Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of UPK1A mRNA] | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of UPK1A mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of UPK1A mRNA | CTD | PMID:19619570 | 17beta-estradiol | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of UPK1A mRNA and [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of UPK1A mRNA | CTD | PMID:26496021 and PMID:32741896 | 17beta-estradiol | increases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Estradiol results in increased expression of UPK1A mRNA | CTD | PMID:19619570 | 17beta-estradiol 3-benzoate | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of UPK1A mRNA | CTD | PMID:32741896 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of UPK1A mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UPK1A mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of UPK1A mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of UPK1A mRNA | CTD | PMID:21998131 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of UPK1A mRNA | CTD | PMID:19619570 | 2-hydroxypropanoic acid | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of UPK1A mRNA | CTD | PMID:30851411 | 4,4'-sulfonyldiphenol | decreases methylation | EXP | | 6480464 | bisphenol S results in decreased methylation of UPK1A promoter | CTD | PMID:33297965 | 5-aza-2'-deoxycytidine | affects expression | ISO | UPK1A (Homo sapiens) | 6480464 | Decitabine affects the expression of UPK1A mRNA | CTD | PMID:23300844 | antirheumatic drug | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Antirheumatic Agents results in decreased expression of UPK1A mRNA | CTD | PMID:24449571 | aristolochic acid A | increases expression | ISO | UPK1A (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of UPK1A mRNA | CTD | PMID:33212167 | arsane | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of UPK1A mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of UPK1A mRNA | CTD | PMID:32525701 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UPK1A mRNA and Benzo(a)pyrene promotes the reaction [AHR protein binds to UPK1A promoter] | CTD | PMID:19654925 and PMID:27858113 | benzo[a]pyrene | increases methylation | ISO | UPK1A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of UPK1A promoter | CTD | PMID:27901495 | benzo[b]fluoranthene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UPK1A mRNA | CTD | PMID:27858113 | Benzo[k]fluoranthene | decreases expression | EXP | | 6480464 | benzo(k)fluoranthene results in decreased expression of UPK1A mRNA | CTD | PMID:26377693 | bisphenol A | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with Estradiol] results in decreased expression of UPK1A mRNA | CTD | PMID:26496021 | bisphenol A | decreases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of UPK1A mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of UPK1A mRNA | CTD | PMID:25181051 | cantharidin | increases expression | EXP | | 6480464 | Cantharidin results in increased expression of UPK1A mRNA | CTD | PMID:36907384 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlordecone | increases expression | EXP | | 6480464 | Chlordecone results in increased expression of UPK1A mRNA | CTD | PMID:33711761 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of UPK1A mRNA | CTD | PMID:37019170 | chrysene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UPK1A mRNA | CTD | PMID:27858113 | cisplatin | affects expression | ISO | UPK1A (Homo sapiens) | 6480464 | Cisplatin affects the expression of UPK1A mRNA | CTD | PMID:23300844 | cisplatin | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of UPK1A mRNA | CTD | PMID:27392435 | cyclophosphamide | decreases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | Cyclophosphamide results in decreased expression of UPK1A mRNA | CTD | PMID:19654953 and PMID:20186394 | cyclophosphamide | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | Mesna inhibits the reaction [Cyclophosphamide results in decreased expression of UPK1A mRNA] | CTD | PMID:20186394 | dibenz[a,h]anthracene | decreases expression | EXP | | 6480464 | 1 more ... | CTD | PMID:26377693 | dimethylarsinic acid | decreases expression | EXP | | 6480464 | Cacodylic Acid results in decreased expression of UPK1A mRNA | CTD | PMID:32052077 | dimethylselenide | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of UPK1A-AS1 mRNA] which results in increased expression of UPK1A mRNA and [[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of UPK1A-AS1 mRNA] which results in increased expression of UPK1A mRNA | CTD | PMID:33656867 | dioxygen | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | 1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1 more ... | CTD | PMID:24403227 | dioxygen | increases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of UPK1A mRNA | CTD | PMID:24403227 | dorsomorphin | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethylparaben | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | ethyl-p-hydroxybenzoate results in decreased expression of UPK1A mRNA | CTD | PMID:37690743 | fipronil | decreases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | fipronil results in decreased expression of UPK1A mRNA | CTD | PMID:34044035 | folic acid | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of UPK1A mRNA] | CTD | PMID:22206623 | furan | increases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | furan results in increased expression of UPK1A mRNA | CTD | PMID:27387713 | gentamycin | increases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of UPK1A mRNA | CTD | PMID:33387578 | hydroxyl | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [[Hydroxyl Radical results in increased oxidation of dimethylselenide] which results in increased expression of UPK1A-AS1 mRNA] which results in increased expression of UPK1A mRNA | CTD | PMID:33656867 | mercury dibromide | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | mercuric bromide results in decreased expression of UPK1A mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPK1A mRNA | CTD | PMID:27188386 | Mesna | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | Mesna inhibits the reaction [Cyclophosphamide results in decreased expression of UPK1A mRNA] | CTD | PMID:20186394 | methylmercury chloride | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of UPK1A mRNA | CTD | PMID:28001369 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of UPK1A mRNA | CTD | PMID:27106289 | ozone | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [[Ozone results in increased oxidation of dimethylselenide] which results in increased expression of UPK1A-AS1 mRNA] which results in increased expression of UPK1A mRNA | CTD | PMID:33656867 | p-chloromercuribenzoic acid | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in decreased expression of UPK1A mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPK1A mRNA | CTD | PMID:27188386 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of UPK1A mRNA | CTD | PMID:17562736 | phenylmercury acetate | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of UPK1A mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UPK1A mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UPK1A mRNA | CTD | PMID:19710929 | progesterone | decreases expression | EXP | | 6480464 | Progesterone results in decreased expression of UPK1A mRNA | CTD | PMID:22238285 | rac-lactic acid | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of UPK1A mRNA | CTD | PMID:30851411 | resveratrol | increases expression | ISO | UPK1A (Homo sapiens) | 6480464 | resveratrol results in increased expression of UPK1A mRNA | CTD | PMID:25888808 | resveratrol | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of UPK1A mRNA | CTD | PMID:23557933 | SB 431542 | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of UPK1A mRNA | CTD | PMID:25895662 | sodium arsenate | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of UPK1A mRNA | CTD | PMID:32525701 | sotorasib | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UPK1A mRNA | CTD | PMID:36139627 | testosterone | multiple interactions | ISO | Upk1a (Rattus norvegicus) | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in decreased expression of UPK1A mRNA | CTD | PMID:32741896 | tetraphene | multiple interactions | EXP | | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of UPK1A mRNA | CTD | PMID:27858113 | titanium dioxide | decreases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | titanium dioxide results in decreased expression of UPK1A mRNA | CTD | PMID:30012374 | trametinib | multiple interactions | ISO | UPK1A (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of UPK1A mRNA | CTD | PMID:36139627 | trichloroethene | increases expression | ISO | Upk1a (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of UPK1A mRNA | CTD | PMID:33387578 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of UPK1A mRNA | CTD | PMID:33045310 | trovafloxacin | increases expression | EXP | | 6480464 | trovafloxacin results in increased expression of UPK1A mRNA | CTD | PMID:35537566 | urethane | decreases expression | ISO | UPK1A (Homo sapiens) | 6480464 | Urethane results in decreased expression of UPK1A mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | UPK1A (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of UPK1A gene | CTD | PMID:29154799 | |