| 1315094 | Usp1 | ubiquitin specific peptidase 1 | This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. D isruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014] | 4 | 98812047 | 98823780 | Mouse | 174 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1557542 | Usp17lc | ubiquitin specific peptidase 17-like C | Enables cysteine-type deubiquitinase activity. Involved in chordate embryonic development. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes i ncluding USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 103065903 | 103068381 | Mouse | 43 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1550376 | Wdr48 | WD repeat domain 48 | Predicted to enable DNA binding activity; deubiquitinase activator activity; and ubiquitin binding activity. Acts upstream of or within several processes, including double-strand break repair via homologous recombination; regulation of protein monoubiquitination; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in femur. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 119723961 | 119755652 | Mouse | 116 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1558121 | Usp10 | ubiquitin specific peptidase 10 | Predicted to enable several functions, including cysteine-type peptidase activity; p53 binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; monoubiquitinated protein deubiquitination; and negative regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosolic ribosome; early endosome; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human USP10 (ubiquitin specific peptidase 10). [provided by Alliance of Genome Resources, Apr 2025] | 8 | 120637099 | 120684299 | Mouse | 180 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1550499 | Usp11 | ubiquitin specific peptidase 11 | Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and transcription corepressor binding activity. Predicted to be involved in protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed i n brain; cortical plate; dorsal root ganglion; and spinal cord. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Jul 2025] | X | 20570148 | 20586778 | Mouse | 112 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317588 | Usp12 | ubiquitin specific peptidase 12 | Enables deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; gonad; metanephros; and retina layer. Orthologous to human USP1 e='font-weight:700;'>USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 146671619 | 146731817 | Mouse | 137 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1552359 | Usp13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | Predicted to enable several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Predicted to be involved in several processes, including protein K63-linked deubiquitination; protein stabilization; and regulation of catabolic process. Predicted to act upstream of or within protein K29-linked deubiquitination and protein K6-linked deubiquitination. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 32870432 | 32992224 | Mouse | 157 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323484 | Usp14 | ubiquitin specific peptidase 14 | Predicted to enable deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Acts upstream of or within chemical synaptic transmission. Located in synapse. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including ali mentary system; cardiovascular system; central nervous system; genitourinary system; and respiratory system. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 9993615 | 10030149 | Mouse | 235 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 733297 | Usp15 | ubiquitin specific peptidase 15 | The protein encoded by this gene is a member of the large ubiquitin specific protease (Usp) family of proteins. These proteins are known to cleave ubiquitin, and contain a conserved cysteine residue (Cys box) and two conserved histidine residues (His box) that are thought to form part of the active site of the protease. This protein has been shown to cleave both the ubiquitin-proline and the ubiquitin-methionine bonds in vitro. This protein is thought to regulate many cellular processes through its deubiquitination activity, including the transforming growth factor beta (TGF-beta) pathway. Cardiac-specific overexpression of the human ortholog of this gene in mice causes enlargement of the heart that is more pronounced in the atrium than in the ventricle. This gene has two pseudogenes on chromosome 14. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms.[provided by RefSeq, Aug 2014] | 10 | 122940911 | 123032924 | Mouse | 221 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1316237 | Usp16 | ubiquitin specific peptidase 16 | Enables histone H2A deubiquitinase activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; early embryo; genitourinary system; nervous sy stem; and sensory organ. Orthologous to human USP16 (ubiquitin specific peptidase 16). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 87251833 | 87280403 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551994 | Usp18 | ubiquitin specific peptidase 18 | Enables ISG15-specific peptidase activity. Involved in response to stilbenoid. Acts upstream of or within response to bacterium. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in axial skeleton; lung; and mandible. Ort hologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 121222865 | 121247876 | Mouse | 252 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1551608 | Usp19 | ubiquitin specific peptidase 19 | Enables K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of skeletal muscle tissue development; protein K48-linked deubiquitination; and protein stabilization. Locate d in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 108367806 | 108379536 | Mouse | 104 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1620124 | Usp17la | ubiquitin specific peptidase 17-like A | Enables cysteine-type deubiquitinase activity and lncRNA binding activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; exocrine gland; intestine; reproductive system; and thymus. Orthologous to several human genes including USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104506223 | 104511874 | Mouse | 43 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1615514 | Usp17lb | ubiquitin specific peptidase 17-like B | Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP1 7L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104489464 | 104491790 | Mouse | 29 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1614006 | Usp17ld | ubiquitin specific peptidase 17-like D | Enables cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to act upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be ac tive in cytosol and nucleus. Orthologous to several human genes including USP17L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 102899293 | 102901712 | Mouse | 39 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1621816 | Usp17le | ubiquitin specific peptidase 17-like E | Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP1 7L11 (ubiquitin specific peptidase 17 like family member 11); USP17L12 (ubiquitin specific peptidase 17 like family member 12); and USP17L15 (ubiquitin specific peptidase 17 like family member 15). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 104417168 | 104426677 | Mouse | 46 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 14701027 | Usp17lf | ubiquitin specific peptidase 17-like F | | | | | Mouse | | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding |
| 1619619 | Usp17le-ps | ubiquitin specific peptidase 17-like E, pseudogene | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine | 7 | 104296456 | 104302361 | Mouse | 1 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1615930 | Usp21 | ubiquitin specific peptidase 21 | Enables cysteine-type deubiquitinase activity and transcription coactivator activity. Involved in transcription initiation-coupled chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; primary oocyt e; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 171109523 | 171115534 | Mouse | 103 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1619991 | Ggnbp1 | gametogenetin binding protein 1 | Involved in mitochondrial fission. Located in Golgi apparatus; mitochondrial intermembrane space; and plasma membrane. Is expressed in ductus deferens; epididymis; jejunum; and testis. Orthologous to human GGNBP1 (gametogenetin binding protein 1 (pseudogene)). [provided by Alliance of Genome Resourc es, Jul 2025] | 17 | 27237009 | 27255352 | Mouse | 53 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |