| 620982 | Tspan2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN myelin sheath (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acryl amide | 2 | 192866212 | 192923489 | Rat | 108 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1344307 | TSPAN2 | tetraspanin 2 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] | 1 | 115048011 | 115089503 | Human | 110 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553173 | Tspan2 | tetraspanin 2 | Acts upstream of or within inflammatory response and nervous system development. Located in myelin sheath and plasma membrane. Is expressed in pituitary gland. Orthologous to human TSPAN2 (tetraspanin 2). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 102642086 | 102679626 | Mouse | 119 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8812521 | Tspan2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN myelin sheath (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog) | NW_004955435 | 18344320 | 18371248 | Chinchilla | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11874302 | TSPAN2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN membrane (inferred); myelin sheath (inferred); nucleoplasm (inferred) | 1 | 87472017 | 87511719 | Bonobo | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12132858 | TSPAN2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN myelin sheath (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog); INTERACTS WITH masitinib | 17 | 52692744 | 52749048 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12483386 | Tspan2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN membrane (inferred); myelin sheath (inferred); nucleoplasm (inferred) | NW_004936627 | 410280 | 438922 | Squirrel | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14157457 | TSPAN2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN membrane (inferred); myelin sheath (inferred); nucleoplasm (inferred) | | | | Pig | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18442716 | TSPAN2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN membrane (inferred); myelin sheath (inferred); nucleoplasm (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935663 | Tspan2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN myelin sheath (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237749 | tspan2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626015182 | Tspan2 | tetraspanin 2 | INVOLVED IN astrocyte development (ortholog); axon development (ortholog); inflammatory response (ortholog); ASSOCIATED WITH stroke (ortholog); FOUND IN myelin sheath (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog) | | | | Black Rat | 15 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155244454 | tspan2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250850 | tspan2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1611678 | Tspan2os | tetraspanin 2, opposite strand | INTERACTS WITH bisphenol A | 3 | 102627547 | 102642733 | Mouse | 4 | symbol , PhenoGen | gene, ncrna, PREDICTED [RefSeq] |
| 733300 | CD151 | CD151 molecule (Raph blood group) | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] | 11 | 832952 | 838831 | Human | 173 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 733301 | Cd151 | CD151 antigen | Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Ort hologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 141047275 | 141051394 | Mouse | 209 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 62327 | Cd37 | CD37 antigen | Acts upstream of or within several processes, including defense response to protozoan; negative regulation of leukocyte activation; and positive regulation of immunoglobulin production. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Is expressed in thymu s primordium. Orthologous to human CD37 (CD37 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 44883056 | 44888701 | Mouse | 106 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1346523 | CD37 | CD37 molecule | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] | 19 | 49335406 | 49340606 | Human | 103 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10313 | Cd53 | CD53 antigen | Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Involved in positive regulation of myoblast fusion. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymph oid system; and liver and biliary system. Orthologous to human CD53 (CD53 molecule). [provided by Alliance of Genome Resources, Apr 2025] | 3 | 106666177 | 106697465 | Mouse | 140 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 737207 | CD53 | CD53 molecule | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] | 1 | 110871210 | 110899922 | Human | 141 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731700 | CD81 | CD81 molecule | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] | 11 | 2376180 | 2397397 | Human | 257 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 731701 | Cd81 | CD81 antigen | Predicted to enable cholesterol binding activity; signaling receptor binding activity; and virus receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of receptor clustering; and syncytium formation by plasma membrane fusion. Acts ups tream of or within regulation of cell motility. Located in membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in common variable immunodeficiency 6. Orthologous to human CD81 (CD81 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 142606487 | 142621667 | Mouse | 299 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1604068 | CD82 | CD82 molecule | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. I ts expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 11 | 44564409 | 44620358 | Human | 150 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1617636 | Cd82 | CD82 antigen | Predicted to be located in phagocytic vesicle. Predicted to be active in plasma membrane. Is expressed in several structures, including choroid plexus; foregut; limb segment; meninges; and olfactory epithelium. Orthologous to human CD82 (CD82 molecule). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 93249447 | 93293295 | Mouse | 160 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732702 | CD9 | CD9 molecule | This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes i ncluding differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011] | 12 | 6199946 | 6238266 | Human | 314 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 732703 | Cd9 | CD9 antigen | Enables integrin binding activity. Involved in several processes, including fusion of sperm to egg plasma membrane involved in single fertilization; myoblast fusion involved in skeletal muscle regeneration; and paranodal junction assembly. Acts upstream of or within negative regulation of cell popul ation proliferation. Located in external side of plasma membrane and extracellular exosome. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in prostate adenocarcinoma. Orthologous to human CD9 (CD9 molecule). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 125437229 | 125471723 | Mouse | 326 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 735709 | PRPH2 | peripherin 2 | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. [provided by RefSeq, Jul 2008] | 6 | 42696598 | 42722597 | Human | 1237 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 735710 | Prph2 | peripherin 2 | Enables protein homodimerization activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; photoreceptor cell outer segment organization; and protein complex oligomerization. Located in photoreceptor outer segment. Is expressed in ey e; head; retina; and retina outer nuclear layer. Used to study partial central choroid dystrophy; patterned macular dystrophy 1; and retinitis pigmentosa 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 47221404 | 47235859 | Mouse | 255 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1314474 | ROM1 | retinal outer segment membrane protein 1 | This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphoge nesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008] | 11 | 62613257 | 62615116 | Human | 227 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1314475 | Rom1 | rod outer segment membrane protein 1 | Enables protein homodimerization activity. Acts upstream of or within several processes, including detection of light stimulus involved in visual perception; protein complex oligomerization; and retina development in camera-type eye. Located in photoreceptor outer segment membrane. Is expressed in p hotoreceptor layer; photoreceptor layer outer segment; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 7. Orthologous to human ROM1 (retinal outer segment membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 8904746 | 8906720 | Mouse | 92 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1320413 | UPK1A | uroplakin 1A | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] | 19 | 35666517 | 35678481 | Human | 96 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1620672 | Upk1a | uroplakin 1A | Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in heart ventricle; lower urinary tract; lung; and rectum. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Re sources, Jul 2025] | 7 | 30302517 | 30312159 | Mouse | 137 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317213 | UPK1B | uroplakin 1B | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] | 3 | 119173598 | 119205143 | Human | 71 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1623269 | Upk1b | uroplakin 1B | Acts upstream of or within response to bacterium. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in genitourinary system; mesothelium; pharyngo-tympanic tube; pharynx epithelium; and skin. Orthologous to human UPK1B (uroplakin 1B). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 38593544 | 38620565 | Mouse | 70 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
