LTA4H (leukotriene A4 hydrolase) - Rat Genome Database

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Gene: LTA4H (leukotriene A4 hydrolase) Canis lupus familiaris
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Symbol: LTA4H
Name: leukotriene A4 hydrolase
RGD ID: 12227618
Description: ENCODES a protein that exhibits leukotriene-A4 hydrolase activity (ortholog); INVOLVED IN leukotriene metabolic process (ortholog); response to peptide hormone (ortholog); response to zinc ion (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH adenocarcinoma (ortholog); asthma (ortholog); atherosclerosis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukotriene A-4 hydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,795,934 - 35,830,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1536,182,408 - 36,217,145 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01536,460,885 - 36,495,697 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,733,722 - 35,768,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,828,282 - 35,863,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,091,485 - 36,126,289 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LTA4H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,795,934 - 35,830,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1536,182,408 - 36,217,145 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01536,460,885 - 36,495,697 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,733,722 - 35,768,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,828,282 - 35,863,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,091,485 - 36,126,289 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LTA4H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381296,000,753 - 96,043,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1296,000,753 - 96,043,520 (-)Ensemblhg38GRCh38
GRCh371296,394,531 - 96,437,298 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,918,742 - 94,953,496 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341294,897,078 - 94,931,833NCBI
Celera1296,060,902 - 96,095,656 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,456,404 - 93,499,169 (-)NCBIHuRef
CHM1_11296,359,522 - 96,402,289 (-)NCBICHM1_1
T2T-CHM13v2.01295,974,750 - 96,017,515 (-)NCBIT2T-CHM13v2.0
Lta4h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,289,258 - 93,320,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,289,273 - 93,320,737 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381093,453,396 - 93,484,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,453,411 - 93,484,875 (+)Ensemblmm10GRCm38
MGSCv371092,916,141 - 92,947,641 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361092,883,229 - 92,914,633 (+)NCBIMGSCv36mm8
Celera1095,436,799 - 95,470,679 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.42NCBI
Lta4h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8729,856,846 - 29,888,642 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl729,856,802 - 29,888,641 (+)EnsemblGRCr8
mRatBN7.2727,969,796 - 28,001,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx729,960,190 - 29,991,962 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,122,406 - 32,154,178 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0731,897,354 - 31,929,083 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,288,333 - 34,320,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)Ensemblrn6Rnor6.0
Rnor_5.0734,353,476 - 34,385,291 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4730,482,213 - 30,515,062 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera725,071,700 - 25,102,147 (+)NCBICelera
RGSC_v3.1730,502,483 - 30,535,333 (+)NCBI
Cytogenetic Map7q13NCBI
Lta4h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,344,925 - 32,378,384 (-)Ensembl
ChiLan1.0NW_00495540532,345,005 - 32,377,685 (-)NCBIChiLan1.0ChiLan1.0
LTA4H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210104,071,540 - 104,106,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112104,067,930 - 104,102,827 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,589,758 - 93,624,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,978,203 - 97,012,427 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,978,203 - 97,012,427 (-)EnsemblpanPan2panpan1.1
Lta4h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,115,386 - 24,153,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,082,068 - 12,120,091 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650712,082,373 - 12,120,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTA4H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,486,512 - 87,518,515 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1587,486,552 - 87,518,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,688,970 - 91,720,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTA4H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,371,383 - 91,413,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1191,371,383 - 91,406,542 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037153,722,667 - 153,757,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lta4h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,274,664 - 11,314,581 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475011,274,506 - 11,314,683 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lta4h
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11172,502,063 - 172,533,672 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in LTA4H
371 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000010410   ⟹   ENSCAFP00000009652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000067391   ⟹   ENSCAFP00000050402
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000080995   ⟹   ENSCAFP00000048378
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043953   ⟹   ENSCAFP00845034446
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845044127   ⟹   ENSCAFP00845034576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845044468   ⟹   ENSCAFP00845034845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1536,460,874 - 36,495,661 (-)Ensembl
RefSeq Acc Id: XM_038496317   ⟹   XP_038352245
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11535,733,722 - 35,768,521 (-)NCBI
RefSeq Acc Id: XM_038558701   ⟹   XP_038414629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01536,091,485 - 36,126,289 (-)NCBI
RefSeq Acc Id: XM_038622617   ⟹   XP_038478545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01535,828,282 - 35,863,043 (-)NCBI
RefSeq Acc Id: XM_038688288   ⟹   XP_038544216
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01536,460,885 - 36,495,697 (-)NCBI
RefSeq Acc Id: XM_539728   ⟹   XP_539728
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11535,795,934 - 35,830,681 (-)NCBI
Dog10K_Boxer_Tasha1536,182,408 - 36,217,145 (-)NCBI
Sequence:
RefSeq Acc Id: XP_539728   ⟸   XM_539728
- UniProtKB: A0A8I3PTW1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000009652   ⟸   ENSCAFT00000010410
Ensembl Acc Id: ENSCAFP00000050402   ⟸   ENSCAFT00000067391
Ensembl Acc Id: ENSCAFP00000048378   ⟸   ENSCAFT00000080995
RefSeq Acc Id: XP_038352245   ⟸   XM_038496317
RefSeq Acc Id: XP_038478545   ⟸   XM_038622617
RefSeq Acc Id: XP_038544216   ⟸   XM_038688288
- UniProtKB: A0A8I3PTW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038414629   ⟸   XM_038558701
- UniProtKB: A0A8I3PTW1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845034845   ⟸   ENSCAFT00845044468
Ensembl Acc Id: ENSCAFP00845034446   ⟸   ENSCAFT00845043953
Ensembl Acc Id: ENSCAFP00845034576   ⟸   ENSCAFT00845044127
Protein Domains
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006440 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021884 UniProtKB/TrEMBL
  ENSCAFG00040005792 UniProtKB/TrEMBL
  ENSCAFG00845024692 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010410.5 UniProtKB/TrEMBL
  ENSCAFT00000067391.2 UniProtKB/TrEMBL
  ENSCAFT00000080995.2 UniProtKB/TrEMBL
  ENSCAFT00030040471.1 UniProtKB/TrEMBL
  ENSCAFT00030040582.1 UniProtKB/TrEMBL
  ENSCAFT00030040692.1 UniProtKB/TrEMBL
  ENSCAFT00040011080.1 UniProtKB/TrEMBL
  ENSCAFT00040011163.1 UniProtKB/TrEMBL
  ENSCAFT00845043953 ENTREZGENE
  ENSCAFT00845043953.1 UniProtKB/TrEMBL
  ENSCAFT00845044127.1 UniProtKB/TrEMBL
  ENSCAFT00845044468.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.390.10 UniProtKB/TrEMBL
  1.25.40.320 UniProtKB/TrEMBL
  2.60.40.1730 UniProtKB/TrEMBL
  3.30.2010.30 UniProtKB/TrEMBL
InterPro Aminopeptidase_N-like_N UniProtKB/TrEMBL
  Aminopeptidase_N-like_N UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  LTA4H UniProtKB/TrEMBL
  LTA4H_cat UniProtKB/TrEMBL
  M1_LTA-4_hydro/amino_C_sf UniProtKB/TrEMBL
  M1_LTA4H UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_C UniProtKB/TrEMBL
  Peptidase_M1_dom UniProtKB/TrEMBL
  Peptidase_M4/M1_CTD_sf UniProtKB/TrEMBL
NCBI Gene LTA4H ENTREZGENE
PANTHER LEUKOTRIENE A-4 HYDROLASE UniProtKB/TrEMBL
  PTHR45726 UniProtKB/TrEMBL
Pfam Leuk-A4-hydro_C UniProtKB/TrEMBL
  Peptidase_M1 UniProtKB/TrEMBL
  Peptidase_M1_N UniProtKB/TrEMBL
PRINTS ALADIPTASE UniProtKB/TrEMBL
SMART Leuk-A4-hydro_C UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF63737 UniProtKB/TrEMBL
UniProt A0A8C0P1E2_CANLF UniProtKB/TrEMBL
  A0A8C0P7C5_CANLF UniProtKB/TrEMBL
  A0A8C0P7K2_CANLF UniProtKB/TrEMBL
  A0A8C0Q6U6_CANLF UniProtKB/TrEMBL
  A0A8C0Q7F7_CANLF UniProtKB/TrEMBL
  A0A8I3PJV4_CANLF UniProtKB/TrEMBL
  A0A8I3PP24_CANLF UniProtKB/TrEMBL
  A0A8I3PTW1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0N8Y0 UniProtKB/TrEMBL
  A0A8P0P075 UniProtKB/TrEMBL
  A0A8P0T197 UniProtKB/TrEMBL
VGNC ID VGNC:42853 ENTREZGENE