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Gene: CLN8 (CLN8 transmembrane ER and ERGIC protein) Canis lupus familiaris

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Symbol:

CLN8

Name:

CLN8 transmembrane ER and ERGIC protein

RGD ID:

12090590

Description:

ENCODES a protein that exhibits ceramide binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); adult walking behavior (ortholog); associative learning (ortholog); ASSOCIATED WITH neuronal ceroid lipofuscinosis 8; Animal Disease Models (ortholog); congenital myopathy 1A (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum-Golgi intermediate compartment (ortholog)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); LOC106558305; protein CLN8; translation initiation factor IF-2-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	30,863,098 - 30,885,831 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	30,867,479 - 30,884,895 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	31,632,530 - 31,649,934 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	30,888,770 - 30,912,784 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	30,894,473 - 30,912,781 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	30,804,432 - 30,821,842 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	30,743,370 - 30,760,756 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	30,752,705 - 30,770,116 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

congenital myopathy 1A (ISO)

epilepsy (ISO)

genetic disease (ISO)

intellectual disability (ISO)

neuronal ceroid lipofuscinosis (ISO)

neuronal ceroid lipofuscinosis 1 (ISO)

neuronal ceroid lipofuscinosis 8 (IAGP,ISO)

neuronal ceroid lipofuscinosis 8 northern epilepsy variant (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult locomotory behavior (ISO)

adult walking behavior (ISO)

associative learning (ISO)

ceramide metabolic process (ISS)

cholesterol metabolic process (ISS)

glutamate reuptake (ISO)

lipid homeostasis (IBA)

lysosome organization (ISO)

mitochondrial membrane organization (ISO)

musculoskeletal movement (ISO)

negative regulation of apoptotic process (ISO)

nervous system development (IBA,ISS)

neurofilament cytoskeleton organization (ISO)

neuromuscular process controlling balance (ISO)

neuromuscular process controlling posture (ISO)

phospholipid metabolic process (IBA,ISO,ISS)

photoreceptor cell maintenance (ISO)

protein catabolic process (ISO)

regulation of cell size (ISO)

retina development in camera-type eye (ISO)

social behavior (ISO)

somatic motor neuron differentiation (ISO)

spinal cord motor neuron differentiation (ISO)

visual perception (ISO)

Cellular Component

endoplasmic reticulum (IBA,IEA,ISS)

endoplasmic reticulum membrane (IEA)

endoplasmic reticulum-Golgi intermediate compartment (ISS)

endoplasmic reticulum-Golgi intermediate compartment membrane (IEA)

membrane (IEA)

Molecular Function

ceramide binding (IBA,ISS)

protein binding (ISO)

References

Additional References at PubMed

PMID:11073223	PMID:15629147	PMID:15958790	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CLN8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	30,863,098 - 30,885,831 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	30,867,479 - 30,884,895 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	31,632,530 - 31,649,934 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	30,888,770 - 30,912,784 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	30,894,473 - 30,912,781 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	30,804,432 - 30,821,842 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	30,743,370 - 30,760,756 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	30,752,705 - 30,770,116 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

CLN8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	1,753,059 - 1,786,570 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	1,755,778 - 1,801,711 (+)	Ensembl			hg38	GRCh38
GRCh37	8	1,711,955 - 1,734,736 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	1,699,277 - 1,722,143 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	1,699,347 - 1,719,857	NCBI
Celera	8	1,654,899 - 1,677,784 (+)	NCBI		Celera
Cytogenetic Map	8	p23.3	NCBI
HuRef	8	1,526,501 - 1,549,279 (+)	NCBI		HuRef
CHM1_1	8	1,711,562 - 1,734,347 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	1,542,478 - 1,565,133 (+)	NCBI		T2T-CHM13v2.0

Cln8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	14,931,335 - 14,951,720 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	14,931,335 - 14,951,720 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	14,881,335 - 14,901,720 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	14,881,335 - 14,901,720 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	14,888,536 - 14,901,720 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	14,888,866 - 14,900,339 (+)	NCBI		MGSCv36	mm8
Celera	8	15,052,911 - 15,066,094 (+)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	7.59	NCBI

Cln8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	81,451,941 - 81,462,046 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	81,451,944 - 81,461,832 (-)	Ensembl				GRCr8
mRatBN7.2	16	74,749,662 - 74,759,553 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	74,749,662 - 74,759,774 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	80,026,976 - 80,036,939 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	83,480,545 - 83,490,508 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	78,729,989 - 78,739,875 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	16	81,395,312 - 81,405,193 (-)	NCBI		Dahl_SR_JrHsd
Lyon_Normotensive	16	82,757,373 - 82,767,293 (-)	NCBI		Lyon_Normotensive
Lyon_Hypertensive	16	83,258,356 - 83,268,276 (-)	NCBI		Lyon_Hypertensive
F344_StmMcwi	16	79,452,225 - 79,462,110 (-)	NCBI		F344_StmMcwi
Rnor_6.0	16	79,828,321 - 79,838,212 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	79,828,324 - 79,838,212 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	79,403,685 - 79,413,576 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	79,569,745 - 79,579,636 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	72,565,615 - 72,575,506 (-)	NCBI		Celera
RGSC_v3.1	16	79,570,012 - 79,579,901 (-)	NCBI
Cytogenetic Map	16	q12.5	NCBI

Cln8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	57,924,873 - 57,938,690 (-)	Ensembl
ChiLan1.0	NW_004955403	57,926,711 - 57,938,698 (-)	NCBI	ChiLan1.0	ChiLan1.0

CLN8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	16,476,734 - 16,495,742 (+)	NCBI		NHGRI_mPanPan1-v2
Mhudiblu_PPA_v0	8	5,587,875 - 5,606,883 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	1,658,644 - 1,677,624 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	1,658,694 - 1,700,754 (+)	Ensembl			panPan2	panpan1.1

Cln8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	980,126 - 1,002,741 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936615	985,634 - 1,003,172 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936615	993,092 - 999,976 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLN8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	33,288,301 - 33,304,631 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	33,282,524 - 33,325,598 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	37,752,783 - 37,782,093 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLN8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	1,424,402 - 1,445,505 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	1,433,953 - 1,445,021 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	43,311,682 - 43,332,398 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cln8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624861	968,219 - 977,467 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624861	960,643 - 977,292 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Cln8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	68,926,354 - 68,936,538 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in CLN8
428 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001012343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005640436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022414959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022414960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038447326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH014565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ875419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000368	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000025898 ⟹ ENSCAFP00000024048

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	37	30,867,479 - 30,884,895 (+)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033703 ⟹ ENSCAFP00845026384

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	37	30,894,473 - 30,912,781 (+)	Ensembl

RefSeq Acc Id:

NM_001012343 ⟹ NP_001012343

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	30,867,479 - 30,884,895 (+)	NCBI
Dog10K_Boxer_Tasha	37	31,632,530 - 31,649,934 (+)	NCBI
ROS_Cfam_1.0	37	30,894,437 - 30,911,848 (+)	NCBI
UMICH_Zoey_3.1	37	30,804,432 - 30,821,842 (+)	NCBI
UNSW_CanFamBas_1.0	37	30,743,370 - 30,760,756 (+)	NCBI
UU_Cfam_GSD_1.0	37	30,752,705 - 30,770,116 (+)	NCBI

Sequence:

show sequence

CCCGCCCCTCGGAACTGCGCATGTGCGGCCGCCTCTGCGGCCCGGTCGGACGGCGCCGGCGATT
GCAGACGGATACATGAAGGTCCGAGGGGCACCTGCACCGCCTCCGCTTCCTTGGACCGGCTGCC
GCGTGGGCCCAAAGCCCGGTGTTGGCCCTGGGACGCCGTTAACGTAATAAATTGAGGACAATGA
CTCCTATGAGCGATGGGGGGACATCAGAAAGCATCTTTGACCTCGACTACACGTCCTGGAAGAT
CCGCTCCACGCTGGCGGTGGCTGGCTTCGTCTTCTACCTGGGAGTCTTTGTGGTCTGCCACCAG
CTCTCGTCCTCCCTGAACGCCACCTACCGCTCTCTGGTGGCCAGAGAGAAGGTCTTCTGGAACC
TGGCGGCCACGCGCGCCGTCTTCGGCGTTCAGAGCACTGCTGCGGGCCTGTGGGCCTTGCTGGT
GGACCCCGTGCTGCACGCTGACAAGGCGCGCGGCCAGCAGAACTGGTGCTGGTTTCACATCGCA
ACGGCAACCGGATTCTTTTTTTTTGAGAACGTAGCAGTTCACCTGTCCAATGTGCTCTTCCGGA
CATTTGACTTGTTTTTGGCCATCCACCATCTCTTCGCCTTTCTGGGATTTCTTGGCTCCGTGGT
CAACCTCGGAGCCGGCCACTATCTGGCTATGAGCACGCTGCTTCTGGAGGCGAGCACTCCCTTC
ACCTGCATTTCCTGGATGCTCCTAAAGGCTGGCTGGTCCGAGTCTCTGTTTTGGAAGCTGAACC
AGTGGCTGATGATCCACATGTTCCACTGCCGCATGGTGCTGACCTACCACATGTGGTGGGTGTG
CTTCTGGCACTGGGACGGTCTGGTCAGCAGCCTGTACCTGCCACACCTGGCACTGTTCCTTGTC
GGGCTGGGCCTCCTCACGCTCGTCATCAATCCCTACTGGACCCATAAGAAGACGCAGCAGCTTC
TCAATCCGGTGGATTGGAACTTCGCGCAGCCGGCACCCAGAAGCAGCCGGCCGGCTGGGGCCAA
CGGTCAGGTGCCACAGAAGAAGGGCCAGTAGCCACCGGGAGCCTGGGACCGCAGAGCGCGGCGG
CCTGTGTGCGTGGGCTCCTGCAGGCGAGGCCCTGAGTGCTCTGTCCAGGATGGTCTCTAAGTCG
GACCGTGTCCTTCATGTGAATTTCTAAGTAGCCGCCAAGTGTTTCTCAAGCCTTGGTTTGCCTC
CGGGGGTTGGGGGGCGGGTCTTTGCCATCACAAGTCTGCTGTCCACTGTGCTTTGTTCCTGCAC
GCCTTAGCGTGTGGGGCCCTGAGGAGCACCACAGAGGGGATCCAGGGCAGACGCCAGGCCACCT
GCCGGGGAGGAGGGGAGCGCCCTGTCTGGGATGCTGTGGTGGCCGCCAGCCTGCTCTTTCCCGT
CACATGGTCAGCGTGTGGGGGAGCTTGTCCAGTCATGCTGTCCTTCCTCGTGGGGCAGAACTGC
CCCAAGCTACAAGGCGGTCCCATCCGTGCCCCCCTCGGAGTGTCCCGTGTGACGTGTGCAGCGC
CGTGTGCAGCAGTGCATCTGGTGGGGGCACATGCAGACAGCTAGGGGGACGCACGGCCCCGGAC
CGGACCCAGCCCGACCAGAGTGTTCGTGACGGCGAGGCCCGTGGGCTTCATGGGTCAGGGGACC
TGTGGGAAAACAAGAGGTGTGTGTTCATACGCTATGGCTCACTTGGCAAAATAA

hide sequence

RefSeq Acc Id:

XM_038447323 ⟹ XP_038303251

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	30,888,770 - 30,912,784 (+)	NCBI

RefSeq Acc Id:

XM_038447324 ⟹ XP_038303252

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	30,894,985 - 30,912,784 (+)	NCBI

RefSeq Acc Id:

XM_038447325 ⟹ XP_038303253

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	30,895,696 - 30,912,784 (+)	NCBI

RefSeq Acc Id:

XM_038447326 ⟹ XP_038303254

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	37	30,893,212 - 30,912,784 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001012343	(Get FASTA)	NCBI Sequence Viewer
	XP_038303251	(Get FASTA)	NCBI Sequence Viewer
	XP_038303252	(Get FASTA)	NCBI Sequence Viewer
	XP_038303253	(Get FASTA)	NCBI Sequence Viewer
	XP_038303254	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAW34405	(Get FASTA)	NCBI Sequence Viewer
	CAI44940	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000024048.3
	ENSCAFP00030025303.1
	ENSCAFP00040020187.1
	ENSCAFP00845026384
	ENSCAFP00845026384.1
GenBank Protein	Q5JZQ7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012343 ⟸ NM_001012343

- UniProtKB:

Q2VUD9 (UniProtKB/Swiss-Prot), Q5JZQ7 (UniProtKB/Swiss-Prot), A0A8C0R8J9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTPMSDGGTSESIFDLDYTSWKIRSTLAVAGFVFYLGVFVVCHQLSSSLNATYRSLVAREKVFW
NLAATRAVFGVQSTAAGLWALLVDPVLHADKARGQQNWCWFHIATATGFFFFENVAVHLSNVLF
RTFDLFLAIHHLFAFLGFLGSVVNLGAGHYLAMSTLLLEASTPFTCISWMLLKAGWSESLFWKL
NQWLMIHMFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLALFLVGLGLLTLVINPYWTHKKTQQ
LLNPVDWNFAQPAPRSSRPAGANGQVPQKKGQ

hide sequence

Ensembl Acc Id:

ENSCAFP00000024048 ⟸ ENSCAFT00000025898

RefSeq Acc Id:	XP_038303251 ⟸ XM_038447323
- Peptide Label:	isoform X1
- UniProtKB:	Q5JZQ7 (UniProtKB/Swiss-Prot), Q2VUD9 (UniProtKB/Swiss-Prot), A0A8C0R8J9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303254 ⟸ XM_038447326
- Peptide Label:	isoform X1
- UniProtKB:	Q5JZQ7 (UniProtKB/Swiss-Prot), Q2VUD9 (UniProtKB/Swiss-Prot), A0A8C0R8J9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303252 ⟸ XM_038447324
- Peptide Label:	isoform X1
- UniProtKB:	Q5JZQ7 (UniProtKB/Swiss-Prot), Q2VUD9 (UniProtKB/Swiss-Prot), A0A8C0R8J9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038303253 ⟸ XM_038447325
- Peptide Label:	isoform X1
- UniProtKB:	Q5JZQ7 (UniProtKB/Swiss-Prot), Q2VUD9 (UniProtKB/Swiss-Prot), A0A8C0R8J9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCAFP00845026384 ⟸ ENSCAFT00845033703

Protein Domains

TLC

Promoters

RGD ID:

13689170

Promoter ID:

EPDNEW_C7238

Type:

single initiation site

Name:

CLN8_1

Description:

Protein CLN8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C7239

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	30,866,737 - 30,866,797	EPDNEW

RGD ID:

13689171

Promoter ID:

EPDNEW_C7239

Type:

multiple initiation site

Name:

CLN8_2

Description:

Protein CLN8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_C7238

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	37	30,867,499 - 30,867,559	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000016330	Ensembl, UniProtKB/Swiss-Prot
	ENSCAFG00030015756	UniProtKB/Swiss-Prot
	ENSCAFG00040012616	UniProtKB/Swiss-Prot
	ENSCAFG00845019093	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSCAFT00000025898.5	UniProtKB/Swiss-Prot
	ENSCAFT00030029025.1	UniProtKB/Swiss-Prot
	ENSCAFT00040023273.1	UniProtKB/Swiss-Prot
	ENSCAFT00845033703	ENTREZGENE
	ENSCAFT00845033703.1	UniProtKB/Swiss-Prot
InterPro	TLC-dom	UniProtKB/Swiss-Prot
	TLCD	UniProtKB/Swiss-Prot
KEGG Report	cfa:488558	UniProtKB/Swiss-Prot
NCBI Gene	CLN8	ENTREZGENE
PANTHER	CT120 PROTEIN	UniProtKB/Swiss-Prot
	PROTEIN CLN8	UniProtKB/Swiss-Prot
Pfam	TRAM_LAG1_CLN8	UniProtKB/Swiss-Prot
PROSITE	TLC	UniProtKB/Swiss-Prot
SMART	TLC	UniProtKB/Swiss-Prot
UniProt	A0A8C0R8J9	ENTREZGENE
	CLN8_CANLF	UniProtKB/Swiss-Prot
	Q2VUD9	ENTREZGENE
	Q5JZQ7	ENTREZGENE
UniProt Secondary	Q2VUD9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	CLN8	CLN8 transmembrane ER and ERGIC protein		CLN8, transmembrane ER and ERGIC protein	Symbol and/or name change	5135510	APPROVED
2017-11-21	CLN8	CLN8, transmembrane ER and ERGIC protein	LOC106558305	translation initiation factor IF-2-like	Data merged from RGD:12274791	737654	PROVISIONAL
2017-03-21	CLN8	CLN8, transmembrane ER and ERGIC protein		ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM