| 1313299 | MDM2 | MDM2 proto-oncogene | This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detect ed in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] | 12 | 68808172 | 68850686 | Human | 974 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 16552663 | AC068044.1 | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) (MDM2) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1354048 | MTBP | MDM2 binding protein | This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012] | 8 | 120445419 | 120523636 | Human | 78 | old_gene_name , name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 38673075 | LOC100130841 | MDM2 oncogene, E3 ubiquitin protein ligase pseudogene | | 2 | 22188333 | 22188847 | Human | | name | gene, pseudo, INFERRED [RefSeq] |
| 16561576 | LOC124902995 | probable ribosome biogenesis protein RLP24 | | 12 | 98794485 | 98795010 | Human | | old_gene_name | gene, pseudo, MODEL [RefSeq] |
| 1319584 | MDM4 | MDM4 regulator of p53 | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011] | 1 | 204516406 | 204558120 | Human | 202 | old_gene_name , description | gene, protein-coding, REVIEWED [RefSeq] |
| 1312969 | TBRG1 | transforming growth factor beta regulator 1 | Involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 124622864 | 124635926 | Human | 88 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1605042 | NAA25 | N-alpha-acetyltransferase 25, NatB auxiliary subunit | This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010] | 12 | 112026689 | 112108783 | Human | 63 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731337 | USP2 | ubiquitin specific peptidase 2 | This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiqu itinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 11 | 119355215 | 119381690 | Human | 261 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 737039 | CDKN2A | cyclin dependent kinase inhibitor 2A | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript i ncludes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012] | 9 | 21967752 | 21995324 | Human | 1906 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1348962 | NUMB | NUMB endocytic adaptor protein | The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS 15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] | 14 | 73275216 | 73458546 | Human | 153 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1606702 | PYHIN1 | pyrin and HIN domain family member 1 | The protein encoded by this gene belongs to the HIN-200 family of interferon-inducible proteins that share a 200-amino acid signature motif at their C-termini. HIN200 proteins are primarily nuclear and are involved in transcriptional regulation of genes important for cell cycle control, differentiat ion, and apoptosis. Downregulation of this gene is associated with breast cancer. This protein acts as a tumor suppressor by promoting ubiquitination and subsequent degradation of MDM2, which leads to stabilization of p53/TP53. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] | 1 | 158931552 | 158990870 | Human | 55 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1349611 | RFWD3 | ring finger and WD repeat domain 3 | Enables MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Located in nucleoplasm and site of double-strand break. Implicated in Fanconi anemia complementation group W. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 74621399 | 74666877 | Human | 246 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1348223 | ZNF280B | zinc finger protein 280B | The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015] | 22 | 22484421 | 22509154 | Human | 84 | description | gene, protein-coding, REVIEWED [RefSeq] |
