| 735242 | Abi2 | abl interactor 2 | Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton orga nization; and regulation of dendritic spine morphogenesis. Acts upstream of or within camera-type eye development; generation of neurons; and learning or memory. Located in adherens junction and dendrite. Is active in dendritic spine; glutamatergic synapse; and postsynaptic actin cytoskeleton. Is expressed in several structures, including future brain; intestine smooth muscle circular layer; lens; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 60444927 | 60521104 | Mouse | 172 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1320118 | Arrdc2 | arrestin domain containing 2 | Predicted to be involved in protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bone; metanephros; and testis. Orthologous to human ARRDC2 (arrestin domain containing 2). [provided by Alliance of Genome Resources , Jul 2025] | 8 | 71287773 | 71293173 | Mouse | 121 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550271 | Arrdc3 | arrestin domain containing 3 | Predicted to enable beta-3 adrenergic receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Is expressed in central nervous system; liver; lung; olfactory epithelium; and retina nuclear layer. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 81031508 | 81044161 | Mouse | 243 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1323389 | Arrdc4 | arrestin domain containing 4 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Res ources, Jul 2025] | 7 | 68386742 | 68398986 | Mouse | 179 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1558009 | Asprv1 | aspartic peptidase, retroviral-like 1 | Enables aspartic-type endopeptidase activity. Involved in protein processing and skin development. Predicted to be located in membrane. Is expressed in anterior naris and external naris. Orthologous to human ASPRV1 (aspartic peptidase retroviral like 1). [provided by Alliance of Genome Resources, Ju l 2025] | 6 | 86605216 | 86606692 | Mouse | 82 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1552455 | Fas | Fas cell surface death receptor | Enables identical protein binding activity. Involved in circadian rhythm; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including activation-induced cell death of T cells ; cellular response to lithium ion; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 34267926 | 34305175 | Mouse | 2016 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1553064 | Fasl | Fas ligand | Predicted to enable cytokine activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane . Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 161608260 | 161616064 | Mouse | 886 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1318069 | Inf2 | inverted formin, FH2 and WH2 domain containing | Predicted to enable actin binding activity and small GTPase binding activity. Acts upstream of or within actin nucleation; gene expression; and regulation of cellular component size. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including adipose tis sue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 112555121 | 112581991 | Mouse | 144 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1312377 | Vps50 | VPS50 EARP/GARPII complex subunit | Predicted to enable SNARE binding activity. Acts upstream of or within endocytic recycling. Predicted to be located in membrane; perinuclear region of cytoplasm; and recycling endosome. Predicted to be part of EARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 3498393 | 3603531 | Mouse | 101 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
