| 732136 | TCP1 | t-complex 1 | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea ch containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010] | 6 | 159778498 | 159789602 | Human | 218 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1352326 | CCT2 | chaperonin containing TCP1 subunit 2 | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea ch containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] | 12 | 69585459 | 69601570 | Human | 221 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1342982 | CCT3 | chaperonin containing TCP1 subunit 3 | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea ch containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010] | 1 | 156308968 | 156338292 | Human | 186 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345648 | CCT4 | chaperonin containing TCP1 subunit 4 | The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008] | 2 | 61868085 | 61888671 | Human | 157 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1354396 | CCT5 | chaperonin containing TCP1 subunit 5 | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea ch containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015] | 5 | 10249921 | 10266412 | Human | 227 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315027 | CCT7 | chaperonin containing TCP1 subunit 7 | This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eigh t different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009] | 2 | 73234308 | 73253005 | Human | 169 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1313488 | CCT8 | chaperonin containing TCP1 subunit 8 | This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is loca ted on chromosome 1. [provided by RefSeq, Sep 2013] | 21 | 29056326 | 29073648 | Human | 159 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 1312394 | CCT6A | chaperonin containing TCP1 subunit 6A | The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea ch containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010] | 7 | 56051765 | 56063989 | Human | 164 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1345746 | CCT6B | chaperonin containing TCP1 subunit 6B | This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eigh t different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015] | 17 | 34927861 | 34961460 | Human | 52 | old_gene_name , name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1605278 | CCT8L2 | chaperonin containing TCP1 subunit 8 like 2 | Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 16590751 | 16592810 | Human | 27 | old_gene_name , name | gene, protein-coding, VALIDATED [RefSeq] |
| 3029011 | CCT3P1 | chaperonin containing TCP1 subunit 3 pseudogene 1 | | 8 | 16275677 | 16276277 | Human | | old_gene_name , name | gene, pseudo, INFERRED [RefSeq] |
| 2974874 | CCT4P1 | chaperonin containing TCP1 subunit 4 pseudogene 1 | | 7 | 140997744 | 140999788 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 3539547 | CCT4P2 | chaperonin containing TCP1 subunit 4 pseudogene 2 | | X | 65270912 | 65273021 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 2837779 | CCT5P1 | chaperonin containing TCP1 subunit 5 pseudogene 1 | | 5 | 115512050 | 115513921 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 3161437 | CCT5P2 | chaperonin containing TCP1 subunit 5 pseudogene 2 | | 13 | 78908899 | 78910728 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 1601895 | CCT6P1 | chaperonin containing TCP1 subunit 6 pseudogene 1 | INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide; aflatoxin B1 | 7 | 65751105 | 65763675 | Human | 8 | name | gene, pseudo, PROVISIONAL [RefSeq] |
| 2837780 | CCT6P2 | chaperonin containing TCP1 subunit 6 pseudogene 2 | | 5 | 14639212 | 14641078 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 2974960 | CCT6P3 | chaperonin containing TCP1 subunit 6 pseudogene 3 | INTERACTS WITH acrylamide; bisphenol A; methylmercury chloride | 7 | 65038354 | 65074713 | Human | 6 | name | gene, pseudo, VALIDATED [RefSeq] |
| 3028800 | CCT6P4 | chaperonin containing TCP1 subunit 6 pseudogene 4 | | 3 | 190714709 | 190717373 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 4144711 | CCT6P5 | chaperonin containing TCP1 subunit 6 pseudogene 5 | | 11 | 109637242 | 109638102 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 3322380 | CCT7P1 | chaperonin containing TCP1 subunit 7 pseudogene 1 | | 6 | 149879894 | 149881722 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 2301496 | CCT7P2 | chaperonin containing TCP1 subunit 7 pseudogene 2 | INTERACTS WITH beta-lapachone | 5 | 92889372 | 92890910 | Human | 1 | name | gene, pseudo, INFERRED [RefSeq] |
| 3539802 | CCT8P1 | chaperonin containing TCP1 subunit 8 pseudogene 1 | INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; crocidolite asbestos | 1 | 147203124 | 147204984 | Human | 4 | name | gene, pseudo, INFERRED [RefSeq] |
| 1605860 | CCT8L1P | chaperonin containing TCP1 subunit 8 like 1, pseudogene | Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of chaperonin-containing T-complex. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 152445217 | 152447276 | Human | 8 | name | gene, pseudo, INFERRED [RefSeq] |
| 38664650 | CCT5-2P | chaperonin containing TCP1, subunit 5 (epsilon) pseudogene 2 | | 13 | 78910722 | 78910831 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16560260 | AP003102.1 | chaperonin containing TCP1, subunit 6A (zeta 1) (CCT6A) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1323048 | TBCA | tubulin folding cofactor A | The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmatio n. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | 5 | 77691166 | 77776339 | Human | 77 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1351377 | TCP1P2 | t-complex 1 pseudogene 2 | | 5 | 41585767 | 41587918 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1351114 | TCP11 | t-complex 11 | Involved in germ cell development. Located in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 35118075 | 35141339 | Human | 50 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1343659 | TCP10L | t-complex 10 like | Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 21 | 32573721 | 32585523 | Human | 39 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348249 | TCP1P1 | t-complex 1 pseudogene 1 | | 7 | 42794772 | 42796859 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1354018 | TCP1P3 | t-complex 1 pseudogene 3 | | 12 | 19941254 | 19943109 | Human | | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1343977 | TCP10L2 | t-complex 10 like 2 (pseudogene) | INTERACTS WITH clothianidin; urethane; 2,3,7,8-tetrachlorodibenzodioxine (ortholog) | 6 | 167170619 | 167196751 | Human | 17 | symbol , COSMIC , Human Proteome Map | gene, pseudo, MODEL [RefSeq] |
| 1316655 | TCP10L3 | t-complex 10 like 3 (pseudogene) | INTERACTS WITH bis(2-ethylhexyl) phthalate; cyclosporin A; silicon dioxide | 6 | 167373090 | 167384510 | Human | 6 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, pseudo, VALIDATED [RefSeq] |
| 1602322 | TCP11L1 | t-complex 11 like 1 | Predicted to be involved in signal transduction. Located in microtubule. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 33039572 | 33073563 | Human | 72 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1605554 | TCP11L2 | t-complex 11 like 2 | Predicted to be involved in muscle cell migration and signal transduction. Predicted to be located in cytoskeleton. Predicted to be part of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 106297935 | 106347003 | Human | 123 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 7244041 | TCP11X1 | t-complex 11 family, X-linked 1 | Predicted to be involved in protein kinase A signaling and regulation of sperm capacitation. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025] | X | 102215301 | 102226795 | Human | 3 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 7243979 | TCP11X2 | t-complex 11 family, X-linked 2 | Predicted to be involved in protein kinase A signaling and regulation of sperm capacitation. Predicted to be active in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025] | X | 102460315 | 102471812 | Human | 15 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 10400279 | TCP11X3P | t-complex 11 family, X-linked 3, pseudogene | | X | 102173100 | 102185021 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 14995505 | CFAP298-TCP10L | CFAP298-TCP10L readthrough | This locus represents naturally occurring readthrough transcription between the neighboring chromosome 21 open reading frame 59 (C21orf59) and TCP10L (t-complex 10 like) genes on chromosome 21. Readthrough transcripts may encode a fusion protein that shares sequ ence identity with each individual gene product. [provided by RefSeq, Apr 2017] | 21 | 32563492 | 32612377 | Human | 3 | symbol , ensembl_gene_symbol , old_gene_name , COSMIC , name , description , ensembl_full_name , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 731671 | ILF3 | interleukin enhancer binding factor 3 | This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-ce ll expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014] | 19 | 10654346 | 10692400 | Human | 181 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1344828 | NXF2 | nuclear RNA export factor 2 | This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 20 13] | X | 102247167 | 102326722 | Human | 35 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1626558 | NXF2B | nuclear RNA export factor 2B | This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Jun 20 15] | X | 102360395 | 102440008 | Human | 46 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1354229 | ACAT2 | acetyl-CoA acetyltransferase 2 | The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] | 6 | 159762045 | 159779112 | Human | 329 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351314 | PFDN6 | prefoldin subunit 6 | PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980 ) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010] | 6 | 33289197 | 33290934 | Human | 81 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 16571783 | AL121935.3 | novel transcript, antisense to TCP10L2 | | | | | Human | | name | gene, lncrna |
| 1315861 | CFAP298 | cilia and flagella associated protein 298 | This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP1 '>TCP10L) gene. [provided by RefSeq, Apr 2017] | 21 | 32599354 | 32612377 | Human | 109 | description | gene, protein-coding, REVIEWED [RefSeq] |
