259 ⟸ ENSSTOT00000010319

Protein Domains

Peptidase M16 C-terminal Peptidase M16 N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000010311	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00015017818	ENTREZGENE
Ensembl Transcript	ENSSTOT00000010319.3	UniProtKB/TrEMBL
Gene3D-CATH	Metalloenzyme, LuxS/M16 peptidase-like	UniProtKB/TrEMBL
InterPro	Metalloenz_LuxS/M16	UniProtKB/TrEMBL
	MPP/UQCRC_Complex	UniProtKB/TrEMBL
	Pept_M16_N	UniProtKB/TrEMBL
	Peptidase_M16_C	UniProtKB/TrEMBL
KEGG Report	iti:101956274	UniProtKB/TrEMBL
NCBI Gene	LOC101956274	ENTREZGENE
PANTHER	CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL	UniProtKB/TrEMBL
	METALLOPROTEASE	UniProtKB/TrEMBL
Pfam	Peptidase_M16	UniProtKB/TrEMBL
	Peptidase_M16_C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63411	UniProtKB/TrEMBL
UniProt	I3MF96	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2025-12-16	Uqcrc1	ubiquinol-cytochrome c reductase core protein 1	LOC101956274	cytochrome b-c1 complex subunit 1, mitochondrial	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB