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Gene: PDHB (pyruvate dehydrogenase E1 subunit beta) Canis lupus familiaris

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Symbol:

PDHB

Name:

pyruvate dehydrogenase E1 subunit beta

RGD ID:

12209069

Description:

ENCODES a protein that exhibits pyruvate dehydrogenase (acetyl-transferring) activity (ortholog); INVOLVED IN pyruvate decarboxylation to acetyl-CoA (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; ASSOCIATED WITH epilepsy (ortholog); genetic disease (ortholog); pyruvate decarboxylase deficiency (ortholog); FOUND IN mitochondrion (ortholog); pyruvate dehydrogenase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

pyruvate dehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 beta subunit; pyruvate dehydrogenase E1 component subunit beta, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	32,185,420 - 32,191,592 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	32,110,558 - 32,116,683 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	32,453,097 - 32,459,222 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	32,453,107 - 32,459,214 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	31,909,791 - 31,915,922 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	32,266,176 - 32,272,302 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	32,438,275 - 32,444,406 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

genetic disease (ISO)

pyruvate decarboxylase deficiency (ISO)

Pyruvate Dehydrogenase E1-Beta Deficiency (ISO)

Pyruvate Dehydrogenase Phosphatase Deficiency (ISO)

renal cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aerobic respiration (IEA)

glucose metabolic process (IEA)

purine-containing compound biosynthetic process (IEA)

pyruvate decarboxylation to acetyl-CoA (IBA,IEA,ISO)

sulfur compound biosynthetic process (IEA)

Cellular Component

mitochondrion (IEA,ISO)

pyruvate dehydrogenase complex (IBA,IEA,ISO)

Molecular Function

metal ion binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

pyruvate dehydrogenase (acetyl-transferring) activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

citric acid cycle pathway (ISO)

fumaric aciduria pathway (ISO)

Leigh disease pathway (ISO)

mitochondrial complex II deficiency pathway (ISO)

primary hyperoxaluria type 2 pathway (ISO)

pyruvate decarboxylase deficiency pathway (ISO)

pyruvate dehydrogenase E1 deficiency pathway (ISO)

pyruvate dehydrogenase E2 deficiency pathway (ISO)

pyruvate dehydrogenase E3 deficiency pathway (ISO)

pyruvate kinase deficiency of red cells pathway (ISO)

pyruvate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

PDHB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	32,185,420 - 32,191,592 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	32,110,558 - 32,116,683 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	32,453,097 - 32,459,222 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	32,453,107 - 32,459,214 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	31,909,791 - 31,915,922 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	32,266,176 - 32,272,302 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	32,438,275 - 32,444,406 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

PDHB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	58,427,630 - 58,433,832 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	58,427,630 - 58,434,012 (-)	Ensembl			hg38	GRCh38
GRCh37	3	58,413,357 - 58,419,559 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	58,388,394 - 58,394,605 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	58,388,397 - 58,394,594	NCBI
Celera	3	58,427,174 - 58,433,398 (-)	NCBI		Celera
Cytogenetic Map	3	p14.3	NCBI
HuRef	3	58,509,470 - 58,515,692 (-)	NCBI		HuRef
CHM1_1	3	58,363,623 - 58,369,848 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	58,468,008 - 58,474,213 (-)	NCBI		T2T-CHM13v2.0

Pdhb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	14,296,470 - 14,303,782 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	14,296,748 - 14,303,777 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	8,165,991 - 8,173,303 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	8,165,996 - 8,173,025 (-)	Ensembl			mm10	GRCm38
MGSCv37	14	8,998,505 - 9,005,506 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	6,956,612 - 6,964,490 (-)	NCBI		MGSCv36	mm8
Celera	14	3,789,851 - 3,797,024 (-)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	4.74	NCBI

Pdhb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	19,182,789 - 19,188,731 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	19,181,208 - 19,188,976 (+)	Ensembl				GRCr8
mRatBN7.2	15	16,752,561 - 16,758,503 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	16,750,980 - 16,758,500 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	18,927,415 - 18,933,373 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	19,885,878 - 19,891,836 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	18,140,784 - 18,146,742 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	15	18,210,774 - 18,216,717 (+)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	15	18,116,574 - 18,122,517 (+)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	15	18,199,320 - 18,205,263 (+)	NCBI		Lyon_Hypertensive
F344_StmMcwi	15	18,798,898 - 18,804,841 (+)	NCBI		F344_StmMcwi
Rnor_6.0	15	18,540,826 - 18,546,855 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	18,539,210 - 18,546,854 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	22,507,861 - 22,513,890 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	18,737,449 - 18,743,391 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	16,710,789 - 16,716,731 (+)	NCBI		Celera
RGSC_v3.1	15	18,737,448 - 18,743,390 (+)	NCBI
Cytogenetic Map	15	p14	NCBI

Pdhb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	1,707,615 - 1,713,541 (+)	Ensembl
ChiLan1.0	NW_004955430	1,707,615 - 1,713,541 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDHB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	58,398,731 - 58,405,135 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	58,403,507 - 58,409,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	58,359,753 - 58,366,094 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	59,776,216 - 59,782,461 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	59,776,618 - 59,782,411 (-)	Ensembl			panPan2	panpan1.1

Pdhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	169,442,034 - 169,447,686 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	2,580,618 - 2,586,266 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	2,580,642 - 2,586,266 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDHB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	40,160,568 - 40,167,476 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	40,161,519 - 40,167,502 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	44,121,821 - 44,127,805 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDHB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	19,718,610 - 19,725,037 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	19,718,353 - 19,725,036 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	147,098,867 - 147,105,329 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdhb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	5,482,173 - 5,488,287 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624822	5,482,177 - 5,488,218 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pdhb
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	78,585,523 - 78,591,411 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in PDHB
89 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_022406525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038427341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038503062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038566031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038630167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_533778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000234	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000291	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00845033884 ⟹ ENSCAFP00845026516

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	32,453,107 - 32,459,191 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033956 ⟹ ENSCAFP00845026573

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	32,453,137 - 32,459,214 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845034025 ⟹ ENSCAFP00845026629

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	20	32,453,160 - 32,459,191 (+)	Ensembl

RefSeq Acc Id:

XM_038427341 ⟹ XP_038283269

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	20	32,453,097 - 32,459,222 (+)	NCBI

RefSeq Acc Id:

XM_038503062 ⟹ XP_038358990

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	20	31,909,791 - 31,915,922 (+)	NCBI

RefSeq Acc Id:

XM_038566031 ⟹ XP_038421959

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	20	32,438,275 - 32,444,406 (+)	NCBI

RefSeq Acc Id:

XM_038630167 ⟹ XP_038486095

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	20	32,266,176 - 32,272,302 (+)	NCBI

RefSeq Acc Id:

XM_533778 ⟹ XP_533778

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	20	32,185,420 - 32,191,592 (+)	NCBI
Dog10K_Boxer_Tasha	20	32,110,558 - 32,116,683 (+)	NCBI

Sequence:

show sequence

GGGGCACGCAGGCGCCGCGCGCTGCCATTGGCCTGAGCTGGCGCGGGAGGCGGAGCCTGAGGCG
ACTGCGGTCCTGCGGTGTTGTCATTCGGCGGCGGCTGGAGGACACGGTCAAGATGGCGGCGGTG
TCTGGCCTGATGCGGAGACCCCTGGAACAGGTGTCGGGGTTGCTGAGGAGGCGCTTCCACCGGA
CGGCGCCGGCGGCGCTGCAGGTGACAGTTCGTGAGGCTATAAACCAAGGTATGGATGAAGAGCT
GGAAAGAGATGAGAAGGTATTTCTCCTTGGGGAAGAAGTTGCCCAGTATGATGGTGCATATAAG
GTTAGTCGAGGCCTGTGGAAGAAATATGGCGATAAGAGAATCATAGATACTCCCATATCTGAGA
TGGGCTTTGCTGGAATTGCTGTGGGTGCAGCTATGGCTGGGTTGAGGCCCATCTGTGAATTTAT
GACCTTCAATTTCTCTATGCAAGCCATTGACCAAGTTATAAATTCAGCTGCCAAGACCTACTAC
ATGTCGGGGGGCCTTCAGCCTGTGCCTATAGTCTTCAGGGGGCCCAATGGTGCCTCAGCAGGTG
TGGCTGCCCAACACTCACAGTGCTTTGCTGCCTGGTATGGGCACTGCCCAGGCTTAAAGGTGGT
CAGCCCCTGGAATTCAGAGGATGCAAAAGGACTTATTAAATCAGCCATTCGGGATAATAATCCA
GTGGTGGTGCTAGAGAACGAACTGATGTATGGAGTTCCTTTTGAATTTCCCTCCGAAGCTCAGT
CAAAAGATTTTCTGATTCCCATTGGAAAAGCCAAAATAGAAAGGCAAGGTACACACATAACTGT
AGTTGCTCATTCAAGACCTGTGGGCCACTGCTTAGAAGCTGCAACAGTGTTATCCAAAGAGGGT
ATTGAATGTGAGGTGATAAATATGCGAACCATCAGACCAATGGACATTGAAACAATAGAAGCCA
GTGTCATGAAGACCAATCATCTCATAACTGTGGAAGGAGGCTGGCCACAGTTTGGAGTAGGAGC
TGAAATTTGTGCCAGGATTATGGAAGGCCCTGCATTCAATTTCCTGGATGCTCCTGCAGTTCGT
GTCACTGGTGCTGATGTCCCTATGCCTTATGCAAAGATTCTAGAAGACAACTCTGTACCTCAAG
TTAAAGACATCATATTTGCAATAAAGAAAACATTAAATATCTAGTTTGGACTTGAATTTCAAGT
CATTGGGATTTACTTAAAATACTTTCTGACAGTTCACCTGAATTGTACTGTAAGACCTTATGAT
TCATAAAGCTATCTCTAAAGCAACATCACAGATGTTTTTGTACTTGGAAGAAGTTTAAATGTGC
TTGTATGTGGAAAAACTCTCCTCTCCTGCCCTAGACTCCATGGGGGGGGGGGGTTGGTCTGTTA
CAGTTATGTTCTTTGAATAAGGCTAACTTAAAATTTTACCCTTTCACAAGGACAAGGTCTGAAC
ATGGCAGAGTTCTGCAGAAAGACATATCCAAAAAGATAACTTGTATGTAAAGATAAAAGCTATT
ATCTACATTTGCTGTTTGATTGTTTTGATAAGGAATAAAAGAATTCCTAAGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038283269	(Get FASTA)	NCBI Sequence Viewer
	XP_038358990	(Get FASTA)	NCBI Sequence Viewer
	XP_038421959	(Get FASTA)	NCBI Sequence Viewer
	XP_038486095	(Get FASTA)	NCBI Sequence Viewer
	XP_533778	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000010899.3
	ENSCAFP00000074890.1
	ENSCAFP00030030546.1
	ENSCAFP00040012686.1
	ENSCAFP00845026516
	ENSCAFP00845026516.1
	ENSCAFP00845026573.1
	ENSCAFP00845026629.1

RefSeq Acc Id:

XP_533778 ⟸ XM_533778

- UniProtKB:

A0A8C0QIK1 (UniProtKB/TrEMBL), A0A8I3S3U9 (UniProtKB/TrEMBL), A0A8I3P8I7 (UniProtKB/TrEMBL), A0A8P0TVT4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAVSGLMRRPLEQVSGLLRRRFHRTAPAALQVTVREAINQGMDEELERDEKVFLLGEEVAQYD
GAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAA
KTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIR
DNNPVVVLENELMYGVPFEFPSEAQSKDFLIPIGKAKIERQGTHITVVAHSRPVGHCLEAATVL
SKEGIECEVINMRTIRPMDIETIEASVMKTNHLITVEGGWPQFGVGAEICARIMEGPAFNFLDA
PAVRVTGADVPMPYAKILEDNSVPQVKDIIFAIKKTLNI

hide sequence

RefSeq Acc Id:

XP_038358990 ⟸ XM_038503062

RefSeq Acc Id:

XP_038486095 ⟸ XM_038630167

RefSeq Acc Id:	XP_038283269 ⟸ XM_038427341
- UniProtKB:	A0A8C0QIK1 (UniProtKB/TrEMBL), A0A8I3S3U9 (UniProtKB/TrEMBL), A0A8I3P8I7 (UniProtKB/TrEMBL), A0A8P0TVT4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038421959 ⟸ XM_038566031
- UniProtKB:	A0A8C0QIK1 (UniProtKB/TrEMBL), A0A8I3P8I7 (UniProtKB/TrEMBL), A0A8I3S3U9 (UniProtKB/TrEMBL), A0A8P0TVT4 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845026629 ⟸ ENSCAFT00845034025

Ensembl Acc Id:

ENSCAFP00845026516 ⟸ ENSCAFT00845033884

Ensembl Acc Id:

ENSCAFP00845026573 ⟸ ENSCAFT00845033956

Protein Domains

Transketolase-like pyrimidine-binding

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000007340	UniProtKB/TrEMBL
	ENSCAFG00030018981	UniProtKB/TrEMBL
	ENSCAFG00040007880	UniProtKB/TrEMBL
	ENSCAFG00845019154	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000011760.5	UniProtKB/TrEMBL
	ENSCAFT00000102456.1	UniProtKB/TrEMBL
	ENSCAFT00030035031.1	UniProtKB/TrEMBL
	ENSCAFT00040014668.1	UniProtKB/TrEMBL
	ENSCAFT00845033884	ENTREZGENE
	ENSCAFT00845033884.1	UniProtKB/TrEMBL
	ENSCAFT00845033956.1	UniProtKB/TrEMBL
	ENSCAFT00845034025.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.920	UniProtKB/TrEMBL
	3.40.50.970	UniProtKB/TrEMBL
InterPro	PDHB	UniProtKB/TrEMBL
	THDP-binding	UniProtKB/TrEMBL
	Transketo_C/PFOR_II	UniProtKB/TrEMBL
	Transketolase-like_Pyr-bd	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
KEGG Report	cfa:476574	UniProtKB/TrEMBL
NCBI Gene	PDHB	ENTREZGENE
PANTHER	PTHR11624	UniProtKB/TrEMBL
	PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	Transket_pyr	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
SMART	Transket_pyr	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52518	UniProtKB/TrEMBL
	SSF52922	UniProtKB/TrEMBL
UniProt	A0A8C0QIK1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P4C2_CANLF	UniProtKB/TrEMBL
	A0A8I3P8I7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3S3U9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TVT4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-26	PDHB	pyruvate dehydrogenase E1 subunit beta	PDHB	pyruvate dehydrogenase E1 beta subunit	Symbol and/or name change	5135510	APPROVED
2017-08-15	PDHB	pyruvate dehydrogenase E1 beta subunit	PDHB	pyruvate dehydrogenase (lipoamide) beta	Symbol and/or name change	5135510	APPROVED
2017-08-15	PDHB	pyruvate dehydrogenase E1 beta subunit		pyruvate dehydrogenase (lipoamide) beta	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB