| 1323372 | PRC1 | protein regulator of cytokinesis 1 | This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mit otic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] | 15 | 90966040 | 90994535 | Human | 261 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 7245141 | PRC1-AS1 | PRC1 antisense RNA 1 | INTERACTS WITH all-trans-retinoic acid; cadmium atom; cadmium dichloride | 15 | 90966369 | 90988624 | Human | 4 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 407447809 | TBC1D3 | TBC1 domain family member 3 | Predicted to enable GTPase activator activity. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38181659 | 38192555 | Human | 19 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605183 | TBC1D3B | TBC1 domain family member 3B | This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokin e genes on chromosome 17q. [provided by RefSeq, Apr 2009] | 17 | 36165683 | 36176636 | Human | 14 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1605182 | TBC1D3C | TBC1 domain family member 3C | This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014] | 17 | 38057693 | 38070301 | Human | 14 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11568725 | TBC1D3D | TBC1 domain family member 3D | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38002322 | 38014908 | Human | 8 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 10059095 | TBC1D3E | TBC1 domain family member 3E | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 38124106 | 38138868 | Human | 17 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604121 | TBC1D3F | TBC1 domain family member 3F | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 36428612 | 36439521 | Human | 18 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1602782 | TBC1D3I | TBC1 domain family member 3I | Predicted to enable GTPase activator activity. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 36253639 | 36264604 | Human | 6 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1348038 | BMI1 | BMI1 proto-oncogene, polycomb ring finger | This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and se lf-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015] | 10 | 22321099 | 22331706 | Human | 251 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1348844 | CBX4 | chromobox 4 | Enables SUMO binding activity; SUMO ligase activity; and enzyme binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nuclear body. Part of PRC1 complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocel lular carcinoma. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 79833156 | 79839440 | Human | 190 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353483 | CBX7 | chromobox 7 | This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefS eq, Oct 2016] | 22 | 39130772 | 39152680 | Human | 179 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1351003 | CBX8 | chromobox 8 | Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2025] | 17 | 79792132 | 79797077 | Human | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2302260 | CDKN2B-AS1 | CDKN2B and CDKN2A antisense cis and trans regulatory RNA 1 | This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. T his region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] | 9 | 21994791 | 22128142 | Human | 19 | description | gene, ncrna, REVIEWED [RefSeq] |
| 1317513 | PHC3 | polyhomeotic homolog 3 | Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of PRC1 complex. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 170087584 | 170181733 | Human | 101 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353453 | SAMD11 | sterile alpha motif domain containing 11 | Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and retinal rod cell development. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025] | 1 | 923923 | 944574 | Human | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1318984 | SAMD7 | sterile alpha motif domain containing 7 | Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; chromatin binding activity; and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of gene expression, epigenetic; and retinal rod cell development. Predicted to be located in cytoplasm. Predicted to be part of PRC1 complex. Predicted to be active in nucleus. Implicated in macular degeneration. [provided by Alliance of Genome Resources, Jul 2025] | 3 | 169911572 | 169939175 | Human | 41 | description | gene, protein-coding, VALIDATED [RefSeq] |