PTGDS (prostaglandin D2 synthase) - Rat Genome Database

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Gene: PTGDS (prostaglandin D2 synthase) Canis lupus familiaris
Analyze
Symbol: PTGDS
Name: prostaglandin D2 synthase
RGD ID: 12406382
Description: ENCODES a protein that exhibits prostaglandin-D synthase activity (ortholog); retinoid binding (ortholog); INVOLVED IN negative regulation of male germ cell proliferation (ortholog); prostaglandin biosynthetic process (ortholog); regulation of circadian sleep/wake cycle, sleep (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH arteriosclerosis (ortholog); carotid artery disease (ortholog); chronic rhinosinusitis with nasal polyps (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; prostaglandin D synthase; prostaglandin D2 synthase 21kDa (brain); prostaglandin-H2 D-isomerase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,647,334 - 48,650,608 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,646,255 - 48,669,814 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,860,991 - 47,864,203 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,525,429 - 49,528,641 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,526,341 - 49,528,664 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,301,642 - 48,304,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,600,355 - 48,603,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,647,517 - 48,650,729 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PTGDS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,647,334 - 48,650,608 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,646,255 - 48,669,814 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha947,860,991 - 47,864,203 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0949,525,429 - 49,528,641 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,526,341 - 49,528,664 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,301,642 - 48,304,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,600,355 - 48,603,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,647,517 - 48,650,729 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
PTGDS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,977,504 - 136,981,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,975,053 - 136,981,750 (+)Ensemblhg38GRCh38
GRCh379139,871,956 - 139,876,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,991,777 - 138,996,015 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349137,147,792 - 137,152,030NCBI
Celera9110,384,087 - 110,388,329 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,331,058 - 109,335,300 (+)NCBIHuRef
CHM1_19140,020,562 - 140,024,952 (+)NCBICHM1_1
T2T-CHM13v2.09149,211,911 - 149,216,153 (+)NCBIT2T-CHM13v2.0
Ptgds
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,356,723 - 25,360,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,356,721 - 25,360,058 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38225,466,709 - 25,470,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,466,709 - 25,470,046 (-)Ensemblmm10GRCm38
MGSCv37225,322,232 - 25,325,269 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36225,288,721 - 25,291,740 (-)NCBIMGSCv36mm8
Celera225,194,223 - 25,197,258 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.28NCBI
Ptgds
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,680,044 - 28,682,978 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl328,680,044 - 28,682,978 (-)EnsemblGRCr8
mRatBN7.238,281,899 - 8,284,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,281,899 - 8,284,833 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx311,386,994 - 11,389,928 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,973,218 - 19,976,152 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,163,066 - 18,166,000 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,686,125 - 2,689,059 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,686,123 - 2,689,084 (-)Ensemblrn6Rnor6.0
Rnor_5.032,667,538 - 2,670,472 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.433,632,683 - 3,635,617 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera33,107,001 - 3,109,935 (-)NCBICelera
RGSC_v3.133,632,682 - 3,635,617 (-)NCBI
Cytogenetic Map3p13NCBI
Ptgds
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,009,625 - 5,012,781 (+)Ensembl
ChiLan1.0NW_0049555135,009,530 - 5,012,781 (+)NCBIChiLan1.0ChiLan1.0
PTGDS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,417,107 - 2,421,310 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,419,441 - 2,423,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,037,994 - 108,042,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,006,601 - 137,010,582 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,006,601 - 137,009,680 (+)EnsemblpanPan2panpan1.1
Ptgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,410,468 - 202,413,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669961,034 - 965,136 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936669961,246 - 964,584 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGDS
(Sus scrofa - pig)		 No map positions available.
PTGDS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,210,567 - 1,214,631 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,211,487 - 1,214,531 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660584,086,821 - 4,090,925 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgds
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760920,877 - 923,283 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624760920,292 - 923,174 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ptgds
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1511,713,729 - 11,716,149 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in PTGDS
30 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000031047   ⟹   ENSCAFP00000028880
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,647,780 - 48,650,631 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000044649   ⟹   ENSCAFP00000043090
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,647,776 - 48,669,814 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000061001   ⟹   ENSCAFP00000061203
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,647,776 - 48,651,524 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000067905   ⟹   ENSCAFP00000046976
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,646,255 - 48,651,524 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000068403   ⟹   ENSCAFP00000065444
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,647,776 - 48,651,524 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000083089   ⟹   ENSCAFP00000049459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,647,776 - 48,657,697 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000088367   ⟹   ENSCAFP00000055808
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl948,646,255 - 48,651,524 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845009214   ⟹   ENSCAFP00845007248
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl949,526,341 - 49,528,664 (-)Ensembl
RefSeq Acc Id: NM_001003131   ⟹   NP_001003131
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,647,334 - 48,650,608 (-)NCBI
Dog10K_Boxer_Tasha947,860,991 - 47,864,203 (-)NCBI
ROS_Cfam_1.0949,525,429 - 49,528,641 (-)NCBI
UMICH_Zoey_3.1948,301,642 - 48,304,854 (-)NCBI
UNSW_CanFamBas_1.0948,600,355 - 48,603,569 (-)NCBI
UU_Cfam_GSD_1.0948,647,517 - 48,650,729 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003131 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA77690 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00845007248
GenBank Protein Q9XS65 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001003131   ⟸   NM_001003131
- Peptide Label: precursor
- UniProtKB: Q9XS65 (UniProtKB/Swiss-Prot),   A0A8C0JNM0 (UniProtKB/TrEMBL),   A0A8C0M732 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000055808   ⟸   ENSCAFT00000088367
Ensembl Acc Id: ENSCAFP00000028880   ⟸   ENSCAFT00000031047
Ensembl Acc Id: ENSCAFP00000046976   ⟸   ENSCAFT00000067905
Ensembl Acc Id: ENSCAFP00000049459   ⟸   ENSCAFT00000083089
Ensembl Acc Id: ENSCAFP00000043090   ⟸   ENSCAFT00000044649
Ensembl Acc Id: ENSCAFP00000065444   ⟸   ENSCAFT00000068403
Ensembl Acc Id: ENSCAFP00000061203   ⟸   ENSCAFT00000061001
Ensembl Acc Id: ENSCAFP00845007248   ⟸   ENSCAFT00845009214
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Promoters
RGD ID:13684750
Promoter ID:EPDNEW_C2820
Type:initiation region
Name:PTGDS_1
Description:Prostaglandin-H2 D-isomerase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1948,650,631 - 48,650,691EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019533 Ensembl
  ENSCAFG00845005146 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845009214 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  Lipocalin UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report cfa:403740 UniProtKB/Swiss-Prot
NCBI Gene PTGDS ENTREZGENE
PANTHER PTHR11430 UniProtKB/Swiss-Prot
  PTHR11430:SF86 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PRINTS LIPOCALIN UniProtKB/Swiss-Prot
  PGNDSYNTHASE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A0A8C0JNM0 ENTREZGENE
  A0A8C0M732 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MUQ9_CANLF UniProtKB/TrEMBL
  A0A8P0NX25_CANLF UniProtKB/TrEMBL
  A0A8P0NZE5_CANLF UniProtKB/TrEMBL
  A0A8P0T802_CANLF UniProtKB/TrEMBL
  PTGDS_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:55792 ENTREZGENE